LOCUS       NM_001415883            1085 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kallikrein related-peptidase 12 (Klk12), transcript
            variant 1, mRNA.
ACCESSION   NM_001415883 XM_006541174
VERSION     NM_001415883.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1085)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1085)
  AUTHORS   Murakami,K., Tanaka,T., Bando,Y. and Yoshida,S.
  TITLE     Differences in Kallikrein-related peptidase mRNA sequences and KLK6
            enzyme activity between mouse strains
  JOURNAL   Protein Pept Lett 22 (3), 204-211 (2014)
   PUBMED   25666037
REFERENCE   3  (bases 1 to 1085)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 1085)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
REFERENCE   5  (bases 1 to 1085)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   6  (bases 1 to 1085)
  AUTHORS   Borgono,C.A., Michael,I.P. and Diamandis,E.P.
  TITLE     Human tissue kallikreins: physiologic roles and applications in
            cancer
  JOURNAL   Mol Cancer Res 2 (5), 257-280 (2004)
   PUBMED   15192120
  REMARK    Review article
REFERENCE   7  (bases 1 to 1085)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151989.4.
            
            On Jan 4, 2023 this sequence version replaced XM_006541174.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995048.2277268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC151989.4         49093-49228         c
            137-192             AC151989.4         48915-48970         c
            193-352             AC151989.4         48341-48500         c
            353-609             AC151989.4         47058-47314         c
            610-743             AC151989.4         46039-46172         c
            744-1085            AC151989.4         44570-44911         c
FEATURES             Location/Qualifiers
     source          1..1085
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.26 cM"
     gene            1..1085
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /note="kallikrein related-peptidase 12"
                     /db_xref="GeneID:69511"
                     /db_xref="MGI:MGI:1916761"
     exon            1..136
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     exon            137..192
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..899
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /note="kallikrein 12"
                     /codon_start=1
                     /product="kallikrein-12 precursor"
                     /protein_id="NP_001402812.1"
                     /db_xref="GeneID:69511"
                     /db_xref="MGI:MGI:1916761"
                     /translation="MRFSILLLLCAVGLSQADREKIYNGVECVKNSQPWQVGLFHGKY
                     LRCGGVLVDRKWVLTAAHCRDKYVVRLGEHSLTKLDWTEQLRHTTFSITHPSYQGAYQ
                     NHEHDLRLLRLNRPIHLTRAVRPVALPSSCVTTGAMCHVSGWGTTNKPWDPFPDRLQC
                     LNLSTVSNETCRAVFPGRVTENMLCAGGEAGKDACQGDSGGPLVCGGVLQGLVSWGSV
                     GPCGQKGIPGVYTKVCKYTDWIRIVIRNN"
     exon            193..352
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     exon            353..609
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     exon            610..743
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1085
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1066..1071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /note="hexamer: AATAAA"
     polyA_site      1085
                     /gene="Klk12"
                     /gene_synonym="2310008B01Rik; KLK-L5"
                     /note="major polyA site"
ORIGIN      
        1 ggacagtaga agtgactctc aaggtggcca gcagatgaaa gggctggaag gtaggtgaac
       61 cgggagataa cagagagaga gagagacagc gagacaggct gaacaggtga taaaccattg
      121 aagacctggc aaacagaccc tggagggagc ccaccatgag gttcagcatt ctcttgctcc
      181 tgtgtgctgt gggtctcagt caggcagaca gggagaagat ctataatggt gtcgagtgtg
      241 tgaagaactc acagccttgg caggtggggc tgttccatgg caaatacctg cgctgtggcg
      301 gtgtccttgt ggaccgcaag tgggtcctta cggctgctca ctgccgtgac aagtacgtgg
      361 tgcgccttgg ggaacacagc ctcaccaagc tggactggac agaacagttg agacacacca
      421 ccttctccat aacacacccc agctaccagg gcgcctatca gaaccatgag catgatcttc
      481 gactcctgcg gctgaacaga cccatccacc tgacccgtgc tgtccggccc gtggccctgc
      541 ccagttcctg tgtaactaca ggggccatgt gtcatgtctc aggatggggt actacaaaca
      601 agccatggga cccattccca gaccggctcc agtgcctcaa cctctccact gtctccaatg
      661 agacgtgccg ggctgtgttt cctggaagag tgacggagaa tatgttgtgt gcaggtggag
      721 aagccgggaa ggatgcctgt cagggtgact ctggaggccc cctggtgtgt ggaggggttc
      781 ttcaaggtct ggtttcctgg ggatctgttg ggccttgtgg tcaaaaaggt attccaggag
      841 tctacacgaa ggtctgcaaa tacacggact ggatcagaat agtcatcagg aataactaag
      901 tgactccctc agcctgcatg cagctctgct tagggaccgc tctgaccctc ggagcaccaa
      961 ggtctcctcc ctcaccactc caggctccca cccttgtgag cttagaacct cttgaaacct
     1021 cgactacacc catggcagcg gagaggcagc tgtacaactg tctggaataa aagttataca
     1081 accaa
//
