LOCUS       NP_001074706             493 aa            linear   ROD 02-MAY-2024
DEFINITION  kelch-like protein 42 isoform a [Mus musculus].
ACCESSION   NP_001074706 NP_778184 XP_485838
VERSION     NP_001074706.1
DBSOURCE    REFSEQ: accession NM_001081237.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (residues 1 to 493)
  AUTHORS   Cummings,C.M., Bentley,C.A., Perdue,S.A., Baas,P.W. and Singer,J.D.
  TITLE     The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for
            normal mitosis in mammalian cells
  JOURNAL   J Biol Chem 284 (17), 11663-11675 (2009)
   PUBMED   19261606
  REMARK    GeneRIF: Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show
            an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5
            is required for efficient p60/katanin removal
REFERENCE   5  (residues 1 to 493)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153575.5.
            
            On or before Mar 17, 2023 this sequence version replaced
            NP_778184.1, XP_485838.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083047.1, AK129335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     Protein         1..493
                     /product="kelch-like protein 42 isoform a"
                     /note="kelch domain-containing protein 5; kelch domain
                     containing 5; cullin-3-binding protein 9; kelch-like
                     protein 42"
                     /calculated_mol_wt=55468
     Region          4..101
                     /region_name="BTB_POZ_KLHL42"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 42 (KLHL42); cd18319"
                     /db_xref="CDD:349628"
     Region          113..225
                     /region_name="BACK_KLHL42_KLHDC5"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 42 (KLHL42); cd18478"
                     /db_xref="CDD:350553"
     Region          179..223
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          183..241
                     /region_name="Kelch 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BFQ9.1)"
     Region          223..469
                     /region_name="NanM"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; COG3055"
                     /db_xref="CDD:442289"
     Region          232..275
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          242..289
                     /region_name="Kelch 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BFQ9.1)"
     Region          279..319
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          291..332
                     /region_name="Kelch 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BFQ9.1)"
     Region          322..360
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          334..379
                     /region_name="Kelch 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BFQ9.1)"
     Region          381..436
                     /region_name="Kelch 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BFQ9.1)"
     Region          438..487
                     /region_name="Kelch 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BFQ9.1)"
     CDS             1..493
                     /gene="Klhl42"
                     /gene_synonym="A330079N23Rik; C230080I20Rik; Ctb9; Klhdc5;
                     mKIAA1340"
                     /coded_by="NM_001081237.2:43..1524"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39716.1"
                     /db_xref="GeneID:232539"
                     /db_xref="MGI:MGI:2444786"
ORIGIN      
        1 msaeemvqir ledrcypvsk sklieqsdyf ralyrsgmre avrpevgpev qqlrglsapg
       61 lrlvldfina ggaregwgls edelaeasvl semveaasfl qvtallrlll shvrlgncle
      121 lyrlaqvygl pdlqdaclrf mvlrfhqvlc qpqfplllsp pqapgdcslk qrlrearmrg
      181 tpvlvalgdf lggplaphpy qgeppsmlry eetterwfpl annlppdlvn vrgygsaild
      241 nylfivggyr itsqeisaah synpitnewl qvasmnqkrs nfklvavnsk lyaiggqavs
      301 nvecynpeqd awnfvaplpn plaefsacec kgkiyviggy ttrdrnmnil qycpsadlwt
      361 lfetcdvhir kqqmvsveet iyivggclhe lgpnrrssqs edmltvqsyn tvtrqwlylk
      421 entsksglnl tcalhndgiy imsrdvtlst slehrvflky nifadsweaf rrfpafghnl
      481 lisslylpnk aet
//
