LOCUS       NM_010114                855 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus kallikrein 1-related peptidase b22 (Klk1b22), mRNA.
ACCESSION   NM_010114
VERSION     NM_010114.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 855)
  AUTHORS   Arwood,M.L., Sun,I.H., Patel,C.H., Sun,I.M., Oh,M.H.,
            Bettencourt,I.A., Claiborne,M.D., Chan-Li,Y., Zhao,L.,
            Waickman,A.T., Mavrothalassitis,O., Wen,J., Aja,S. and Powell,J.D.
  TITLE     Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator
            of Systemic Metabolism
  JOURNAL   Immunohorizons 7 (6), 493-507 (2023)
   PUBMED   37358498
  REMARK    GeneRIF: Serendipitous Discovery of T Cell-Produced KLK1b22 as a
            Regulator of Systemic Metabolism.
REFERENCE   2  (bases 1 to 855)
  AUTHORS   Chen,J.Q., Mori,H., Cardiff,R.D., Trott,J.F., Hovey,R.C.,
            Hubbard,N.E., Engelberg,J.A., Tepper,C.G., Willis,B.J., Khan,I.H.,
            Ravindran,R.K., Chan,S.R., Schreiber,R.D. and Borowsky,A.D.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 855)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   4  (bases 1 to 855)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   5  (bases 1 to 855)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
REFERENCE   6  (bases 1 to 855)
  AUTHORS   Peters,J., Takahashi,S., Tada,M. and Miyake,Y.
  TITLE     mGK-6-derived true tissue kallikrein is synthesized, processed, and
            targeted through a regulated secretory pathway in mouse pituitary
            AtT-20 cells
  JOURNAL   J Biochem 111 (5), 643-648 (1992)
   PUBMED   1639762
REFERENCE   7  (bases 1 to 855)
  AUTHORS   Fahnestock,M., Woo,J.E., Lopez,G.A., Snow,J., Walz,D.A., Arici,M.J.
            and Mobley,W.C.
  TITLE     beta-NGF-endopeptidase: structure and activity of a kallikrein
            encoded by the gene mGK-22
  JOURNAL   Biochemistry 30 (14), 3443-3450 (1991)
   PUBMED   2012805
REFERENCE   8  (bases 1 to 855)
  AUTHORS   Drinkwater,C.C., Evans,B.A. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes: identification and
            characterization of the genes encoding the epidermal growth factor
            binding proteins
  JOURNAL   Biochemistry 26 (21), 6750-6756 (1987)
   PUBMED   3322387
REFERENCE   9  (bases 1 to 855)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
REFERENCE   10 (bases 1 to 855)
  AUTHORS   van Leeuwen,B.H., Evans,B.A., Tregear,G.W. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Identification, structure, and
            expression of the renal kallikrein gene
  JOURNAL   J Biol Chem 261 (12), 5529-5535 (1986)
   PUBMED   3007510
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124176.3.
            
            On Feb 23, 2016 this sequence version replaced NM_010114.1.
            
            Summary: This gene encodes the beta subunit of the 7S nerve growth
            factor (NGF) complex that is essential for the differentiation and
            survival of distinct populations of neurons in both the central and
            the peripheral nervous systems. The encoded preproprotein undergoes
            proteolytic processing to generate a functional, mature peptide.
