LOCUS       NM_001362415            7205 bp    mRNA    linear   ROD 13-MAR-2023
DEFINITION  Mus musculus kelch-like 3 (Klhl3), transcript variant 1, mRNA.
ACCESSION   NM_001362415 XM_006517008
VERSION     NM_001362415.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7205)
  AUTHORS   Jang JH, Lee JW, Cho MJ, Hwang B, Kwon MG, Kim DH, Lee NK, Lee J,
            Park YJ, Yang YR, Kim J, Kim YH, An TH, Oh KJ, Bae KH, Park JG and
            Min JK.
  TITLE     KLHL3 deficiency in mice ameliorates obesity, insulin resistance,
            and nonalcoholic fatty liver disease by regulating energy
            expenditure
  JOURNAL   Exp Mol Med 54 (8), 1250-1261 (2022)
   PUBMED   36028759
  REMARK    GeneRIF: KLHL3 deficiency in mice ameliorates obesity, insulin
            resistance, and nonalcoholic fatty liver disease by regulating
            energy expenditure.
REFERENCE   2  (bases 1 to 7205)
  AUTHORS   Lin CM, Sung CC, Yang SS, Chen YC, Huang SM and Lin SH.
  TITLE     Generation and analysis of pseudohypoaldosteronism type II knock-in
            mice caused by a nonsense KLHL3 mutation in the Kelch domain
  JOURNAL   FASEB J 36 (6), e22363 (2022)
   PUBMED   35621709
  REMARK    GeneRIF: Generation and analysis of pseudohypoaldosteronism type II
            knock-in mice caused by a nonsense KLHL3 mutation in the Kelch
            domain.
REFERENCE   3  (bases 1 to 7205)
  AUTHORS   Maeoka Y, Ferdaus MZ, Cornelius RJ, Sharma A, Su XT, Miller LN,
            Robertson JA, Gurley SB, Yang CL, Ellison DH and McCormick JA.
  TITLE     Combined Kelch-like 3 and Cullin 3 Degradation is a Central
            Mechanism in Familial Hyperkalemic Hypertension in Mice
  JOURNAL   J Am Soc Nephrol 33 (3), 584-600 (2022)
   PUBMED   35064051
  REMARK    GeneRIF: Combined Kelch-like 3 and Cullin 3 Degradation is a
            Central Mechanism in Familial Hyperkalemic Hypertension in Mice.
REFERENCE   4  (bases 1 to 7205)
  AUTHORS   Ostrosky-Frid M, Chavez-Canales M, Zhang J, Andrukhova O, Argaiz
            ER, Lerdo-de-Tejada F, Murillo-de-Ozores A, Sanchez-Navarro A,
            Rojas-Vega L, Bobadilla NA, Vazquez N, Castaneda-Bueno M, Alessi DR
            and Gamba G.
  TITLE     Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression
  JOURNAL   Am J Physiol Renal Physiol 320 (5), F734-F747 (2021)
   PUBMED   33682442
  REMARK    GeneRIF: Role of KLHL3 and dietary K(+) in regulating KS-WNK1
            expression.
REFERENCE   5  (bases 1 to 7205)
  AUTHORS   Guo Q, Zhang Y, Jiang GR and Zhang C.
  TITLE     Decreased KLHL3 expression is involved in the activation of
            WNK-OSR1/SPAK-NCC cascade in type 1 diabetic mice
  JOURNAL   Pflugers Arch 473 (2), 185-196 (2021)
   PUBMED   33432425
  REMARK    GeneRIF: Decreased KLHL3 expression is involved in the activation
            of WNK-OSR1/SPAK-NCC cascade in type 1 diabetic mice.
REFERENCE   6  (bases 1 to 7205)
  AUTHORS   Gong Y, Wang J, Yang J, Gonzales E, Perez R and Hou J.
  TITLE     KLHL3 regulates paracellular chloride transport in the kidney by
            ubiquitination of claudin-8
  JOURNAL   Proc Natl Acad Sci U S A 112 (14), 4340-4345 (2015)
   PUBMED   25831548
  REMARK    GeneRIF: KLHL3 regulates paracellular chloride transport in the
            kidney by ubiquitination of claudin-8
REFERENCE   7  (bases 1 to 7205)
  AUTHORS   McCormick,J.A., Yang,C.L., Zhang,C., Davidge,B., Blankenstein,K.I.,
            Terker,A.S., Yarbrough,B., Meermeier,N.P., Park,H.J., McCully,B.,
            West,M., Borschewski,A., Himmerkus,N., Bleich,M., Bachmann,S.,
            Mutig,K., Argaiz,E.R., Gamba,G., Singer,J.D. and Ellison,D.H.
