LOCUS       NM_001081237            6154 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kelch-like 42 (Klhl42), transcript variant 1, mRNA.
ACCESSION   NM_001081237 NM_175019 XM_485838
VERSION     NM_001081237.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6154)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6154)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6154)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (bases 1 to 6154)
  AUTHORS   Cummings,C.M., Bentley,C.A., Perdue,S.A., Baas,P.W. and Singer,J.D.
  TITLE     The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for
            normal mitosis in mammalian cells
  JOURNAL   J Biol Chem 284 (17), 11663-11675 (2009)
   PUBMED   19261606
  REMARK    GeneRIF: Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show
            an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5
            is required for efficient p60/katanin removal
REFERENCE   5  (bases 1 to 6154)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153575.5.
            
            On or before Mar 17, 2023 this sequence version replaced
            NM_175019.1, NM_001081237.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083047.1, AK129335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-878               AC153575.5         139730-140607
            879-1072            AC153575.5         149806-149999
            1073-6154           AC153575.5         155935-161016
FEATURES             Location/Qualifiers
     source          1..6154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     gene            1..6154
                     /gene="Klhl42"
                     /gene_synonym="A330079N23Rik; C230080I20Rik; Ctb9; Klhdc5;
                     mKIAA1340"
                     /note="kelch-like 42"
                     /db_xref="GeneID:232539"
                     /db_xref="MGI:MGI:2444786"
     exon            1..878
                     /gene="Klhl42"
                     /gene_synonym="A330079N23Rik; C230080I20Rik; Ctb9; Klhdc5;
                     mKIAA1340"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1524
                     /gene="Klhl42"
                     /gene_synonym="A330079N23Rik; C230080I20Rik; Ctb9; Klhdc5;
                     mKIAA1340"
                     /note="isoform a is encoded by transcript variant 1; kelch
                     domain-containing protein 5; kelch domain containing 5;
                     cullin-3-binding protein 9; kelch-like protein 42"
                     /codon_start=1
                     /product="kelch-like protein 42 isoform a"
                     /protein_id="NP_001074706.1"
                     /db_xref="CCDS:CCDS39716.1"
                     /db_xref="GeneID:232539"
                     /db_xref="MGI:MGI:2444786"
                     /translation="MSAEEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRP
                     EVGPEVQQLRGLSAPGLRLVLDFINAGGAREGWGLSEDELAEASVLSEMVEAASFLQV
                     TALLRLLLSHVRLGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLLSP
                     PQAPGDCSLKQRLREARMRGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEETTERWF
                     PLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPITNEWLQVASMN
                     QKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKI
                     YVIGGYTTRDRNMNILQYCPSADLWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELG
                     PNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLST
                     SLEHRVFLKYNIFADSWEAFRRFPAFGHNLLISSLYLPNKAET"
     exon            879..1072
                     /gene="Klhl42"
                     /gene_synonym="A330079N23Rik; C230080I20Rik; Ctb9; Klhdc5;
                     mKIAA1340"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..6154
                     /gene="Klhl42"
                     /gene_synonym="A330079N23Rik; C230080I20Rik; Ctb9; Klhdc5;
                     mKIAA1340"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6135..6140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl42"
