LOCUS       NM_001039042            1033 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kallikrein related-peptidase 13 (Klk13), mRNA.
ACCESSION   NM_001039042 XM_355892 XM_901299 XM_916973 XM_924593
VERSION     NM_001039042.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1033)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1033)
  AUTHORS   Murakami,K., Tanaka,T., Bando,Y. and Yoshida,S.
  TITLE     Differences in Kallikrein-related peptidase mRNA sequences and KLK6
            enzyme activity between mouse strains
  JOURNAL   Protein Pept Lett 22 (3), 204-211 (2014)
   PUBMED   25666037
REFERENCE   3  (bases 1 to 1033)
  AUTHORS   Yao,C., Karabasil,M.R., Purwanti,N., Li,X., Akamatsu,T.,
            Kanamori,N. and Hosoi,K.
  TITLE     Tissue kallikrein mK13 is a candidate processing enzyme for the
            precursor of interleukin-1beta in the submandibular gland of mice
  JOURNAL   J Biol Chem 281 (12), 7968-7976 (2006)
   PUBMED   16423834
  REMARK    GeneRIF: kallikrein mK13 is a plausible candidate for the
            processing enzyme for pro-IL-1beta in the submandibular gland of
            mice
REFERENCE   4  (bases 1 to 1033)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
REFERENCE   5  (bases 1 to 1033)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   6  (bases 1 to 1033)
  AUTHORS   Kikkawa,Y., Yamanaka,N., Tada,J., Kanamori,N., Tsumura,K. and
            Hosoi,K.
  TITLE     Prorenin processing and restricted endoproteolysis by mouse tissue
            kallikrein family enzymes (mK1, mK9, mK13, and mK22)
  JOURNAL   Biochim Biophys Acta 1382 (1), 55-64 (1998)
   PUBMED   9507064
REFERENCE   7  (bases 1 to 1033)
  AUTHORS   Kim,W.S., Nakayama,K. and Murakami,K.
  TITLE     The presence of two types of prorenin converting enzymes in the
            mouse submandibular gland
  JOURNAL   FEBS Lett 293 (1-2), 142-144 (1991)
   PUBMED   1959648
REFERENCE   8  (bases 1 to 1033)
  AUTHORS   Kim,W.S., Nakayama,K., Nakagawa,T., Kawamura,Y., Haraguchi,K. and
            Murakami,K.
  TITLE     Mouse submandibular gland prorenin-converting enzyme is a member of
            glandular kallikrein family
  JOURNAL   J Biol Chem 266 (29), 19283-19287 (1991)
   PUBMED   1918045
REFERENCE   9  (bases 1 to 1033)
  AUTHORS   Drinkwater,C.C., Evans,B.A. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes: identification and
            characterization of the genes encoding the epidermal growth factor
            binding proteins
  JOURNAL   Biochemistry 26 (21), 6750-6756 (1987)
   PUBMED   3322387
REFERENCE   10 (bases 1 to 1033)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC063763.1.
            
            On Jul 26, 2006 this sequence version replaced NM_001039042.1.
            
            SUMMARY: Kallikreins are serine proteases encoded by a cluster of
            highly related genes on chromosome 7. When genomic sequence became
            available, it was possible to clarify the gene-to-sequence
            relationship for this family. Until January, 2006, NM_010115 was
            called kallikrein 13. After that time, NM_001039042 was called
            Klk13 and NM_010115 was called Klk1b26. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063763.1, AB981045.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               BC063763.1         1-285
            286-1033            BC063763.1         287-1034
FEATURES             Location/Qualifiers
     source          1..1033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.26 cM"
     gene            1..1033
                     /gene="Klk13"
                     /gene_synonym="Egfbp-2; mGk-13"
                     /note="kallikrein related-peptidase 13"
                     /db_xref="GeneID:626834"
                     /db_xref="MGI:MGI:3615275"
     exon            1..138
                     /gene="Klk13"
                     /gene_synonym="Egfbp-2; mGk-13"
                     /inference="alignment:Splign:2.1.0"
     exon            139..229
                     /gene="Klk13"
                     /gene_synonym="Egfbp-2; mGk-13"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1008
                     /gene="Klk13"
                     /gene_synonym="Egfbp-2; mGk-13"
                     /note="kallikrein 13"
                     /codon_start=1
                     /product="kallikrein-13 precursor"
                     /protein_id="NP_001034131.2"
                     /db_xref="CCDS:CCDS39933.1"
                     /db_xref="GeneID:626834"
                     /db_xref="MGI:MGI:3615275"
                     /translation="MWPLVATIACLTLALSEGISRDYPKILNGTNGTSGFLPGGYTCL
                     PHSQPWQAALLIRGRLLCGGVLVHPKWVLTAAHCRKDGYTVHLGKHALGRVENGEQAM
                     EVVRSIPHPEYQVTPTHLNHDHDIMLLELKSPVQLSSHVRTLKLSADDCLPTGTCCRV
                     SGWGTTTSPQVNYPKTLQCANIELRSDEECRQVYPGKITANMLCAGTKEGGKDSCEGD
                     SGGPLICNGKLYGIISWGDFPCGQPNRPGVYTRVSKYLRWIREIIRNTPEQRWTKGTQ
                     "
     exon            230..419
                     /gene="Klk13"
                     /gene_synonym="Egfbp-2; mGk-13"
                     /inference="alignment:Splign:2.1.0"
     exon            420..688
                     /gene="Klk13"
                     /gene_synonym="Egfbp-2; mGk-13"
                     /inference="alignment:Splign:2.1.0"
     exon            689..825
                     /gene="Klk13"
                     /gene_synonym="Egfbp-2; mGk-13"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1033
                     /gene="Klk13"
                     /gene_synonym="Egfbp-2; mGk-13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagactct tcctgacagg agcccagggg cacttgatac actcttaggc ctggcaccta
       61 tggtggcgtg tgtcttggga aagaggtgac gaacatatgt ggtcatcacc ttaaatttca
      121 gaagaaaaaa gactggaggc cccgcccacc ctgcccaccc cccatcccgg agctatcatg
      181 tggcccctag tggctaccat cgcttgcctg accttggcct tgtccgaagg aatctcccgg
      241 gactacccca agattctcaa tggtaccaat gggactagtg gttttctccc aggtggctac
      301 acctgccttc cccactctca gccttggcag gcagctctac tgatccgcgg acgacttctc
      361 tgtggagggg ttctggttca ccccaaatgg gtactcacag cggctcactg caggaaagat
      421 gggtacacag ttcatctggg caagcatgcc ctggggcgtg tggagaacgg tgagcaggca
      481 atggaggtgg tccgctctat cccccatcct gaataccagg tcacccccac ccacctgaac
      541 cacgaccatg acatcatgct tctggagctg aagtctccag tccagctcag cagccacgtc
      601 cgtaccctga aactctctgc agatgactgc ctgcccactg gcacctgctg ccgtgtttct
      661 ggctggggca ccaccaccag cccccaggtg aattatccca aaaccctgca gtgcgccaac
      721 attgaactgc gctcagatga ggagtgccgg caggtgtacc ctgggaagat cactgccaac
      781 atgctctgtg ctggtaccaa agaaggggga aaggactcct gtgagggtga ttctgggggc
      841 ccactgattt gcaatggcaa actctacggc atcatctcat ggggagattt tccatgtgga
      901 cagcccaacc gacctggcgt ttacacacga gtctcaaaat acctgcgttg gatccgggag
      961 atcatcagaa acactccaga gcagagatgg acaaagggca cacaataaaa ttgtgttcat
     1021 ttgcccgcct ccc
//
