LOCUS       NM_001370764            5490 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kelch-like 33 (Klhl33), transcript variant 1, mRNA.
ACCESSION   NM_001370764 XM_006519291
VERSION     NM_001370764.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5490)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC027184.15.
            
            On May 29, 2019 this sequence version replaced XM_006519291.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.16989.1,
                                           SRR7345562.3720540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1036              AC027184.15        29853-30888
            1037-1961           AC027184.15        34037-34961
            1962-2129           AC027184.15        35051-35218
            2130-5490           AC027184.15        35395-38755
FEATURES             Location/Qualifiers
     source          1..5490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.29 cM"
     gene            1..5490
                     /gene="Klhl33"
                     /gene_synonym="EG546611"
                     /note="kelch-like 33"
                     /db_xref="GeneID:546611"
                     /db_xref="MGI:MGI:3644593"
     exon            1..1036
                     /gene="Klhl33"
                     /gene_synonym="EG546611"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2682
                     /gene="Klhl33"
                     /gene_synonym="EG546611"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="kelch-like protein 33 isoform 1"
                     /protein_id="NP_001357693.1"
                     /db_xref="CCDS:CCDS88651.1"
                     /db_xref="GeneID:546611"
                     /db_xref="MGI:MGI:3644593"
                     /translation="MASLSSDLEHVSLPIEKDSLELPVPAGRTFSRSPSSDEDPGLFS
                     FSLAEPDPPSPFVSGNLPFLASSPEKGKKQDDSDDSAEPEMLCSVEHPCQFFAEAQRL
                     REQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAA
                     LTFAYEGVLGPASQDEVLAAAEALGAPRVKKAAQLKPEGLGKARGNEKKLSQAEELRE
                     NLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTL
                     RTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPAL
                     CLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQE
                     EFEAFSAARCWLAANPETHESEAKALLRCVRFGRMSTRELRKVRAAGLPPSLPPDLLY
                     QLMVEAEVPGQERWREPDQALVVIGGDGLRPDMDRRQPSCKVWWARAFHCGMGLVRTV
                     EWCRLPNLPAPGRFRHGAASLTGSELYVCGGQDFYSHNSTLASTLRWSSSQEDWEEMA
                     PLCQARSFFPLVVFDGQLYALGGRDNGVALNSVETYNPELNVWRPAPALPAPCFAHAA
                     AILEDRLYVSGGCSGTGQYLDSLIHYDPKLKRPGTLLSPMGVARASHVMAALGGKLYV
                     AGGVGDTGDLLSFEAYEPKSDSWTQLASLPSPHVGAAGAVLQGELLVLGGYSHRTYAI
                     SHLVHAYCPGLDRWLCLGTLPRPRAEMPACILTLPSVQHIALVPTQHQNKPAG"
     exon            1037..1961
                     /gene="Klhl33"
                     /gene_synonym="EG546611"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2129
                     /gene="Klhl33"
                     /gene_synonym="EG546611"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..5490
                     /gene="Klhl33"
                     /gene_synonym="EG546611"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5463..5468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl33"
                     /gene_synonym="EG546611"
                     /note="hexamer: AATAAA"
     polyA_site      5487
                     /gene="Klhl33"
