LOCUS       NM_027097               1029 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kallikrein related-peptidase 12 (Klk12), transcript
            variant 2, mRNA.
ACCESSION   NM_027097 XM_893506 XM_914283
VERSION     NM_027097.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1029)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1029)
  AUTHORS   Murakami,K., Tanaka,T., Bando,Y. and Yoshida,S.
  TITLE     Differences in Kallikrein-related peptidase mRNA sequences and KLK6
            enzyme activity between mouse strains
  JOURNAL   Protein Pept Lett 22 (3), 204-211 (2014)
   PUBMED   25666037
REFERENCE   3  (bases 1 to 1029)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 1029)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
REFERENCE   5  (bases 1 to 1029)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   6  (bases 1 to 1029)
  AUTHORS   Borgono,C.A., Michael,I.P. and Diamandis,E.P.
  TITLE     Human tissue kallikreins: physiologic roles and applications in
            cancer
  JOURNAL   Mol Cancer Res 2 (5), 257-280 (2004)
   PUBMED   15192120
  REMARK    Review article
REFERENCE   7  (bases 1 to 1029)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151989.4.
            
            On Jan 4, 2023 this sequence version replaced NM_027097.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147463.1, AB981044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC151989.4         48915-49050         c
            137-296             AC151989.4         48341-48500         c
            297-553             AC151989.4         47058-47314         c
            554-687             AC151989.4         46039-46172         c
            688-1029            AC151989.4         44570-44911         c
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.26 cM"
     gene            1..1029
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /note="kallikrein related-peptidase 12"
                     /db_xref="GeneID:69511"
                     /db_xref="MGI:MGI:1916761"
     exon            1..136
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..843
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /note="kallikrein 12"
                     /codon_start=1
                     /product="kallikrein-12 precursor"
                     /protein_id="NP_081373.1"
                     /db_xref="CCDS:CCDS52226.1"
                     /db_xref="GeneID:69511"
                     /db_xref="MGI:MGI:1916761"
                     /translation="MRFSILLLLCAVGLSQADREKIYNGVECVKNSQPWQVGLFHGKY
                     LRCGGVLVDRKWVLTAAHCRDKYVVRLGEHSLTKLDWTEQLRHTTFSITHPSYQGAYQ
                     NHEHDLRLLRLNRPIHLTRAVRPVALPSSCVTTGAMCHVSGWGTTNKPWDPFPDRLQC
                     LNLSTVSNETCRAVFPGRVTENMLCAGGEAGKDACQGDSGGPLVCGGVLQGLVSWGSV
                     GPCGQKGIPGVYTKVCKYTDWIRIVIRNN"
     exon            137..296
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     exon            297..553
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     exon            554..687
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     exon            688..1029
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1010..1015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /note="hexamer: AATAAA"
     polyA_site      1029
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcaggg gacagagaaa agagggcagg ggtgagggca caggggagga tgagctcaga
       61 taccccatct ttcctggcag accctggagg gagcccacca tgaggttcag cattctcttg
      121 ctcctgtgtg ctgtgggtct cagtcaggca gacagggaga agatctataa tggtgtcgag
      181 tgtgtgaaga actcacagcc ttggcaggtg gggctgttcc atggcaaata cctgcgctgt
      241 ggcggtgtcc ttgtggaccg caagtgggtc cttacggctg ctcactgccg tgacaagtac
      301 gtggtgcgcc ttggggaaca cagcctcacc aagctggact ggacagaaca gttgagacac
      361 accaccttct ccataacaca ccccagctac cagggcgcct atcagaacca tgagcatgat
      421 cttcgactcc tgcggctgaa cagacccatc cacctgaccc gtgctgtccg gcccgtggcc
      481 ctgcccagtt cctgtgtaac tacaggggcc atgtgtcatg tctcaggatg gggtactaca
      541 aacaagccat gggacccatt cccagaccgg ctccagtgcc tcaacctctc cactgtctcc
      601 aatgagacgt gccgggctgt gtttcctgga agagtgacgg agaatatgtt gtgtgcaggt
      661 ggagaagccg ggaaggatgc ctgtcagggt gactctggag gccccctggt gtgtggaggg
      721 gttcttcaag gtctggtttc ctggggatct gttgggcctt gtggtcaaaa aggtattcca
      781 ggagtctaca cgaaggtctg caaatacacg gactggatca gaatagtcat caggaataac
      841 taagtgactc cctcagcctg catgcagctc tgcttaggga ccgctctgac cctcggagca
      901 ccaaggtctc ctccctcacc actccaggct cccacccttg tgagcttaga acctcttgaa
      961 acctcgacta cacccatggc agcggagagg cagctgtaca actgtctgga ataaaagtta
     1021 tacaaccaa
//