                     /gene_synonym="A330079N23Rik; C230080I20Rik; Ctb9; Klhdc5;
                     mKIAA1340"
                     /note="hexamer: AATAAA"
     polyA_site      6154
                     /gene="Klhl42"
                     /gene_synonym="A330079N23Rik; C230080I20Rik; Ctb9; Klhdc5;
                     mKIAA1340"
                     /note="major polyA site"
ORIGIN      
        1 aggagcctga gcggccgagc ggcggggcgc agcggcccag ccatgtcggc cgaggagatg
       61 gtgcagatcc gcctggaaga ccgctgctac ccggtgagca agagcaagct gatcgaacag
      121 agcgactact tccgcgcgct ctaccgctcc ggcatgcgcg aggccgtgcg gcccgaggtg
      181 ggcccggagg tgcagcagct gcgcggcctg agcgctccgg gcctgcggct ggtgctggac
      241 ttcatcaacg cgggcggcgc gcgcgagggc tggggcctga gcgaggacga gctggccgag
      301 gctagtgtgc tgtccgagat ggtggaggcc gcgtcctttc tgcaggtcac ggcgcttctg
      361 cgcttgctgc tgtcgcacgt gcgtctgggc aactgcctgg agctgtaccg cctggcgcag
      421 gtgtacggac tgcccgacct gcaggacgcc tgcctgcgct tcatggtgct gcgcttccac
      481 caggtgctgt gtcagccgca attcccgcta ctgttgtcgc cgccgcaggc ccccggggac
      541 tgcagcctga agcagaggct gagggaggcc cgcatgcgcg ggaccccggt cctggtggcc
      601 ctgggggact tcctcggggg accccttgcc ccgcacccgt atcaggggga acccccgtcc
      661 atgcttaggt acgaggagac cacggagcgc tggttccccc tggccaacaa cctgcccccc
      721 gacctggtga acgtcagggg ctacggctca gccattttgg acaactacct cttcatcgtg
      781 ggtggttaca ggatcaccag ccaggagatc tctgccgcac actcctacaa tcccatcacc
      841 aacgagtggc tgcaggtggc ctccatgaac cagaagcgat ctaacttcaa acttgtggct
      901 gtcaattcaa agctttacgc catcggtggg caggctgttt ctaacgtgga atgctacaat
      961 cccgagcaag atgcgtggaa ttttgtggct cccctgccaa accctctggc tgagttctct
     1021 gcctgcgagt gcaaggggaa gatttacgtc attggcggat ataccacccg agatcgcaac
     1081 atgaacatcc tgcagtactg cccctccgcc gacctctgga cgctgtttga gacctgtgac
     1141 gtccatatcc gcaagcagca gatggtgtcc gtggaggaga ccatctacat cgtgggtggg
     1201 tgtctccatg aactggggcc caaccgcagg agcagccaga gtgaggacat gctcaccgtg
     1261 cagtcctaca acacagtcac gcgtcagtgg ctctacctga aggagaacac gtccaaatcg
     1321 ggcctgaact tgacatgcgc actgcacaat gacggcatct acattatgag cagggacgtc
     1381 accctgtcca ccagcttgga gcaccgagtg tttctcaagt acaacatctt tgctgacagc
     1441 tgggaagcct tccggcggtt cccagctttc ggacataact tgttgatttc ctctctctat
     1501 ctgcccaata aagcagagac ctgactgatt caacggtatt taaaagaaaa gtctggttca
     1561 agggggaaaa agcaagcctt tgaagtcctg actcctgaag ggacagagcg ggctaacgta
     1621 ggtcacgtat gtaggcggct cagctgtaaa taagctttct tgaactaatt acttgaaaac
     1681 ttggggtgaa gagaccaacc ctattttttc cagattatta ttattattat tattattttg
     1741 tatcatggga acaaatatca tgatattcat ccaaacctaa cagtcttgga ccaacagcta
     1801 aaacccacca ttaaaaagta gactgctagg gtctgctttg tacgggccaa ggtcagtagc
     1861 taacctgtta gtaatggttt tgttttgtgt ttttttcctg ctgggaatgg aatccagggc
     1921 ctcatggtag tcctggaaaa gatgacatta aaaatgccct ttcttcaggt cacctgagat
     1981 ctcctcagaa gggacattcc ttttggcgat cggtttattt gacaagcatt aggatccgtc
     2041 acctccttag cttccgactc ccttgtcacc ctgtctctct gggcaggcat tttatcttat
     2101 atttgttttc agaaacgcta acaggtgtgt acaacctttt gatatttaga aatcatatta
     2161 tcatttataa acctttaaag aagtctcttc atgttctaag taagtacctg atgttgtgtt
     2221 ggctgcttcg tagctgtcct tggggcccac aagctatggc tgccttgcct gctacaagga
     2281 tagaggcagc cagagcatcc acataagcag ccagagcatc cacaaacgtg gataaacacg
     2341 ttctcagcca ctttcccagt ctttgtgcaa ttgaaaatgc tgtctaaagt agactagtga
     2401 acctcttatg tcatgtgtgg caaatgaggg tctgtgtggg tcaccacagc tgcattgtga
     2461 ggactttgtt tttagaagat tgctataaac actataaatt gagtcttaga tgaggaggag
     2521 gaccacatga ggaaagatgc ctttaggagt tattttaatt gaatgtattt aacctagttc
     2581 ttgttttaag acagaaatca aaaccaaacc aaaccaacgt ttgcacattt acttaggttt
     2641 tctcctagct tgatcttagc cttagatgtt cagccgtgtt ttgccttttt aagggaagga
     2701 tggctgtagc tgatgtgtgc tagaaagcag gggagatgtc ctttacagac atgggaaggc
     2761 ctctgctggc ctttctgact tgaggtgagg tgctggcttc agagctctca tgccaacaac
     2821 ggtgcataac ttaaggacct gccaatcatg ggtctgtgtt tcttaaaaga ctcaaggacc
     2881 tacttagcac gcatgagagg ccccaggttt aatctccggc acttacagca acagcaacaa
