LOCUS       NM_019974               1285 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kallikrein related-peptidase 11 (Klk11), transcript
            variant 2, mRNA.
ACCESSION   NM_019974
VERSION     NM_019974.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1285)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1285)
  AUTHORS   Gong,Z., Dai,S., Jiang,X., Lee,M., Zhu,X., Wang,H. and Lin,Z.
  TITLE     Variants in KLK11, affecting signal peptide cleavage of
            kallikrein-related peptidase 11, cause an autosomal-dominant
            cornification disorder
  JOURNAL   Br J Dermatol 188 (1), 100-111 (2023)
   PUBMED   36689511
  REMARK    GeneRIF: Variants in KLK11, affecting signal peptide cleavage of
            kallikrein-related peptidase 11, cause an autosomal-dominant
            cornification disorder.
REFERENCE   3  (bases 1 to 1285)
  AUTHORS   Wang,Y., Liao,H., Wang,Y., Zhou,J., Wang,F., Xie,Y., Zhao,K. and
            Gao,W.
  TITLE     KLK11 promotes the activation of mTOR and protein synthesis to
            facilitate cardiac hypertrophy
  JOURNAL   BMC Cardiovasc Disord 21 (1), 266 (2021)
   PUBMED   34059001
  REMARK    GeneRIF: KLK11 promotes the activation of mTOR and protein
            synthesis to facilitate cardiac hypertrophy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1285)
  AUTHORS   Nimpong,J.A., Gebregziabher,W., Singh,U.P., Nagarkatti,P.,
            Nagarkatti,M., Hodge,J., Liu,C., Fan,D. and Ai,W.
  TITLE     Deficiency of KLF4 compromises the lung function in an acute mouse
            model of allergic asthma
  JOURNAL   Biochem Biophys Res Commun 493 (1), 598-603 (2017)
   PUBMED   28867182
  REMARK    GeneRIF: Together, our results suggest that KLF4 regulates asthma
            development in a TSLP- and fibrocyte-dependent manner.
REFERENCE   5  (bases 1 to 1285)
  AUTHORS   Murakami,K., Tanaka,T., Bando,Y. and Yoshida,S.
  TITLE     Differences in Kallikrein-related peptidase mRNA sequences and KLK6
            enzyme activity between mouse strains
  JOURNAL   Protein Pept Lett 22 (3), 204-211 (2014)
   PUBMED   25666037
REFERENCE   6  (bases 1 to 1285)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   7  (bases 1 to 1285)
  AUTHORS   Borgono,C.A., Michael,I.P. and Diamandis,E.P.
  TITLE     Human tissue kallikreins: physiologic roles and applications in
            cancer
  JOURNAL   Mol Cancer Res 2 (5), 257-280 (2004)
   PUBMED   15192120
  REMARK    Review article
REFERENCE   8  (bases 1 to 1285)
  AUTHORS   Mitsui,S., Okui,A., Kominami,K., Uemura,H. and Yamaguchi,N.
  TITLE     cDNA cloning and tissue-specific splicing variants of mouse
            hippostasin/TLSP (PRSS20)
  JOURNAL   Biochim Biophys Acta 1494 (1-2), 206-210 (2000)
   PUBMED   11072088
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC151989.4 and AB016226.1.
