LOCUS       NM_028202               2455 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kelch-like 40 (Klhl40), mRNA.
ACCESSION   NM_028202 XM_914285 XM_984780 XM_987841
VERSION     NM_028202.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2455)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2455)
  AUTHORS   Ramirez-Martinez,A., Cenik,B.K., Bezprozvannaya,S., Chen,B.,
            Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic
            ubiquitination
  JOURNAL   Elife 6, e26439 (2017)
   PUBMED   28826497
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2455)
  AUTHORS   Wang,Y., Baeyens,N., Corti,F., Tanaka,K., Fang,J.S., Zhang,J.,
            Jin,Y., Coon,B., Hirschi,K.K., Schwartz,M.A. and Simons,M.
  TITLE     Syndecan 4 controls lymphatic vasculature remodeling during mouse
            embryonic development
  JOURNAL   Development 143 (23), 4441-4451 (2016)
   PUBMED   27789626
REFERENCE   4  (bases 1 to 2455)
  AUTHORS   Gong,W., Gohla,R.M., Bowlin,K.M., Koyano-Nakagawa,N., Garry,D.J.
            and Shi,X.
  TITLE     Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates
            Skeletal Muscle Myogenesis through the E2F1-DP1 Complex
  JOURNAL   J Biol Chem 290 (24), 15350-15361 (2015)
   PUBMED   25940086
  REMARK    GeneRIF: Kbtbd5 regulates skeletal muscle myogenesis through the
            regulation of E2F1-DP1 activity
REFERENCE   5  (bases 1 to 2455)
  AUTHORS   Garg,A., O'Rourke,J., Long,C., Doering,J., Ravenscroft,G.,
            Bezprozvannaya,S., Nelson,B.R., Beetz,N., Li,L., Chen,S.,
            Laing,N.G., Grange,R.W., Bassel-Duby,R. and Olson,E.N.
  TITLE     KLHL40 deficiency destabilizes thin filament proteins and promotes
            nemaline myopathy
  JOURNAL   J Clin Invest 124 (8), 3529-3539 (2014)
   PUBMED   24960163
  REMARK    GeneRIF: NEB and LMOD3 were reduced in skeletal muscle of Klhl40-/-
            mice, providing a potential basis for the development of
            experimental nemaline myopathy.
REFERENCE   6  (bases 1 to 2455)
  AUTHORS   Bowlin,K.M., Embree,L.J., Garry,M.G., Garry,D.J. and Shi,X.
  TITLE     Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage
  JOURNAL   Differentiation 86 (4-5), 184-191 (2013)
   PUBMED   24361185
  REMARK    GeneRIF: we have demonstrated that Kbtbd5 is the direct downstream
            target gene of the Myod family and regulates myogenic
            differentiation.
REFERENCE   7  (bases 1 to 2455)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2455)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC125576.1 and AK160799.1.
            
            On Sep 19, 2009 this sequence version replaced NM_028202.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078669.1, AK009491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               BC125576.1         1-141
            142-2114            AK160799.1         2-1974
            2115-2455           AK160799.1         1977-2317
FEATURES             Location/Qualifiers
     source          1..2455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.61 cM"
     gene            1..2455
                     /gene="Klhl40"
                     /gene_synonym="2310024D23Rik; Kbtbd5"
                     /note="kelch-like 40"
                     /db_xref="GeneID:72330"
                     /db_xref="MGI:MGI:1919580"
     exon            1..1321
                     /gene="Klhl40"
                     /gene_synonym="2310024D23Rik; Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2035
                     /gene="Klhl40"
                     /gene_synonym="2310024D23Rik; Kbtbd5"
                     /note="kelch repeat and BTB domain-containing protein 5;
                     kelch repeat and BTB (POZ) domain containing 5"
                     /codon_start=1
                     /product="kelch-like protein 40"
                     /protein_id="NP_082478.1"
                     /db_xref="CCDS:CCDS23637.1"
                     /db_xref="GeneID:72330"
                     /db_xref="MGI:MGI:1919580"
                     /translation="MTLGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRVGEREF
                     PCHRLVLAACSPYFRARFLAEPDSAGEVRLEEVSPDVVSQVLHYLYTSEIALDEASVQ
                     DLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLAVAARDFICARF
                     PLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDAEAQAERQRALP
                     TVFESVRCRLLPRAFLETRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKG
                     EQTARAKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVAYDPA
                     ANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEW
                     LGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPY
                     AVYGHTVLSHMDLVYVIGGKGKDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVH
                     DGRIFVAAGVTDTGLTSSSEVYSIADNKWTSFEAFPQERSSLSLVSLAGTLYALGGFA
                     TLETESGELVPTELNDIWRYNEDEKKWEGVLREIAYAAGATFLPVRLNVLRLTKM"
     exon            1322..1482
                     /gene="Klhl40"
                     /gene_synonym="2310024D23Rik; Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1590
                     /gene="Klhl40"
                     /gene_synonym="2310024D23Rik; Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1776
                     /gene="Klhl40"
                     /gene_synonym="2310024D23Rik; Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1923
                     /gene="Klhl40"
                     /gene_synonym="2310024D23Rik; Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2455
                     /gene="Klhl40"
                     /gene_synonym="2310024D23Rik; Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtgcgtca tgtgcaggag gccagcagct cctcttacag gttctgggca tcctctatat
       61 atagcccagg gcagacagct gcgcagtcag tgcacagccc cacaagacag cagaggtgtg
      121 cagggctgcc ctcgatacac agacttgctg agttccaggg agccgcacca tgacgctggg
      181 cttggagcag gcggaggaac agcgtctgta ccagcagacg ctcctgcaag acggcctcaa
      241 ggacatgctg gaccacggca agttcctaga ctgtgtagtg cgcgtgggtg agcgcgagtt
      301 cccgtgccac cgcctggtgc tagccgcctg tagcccctac ttccgcgcgc gcttcctggc
      361 tgagccagat agcgcgggag aggtacgcct ggaggaggtg tcgccagacg tagtgtccca
      421 ggtgctgcac tacctgtaca catcagagat cgcgctggat gaggcaagcg tgcaagacct
      481 gtttgccgcg gcgcatcgat tccagatccc gtccatcttc accatctgcg tgtcgtttct
      541 gcagaagcgc ctgtgcttgg ccaattgcct ggctgtcttc cgcctcggcc tcctgctgga
      601 ctgcgcgcgt ctggctgtgg ccgcgcgcga cttcatctgc gcgcgcttcc cgctggtggc
      661 gcgggacaac gacttcctgg gactctcggc tgacgagctg atcgccatca tctccagcga
      721 cggcctcaac gtagagaagg aggaggcagt gtttgaggct gtgatgcgct gggccagcag
      781 cggagatgct gaggcgcagg cggagcgcca gcgcgcgctg cccacggtct tcgagagcgt
      841 tcgctgccgc ctgctgcctc gtgctttcct ggagactcgc gtggagcgcc acccacttgt
      901 gcgctcccag cccgagctgt tgcgcaaggt gcagatggtg aaggatgcac atgagggccg
      961 cctcactaca ctgcgcaaga agaagaagga aaagggtgag cagacagctc gggccaagga
     1021 ggccaaccag ggcacagaag acaccaaggc tgaggacgat gaggaacgag tactgcccgg
     1081 gatcctcaat gacactctgc gcttcggcat gttccttcag gatctcatct tcatgatcag
     1141 cgaggaaggc gccgtggctt acgacccagc cgccaacgag tgctactgtg catccctgtc
     1201 cacccagatc cccaagaacc atgtcagtct ggtgaccaag gagaaccaag tcttcgtggc
     1261 cggtggcctc ttctacaatg aggacaacaa ggaggaccct atgagtgctt acttcctgca
     1321 gtttgaccac ttggactctg agtggctggg gatgccgcct ctcccttcac ctcgctgcct
     1381 cttcggcctg ggggaggctc tcaacgccat ctacgtggtc ggcggccggg aactcaagga
     1441 cagcgaagac agcctggact cagtcctgtg ctacgacagg ctgtcattca aatggggtga
     1501 gtcagacccg ctgccctacg ccgtgtacgg ccacacagtc ctttcccaca tggacctggt
     1561 ctatgtcatt ggtggcaaag gcaaagacag gaaatgtctg aacaagatgt gtgtctacga
     1621 ccccaagaag tttgagtgga aggagctagc acccatgcag acagcccgat cgctctttgg
     1681 ggccacggtc catgacggcc gcatctttgt ggccgcaggg gtgacagaca caggacttac
     1741 cagctcttca gaggtgtaca gcattgcaga caacaagtgg acctcctttg aggccttccc
     1801 acaggaacga agctcgctca gcctggtcag cctagctggc actctttatg ccttgggtgg
     1861 ctttgccact ctggagacgg agtctggaga gctggtcccc acggagctca atgacatctg
     1921 gagatacaac gaggatgaga aaaagtggga gggggtccta cgggagatcg cctacgcagc
     1981 tggcgccacc ttcctccctg tgcgcctcaa tgtgcttcgc ctgaccaaga tgtgaccgat
     2041 gtgactggtg caggaccctc actgagcctc cttcctgtcc tgtggcttca gaaaaaaaaa
     2101 aaaaaaaaaa aaaaggagca tcatgagatc cagggaggag ctgggagagg ccagagccct
     2161 ttgggttccc aggatgagtc agaaagggta cttcagtcag ggaagggaca ttgctgcctg
     2221 cttctcaatg tccctctggg gacaccatgt cttcccaagg actgcaaagc tataggccgg
     2281 catcccaggt tgtgtcctgg ccctaccctg gctggctgtg tgtgccatag ggtctcccaa
     2341 gggactcagt acccgtgctg atcagatggg agtgtctccg tcgatggcac cttcttgtgc
     2401 taacccagat ctcccgtagg aatctcagga acaataaagt gctttccgag catct
//
