LOCUS       NM_001417212            2456 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus kelch-like 6 (Klhl6), transcript variant 2, mRNA.
ACCESSION   NM_001417212
VERSION     NM_001417212.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2456)
  AUTHORS   Bertocci,B., Lecoeuche,D., Sterlin,D., Kuhn,J., Gaillard,B., De
            Smet,A., Lembo,F., Bole-Feysot,C., Cagnard,N., Fadeev,T., Dahan,A.,
            Weill,J.C. and Reynaud,C.A.
  TITLE     Klhl6 Deficiency Impairs Transitional B Cell Survival and
            Differentiation
  JOURNAL   J Immunol 199 (7), 2408-2420 (2017)
   PUBMED   28807996
  REMARK    GeneRIF: report that KLHL6, which is recurrently mutated in B cell
            lymphomas, is an off-target of the normal somatic hypermutation
            process taking place in germinal center (GC) B cells leaving open
            whether, despite the lack of impact of Klhl6 deficiency on GC B
            cell expansion, mutants could contribute to the oncogenic process
REFERENCE   2  (bases 1 to 2456)
  AUTHORS   Sharma,P.R., Mackey,A.J., Dejene,E.A., Ramadan,J.W.,
            Langefeld,C.D., Palmer,N.D., Taylor,K.D., Wagenknecht,L.E.,
            Watanabe,R.M., Rich,S.S. and Nunemaker,C.S.
  TITLE     An Islet-Targeted Genome-Wide Association Scan Identifies Novel
            Genes Implicated in Cytokine-Mediated Islet Stress in Type 2
            Diabetes
  JOURNAL   Endocrinology 156 (9), 3147-3156 (2015)
   PUBMED   26018251
  REMARK    GeneRIF: related to islet dysfunction during the development of
            type 2 diabetes
REFERENCE   3  (bases 1 to 2456)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 2456)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   5  (bases 1 to 2456)
  AUTHORS   Costello,I., Pimeisl,I.M., Drager,S., Bikoff,E.K., Robertson,E.J.
            and Arnold,S.J.
  TITLE     The T-box transcription factor Eomesodermin acts upstream of Mesp1
            to specify cardiac mesoderm during mouse gastrulation
  JOURNAL   Nat Cell Biol 13 (9), 1084-1091 (2011)
   PUBMED   21822279
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2456)
  AUTHORS   Kroll,J., Shi,X., Caprioli,A., Liu,H.H., Waskow,C., Lin,K.M.,
            Miyazaki,T., Rodewald,H.R. and Sato,T.N.
  TITLE     The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen
            receptor signaling and germinal center formation
  JOURNAL   Mol Cell Biol 25 (19), 8531-8540 (2005)
   PUBMED   16166635
REFERENCE   7  (bases 1 to 2456)
  AUTHORS   Gupta-Rossi,N., Storck,S., Griebel,P.J., Reynaud,C.A., Weill,J.C.
            and Dahan,A.
  TITLE     Specific over-expression of deltex and a new Kelch-like protein in
            human germinal center B cells
  JOURNAL   Mol Immunol 39 (13), 791-799 (2003)
   PUBMED   12617994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165282.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861894.2100160.1,
                                           SRR13862101.908561.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164142
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AC165282.2         145461-145760
            301-384             AC165282.2         160628-160711
            385-550             AC165282.2         162378-162543
            551-1000            AC165282.2         171124-171573
            1001-1238           AC165282.2         174787-175024
            1239-1441           AC165282.2         178825-179027
            1442-1655           AC165282.2         180179-180392
            1656-2456           AC165282.2         181185-181985
FEATURES             Location/Qualifiers
     source          1..2456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.32 cM"
     gene            1..2456
                     /gene="Klhl6"
                     /note="kelch-like 6"
                     /db_xref="GeneID:239743"
                     /db_xref="MGI:MGI:2686922"
     exon            1..300
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1957
                     /gene="Klhl6"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kelch-like protein 6"
                     /codon_start=1
                     /product="kelch-like protein 6 isoform 2"
                     /protein_id="NP_001404141.1"
                     /db_xref="GeneID:239743"
                     /db_xref="MGI:MGI:2686922"
                     /translation="MAGQRGACTMSDVVERSLEGPLALTTDKSSQKRGDLVEILTGEK
                     VKFDDTRLSLILQNGLETLREENALTDVILCVDVQEFSCHRVVLAAASNYFRLQVRAL