  TITLE     Hyperkalemic hypertension-associated cullin 3 promotes WNK
            signaling by degrading KLHL3
  JOURNAL   J Clin Invest 124 (11), 4723-4736 (2014)
   PUBMED   25250572
REFERENCE   8  (bases 1 to 7205)
  AUTHORS   Shibata S, Arroyo JP, Castaneda-Bueno M, Puthumana J, Zhang J,
            Uchida S, Stone KL, Lam TT and Lifton RP.
  TITLE     Angiotensin II signaling via protein kinase C phosphorylates
            Kelch-like 3, preventing WNK4 degradation
  JOURNAL   Proc Natl Acad Sci U S A 111 (43), 15556-15561 (2014)
   PUBMED   25313067
REFERENCE   9  (bases 1 to 7205)
  AUTHORS   Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura
            N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N,
            Sasaki S and Uchida S.
  TITLE     Impaired degradation of WNK1 and WNK4 kinases causes PHAII in
            mutant KLHL3 knock-in mice
  JOURNAL   Hum Mol Genet 23 (19), 5052-5060 (2014)
   PUBMED   24821705
  REMARK    GeneRIF: increased protein expression levels of WNK1 and WNK4
            kinases cause PHAII by KLHL3 R528H mutation due to impaired
            KLHL3-Cullin3-mediated ubiquitination.
REFERENCE   10 (bases 1 to 7205)
  AUTHORS   Shibata S, Zhang J, Puthumana J, Stone KL and Lifton RP.
  TITLE     Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via
            ubiquitination and degradation of WNK4
  JOURNAL   Proc Natl Acad Sci U S A 110 (19), 7838-7843 (2013)
   PUBMED   23576762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165251.2.
            
            [WARNING] On Apr 13, 2023 this sequence was replaced by
            NM_001362415.3.
            
            On Mar 6, 2019 this sequence version replaced NM_001362415.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.16078.1,
                                           SRR10662772.3960317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               AC165251.2         21432-21937
            507-626             AC165251.2         39864-39983
            627-733             AC165251.2         49922-50028
            734-855             AC165251.2         63398-63519
            856-1018            AC165251.2         71216-71378
            1019-1128           AC165251.2         83941-84050
            1129-1245           AC165251.2         101737-101853
            1246-1395           AC165251.2         104517-104666
            1396-1513           AC165251.2         115593-115710
            1514-1711           AC165251.2         116085-116282
            1712-1813           AC165251.2         118532-118633
            1814-1942           AC165251.2         121121-121249
            1943-2083           AC165251.2         123845-123985
            2084-2227           AC165251.2         125659-125802
            2228-7205           AC165251.2         129875-134852
FEATURES             Location/Qualifiers
     source          1..7205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..7205
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /note="kelch-like 3"
                     /db_xref="GeneID:100503085"
                     /db_xref="MGI:MGI:2445185"
     exon            1..506
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     CDS             493..2256
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kelch-like protein 3"
                     /codon_start=1
                     /product="kelch-like protein 3 isoform 1"
                     /protein_id="NP_001349344.2"
                     /db_xref="CCDS:CCDS88463.1"
                     /db_xref="GeneID:100503085"
                     /db_xref="MGI:MGI:2445185"
                     /translation="MEGESVKPSPQPTAQAEDEEKNRRTVTVNAAHMGKAFKVMNELR
                     SKRLLCDVMIVAEDVEVEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLS
                     KLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFAD
                     VHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVI
                     SWINYEKETRLDHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH
                     LLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEGRWDQIAELP
                     SRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVL
                     NDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD
                     GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVE
                     VYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTL
                     LPTNMSTGRSYAGVAVIHKSL"
     exon            507..626
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            627..733
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            734..855
