LOCUS       NM_183390               2372 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus kelch-like 6 (Klhl6), transcript variant 1, mRNA.
ACCESSION   NM_183390 XM_986759
VERSION     NM_183390.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   Bertocci,B., Lecoeuche,D., Sterlin,D., Kuhn,J., Gaillard,B., De
            Smet,A., Lembo,F., Bole-Feysot,C., Cagnard,N., Fadeev,T., Dahan,A.,
            Weill,J.C. and Reynaud,C.A.
  TITLE     Klhl6 Deficiency Impairs Transitional B Cell Survival and
            Differentiation
  JOURNAL   J Immunol 199 (7), 2408-2420 (2017)
   PUBMED   28807996
  REMARK    GeneRIF: report that KLHL6, which is recurrently mutated in B cell
            lymphomas, is an off-target of the normal somatic hypermutation
            process taking place in germinal center (GC) B cells leaving open
            whether, despite the lack of impact of Klhl6 deficiency on GC B
            cell expansion, mutants could contribute to the oncogenic process
REFERENCE   2  (bases 1 to 2372)
  AUTHORS   Sharma,P.R., Mackey,A.J., Dejene,E.A., Ramadan,J.W.,
            Langefeld,C.D., Palmer,N.D., Taylor,K.D., Wagenknecht,L.E.,
            Watanabe,R.M., Rich,S.S. and Nunemaker,C.S.
  TITLE     An Islet-Targeted Genome-Wide Association Scan Identifies Novel
            Genes Implicated in Cytokine-Mediated Islet Stress in Type 2
            Diabetes
  JOURNAL   Endocrinology 156 (9), 3147-3156 (2015)
   PUBMED   26018251
  REMARK    GeneRIF: related to islet dysfunction during the development of
            type 2 diabetes
REFERENCE   3  (bases 1 to 2372)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 2372)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   5  (bases 1 to 2372)
  AUTHORS   Costello,I., Pimeisl,I.M., Drager,S., Bikoff,E.K., Robertson,E.J.
            and Arnold,S.J.
  TITLE     The T-box transcription factor Eomesodermin acts upstream of Mesp1
            to specify cardiac mesoderm during mouse gastrulation
  JOURNAL   Nat Cell Biol 13 (9), 1084-1091 (2011)
   PUBMED   21822279
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2372)
  AUTHORS   Kroll,J., Shi,X., Caprioli,A., Liu,H.H., Waskow,C., Lin,K.M.,
            Miyazaki,T., Rodewald,H.R. and Sato,T.N.
  TITLE     The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen
            receptor signaling and germinal center formation
  JOURNAL   Mol Cell Biol 25 (19), 8531-8540 (2005)
   PUBMED   16166635
REFERENCE   7  (bases 1 to 2372)
  AUTHORS   Gupta-Rossi,N., Storck,S., Griebel,P.J., Reynaud,C.A., Weill,J.C.
            and Dahan,A.
  TITLE     Specific over-expression of deltex and a new Kelch-like protein in
            human germinal center B cells
  JOURNAL   Mol Immunol 39 (13), 791-799 (2003)
   PUBMED   12617994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165282.2.
            
            On Mar 1, 2023 this sequence version replaced NM_183390.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100568.1, AY350736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AC165282.2         145461-145760
            301-466             AC165282.2         162378-162543
            467-916             AC165282.2         171124-171573
            917-1154            AC165282.2         174787-175024
            1155-1357           AC165282.2         178825-179027
            1358-1571           AC165282.2         180179-180392
            1572-2372           AC165282.2         181185-181985
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.32 cM"
     gene            1..2372
                     /gene="Klhl6"
                     /note="kelch-like 6"
                     /db_xref="GeneID:239743"
                     /db_xref="MGI:MGI:2686922"
     exon            1..300
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1873
                     /gene="Klhl6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kelch-like protein 6"
                     /codon_start=1
                     /product="kelch-like protein 6 isoform 1"
                     /protein_id="NP_899246.2"
                     /db_xref="CCDS:CCDS28041.2"
                     /db_xref="GeneID:239743"
                     /db_xref="MGI:MGI:2686922"
                     /translation="MAGQRGACTMSDVVERSLEGPLALTTDKSSQKRGDLVEILTGEK
                     VKFDDTRLSLILQNGLETLREENALTDVILCVDVQEFSCHRVVLAAASNYFRAMFCND
