LOCUS       NM_010640                863 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus kallikrein 1-related peptidase b11 (Klk1b11), mRNA.
ACCESSION   NM_010640
VERSION     NM_010640.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 863)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   2  (bases 1 to 863)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
REFERENCE   3  (bases 1 to 863)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   4  (bases 1 to 863)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
REFERENCE   5  (bases 1 to 863)
  AUTHORS   Drinkwater,C.C. and Richards,R.I.
  TITLE     Sequence of mGK-11, a mouse glandular kallikrein gene
  JOURNAL   Nucleic Acids Res 16 (22), 10918 (1988)
   PUBMED   3205728
REFERENCE   6  (bases 1 to 863)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
REFERENCE   7  (bases 1 to 863)
  AUTHORS   van Leeuwen,B.H., Evans,B.A., Tregear,G.W. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Identification, structure, and
            expression of the renal kallikrein gene
  JOURNAL   J Biol Chem 261 (12), 5529-5535 (1986)
   PUBMED   3007510
REFERENCE   8  (bases 1 to 863)
  AUTHORS   Evans,B.A. and Richards,R.I.
  TITLE     Genes for the alpha and gamma subunits of mouse nerve growth factor
            are contiguous
  JOURNAL   EMBO J 4 (1), 133-138 (1985)
   PUBMED   3848399
REFERENCE   9  (bases 1 to 863)
  AUTHORS   Mason,A.J., Evans,B.A., Cox,D.R., Shine,J. and Richards,R.I.
  TITLE     Structure of mouse kallikrein gene family suggests a role in
            specific processing of biologically active peptides
  JOURNAL   Nature 303 (5915), 300-307 (1983)
   PUBMED   6602295
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC134858.6.
            
            On Feb 24, 2016 this sequence version replaced NM_010640.1.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, Feb 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013660.1, BG866802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC134858.6         185975-186048
            75-234              AC134858.6         187788-187947
            235-521             AC134858.6         188875-189161
            522-658             AC134858.6         189258-189394
            659-863             AC134858.6         189769-189973
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.48 cM"
     gene            1..863
                     /gene="Klk1b11"
                     /gene_synonym="Klk11; mGK-11"
                     /note="kallikrein 1-related peptidase b11"
                     /db_xref="GeneID:16613"
                     /db_xref="MGI:MGI:892023"
     exon            1..74
                     /gene="Klk1b11"
                     /gene_synonym="Klk11; mGK-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..814
                     /gene="Klk1b11"
                     /gene_synonym="Klk11; mGK-11"
                     /EC_number="3.4.21.35"
                     /note="tissue kallikrein-11; glandular kallikrein K11"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b11
                     preproprotein"
                     /protein_id="NP_034770.1"
                     /db_xref="CCDS:CCDS21192.1"
                     /db_xref="GeneID:16613"
                     /db_xref="MGI:MGI:892023"
                     /translation="MWFLILFLALSLGGIDAAPPVQSRIVGGFNCEKNSQPWHVAVYR
                     YNKYICGGVLLDRNWVLTAAHCHVSQYNVWLGKTKLFQREPSAQHRMVSKSFPHPDYN
                     MSLLIIHNPEPEDDESNDLMLLRLSEPADITDAVKPIALPTEEPKLGSTCLVSGWGSI
                     TPTKFQTPDDLQCVSIKLLPNEVCVKNHNQKVTDVMLCAGEMGGGKDTCKGDSGGPLI
                     CDGVLHGITAWGPIPCGKPNTPGVYTKLIKFTNWIKDTMAKNP"
     exon            75..234
                     /gene="Klk1b11"
                     /gene_synonym="Klk11; mGK-11"
                     /inference="alignment:Splign:2.1.0"
     exon            235..521
                     /gene="Klk1b11"
                     /gene_synonym="Klk11; mGK-11"
                     /inference="alignment:Splign:2.1.0"
     exon            522..658
                     /gene="Klk1b11"
                     /gene_synonym="Klk11; mGK-11"
                     /inference="alignment:Splign:2.1.0"
     exon            659..863
                     /gene="Klk1b11"
                     /gene_synonym="Klk11; mGK-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      843..848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b11"
                     /gene_synonym="Klk11; mGK-11"
                     /note="hexamer: AATACA"
     polyA_site      863
                     /gene="Klk1b11"
                     /gene_synonym="Klk11; mGK-11"
                     /note="major polyA site"
ORIGIN      
        1 ctcctgcagc tcctggacac ctgttaccat gtggttcctg atcctgttcc tagccctgtc
       61 cctaggaggg attgatgctg cacctcctgt ccagtctcga attgttggag gatttaactg
      121 tgagaagaat tcccaaccct ggcatgtggc tgtgtaccgc tacaacaaat atatatgcgg
      181 gggagtcctg ttggaccgta actgggttct cacagctgcc cactgccatg tcagccagta
      241 taatgtttgg ctgggcaaaa caaagctatt ccaacgtgaa ccctctgctc agcaccgaat
      301 ggtcagcaaa agcttccccc accctgacta caacatgagc ctcctcataa tccacaaccc
      361 agaacctgag gacgatgaga gcaatgacct gatgttacta cgcctcagcg agccagctga
      421 catcacagat gctgtgaagc ccatcgccct gcccactgag gagcccaagc tggggagcac
      481 atgcctagtc tcaggctggg gcagcattac acccacgaaa ttccaaaccc cagatgatct
      541 ccagtgtgtg tccatcaagc tcctgcctaa tgaggtctgt gtcaaaaacc acaatcaaaa
      601 ggtgacagat gtcatgttgt gtgcaggaga gatgggtgga ggcaaagata cttgcaaggg
      661 tgactcagga ggcccactga tctgtgatgg tgttctccat ggtatcacag catggggccc
      721 tatcccatgt ggcaaaccca atacgccggg agtctacaca aaacttatta agtttaccaa
      781 ctggataaaa gacactatgg caaaaaaccc ctgagtgtca cattatctgc tgttctcaat
      841 aaaatacacc atgaaacaaa tga
//