            
            On Apr 7, 2010 this sequence version replaced NM_019974.1.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR and uses a downstream start codon, compared to
            variant 1. The resulting isoform (2) has a shorter N-terminus,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC151989.4         41660-41821         c
            163-1285            AB016226.1         47-1169
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.26 cM"
     gene            1..1285
                     /gene="Klk11"
                     /gene_synonym="2310015I08Rik; Prss20; TLSP"
                     /note="kallikrein related-peptidase 11"
                     /db_xref="GeneID:56538"
                     /db_xref="MGI:MGI:1929977"
     exon            1..226
                     /gene="Klk11"
                     /gene_synonym="2310015I08Rik; Prss20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..939
                     /gene="Klk11"
                     /gene_synonym="2310015I08Rik; Prss20; TLSP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     hippostasin; kallikrein-11; serine protease 20"
                     /codon_start=1
                     /product="kallikrein-11 isoform 2"
                     /protein_id="NP_064358.1"
                     /db_xref="CCDS:CCDS39935.1"
                     /db_xref="GeneID:56538"
                     /db_xref="MGI:MGI:1929977"
                     /translation="MILRLIALALVTGHVGGETRIIKGYECRPHSQPWQVALFQKTRL
                     LCGATLIAPKWLLTAAHCRKPHYVILLGEHNLEKTDGCEQRRMATESFPHPDFNNSLP
                     NKDHRNDIMLVKMSSPVFFTRAVQPLTLSPHCVAAGTSCLISGWGTTSSPQLRLPHSL
                     RCANVSIIEHKECEKAYPGNITDTMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISW
                     GQDPCAVTRKPGVYTKVCKYFNWIHEVMRNN"
     exon            227..383
                     /gene="Klk11"
                     /gene_synonym="2310015I08Rik; Prss20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     exon            384..649
                     /gene="Klk11"
                     /gene_synonym="2310015I08Rik; Prss20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     exon            650..786
                     /gene="Klk11"
                     /gene_synonym="2310015I08Rik; Prss20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1265
                     /gene="Klk11"
                     /gene_synonym="2310015I08Rik; Prss20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1242..1247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk11"
                     /gene_synonym="2310015I08Rik; Prss20; TLSP"
                     /note="hexamer: AATAAA"
     polyA_site      1265
                     /gene="Klk11"
                     /gene_synonym="2310015I08Rik; Prss20; TLSP"
                     /note="major polyA site"
ORIGIN      
        1 gattggtgtg agaaccagga ggttcccctg ggggaaggag gcaggtagtc agagaagcag
       61 agagacccaa caggtgaagg aaagaagaaa acccaaaagc cagcattctg atcgcctctt
      121 aaagtgatta gacctccctc cttgtcccca ggggaacctg gcgcccgccc tgccctactc
      181 caggccagga tgattctccg actcattgca cttgctctgg taacagggca cgtaggggga
      241 gagacgagga tcatcaaggg ttatgagtgc aggcctcact cacagccatg gcaggtggcc
      301 ctctttcaga agacacggct tctctgtggg gcaaccctca tcgcccccaa atggctcctg
      361 acagcagccc actgccgcaa gccccattac gtgatcctcc ttggagagca caatctagag
      421 aagacagacg gctgtgagca gaggcggatg gccactgagt ccttccccca ccccgacttc
      481 aacaacagcc tccccaacaa agaccaccgg aatgacataa tgcttgtgaa gatgtcgtct
      541 cccgtcttct ttacccgagc tgtgcagcca ctcaccctgt ccccacactg tgtcgctgca
      601 ggcaccagct gcctcatttc tggatggggc accacgtcca gcccccagtt gcgcctgcct
      661 cattccttgc gatgtgccaa tgtctccatc atcgaacaca aggagtgtga gaaggcctac
      721 ccgggcaaca tcacagacac catgctgtgc gccagtgttc ggaaagaggg caaggactcc
      781 tgtcagggtg actctggagg ccccctggtc tgcaacggat ctcttcaagg catcatctcc
      841 tggggtcagg acccatgtgc cgtcaccaga aagcctggtg tctatacaaa agtctgcaaa
      901 tactttaact ggatccacga ggttatgagg aacaattaga ggggacctgc ttcccaccac
      961 ccaacccctc caacctcttc ttaatgcttt gacttctctt cattctgccc taagaagtcc
     1021 tcagctggga ccctggcatg tactctctcc gacccaccat gagtatagta tagggatgct
     1081 ctaacttgat gatcgacctg gggcctggaa tcaaatcctg acttgaacta aattgtgact
     1141 ctggacatga tcaccactgg ttttgtttgt ttggttgttt tttgttttgt tttgttttgt
     1201 tcccagcttt gaagacagtc cctggcatat cccagggttt caataaatat ttgttaaatg
     1261 ataaaaaaaa aaaaaaaaaa aaaaa
//
