LOCUS       NM_010642                868 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus kallikrein 1-related peptidase b21 (Klk1b21), mRNA.
ACCESSION   NM_010642
VERSION     NM_010642.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 868)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 868)
  AUTHORS   Isbel,L., Srivastava,R., Oey,H., Spurling,A., Daxinger,L.,
            Puthalakath,H. and Whitelaw,E.
  TITLE     Trim33 Binds and Silences a Class of Young Endogenous Retroviruses
            in the Mouse Testis; a Novel Component of the Arms Race between
            Retrotransposons and the Host Genome
  JOURNAL   PLoS Genet 11 (12), e1005693 (2015)
   PUBMED   26624618
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 868)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   4  (bases 1 to 868)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   5  (bases 1 to 868)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
REFERENCE   6  (bases 1 to 868)
  AUTHORS   Matsui,H. and Takahashi,T.
  TITLE     Mouse testicular Leydig cells express Klk21, a tissue kallikrein
            that cleaves fibronectin and IGF-binding protein-3
  JOURNAL   Endocrinology 142 (11), 4918-4929 (2001)
   PUBMED   11606460
REFERENCE   7  (bases 1 to 868)
  AUTHORS   Chan,C.S., Harvey,M.B. and Clements,J.A.
  TITLE     Temporal and tissue-specific expression of kallikrein (Klk) genes
            and identification of a novel Klk messenger ribonucleic acid
            transcript during early development in the mouse
  JOURNAL   Biol Reprod 61 (3), 621-628 (1999)
   PUBMED   10456837
REFERENCE   8  (bases 1 to 868)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
REFERENCE   9  (bases 1 to 868)
  AUTHORS   van Leeuwen,B.H., Evans,B.A., Tregear,G.W. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Identification, structure, and
            expression of the renal kallikrein gene
  JOURNAL   J Biol Chem 261 (12), 5529-5535 (1986)
   PUBMED   3007510
REFERENCE   10 (bases 1 to 868)
  AUTHORS   Mason,A.J., Evans,B.A., Cox,D.R., Shine,J. and Richards,R.I.
  TITLE     Structure of mouse kallikrein gene family suggests a role in
            specific processing of biologically active peptides
  JOURNAL   Nature 303 (5915), 300-307 (1983)
   PUBMED   6602295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151051.2 and AC124176.3.
            
            On Jun 4, 2021 this sequence version replaced NM_010642.3.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, Feb 2016].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144221.1, AB039276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC151051.2         192727-192808
            83-242              AC151051.2         194739-194898
            243-529             AC151051.2         195888-196174
            530-547             AC151051.2         196271-196288
            548-666             AC124176.3         40596-40714
            667-868             AC124176.3         41085-41286
FEATURES             Location/Qualifiers
     source          1..868
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.6 cM"
     gene            1..868
                     /gene="Klk1b21"
                     /gene_synonym="Klk21; mGk-21"
                     /note="kallikrein 1-related peptidase b21"
                     /db_xref="GeneID:16616"
                     /db_xref="MGI:MGI:892022"
     exon            1..82
                     /gene="Klk1b21"
                     /gene_synonym="Klk21; mGk-21"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..822
                     /gene="Klk1b21"
                     /gene_synonym="Klk21; mGk-21"
                     /EC_number="3.4.21.35"
                     /note="tissue kallikrein 21; glandular kallikrein K21"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b21
                     preproprotein"
                     /protein_id="NP_034772.1"
                     /db_xref="CCDS:CCDS21195.1"
                     /db_xref="GeneID:16616"
                     /db_xref="MGI:MGI:892022"
                     /translation="MRFLILFLALSLGEIDAAPPVQSRIVGGFNCEKNSQPWHVAVFR
                     YNKYICGGVLLNPNWVLTAAHCYGNQYNVWLGKNKLFQHESSAQHRLVSKSFPHPDYN
                     MSLMNDHTPHPEDDYSNDLMLLRLSKPADITDAVKPIDLPTEEPKLGSTCLASGWGSI
                     TPTKWQIPNDLQCGFIKPLPNENCAKAYIHKVTDVMLCAGEMGGGKDTCAGDSGGPLI
                     CDGVLQGITSWGSIPCAKPNAPAIYTKLIKFTSWIKDTMAKNP"
     exon            83..242
                     /gene="Klk1b21"
                     /gene_synonym="Klk21; mGk-21"
                     /inference="alignment:Splign:2.1.0"
     exon            243..529
                     /gene="Klk1b21"
                     /gene_synonym="Klk21; mGk-21"
                     /inference="alignment:Splign:2.1.0"
     exon            530..666
                     /gene="Klk1b21"
                     /gene_synonym="Klk21; mGk-21"
                     /inference="alignment:Splign:2.1.0"
     exon            667..868
                     /gene="Klk1b21"
                     /gene_synonym="Klk21; mGk-21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      846..851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b21"
                     /gene_synonym="Klk21; mGk-21"
                     /note="hexamer: AATAAA"
     polyA_site      868
                     /gene="Klk1b21"
                     /gene_synonym="Klk21; mGk-21"
                     /note="major polyA site"
ORIGIN      
        1 aagctcactg cctgcggaac ctggacacct gttaccatga ggttcctgat cctgttcctt
       61 gccctgtccc taggagagat tgatgctgca cctcctgtcc agtctcgaat tgttggagga
      121 tttaactgtg agaagaattc tcaaccctgg catgtggctg tgttccgcta caacaaatat
      181 atatgcgggg gagtcctgtt gaaccccaac tgggttctca cagctgccca ctgctatggc
      241 aaccagtata atgtttggct gggcaaaaac aagctattcc aacatgaatc ctctgctcag
      301 caccgattgg tcagcaaaag cttccctcac cctgactaca acatgagcct catgaatgac
      361 cacaccccac atcctgagga tgactacagc aatgacctga tgttactacg cctcagcaag
      421 cctgctgaca tcacagatgc tgtgaagccc atcgacctgc ccactgagga gcccaagctg
      481 gggagcacat gcctagcctc aggctggggc agcattacac ccacgaaatg gcaaatccca
      541 aatgatctcc agtgtgggtt catcaagccc ctgcctaatg aaaattgtgc caaagcctac
      601 atacataaag tcacagatgt catgctgtgt gcaggagaga tgggtggagg caaagacact
      661 tgtgcgggtg actcaggagg cccactgatc tgtgatggtg ttctacaagg tatcacatca
      721 tggggctcta tcccatgcgc taaacccaat gcgccggcca tctacaccaa acttattaag
      781 tttacctcct ggataaaaga cactatggcc aaaaacccct gaatgtcaca ttatctgctg
      841 ttctcaataa aatgcaccat gcaacaaa
//