            This gene is located in a cluster of several related kallikrein
            genes on chromosome 7. [provided by RefSeq, Feb 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106155.1, BF299893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC124176.3         47379-47453
            76-235              AC124176.3         49402-49561
            236-516             AC124176.3         50538-50818
            517-653             AC124176.3         50915-51051
            654-855             AC124176.3         51427-51628
FEATURES             Location/Qualifiers
     source          1..855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.61 cM"
     gene            1..855
                     /gene="Klk1b22"
                     /gene_synonym="EGF-BP A; Egfbp-1; Egfbp1; Klk22; mGk-22"
                     /note="kallikrein 1-related peptidase b22"
                     /db_xref="GeneID:13646"
                     /db_xref="MGI:MGI:95291"
     exon            1..75
                     /gene="Klk1b22"
                     /gene_synonym="EGF-BP A; Egfbp-1; Egfbp1; Klk22; mGk-22"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..809
                     /gene="Klk1b22"
                     /gene_synonym="EGF-BP A; Egfbp-1; Egfbp1; Klk22; mGk-22"
                     /EC_number="3.4.21.35"
                     /note="nerve growth factor beta chain endopeptidase;
                     tissue kallikrein 22; beta-NGF-endopeptidase; glandular
                     kallikrein K22; epidermal growth factor-binding protein
                     type A"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b22
                     preproprotein"
                     /protein_id="NP_034244.1"
                     /db_xref="CCDS:CCDS21196.1"
                     /db_xref="GeneID:13646"
                     /db_xref="MGI:MGI:95291"
                     /translation="MRFLILFLTLSLGGIDAAPPVQSRILGGFKCEKNSQPWQVAVYY
                     LDEYLCGGVLLDRNWVLTAAHCYEDKYNIWLGKNKLFQDEPSAQHRLVSKSFPHPDFN
                     MSLLQSVPTGADLSNDLMLLRLSKPADITDVVKPIDLPTTEPKLGSTCLASGWGSINQ
                     LIYQNPNDLQCVSIKLHPNEVCVKAHILKVTDVMLCAGEMNGGKDTCKGDSGGPLICD
                     GVLQGITSWGSTPCGEPNAPAIYTKLIKFTSWIKDTMAKNP"
     exon            76..235
                     /gene="Klk1b22"
                     /gene_synonym="EGF-BP A; Egfbp-1; Egfbp1; Klk22; mGk-22"
                     /inference="alignment:Splign:2.1.0"
     exon            236..516
                     /gene="Klk1b22"
                     /gene_synonym="EGF-BP A; Egfbp-1; Egfbp1; Klk22; mGk-22"
                     /inference="alignment:Splign:2.1.0"
     exon            517..653
                     /gene="Klk1b22"
                     /gene_synonym="EGF-BP A; Egfbp-1; Egfbp1; Klk22; mGk-22"
                     /inference="alignment:Splign:2.1.0"
     exon            654..855
                     /gene="Klk1b22"
                     /gene_synonym="EGF-BP A; Egfbp-1; Egfbp1; Klk22; mGk-22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      833..838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b22"
                     /gene_synonym="EGF-BP A; Egfbp-1; Egfbp1; Klk22; mGk-22"
                     /note="hexamer: AATAAA"
     polyA_site      855
                     /gene="Klk1b22"
                     /gene_synonym="EGF-BP A; Egfbp-1; Egfbp1; Klk22; mGk-22"
                     /note="major polyA site"
ORIGIN      
        1 cctcctgcag ctcctggaca cctgttacca tgaggttcct gatcctgttc ctaaccctgt
       61 ccctaggagg gattgatgct gcacctcctg tccagtctcg aatacttgga ggatttaaat
      121 gtgagaagaa ttcccaaccc tggcaggtgg ctgtgtacta cttagatgag tacctatgcg
      181 ggggagtcct gttggaccgc aactgggttc tcacagctgc ccactgctat gaagacaagt
      241 ataatatttg gctgggcaaa aacaagctat tccaagatga accctctgct cagcaccgat
      301 tggtcagcaa aagcttccct catcctgact tcaacatgag cctcctccaa agtgtaccta
      361 ctggggccga cttaagcaat gacctgatgc tgctccgcct cagcaagcct gctgacatca
      421 cagatgttgt gaagcccatc gacctgccca ctacggagcc caagctgggg agcacatgcc
      481 tagcctcagg ctggggcagc attaaccagt taatatacca aaacccaaat gatctccagt
      541 gtgtgtccat caagctccat cctaatgagg tctgtgtgaa agcccatata ctgaaggtga
      601 cagatgtcat gctgtgtgca ggagagatga atggaggcaa agacacttgt aagggagact
      661 caggaggccc actgatctgt gatggtgttc tacaaggtat cacatcatgg ggctctaccc
      721 catgtggtga acccaatgca ccggccatct acaccaaact tattaagttt acctcctgga
      781 taaaagacac tatggccaaa aacccctgag tgtcacatta tctgctgttc tcaataaaat
      841 ataccatgca acata
//