                     /gene_synonym="EG546611"
                     /note="major polyA site"
ORIGIN      
        1 aagcagactg ggaactcaag agagggcaag cagaagcccg gtgtctcctg cctgggatta
       61 aaagaaaacg agtggaaagc ggggctttgt cctgagccag atggctacag gcgtttgtgg
      121 ttctgttgca cttggtgaac cctatggtta gttagcgcca tatagcccaa agttagtgtg
      181 tcaccggacg gagtgaggga ctgacagctg aattgaagac agttctgttt tcctgagtgc
      241 tgctcaggta tacttctctc atgcctgggc acctgcggca acctcacaag cgtctggaag
      301 atggcaagcc tttcctcaga cttggagcat gtctcccttc ctatcgagaa ggacagtctt
      361 gaactacctg tgcctgccgg aagaaccttc tcccggtctc cctcttccga tgaggatccc
      421 ggcttgtttt ccttttctct ggcagagcct gacccaccta gccccttcgt ttcaggaaac
      481 cttccctttc tagcttcatc tccggagaaa gggaagaagc aggatgacag cgacgactca
      541 gcggagcctg agatgctgtg cagcgtggag cacccctgcc agttcttcgc tgaagcgcag
      601 agactgcggg agcagaagct gctgctggat gaagaggtgt ctgtgggggg acaggtatat
      661 ggggtgcatc gggtgatctt ggctgcaatt agcagcctct tccgaggcag gctgctgagc
      721 ggtgggggtc agcagcccag tttcagcctt gatgtgaccc cgaggggctg ggaggctgcg
      781 ctgacctttg cctacgaggg ggtgctgggc cccgcctcac aggacgaagt gctggctgct
      841 gcagaggcgc tgggagcacc ccgggtgaag aaggcggccc agctgaagcc agaaggactt
      901 ggtaaagcca ggggaaatga aaagaagctc agccaggcag aggagctgag ggagaatctg
      961 cacagcattg agcgtctgta tcgagagggc atcgggtgcg acttggagct ggaggcagag
     1021 ggctaccgcc tgcgggtgca ccgagtagcc ctggcctgtg gcagtgagtt ctttggggcc
     1081 atgcttctga gtgggatgag ggagtcccag ggcacaaagg tgactctgcg taccatctct
     1141 tcccaagacc tgagactcct cgtttctttt gcctacactg gagttgttcg agaaagatgg
     1201 ccaggattgc taagagctgc ccaggctgct ctgcaatacc agagctcttc ctgtctggat
     1261 ttgtgtcaga aagccttggc acaaagcctc tgccccgccc tttgcctagc tttgttccct
     1321 atgattgagg cccctggctt ggagaaagtc tgggggaaag cccacgatta cctcctcagt
     1381 cacctgcctg ctgtggcttc gtgccctacc ttttcatcct tgccagttac ctgcctggct
     1441 gagctcctgg acagtgatga actccatgtg caagaagagt ttgaggcttt ctcagctgca
     1501 cggtgttggc tggctgccaa ccccgagacc cacgagtcag aggccaaggc actgttgcga
     1561 tgtgttcgct ttggccgcat gtctaccaga gagctgcgaa aggtgcgggc agctgggctc
     1621 cccccatctc tgccccccga tctgctgtac cagctgatgg tggaagctga agttccaggt
     1681 caagagagat ggagggagcc tgaccaagcc ctggtggtga ttggtgggga tgggcttaga
     1741 cctgacatgg accgaagaca gccatcatgc aaagtgtggt gggcccgggc atttcactgt
     1801 ggcatgggtc tggtacgaac tgtggagtgg tgccggctgc ccaatttgcc tgccccaggg
     1861 cgctttcggc acggagctgc gagcctaaca ggaagtgaac tctatgtgtg tgggggacag
     1921 gatttctaca gccacaatag cactctggct tcaactctca gatggagttc cagtcaagaa
     1981 gactgggagg agatggcacc tttgtgccag gctcggagct tcttcccttt ggtggtattt
     2041 gatggacagc tttatgccct aggtggacga gacaatggtg ttgcccttaa ttctgttgag
     2101 acctataacc ctgaactcaa tgtctggagg ccagcacctg ctcttccagc tccatgcttt
     2161 gcccatgcag ctgctatcct tgaggaccga ttatatgtca gcggtggctg tagcgggact
     2221 ggccagtact tggactcact gatacactat gaccccaaac ttaagaggcc tgggacgctt
     2281 ctgagcccaa tgggagttgc ccgggctagc cacgtgatgg cggcactggg tgggaagttg
     2341 tatgtggcag gtggagtagg ggacactggg gacctactaa gctttgaagc ctatgaacca
     2401 aagagcgata gctggactca gctggcatcc ttgccctccc cccatgtggg ggctgcaggt
     2461 gccgtgctac agggggagct cctggtacta gggggctaca gccaccgtac ttacgccatc
     2521 tcccaccttg ttcatgccta ctgccctggt ctggatcgct ggctatgcct ggggactctg
     2581 ccaaggcctc gagctgagat gccggcctgc atcttgacat tgcccagtgt gcagcacata
     2641 gctttggttc ctactcagca ccaaaacaaa cctgctgggt gactgaggat cagcaggttg
