LOCUS       NM_133712               1354 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus kallikrein related-peptidase 10 (Klk10), mRNA.
ACCESSION   NM_133712
VERSION     NM_133712.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1354)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 1354)
  AUTHORS   Williams,D., Mahmoud,M., Liu,R., Andueza,A., Kumar,S., Kang,D.W.,
            Zhang,J., Tamargo,I., Villa-Roel,N., Baek,K.I., Lee,H., An,Y.,
            Zhang,L., Tate,E.W., Bagchi,P., Pohl,J., Mosnier,L.O.,
            Diamandis,E.P., Mihara,K., Hollenberg,M.D., Dai,Z. and Jo,H.
  TITLE     Stable flow-induced expression of KLK10 inhibits endothelial
            inflammation and atherosclerosis
  JOURNAL   Elife 11, e72579 (2022)
   PUBMED   35014606
  REMARK    GeneRIF: Stable flow-induced expression of KLK10 inhibits
            endothelial inflammation and atherosclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1354)
  AUTHORS   Cao,X.Y., Zhang,X.X., Yang,M.W., Hu,L.P., Jiang,S.H., Tian,G.A.,
            Zhu,L.L., Li,Q., Sun,Y.W. and Zhang,Z.G.
  TITLE     Aberrant upregulation of KLK10 promotes metastasis via enhancement
            of EMT and FAK/SRC/ERK axis in PDAC
  JOURNAL   Biochem Biophys Res Commun 499 (3), 584-593 (2018)
   PUBMED   29621546
  REMARK    GeneRIF: blockade of KLK10 attenuates epithelial-mesenchymal
            transition and activation of FAK-SRC-ERK signaling, which explains
            the mechanism of KLK10 in promoting metastasis.
            Erratum:[Biochem Biophys Res Commun. 2024 Feb 12;696:149426. doi:
            10.1016/j.bbrc.2023.149426. PMID: 38211371]
REFERENCE   4  (bases 1 to 1354)
  AUTHORS   Murakami,K., Tanaka,T., Bando,Y. and Yoshida,S.
  TITLE     Differences in Kallikrein-related peptidase mRNA sequences and KLK6
            enzyme activity between mouse strains
  JOURNAL   Protein Pept Lett 22 (3), 204-211 (2014)
   PUBMED   25666037
REFERENCE   5  (bases 1 to 1354)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
REFERENCE   6  (bases 1 to 1354)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   7  (bases 1 to 1354)
  AUTHORS   Borgono,C.A., Michael,I.P. and Diamandis,E.P.
  TITLE     Human tissue kallikreins: physiologic roles and applications in
            cancer
  JOURNAL   Mol Cancer Res 2 (5), 257-280 (2004)
   PUBMED   15192120
  REMARK    Review article
REFERENCE   8  (bases 1 to 1354)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC151989.4.
            
            On Nov 17, 2006 this sequence version replaced NM_133712.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002100.2, AK009000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC151989.4         37004-37096         c
            94-220              AC151989.4         36525-36651         c
            221-404             AC151989.4         35231-35414         c
            405-679             AC151989.4         34419-34693         c
            680-813             AC151989.4         33701-33834         c
            814-1354            AC151989.4         32740-33280         c
FEATURES             Location/Qualifiers
     source          1..1354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.26 cM"
     gene            1..1354
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /note="kallikrein related-peptidase 10"
                     /db_xref="GeneID:69540"
                     /db_xref="MGI:MGI:1916790"
     exon            1..93
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..220
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..966
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /EC_number="3.4.21.35"
                     /note="kallikrein 10"
                     /codon_start=1
                     /product="kallikrein-10 precursor"
                     /protein_id="NP_598473.1"
                     /db_xref="CCDS:CCDS39936.1"
                     /db_xref="GeneID:69540"
                     /db_xref="MGI:MGI:1916790"
                     /translation="MRVPLLHLSTASGSWSLVKLLLPLLMVQLWAAQALLLPGNATRV
                     DLEASGAQCERDYHPWQVSLFHNLQFQCAGVLVDQNWVLTAAHCWRNKPLRARVGDDH
                     LLLFQKEQLRSTSSPVFHPKYQACSGPILPHRSDEHDLMMLKLSSPVMLTSNVHPVQL
                     PFRCSQPGQECQVSGWGTSASRRVKYNRSLSCSKVTLLSQKQCETFYPGVITNSMICA
                     EADGNQDSCQSDSGGPLVCDDTLHGVLSWGIYPCGAAQHPSVYSEICKYTPWIRRVIR
                     FK"
     exon            221..404
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..679
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..813
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1354
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1334..1339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /note="hexamer: ATTAAA"
     polyA_site      1354
                     /gene="Klk10"
                     /gene_synonym="2300002A13Rik; NES1; PRSSL1"
                     /note="major polyA site"
ORIGIN      
        1 cccaggggtc cctggtcaga ggactgtttg cagcccacac tgcagggcaa gagccacttc
       61 tgagtctcct ttcttcttac tggcgactcc caggcctcca ctccagcctc tgcaagccaa
      121 gtatcagcta tgagggtccc gcttcttcac ctctccactg cctctggctc ctggtccctg
      181 gtgaagcttc tgctgccgct actgatggtg caactctggg cggcgcaggc tctgctgctc
      241 ccgggaaacg ccacgcgcgt ggacctcgag gcctccggcg cccagtgcga gcgtgactat
      301 catccctggc aggtctccct cttccataac ctccagttcc aatgtgcggg tgtcctggtg
      361 gaccagaact gggtgctcac ggccgcacat tgctggagaa ataagccact gagagctcga
      421 gttggcgatg accacttgct gcttttccag aaggagcaac tgcggtccac gagttcacct
      481 gttttccacc ccaagtatca ggcttgctca ggccccatcc tgccacatcg ctcagatgaa
      541 cacgacctca tgatgctgaa actgagcagt cctgtaatgc tgacgtccaa cgtgcatccc
      601 gtgcaactgc ccttccgctg ctctcagcca gggcaagagt gtcaggtctc aggctggggg
      661 acctcagcca gccgaagagt gaagtacaat aggagcctga gctgttccaa ggtaactctc
      721 cttagccaga agcagtgtga gaccttctac ccaggtgtga tcaccaacag catgatttgt
      781 gctgaggcag acggaaacca agactcttgc cagagtgact ccggtggccc cctggtgtgt
      841 gatgacaccc tgcatggcgt cctctcgtgg ggcatttacc catgtggtgc tgcccagcac
      901 ccatctgtct actcagagat ctgcaaatac accccctgga tccgaagagt cattcgtttc
      961 aaatgaccgt ctgcccctct cctcctctca tgcccaccca cccctcttcc ttcatccctt
     1021 gtccactcct gttctctgct cacaaatgca gaaaatggtg gctgagaaag ttctagtacc
     1081 ccaaggaagc tagcagtccc caagtctcta agaaaagtta cctgtcattc aacctctacc
     1141 tccctcctct gtgtgactgg gacaagcctg gtactctctc tgagccttgg tttccttgtc
     1201 tgtaaaatgg ggacaatgaa ttgtctacct cttacatatg ttgtatggag accatgatgg
     1261 aatatgtgtg tgtgtgtatg tgtgtgttta tggtcactga cacaggaaca tgaacaccat
     1321 ctggttatca ctgattaaac actaccaaat ctga
//
