LOCUS       NM_174866               1533 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus kallikrein related-peptidase 14 (Klk14), mRNA.
ACCESSION   NM_174866 XM_001001713
VERSION     NM_174866.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1533)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1533)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1533)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1533)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1533)
  AUTHORS   Murakami,K., Tanaka,T., Bando,Y. and Yoshida,S.
  TITLE     Differences in Kallikrein-related peptidase mRNA sequences and KLK6
            enzyme activity between mouse strains
  JOURNAL   Protein Pept Lett 22 (3), 204-211 (2014)
   PUBMED   25666037
REFERENCE   6  (bases 1 to 1533)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
REFERENCE   7  (bases 1 to 1533)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   8  (bases 1 to 1533)
  AUTHORS   Borgono,C.A., Michael,I.P. and Diamandis,E.P.
  TITLE     Human tissue kallikreins: physiologic roles and applications in
            cancer
  JOURNAL   Mol Cancer Res 2 (5), 257-280 (2004)
   PUBMED   15192120
  REMARK    Review article
REFERENCE   9  (bases 1 to 1533)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
REFERENCE   10 (bases 1 to 1533)
  AUTHORS   Hernandez,A., Fiering,S., Martinez,E., Galton,V.A. and St
            Germain,D.
  TITLE     The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is
            imprinted in the fetus and expresses antisense transcripts
  JOURNAL   Endocrinology 143 (11), 4483-4486 (2002)
   PUBMED   12399446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC151989.4.
            
            On Jan 25, 2023 this sequence version replaced NM_174866.3.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that have diverse physiological functions such as
            regulation of blood pressure and desquamation. The encoded protein
            is a precursor that undergoes proteolytic cleavage of the
            activation peptide to generate the functional enzyme. The encoded
            enzyme was found to activate the complement pathway by cleavage of
            C3 to release C3a anaphylotoxin. This gene is one of the several
            glandular kallikrein genes located in a cluster on chromosome 7.
            [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB981046.1, BC128019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC151989.4         127692-127994       c
            304-472             AC151989.4         126016-126184       c
            473-726             AC151989.4         123942-124195       c
            727-863             AC151989.4         123680-123816       c
            864-1533            AC151989.4         122614-123283       c
FEATURES             Location/Qualifiers
     source          1..1533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.26 cM"
     gene            1..1533
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /note="kallikrein related-peptidase 14"
                     /db_xref="GeneID:317653"
                     /db_xref="MGI:MGI:2447564"
     exon            1..303
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1016
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /note="kallikrein-14; glandular kallikrein KLK14"
                     /codon_start=1
                     /product="kallikrein-14 preproprotein"
                     /protein_id="NP_777355.1"
                     /db_xref="CCDS:CCDS21180.1"
                     /db_xref="GeneID:317653"
                     /db_xref="MGI:MGI:2447564"
                     /translation="MFLLLIILQALAVAIAQSQGDHKIIGGYRCVRNSQPWQVALQAG
                     PGHRFLCGGVLLSDQWVITAAHCARPILHVALGKHNIRRWEATQQVVRVARQVPHPQY
                     QPQAHDNDLMLLKLQKKVRLGRAVKTISVASSCASPGTPCRVSGWGTIASPIARYPTA
                     LQCVNVNIMSEQACHRAYPGIITSGMVCAGVPEGGKDSCQGDSGGPLVCGGQLQGLVS
                     WGMERCAMPGYPGVYANLCNYHSWIQRTMQSN"
     exon            304..472
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /inference="alignment:Splign:2.1.0"
     exon            473..726
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /inference="alignment:Splign:2.1.0"
     exon            727..863
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1533
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1507..1512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /note="hexamer: AATAAA"
     regulatory      1513..1518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /note="hexamer: AATGAA"
     polyA_site      1528
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /note="major polyA site"
     polyA_site      1533
                     /gene="Klk14"
                     /gene_synonym="GK14"
                     /note="major polyA site"
ORIGIN      
        1 gacaccaccc ctccctcttt caagcttgca aggagccaaa gtgactggat cctggtaggc
       61 atcttttctt cacagtctgg gggagcctgt gacccccacc ctctccaact ctgccatcta
      121 cacctctgtt ctgattccat gtcactgggg gtctaggcct cagtgtgagt ggtactcact
      181 gcccctgagt cttttttctg ccttggattc ccccccttcc acttgctctc tgcatttgtt
      241 agacttggac ctccagttcc agaatgttcc ttctactgat catactccaa gccttggctg
      301 tagccatagc ccagagccaa ggagatcata aaattattgg tggctacaga tgtgtccgga
      361 actcccagcc atggcaggtc gctctgcaag cagggcctgg gcatcgcttc ctgtgtggag
      421 gagtcctgtt gtcagatcaa tgggtcatca ctgctgctca ttgtgcccgc ccgattcttc
      481 atgtagccct gggcaagcac aacataagaa ggtgggaagc gactcagcag gtggtgcgtg
      541 tggcccgcca ggtgccacat ccccagtatc aaccccaggc ccacgataat gacctcatgc
      601 tgctgaagct gcagaaaaag gtgcggctgg gacgagcagt gaagaccatc tctgtggcca
      661 gctcctgtgc cagcccaggg actccctgcc gagtgtcggg ctggggaacc atagccagtc
      721 ccattgccag gtaccccact gctctgcagt gtgtgaatgt caacatcatg tcggagcagg
      781 catgccatcg agcctaccct ggaatcataa catctggcat ggtctgtgct ggggtccccg
      841 aaggcgggaa ggactcctgt cagggtgatt ctgggggacc cctggtgtgt gggggacagc
      901 tccagggcct tgtgtcctgg ggaatggaac gttgtgctat gcctggctac ccaggagtct
      961 acgccaacct gtgcaattac cacagctgga tccagaggac aatgcaaagc aactgatcac
     1021 ccatcaccat ctgatcatcc ccagctgtct ctgtgctttc atggtctcct ccattagaca
     1081 tttgagtcct ccccaagaca cttgagtcct ccttagctct tcttcttctt cttcttcttc
     1141 ttcttcttct tcttcttctt cttcttcttc ttcttcttct tcttcttctt cttcttcttc
     1201 ttcttcttct tcttcttctc acttgagact ccagacccta gcctcttact tcaggcccag
     1261 gcccctgagg tccctggctc cttccctcag accagcttcc tccctcagac ccaatagctt
     1321 tgcctttatt ccaggctcca ccttccgtcc ccgtccccgg gtcttggctc tggaatctct
     1381 ctcacagctt gttgtcacag tttgagactc actgagccca gaggctggag tgcaaatgct
     1441 ctgcatcaat atcttcatcc aaagacgtct gcttccaaaa ctcttactgt ctctagaatc
     1501 caaataaata aaaatgaaaa tggagtcatc cca
//