     2701 tgagggagga agggataagc aataccacga caaaaggaca gaacttatga gaggagaaga
     2761 cggtcttact tgcttgttta ctttttaaag ttattattat taggaaggtt ttttcaattg
     2821 tagctctggc tggccttgaa cttgatatgt agcctgggct ggcttcaaac tcaaaatccc
     2881 ctgggtgcta ggattgcatg ctctacccca tcttgattga gaggcatggt gatgatggtg
     2941 gtggtggtga tgtcggtgat gatgattgac agggtctctt gtatcccagg ctggcttaca
     3001 actccctatg tagtcaagga tgaccttgag ctcctgatcc tactgcctcc acctcgaaag
     3061 agttgggata gacgggtgtg ggggtgcacg cctttgatcc cagcactcgg gaggcagagg
     3121 caggtggatt tctgagttcg aggccagcct ggtctacaaa gtgacttcca ggacagccag
     3181 ggctacacag agaaaccctg tctcgaaaaa ccaaaaaaaa caaaacaaaa aagaaagaaa
     3241 gaaaaaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaacaaaga aacaaagaaa
     3301 gaaagaaaga aagaaacaaa gaaagaaaga aagaaagaaa gagttgggat cataggcata
     3361 tactaccacc cctgatcaac cttaggactt cctgcatcct aagtaggtat tctgcctact
     3421 tacctctatt cttaaccctc aaagaaggct ttattctttt tgtttgcttg ttttgttttt
     3481 aattgtttaa tatttatttt atggagatgg gtgttttgct tgcatatctg tgcacacatt
     3541 tgtatctggt gcctgcagag gccagaagag aacagcagat cctttggagc tggacttaca
     3601 gatggttgtg agcaacagtg tggatgctgg gaactgatcc ctggtccttg ggaagagcaa
     3661 accactgagc tatctttcca ccccctgctt ttgtgatttg aggcagtctc attatgtagt
     3721 gcagatgaga aggctttgtt cttgatggta ttttactgca cattacacct tgaaactcat
     3781 acactgcttt tgtatatgat ctctactaag aaaagggtac ttctagaact catgggaagc
     3841 aggccttgga gaaaagattg gcagataaat atttgggtat aggaggcaac caggaagaac
     3901 tccacaagga ttaaagagga gttttgtttt gttgttgtta ttttcgagac agggtttctc
     3961 tgtgtagccc ttgctgtcct ggaactcact cagtagacca ggctggcctc gaagacagag
     4021 atctacctgc ctctgcctct caagtgctga gattaaaagg cttgtgtcac cactgcccag
     4081 caaagaggag ttttttgttt ttgttttttt cgagacaagg tttctctgtg tagccctggc
     4141 tctcctggaa ctcactctgt agaccaggct ggcctcgaac tcagaaatct gtctgcctct
     4201 gcctcccaag tgctgggatt aaaggcgtgt gccaccatgc ccagttacca aagaggagtt
     4261 tttgatgaaa gaaatacagt tagttgggag ttaaaagtgg aactttttgg tagagtacat
     4321 atttggtatg cataaagttc tggttctata atctctgaaa agtttttttt aaaagtaaaa
     4381 caagcaaaca aacaaacaaa aacccagact tcagtaatca aagtataggg accaggaaaa
     4441 cactgggaca tttcaaaaat cagtggagga gtttggaggg aactaaacag tcctcccttt
     4501 ctttggcatt ttactctcta gtctccagga tgcctgaatt ttagccatat tctttcttgg
     4561 gtagttttgt aggcccagcc ttgactccac aggttgcctg tggagtcttt tagttcccac
     4621 ttgagacaga aatgcccagg tctgactaca cgggctgtac cattaggtgg tatacccagg
     4681 gaattctggc acttgaaagg aggaagcagg aggatcagga tttgaactgt ttcaagaaaa
     4741 ccaaaccaca tccaacaaaa caaacaaaca ccaaaaggga gaagctccca tcaagaattg
     4801 cacagcacag gaacctgaag ccaggcagga ctagcagggt gaggtgggag cactctaggg
     4861 gttggggagg agaaaggcca agcagagagc atccttggta gaaaaaagga aagaatgagg
     4921 tttgatgaga tggtgggaga atccactcaa atgtctttcc ttccctttgg atgaactcaa
     4981 gaaccaggat gggatcaaga cgatgagaga acatggctga gaaggtgaca gataaagaaa
     5041 ggcagttggg aaggaagttt cttcttgtca gccccttccc cttcacatta ttttcgactt
     5101 gtttcctcta tttttttgtt taggtttttg tttattttgt tgttgctcta gacaaggtct
     5161 catgtagccg aggctagcct caatctcatt gtgtagccga ggctagcctc aatctcattg
     5221 tgtagttggg gatgtccttg aacttctgat cctccttgtt tccaacacca gagtcttggg
     5281 attacaggtg tggaccacca tgatggggta aatgtctatg tttaagatag gcaaggaata
     5341 tagttgaaaa tgagaaagtt tagttagact acataaaaga aaaaagaaga ttgaaaaaga
     5401 aaaggaagaa gggaattggg gggtgcacat ttttttgtga tttgttcata aagatgagct
     5461 taaataaaaa atttcgcatg gacaaaataa
//
