LOCUS       NM_010645                867 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus kallikrein 1-related peptidase b1 (Klk1b1), mRNA.
ACCESSION   NM_010645
VERSION     NM_010645.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 867)
  AUTHORS   Desposito,D., Zadigue,G., Taveau,C., Adam,C., Alhenc-Gelas,F.,
            Bouby,N. and Roussel,R.
  TITLE     Neuroprotective effect of kinin B1 receptor activation in acute
            cerebral ischemia in diabetic mice
  JOURNAL   Sci Rep 7 (1), 9410 (2017)
   PUBMED   28842604
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 867)
  AUTHORS   Youcef,G., Belaidi,E., Waeckel,L., Fazal,L., Clemessy,M.,
            Vincent,M.P., Zadigue,G., Richer,C., Alhenc-Gelas,F., Ovize,M. and
            Pizard,A.
  TITLE     Tissue kallikrein is required for the cardioprotective effect of
            cyclosporin A in myocardial ischemia in the mouse
  JOURNAL   Biochem Pharmacol 94 (1), 22-29 (2015)
   PUBMED   25623731
REFERENCE   3  (bases 1 to 867)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   4  (bases 1 to 867)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   5  (bases 1 to 867)
  AUTHORS   Bergaya,S., Hilgers,R.H., Meneton,P., Dong,Y., Bloch-Faure,M.,
            Inagami,T., Alhenc-Gelas,F., Levy,B.I. and Boulanger,C.M.
  TITLE     Flow-dependent dilation mediated by endogenous kinins requires
            angiotensin AT2 receptors
  JOURNAL   Circ Res 94 (12), 1623-1629 (2004)
   PUBMED   15131008
REFERENCE   6  (bases 1 to 867)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
REFERENCE   7  (bases 1 to 867)
  AUTHORS   van Leeuwen,B.H., Evans,B.A., Tregear,G.W. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Identification, structure, and
            expression of the renal kallikrein gene
  JOURNAL   J Biol Chem 261 (12), 5529-5535 (1986)
   PUBMED   3007510
REFERENCE   8  (bases 1 to 867)
  AUTHORS   .
  TITLE     Abstracts of meeting presentations: Human gene mapping 7, Los
            Angeles Conference (1983), Seventh International Workshop on Human
            Gene Mapping
  JOURNAL   Cytogenet Cell Genet 37 (1-4), 399-616 (1984)
   PUBMED   6690234
REFERENCE   9  (bases 1 to 867)
  AUTHORS   Mason,A.J., Evans,B.A., Cox,D.R., Shine,J. and Richards,R.I.
  TITLE     Structure of mouse kallikrein gene family suggests a role in
            specific processing of biologically active peptides
  JOURNAL   Nature 303 (5915), 300-307 (1983)
   PUBMED   6602295
REFERENCE   10 (bases 1 to 867)
  AUTHORS   Richards,R.I., Catanzaro,D.F., Mason,A.J., Morris,B.J., Baxter,J.D.
            and Shine,J.
  TITLE     Mouse glandular kallikrein genes. Nucleotide sequence of cloned
            cDNA coding for a member of the kallikrein arginyl esteropeptidase
            group of serine proteases
  JOURNAL   J Biol Chem 257 (6), 2758-2761 (1982)
   PUBMED   6174512
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK089370.1 and AC134858.6.
            
            On Feb 23, 2016 this sequence version replaced NM_010645.2.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089370.1, BC026378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AK089370.1         2-166
            166-166             AC134858.6         159428-159428
            167-656             AK089370.1         168-657
            657-657             AC134858.6         160833-160833
            658-867             AK089370.1         659-868
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.44 cM"
     gene            1..867
                     /gene="Klk1b1"
                     /gene_synonym="Klk1; mGK-1; mK1"
                     /note="kallikrein 1-related peptidase b1"
                     /db_xref="GeneID:16623"
                     /db_xref="MGI:MGI:892019"
     exon            1..82
                     /gene="Klk1b1"
                     /gene_synonym="Klk1; mGK-1; mK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..822
                     /gene="Klk1b1"
                     /gene_synonym="Klk1; mGK-1; mK1"
                     /EC_number="3.4.21.35"
                     /note="glandular kallikrein K1"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b1 preproprotein"
                     /protein_id="NP_034775.1"
                     /db_xref="CCDS:CCDS21190.1"
                     /db_xref="GeneID:16623"
                     /db_xref="MGI:MGI:892019"
                     /translation="MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWHVAVYR
                     YKEYICGGVLLDANWVLTAAHCYYEKNNVWLGKNNLYQDEPSAQHRLVSKSFLHPCYN
                     MSLHRNRIQNPQDDYSYDLMLLRLSKPADITDVVKPIALPTEEPKLGSTCLASGWGSI
                     IPVKFQYAKDLQCVNLKLLPNEDCDKAYVQKVTDVMLCAGVKGGGKDTCKGDSGGPLI
                     CDGVLQGLTSWGYNPCGEPKKPGVYTKLIKFTSWIKDTLAQNP"
     exon            83..242
                     /gene="Klk1b1"
                     /gene_synonym="Klk1; mGK-1; mK1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..529
                     /gene="Klk1b1"
                     /gene_synonym="Klk1; mGK-1; mK1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..666
                     /gene="Klk1b1"
                     /gene_synonym="Klk1; mGK-1; mK1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..867
                     /gene="Klk1b1"
                     /gene_synonym="Klk1; mGK-1; mK1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagctcactg cctgctgctc ctgaacacct gttaccatgt ggttcctgat cctgttccta
       61 gccctgtccc taggagggat tgatgctgca cctcctgtcc agtctcgaat agttggagga
      121 tttaaatgtg agaagaactc ccagccctgg catgtggctg tgtaccgcta caaggaatat
      181 atatgcgggg gagtcctgtt ggatgccaac tgggttctca cagctgccca ctgctattat
      241 gaaaagaaca acgtttggct gggcaaaaac aacctatacc aagatgaacc ctctgctcag
      301 caccgattag tcagcaaaag cttccttcac ccttgctaca acatgagcct ccatcggaac
      361 cgcatccaaa atcctcagga cgactacagc tatgacctga tgctgctccg cctcagcaag
      421 cctgctgaca tcacagatgt tgtgaagccc atcgccctgc ccactgagga gcccaagctg
      481 gggagcacat gccttgcctc aggctggggc agcattatac ctgtcaagtt ccaatatgca
      541 aaagatctcc agtgtgtgaa cctcaagctc ctgcctaatg aggactgtga caaagcctat
      601 gtacagaaag tcacagatgt catgctgtgt gcaggagtga agggtggagg caaagacact
      661 tgtaagggag actcaggagg cccactgatc tgtgatggtg ttctccaagg tctcacatca
      721 tggggctata acccatgtgg tgaacccaaa aagccgggcg tctacaccaa acttattaag
      781 ttcacctcct ggatcaaaga cactttggcc caaaacccct gagtgacaca ctgtctgttc
      841 tcaataaaat ccaccatgca acaaatg
//
