LOCUS       NM_008454                864 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus kallikrein 1-related peptidase b16 (Klk1b16), mRNA.
ACCESSION   NM_008454
VERSION     NM_008454.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 864)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   2  (bases 1 to 864)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   3  (bases 1 to 864)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
REFERENCE   4  (bases 1 to 864)
  AUTHORS   Drinkwater,C.C., Evans,B.A. and Richards,R.I.
  TITLE     Sequence and expression of mouse gamma-renin
  JOURNAL   J Biol Chem 263 (18), 8565-8568 (1988)
   PUBMED   3288617
REFERENCE   5  (bases 1 to 864)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
REFERENCE   6  (bases 1 to 864)
  AUTHORS   van Leeuwen,B.H., Evans,B.A., Tregear,G.W. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Identification, structure, and
            expression of the renal kallikrein gene
  JOURNAL   J Biol Chem 261 (12), 5529-5535 (1986)
   PUBMED   3007510
REFERENCE   7  (bases 1 to 864)
  AUTHORS   Mason,A.J., Evans,B.A., Cox,D.R., Shine,J. and Richards,R.I.
  TITLE     Structure of mouse kallikrein gene family suggests a role in
            specific processing of biologically active peptides
  JOURNAL   Nature 303 (5915), 300-307 (1983)
   PUBMED   6602295
REFERENCE   8  (bases 1 to 864)
  AUTHORS   Poe,M., Wu,J.K., Florance,J.R., Rodkey,J.A., Bennett,C.D. and
            Hoogsteen,K.
  TITLE     Purification and properties of renin and gamma-renin from the mouse
            submaxillary gland
  JOURNAL   J Biol Chem 258 (4), 2209-2216 (1983)
   PUBMED   6337154
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124176.3.
            
            On Feb 24, 2016 this sequence version replaced NM_008454.2.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, Feb 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG865287.1, BC012237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC124176.3         71996-72070
            76-235              AC124176.3         74097-74256
            236-522             AC124176.3         75220-75506
            523-659             AC124176.3         75602-75738
            660-864             AC124176.3         76112-76316
FEATURES             Location/Qualifiers
     source          1..864
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.64 cM"
     gene            1..864
                     /gene="Klk1b16"
                     /gene_synonym="Klk16; mGk-16"
                     /note="kallikrein 1-related peptidase b16"
                     /db_xref="GeneID:16615"
                     /db_xref="MGI:MGI:891982"
     exon            1..75
                     /gene="Klk1b16"
                     /gene_synonym="Klk16; mGk-16"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..815
                     /gene="Klk1b16"
                     /gene_synonym="Klk16; mGk-16"
                     /EC_number="3.4.21.54"
                     /note="gamma-renin, submandibular gland; glandular
                     kallikrein K16"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b16
                     preproprotein"
                     /protein_id="NP_032480.1"
                     /db_xref="CCDS:CCDS21197.1"
                     /db_xref="GeneID:16615"
                     /db_xref="MGI:MGI:891982"
                     /translation="MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWQVAVYY
                     HKEHICGGVLLDRNWVLTAAHCYVDECEVWLGKNQLFQEEPSAQNRLVSKSFPHPGFN
                     MTLLTFEKLPPGADFSNDLMLLRLSKPADITDVVKPIDLPTKEPKLDSTCLVSGWGSI
                     TPTKWQKPDDLQCMFTKLLPNENCAKAYLLKVTDVMLCTIEMGEDKGPCVGDSGGPLI
                     CDGVLQGTVSIGPDPCGIPGVSAIYTNLVKFNSWIKDTMMKNA"
     exon            76..235
                     /gene="Klk1b16"
                     /gene_synonym="Klk16; mGk-16"
                     /inference="alignment:Splign:2.1.0"
     exon            236..522
                     /gene="Klk1b16"
                     /gene_synonym="Klk16; mGk-16"
                     /inference="alignment:Splign:2.1.0"
     exon            523..659
                     /gene="Klk1b16"
                     /gene_synonym="Klk16; mGk-16"
                     /inference="alignment:Splign:2.1.0"
     exon            660..864
                     /gene="Klk1b16"
                     /gene_synonym="Klk16; mGk-16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      839..844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b16"
                     /gene_synonym="Klk16; mGk-16"
                     /note="hexamer: AATAAA"
     polyA_site      861
                     /gene="Klk1b16"
                     /gene_synonym="Klk16; mGk-16"
                     /note="major polyA site"
ORIGIN      
        1 ctccctgaag ctcctggaca cctgttacca tgtggttcct gatcctgttc ctagccctgt
       61 ccctaggagg gattgatgct gcacctcctg tccagtctcg aatagttgga ggatttaaat
      121 gtgagaagaa ttcccaaccc tggcaggtgg ctgtgtacta ccacaaggaa cacatttgcg
      181 ggggagtcct gttggaccgc aactgggttc tcacagctgc ccactgctat gtcgatgagt
      241 gtgaggtttg gctgggcaaa aaccagttat tccaagagga accctctgct caaaaccgat
      301 tggtcagcaa aagcttccct caccctggct tcaacatgac cctcctgacc tttgaaaagt
      361 tacctcctgg ggctgacttc agcaatgacc tgatgctgct ccgcctcagc aagcctgctg
      421 acatcacaga tgttgtgaag cccatcgacc tgcccacaaa ggagcccaag ctggatagca
      481 catgtctagt gtcaggctgg ggcagcatta cacccacaaa atggcaaaag ccagatgatc
      541 ttcagtgtat gttcaccaag ctcctgccca atgagaactg tgccaaagcc tacctactga
      601 aagtcacaga tgtcatgctg tgtacaatag agatgggtga agacaaaggc ccttgtgtgg
      661 gtgactcagg aggcccactg atttgtgatg gtgttctcca aggaaccgta tcaattggcc
      721 ctgacccatg cggtatacct ggtgtatcag ccatctacac caaccttgtt aagttcaact
      781 cctggataaa agatactatg atgaaaaatg cttgagtgtc acattgttcc atgttttcaa
      841 taaaacccaa catgaagcaa atga
//