                     SSTYSVSSVTGHHGDQNLSMHVAMFCNDLKEKYEKRIIIKGVDAETMHTLLVYTYTSK
                     ALITKQNVQRVLEAANLFQFLQLVDACASFLTEALNPENCIGILRLADTHSLDSLKMQ
                     VQSYIIQNFVQILNSEEFLELPVDTLYHILRSDDLCVTEEAQVFETVMSWVRHKQSER
                     LCLLPCVLENVRLPLLDPWYFVEMVEADPLIRQCPEVFPLLQEARMYHLSGNEIISER
                     TKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKK
                     WVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVY
                     VLGGFDGLQRINNVETYDPFHNCWSEAAPLHVHVSSFAATSHKKKLYVIGGGPNGKLA
                     TDKTQCYDPSTNKWVLKSAMPVEAKCINAVSFQDHIYVVGGAMRALYAYSPLEDSWCL
                     VTQLSHERASCGIAPCNNKLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSH
                     HGSVTIRKSYTHIRRVVPGAVSV"
     exon            301..384
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            385..550
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            551..1000
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1238
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1441
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1655
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..2456
                     /gene="Klhl6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl6"
                     /note="hexamer: AATAAA"
     polyA_site      2456
                     /gene="Klhl6"
                     /note="major polyA site"
ORIGIN      
        1 agtctagacg ttgatggcag gacaaagagg cgcctgcacc atgagcgatg tggtagagag
       61 gagcttggaa ggacccttag cactgactac agacaagtcc tcccagaaaa ggggagactt
      121 ggtggaaata ttaactgggg agaaggtaaa atttgacgac acgagacttt ctttaattct
      181 tcagaacggc ctggagacgc tgagagagga aaatgctttg acagacgtca tcttgtgtgt
      241 ggatgttcag gaattctctt gccatcgagt ggtgcttgct gcagccagca actatttcag
      301 gctccaggta agggccctaa gttctactta tagtgtctct tctgtgactg gccaccatgg
      361 agaccaaaat ttgtccatgc atgtggccat gttctgcaac gacttaaaag aaaagtatga
      421 gaagaggatc attattaaag gggtggatgc tgagaccatg cacactctcc tggtctacac
      481 atacacaagc aaggctctga tcaccaagca gaatgttcag cgggttctgg aggctgccaa
      541 ccttttccag tttttacagc tggtggatgc ctgtgccagc tttctcacag aagcattgaa
      601 cccggaaaat tgtattggaa tactgaggct ggcagacaca cattctttgg acagtttaaa
      661 gatgcaagtc caaagttaca tcattcaaaa ctttgttcag attctgaatt ccgaggagtt
      721 ccttgaactt cctgtggaca ctttgtacca catcttgagg agtgacgacc tgtgtgtgac
      781 tgaagaggct caggtgtttg agactgtgat gagctgggtc cggcacaaac aatcagaacg
      841 actctgcctg ctcccttgtg tcctcgagaa tgtgcgttta ccacttctgg atccgtggta
      901 cttcgtggag atggttgaag cagaccctct tattagacag tgccctgaag tcttcccgct
      961 gcttcaggaa gccaggatgt accacctttc tggcaatgag atcatttcgg agcgcaccaa
     1021 gcccaggatg catgagttcc agtctgaggt gttcatgatt attggcggct gtacaaagga
     1081 tgaacgattt gtggcagagg taacctgcct ggaccccctg aggcgcagtc gcctggaggt
     1141 ggccaagctc ccactgacag agcatgaact ggagagtgag aataagaagt gggtggagtt
     1201 tgcatgtgtg acattaaaaa atgaggtcta catatcaggt ggcaaagaaa cacagcatga
     1261 tgtttggaag tacaattcct ccatcaacaa atggattcag atcgaatatt taaacatagg
     1321 tcgctggagg cataagatgg tcgtattggg tggcaaagtc tatgtacttg ggggttttga
     1381 tggcttacaa agaatcaaca atgtggagac atatgacccc ttccacaact gctggtcaga
     1441 ggctgcaccc ctccatgtcc atgtcagttc ttttgcagct accagccaca agaagaagtt
     1501 gtatgtcatt ggaggaggac ccaatggaaa gcttgccaca gacaagactc agtgttatga
     1561 tccttccacc aataaatggg ttttgaagtc agccatgcca gtagaggcta aatgcatcaa
     1621 tgcagtgagt ttccaggatc acatctatgt tgttggtggt gccatgagag cactctacgc
     1681 ttatagccct ctggaagaca gctggtgtct ggtgacacag ctcagccatg agcgagccag
     1741 ctgtggcatc gcaccctgca acaacaagct gtatatcacg ggtgggaggg acgagaagaa
     1801 tgaggtcatt gccactgtgc tctgctggga ccctgaggct cagaagctga ctgaggaatg
     1861 tgtgctgcca cgaggagtat cacatcatgg cagtgttacc atcaggaagt catatactca
     1921 catccggagg gttgtccctg gagcagtgtc tgtgtgacta cccctggagt ctctgagcac
     1981 ctatacccta gcttgcccac gtcgttcctt gtgagccata ggcttggctt gggcttaagg
     2041 ttcatcatgg ggcacctagg aagacaaaga ttgggatatg tgagaccagc caggaatgct
     2101 tgtgtgaact acctcaggat gaagggtaat gtttaacatt ccatacatgc ctactgtgcc
     2161 agacacttac ccattgtaat ttacttaact atggtaatgg cctgctgcca gatagcatca
     2221 tgcctgtctt agaggaaggg aaaaggagtt tcagacagac cagttttcag tgggtctctc
     2281 aggaagcaag aagctaagcc aaaataaatc caggtctttc cacgccagtc agtgtgtctc
     2341 ccaccatact gcctaattca gagaggaaaa caggaagcca accacaaatt cggctggtgt
     2401 ctctgtctgg caagtttgct aaagataagg gaataaagat atttctctgt gctgtc
//