     2941 ggtcctcacc tacaggaatt ttgattgaag agaatttgct gcaaccagct gctatcttgt
     3001 aatagagttg gctaaaggga ccggactcca tctccacacc agcagcgggc tgccgccttg
     3061 cacattaaag aaagctccac agagaaccaa gagctacagg cagattcttc ctggttcctt
     3121 gcacagctgc tttcctggta gctggccatg ggagagggaa gctgacccct agtaggtctt
     3181 cagtgttaat gagggagtca cttcagagtt tctttgcagc catgcctcta atacagcttt
     3241 agagcctcgt tataaaactc ttctttgcac agtggtttag aatctctgct agtctttatt
     3301 tgggacatgg tgacaattct tagtgtcttg tcatgaaatc taccaatatc caatcaacct
     3361 gcttataatg tcattggaag cttacaggcc atttccagcc acatctgttt tcaaacacta
     3421 agtctgtttt tcttactccc accccctttt tttccctctc taagacaggg tattgcctta
     3481 caatccagga taactccaaa ctggagactc tcacctcagc ctcttgcttc tgtgcctgtc
     3541 tttatgtatt acttttaaaa ttgttttgct gggctctttt caaataacaa aaaactctga
     3601 gctaaaatct tcaccaaaat ggtacttata taatagattt aatttatatt cactttagaa
     3661 ttgaattttg gaggagtcta taatttcatt actgcacttt aaagtctaat ttatgtttgt
     3721 tgttatggct cttcattttt atgcagccta gtcctgaata ttcagaggaa actggcagat
     3781 gaattagcaa tggacaaaga tgggcaatta tcttgtgaaa atacagatct taaaagccca
     3841 tcatggcatc tacctgttga cttgttctct tcctgatggc catctttgga catatttcct
     3901 aatgccagca actagattct tggaccaaat gaagttctaa cactgacatc cacaaagctc
     3961 tcaccccagg cttaacatgt agcctgtgtg cagtatatgg ctctggggtt tagatgcaca
     4021 gactcccagc agaagtttgt tgttcttgct gtcatctatg cttggagaag agagtcatgt
     4081 catagaactg ggagggtttt atgacatctg tctgcctgtg ccctttctga gcattctgag
     4141 agcacttgga gttcagctgg tgccgactgc agacttcgcc aggatgatag tgttcctttg
     4201 gaaaccttcc cttcctcaga caactcctta tgcgatactt cgtatttctt tccattctct
     4261 gttgccttac tccccctacc accagcttct gaggggttct agctcccact gtgtagcagg
     4321 aagtgtctgg gagtaccccc aagggagctt cctgtcaagt gtgcactcct actccgggag
     4381 gcttctcccc ttggcaccag aaaggttctg agatgattgt gtgagaatct ctaacttctg
     4441 cgatctgagc taggacatat tgtcaaagaa cctacaaggt gggggatgct ggcaagaaac
     4501 gcatacggct taggattaag catgaaacca aagagacctt gaccctgctg tgttctgttg
     4561 tttctaacgc caagaaccca agcaaactta aatgccttag gtttccgttc aagcagaggg
     4621 aaggcgagga tactgtagct ctatactggg agaacagagg aaaatgtttc tttttaataa
     4681 atagttgttt atagactatt agaggagcag tcctcataat tccagggaaa gttataagcc
     4741 tgtttggcca aagaggtaaa tagaaggggc cctgatgtct ttgtcaaggt gttgggtgag
     4801 cttagcttag cactgctgac gtgaggggct gcaggacaaa gggatcatgc tgaaggctgt
     4861 cttgacctta cccaggagta cggggtctgt gtgtacactc gctctgtcag ggtttgcact
     4921 taggagacct gtcaatcagt gctaccagac atcctgccag cctaccagag tgaagtgaat
     4981 gccagttcct gcccctgcct ccgagatagt cagtatgaag ggagctgtga tctctggaag
     5041 tagtgagcta catcaattcc attccttggt gaccagaaac attaagtgtt ggtgtgagac
     5101 agagcctagc ctggggacac tgactgagcc actgtccctg ggacaatgtg ctctcatttc
     5161 agccatggtg tagtcagaga tgcccacttt agtcaggcac actgggccca ctgcccactg
     5221 ccttgtgatt cagtaataac catgggagct tgtttgccct taaatctgaa catcatatcc
     5281 catgtttcag gttttttttt tttttactgt gtgttttttc tttttttttc ttttaaagtt
     5341 aactactttt tataatcctt gcacttcgca gtttgtgaaa acacagaaat gatgtggaat
     5401 gtgttttact tagaactcac tcagcactgt agccccgcag atggttctaa tgaaggagga
     5461 agaagagaag gtgaagattt ggcacgagta agctcagcgc tggtacgttt acgcctttgc
     5521 ctttaaaaca ttcccgtgga agaactcagc aatgctccct tggatacttt atcacggagg
     5581 atggttgagt tcgccttgct gatgactgtc gagtggtttc caccttaggt ttagtacacg
     5641 tgtttgcttt tcactttcgt tagtttggaa acacaacagg aaatacatag tgactgccag
     5701 ctgccacttg acatagccat attcacccat tcctacagga agcccgtgaa atgaaaaaga
     5761 gggtccattc cgtagagccc agggtgctca gtgtttccgt agggctggtt ggtgctttcc
     5821 atagcttgtt actggcaaag caaaggaaaa tgtgatttgt tgtatcactt cagggtgcga
     5881 catttctctg tccctccagt gttttcttac ctagttattt ttatggaaaa gaataaccct
     5941 caagttacat tctgttatga ctgacacttt ctttgtttga aatattgtac tgagtctgta
     6001 gtttggagtg tggcataaac acacacatca gcattgtcgc atatctatag ccgtgtttgt
     6061 acatttgaca cctgtgaacc acagagctgt gttcattttt tttttttttt ggactatgga
     6121 atgaaatgcc tttaaataaa agagttctca atca
//