                     LKEKYEKRIIIKGVDAETMHTLLVYTYTSKALITKQNVQRVLEAANLFQFLQLVDACA
                     SFLTEALNPENCIGILRLADTHSLDSLKMQVQSYIIQNFVQILNSEEFLELPVDTLYH
                     ILRSDDLCVTEEAQVFETVMSWVRHKQSERLCLLPCVLENVRLPLLDPWYFVEMVEAD
                     PLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAE
                     VTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKY
                     NSSINKWIQIEYLNIGRWRHKMVVLGGKVYVLGGFDGLQRINNVETYDPFHNCWSEAA
                     PLHVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWVLKSAMPVEAKCIN
                     AVSFQDHIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNKLYITGGRDE
                     KNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRVVPGAVSV"
     exon            301..466
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            467..916
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1154
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1357
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1571
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..2372
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2348..2353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl6"
                     /note="hexamer: AATAAA"
     polyA_site      2372
                     /gene="Klhl6"
                     /note="major polyA site"
ORIGIN      
        1 agtctagacg ttgatggcag gacaaagagg cgcctgcacc atgagcgatg tggtagagag
       61 gagcttggaa ggacccttag cactgactac agacaagtcc tcccagaaaa ggggagactt
      121 ggtggaaata ttaactgggg agaaggtaaa atttgacgac acgagacttt ctttaattct
      181 tcagaacggc ctggagacgc tgagagagga aaatgctttg acagacgtca tcttgtgtgt
      241 ggatgttcag gaattctctt gccatcgagt ggtgcttgct gcagccagca actatttcag
      301 ggccatgttc tgcaacgact taaaagaaaa gtatgagaag aggatcatta ttaaaggggt
      361 ggatgctgag accatgcaca ctctcctggt ctacacatac acaagcaagg ctctgatcac
      421 caagcagaat gttcagcggg ttctggaggc tgccaacctt ttccagtttt tacagctggt
      481 ggatgcctgt gccagctttc tcacagaagc attgaacccg gaaaattgta ttggaatact
      541 gaggctggca gacacacatt ctttggacag tttaaagatg caagtccaaa gttacatcat
      601 tcaaaacttt gttcagattc tgaattccga ggagttcctt gaacttcctg tggacacttt
      661 gtaccacatc ttgaggagtg acgacctgtg tgtgactgaa gaggctcagg tgtttgagac
      721 tgtgatgagc tgggtccggc acaaacaatc agaacgactc tgcctgctcc cttgtgtcct
      781 cgagaatgtg cgtttaccac ttctggatcc gtggtacttc gtggagatgg ttgaagcaga
      841 ccctcttatt agacagtgcc ctgaagtctt cccgctgctt caggaagcca ggatgtacca
      901 cctttctggc aatgagatca tttcggagcg caccaagccc aggatgcatg agttccagtc
      961 tgaggtgttc atgattattg gcggctgtac aaaggatgaa cgatttgtgg cagaggtaac
     1021 ctgcctggac cccctgaggc gcagtcgcct ggaggtggcc aagctcccac tgacagagca
     1081 tgaactggag agtgagaata agaagtgggt ggagtttgca tgtgtgacat taaaaaatga
     1141 ggtctacata tcaggtggca aagaaacaca gcatgatgtt tggaagtaca attcctccat
     1201 caacaaatgg attcagatcg aatatttaaa cataggtcgc tggaggcata agatggtcgt
     1261 attgggtggc aaagtctatg tacttggggg ttttgatggc ttacaaagaa tcaacaatgt
     1321 ggagacatat gaccccttcc acaactgctg gtcagaggct gcacccctcc atgtccatgt
     1381 cagttctttt gcagctacca gccacaagaa gaagttgtat gtcattggag gaggacccaa
     1441 tggaaagctt gccacagaca agactcagtg ttatgatcct tccaccaata aatgggtttt
     1501 gaagtcagcc atgccagtag aggctaaatg catcaatgca gtgagtttcc aggatcacat
     1561 ctatgttgtt ggtggtgcca tgagagcact ctacgcttat agccctctgg aagacagctg
     1621 gtgtctggtg acacagctca gccatgagcg agccagctgt ggcatcgcac cctgcaacaa
     1681 caagctgtat atcacgggtg ggagggacga gaagaatgag gtcattgcca ctgtgctctg
     1741 ctgggaccct gaggctcaga agctgactga ggaatgtgtg ctgccacgag gagtatcaca
     1801 tcatggcagt gttaccatca ggaagtcata tactcacatc cggagggttg tccctggagc
     1861 agtgtctgtg tgactacccc tggagtctct gagcacctat accctagctt gcccacgtcg
     1921 ttccttgtga gccataggct tggcttgggc ttaaggttca tcatggggca cctaggaaga
     1981 caaagattgg gatatgtgag accagccagg aatgcttgtg tgaactacct caggatgaag
     2041 ggtaatgttt aacattccat acatgcctac tgtgccagac acttacccat tgtaatttac
     2101 ttaactatgg taatggcctg ctgccagata gcatcatgcc tgtcttagag gaagggaaaa
     2161 ggagtttcag acagaccagt tttcagtggg tctctcagga agcaagaagc taagccaaaa
     2221 taaatccagg tctttccacg ccagtcagtg tgtctcccac catactgcct aattcagaga
     2281 ggaaaacagg aagccaacca caaattcggc tggtgtctct gtctggcaag tttgctaaag
     2341 ataagggaat aaagatattt ctctgtgctg tc
//
