LOCUS       NM_174865               1285 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kallikrein related-peptidase 15 (Klk15), mRNA.
ACCESSION   NM_174865 XM_006540952
VERSION     NM_174865.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1285)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1285)
  AUTHORS   Murakami,K., Tanaka,T., Bando,Y. and Yoshida,S.
  TITLE     Differences in Kallikrein-related peptidase mRNA sequences and KLK6
            enzyme activity between mouse strains
  JOURNAL   Protein Pept Lett 22 (3), 204-211 (2014)
   PUBMED   25666037
REFERENCE   3  (bases 1 to 1285)
  AUTHORS   Szabo,R., Hobson,J.P., Christoph,K., Kosa,P., List,K. and
            Bugge,T.H.
  TITLE     Regulation of cell surface protease matriptase by HAI2 is essential
            for placental development, neural tube closure and embryonic
            survival in mice
  JOURNAL   Development 136 (15), 2653-2663 (2009)
   PUBMED   19592578
REFERENCE   4  (bases 1 to 1285)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   5  (bases 1 to 1285)
  AUTHORS   Borgono,C.A., Michael,I.P. and Diamandis,E.P.
  TITLE     Human tissue kallikreins: physiologic roles and applications in
            cancer
  JOURNAL   Mol Cancer Res 2 (5), 257-280 (2004)
   PUBMED   15192120
  REMARK    Review article
REFERENCE   6  (bases 1 to 1285)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134858.6.
            
            On or before Jun 4, 2020 this sequence version replaced
            XM_006540952.3, NM_174865.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.2639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC134858.6         121773-121819
            48-115              AC134858.6         123841-123908
            116-266             AC134858.6         127503-127653
            267-550             AC134858.6         128439-128722
            551-687             AC134858.6         128843-128979
            688-1285            AC134858.6         129536-130133
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.41 cM"
     gene            1..1285
                     /gene="Klk15"
                     /note="kallikrein related-peptidase 15"
                     /db_xref="GeneID:317652"
                     /db_xref="MGI:MGI:2447533"
     exon            1..47
                     /gene="Klk15"
                     /inference="alignment:Splign:2.1.0"
     exon            48..115
                     /gene="Klk15"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..840
                     /gene="Klk15"
                     /note="kallikrein 15"
                     /codon_start=1
                     /product="kallikrein-15 precursor"
                     /protein_id="NP_777354.1"
                     /db_xref="CCDS:CCDS21187.1"
                     /db_xref="GeneID:317652"
                     /db_xref="MGI:MGI:2447533"
                     /translation="MWLLLAFVLLVSAAQDGDKVLEGEECVPHSQPWQVALFERGRFN
                     CGAFLISPRWVLTAAHCQTRFMRVRLGEHNLRKFDGPEQLRSVSRIIPHPGYEARTHR
                     HDIMLLRLFKPARLTAYVRPVALPRRCPLIGEDCVVSGWGLLSDNNPGATGSQKSHVR
                     LPDTLHCANISIISEASCNKDYPGRVLPTMVCAGVEGGGTDSCEGDSGGPLVCGGALQ
                     GIVSWGDVPCDTTTKPGVYTKVCSYLEWIWENVRRY"
     exon            116..266
                     /gene="Klk15"
                     /inference="alignment:Splign:2.1.0"
     exon            267..550
                     /gene="Klk15"
                     /inference="alignment:Splign:2.1.0"
     exon            551..687
                     /gene="Klk15"
                     /inference="alignment:Splign:2.1.0"
     exon            688..1285
                     /gene="Klk15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1265..1270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk15"
                     /note="hexamer: AATAAA"
     polyA_site      1285
                     /gene="Klk15"
ORIGIN      
        1 cttccggcat cccagctgcc ccgatgtcac tggaggaccc ggaggggatc tctaagaccc
       61 ggaccttctt ctgcaatgtg gcttctcctt gctttcgtct tgctggtgtc tgcagcgcag
      121 gatggcgaca aggtgctaga aggcgaggag tgtgtgcccc attcacagcc ctggcaagta
      181 gccctcttcg aacgtggccg gtttaattgt ggcgctttcc tcatctcacc acgctgggtg
      241 ttgactgccg cccactgcca aacccgcttc atgagagtgc gcctgggtga gcacaatctc
      301 cgcaagttcg atggtccaga gcaactgcgc tccgtctctc gcatcattcc acatccgggc
      361 tacgaggctc gcacccaccg ccatgacatt atgctgttgc gacttttcaa acctgcccgg
      421 ctgacagcct acgtgcgtcc tgtggcgctg cccagacgtt gccctcttat cggtgaggac
      481 tgcgtggtgt caggctgggg tctgttatca gacaacaacc ctggagccac agggagccag
      541 aagtcacacg tgagactccc tgatacgttg cattgtgcca acatcagcat tatctctgaa
      601 gcatcttgca acaaggacta cccgggtcga gtgttgccca ccatggtgtg tgccggcgtc
      661 gaaggcggtg gcacggactc ctgtgagggt gactccggag gacccttggt ctgtgggggt
      721 gccctgcagg gcattgtctc ctggggcgat gtcccctgtg atactaccac caagcctggc
      781 gtctacacaa aagtctgcag ctacttggag tggatctggg aaaatgtgag aaggtactga
      841 ctcattggcc caccacctac gaccctcatg gaccacctgg gactctgacc aagaatcccc
      901 cgtagctggc cagcagcacc attcctgcct gagacagagc cgagaccctc tgcatatcaa
      961 tatttgctgt tagccagggc ctcttccctc ctgatgtcac ctgtttagaa gaaaacagtt
     1021 ttggtagggt ggcagtggtg gctgcggagg gtctttgatc ccagcactca ggaatcagag
     1081 gcaggtagat ctctgacttt gaggccagct tgtactacaa aatgtgttcc aggatagcca
     1141 gggctacaca gtgaaacctt ctctttaaaa aaagaaaaag aaaagaaaat agtgttgatc
     1201 catagtgttg atccaacttt ctctgtaagg gtgtgacttt ctttctttag gtattgttgt
     1261 ggtaaataaa atttgggggt ttcaa
//