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1018
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1128
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1245
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1395
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1513
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1711
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1813
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1942
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2083
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2227
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..7205
                     /gene="Klhl3"
                     /gene_synonym="7530408C15Rik; EG627648"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttttctc tgttagcgtt agagaggatc cctctgatcc gctgtagtgc agcctaggag
       61 gcaggagact gtggggtggg ctagtcgcta gggctgggga tgcctgagca gatgtggaaa
      121 cagctggaaa ggtggcacag cccttgggtc gccgccgccg ccgccgaagc tgtggctgtt
      181 tctaggagac agaggagaag ccagcctgcg ggggagggga agcgagtggg ttgctgcttt
      241 tagcagctga aagggctgca gggagctctg ggtaagacat tttctagcac cgtcgctttt
      301 gcggtagaag cctgccgcga gtaagtcaag aggaaggagg attgggaggg aggaggtctc
      361 agttgcagcc atgctgaatc acggttgctg atcagggtcc ctcacgggtc tgctgggaga
      421 acccagcgag cagcgccagt tcccgggtgc atgcacagtt tgatgactac taaccctgcc
      481 gggcctccca caatggaggg cgaaagtgtc aagccgagcc ctcagcccac ggcgcaggct
      541 gaggatgaag agaagaaccg gaggactgta accgtcaacg ctgcccacat ggggaaggcc
      601 ttcaaggtca tgaatgagct gcgaagtaag cggctgctgt gtgacgtgat gatcgtggct
      661 gaagacgtgg aagtagaagc tcaccgtgtg gtcctggcag cctgcagccc ttacttctgt
      721 gcaatgttca caggtgacat gtctgagagc aaggccaaga agatcgaaat caaggacgtg
      781 gacggacaga ctctcagcaa gctcatcgac tacatctaca ccgcagagat cgaggtgaca
      841 gaagagaacg tgcaggtgct gcttccagca gccagcttgc tgcagctcat ggatgtgcga
      901 cagaactgct gtgatttcct gcagtctcag ctgcatccca ccaactgcct gggcatccga
      961 gcttttgcag atgtgcacac gtgcaccgac ctcctgcagc aggcgaacgc ctatgcagag
     1021 cagcacttcc cagaggtgat gctgggggaa gagtttctga gcttaagtct ggaccaggtg
     1081 tgcagcttga tatccagcga caagctgacg gtctcctcag aagagaaggt gttcgaagct
     1141 gtgatttcat ggatcaatta cgagaaggag actcgcctag accacatggc aaagctgatg
     1201 gagcacgtcc ggctccctct gttaccgaga gattacctgg tccagacagt tgaggaggaa
     1261 gctttgatca agaacaacaa cacctgtaag gacttcctca tcgaagccat gaagtaccac
     1321 ctcctgcctc ttgaccagag gctcttgatc aagaacccca ggaccaagcc ccggactcca
     1381 gtcagcctgc ccaaggtcat gattgtggtt ggtggccagg cacccaaggc gatccgcagc
     1441 gtggagtgct atgacttcga ggagggccgc tgggaccaga tagccgagct tccctccaga
     1501 agatgcagag caggtgtggt gttcatggca ggccacgtgt atgccgtggg tggctttaac
     1561 ggctctctgc gggtccggac agtggatgtg tacgatggag tgaaggacca gtggacgtcc
     1621 attgccagca tgcaggagcg ccggagcacc ctgggtgcgg ccgtgctcaa tgaccttctc
     1681 tacgcagtcg gaggcttcga cggcagtacc ggcctggcat ccgtagaagc ctacagctac
     1741 aagaccaatg agtggttctt cgtggcccct atgaacacac ggcggagcag cgtgggagtg
     1801 ggtgttgtgg aggggaagct gtatgccgtc gggggttacg atggtgcttc caggcagtgc
     1861 ctgagcaccg tggagcagta caacccagcc accaacgagt ggatatacgt ggcagacatg
     1921 agcacccgac gcagtggcgc tggggttggg gtgctcagcg gacagctgta tgccaccggg
     1981 ggacatgacg gacccttggt gaggaagagt gttgaagttt acgatcctgg gacaaacact
     2041 tggaagcagg tggcagacat gaacatgtgc cggcgcaacg caggggtctg tgcggtgaat
     2101 gggctactgt acgtagttgg aggggacgac ggatcgtgca atctggcttc agtagagtac
     2161 tacaacccag tcacagacaa gtggacactg ctgcccacca acatgagcac tgggaggagc
     2221 tatgcaggtg ttgctgtgat tcacaaatcc ctgtgaccca aactccctca gccaggaggt
     2281 aggggaagaa gctgcaggcc actgcccgtg gcaacaggac cacagcaagt gaggagagga
     2341 gctgggaggc tctgccgtgg ttcgacaacc accctcattg tctcagcaga ccaacctcct
     2401 tcttcttcat gtggacactg atgacccact tcttattgct ccaaggtgct ttggattctg
     2461 tcctaaacag ttgagttcct gacagcccca gcagcaccct agggcatgca catttgggaa
     2521 cactttgtgt gtgtgtgtgt gtgtgtgtgt gtgtgaaaca tttcattcag tgggggctgg
     2581 acctgtgtga gtgtctactg gatttcttta ctactgatct ttttactatg ctaaaactcc
     2641 tacaaacaac tttttggact cgtacaatgg gccctagatg actacagatg ctgtcttctg
     2701 gaggtccaga gagaactagc caaaagcagc actccgacca cgtctgggac catgacttga
     2761 ctactgcggt tgtgtggaag agcaggggct tcctcaaagc tgctccacgg cctctccctg
     2821 ggccgctgcc tcctccttga ctggactcta ggaggcggat gagaactgtt ttgccttcat
     2881 agtttgacct gatgtcatga attccagatt tggaagattt ttttcccttc tcagcaggga
     2941 aaacaaactc ttcagataag ccccaggaaa aaacactgga gagaaacaga taagaaaagg
     3001 aagcaagcaa gcaaaagaag aaagtgatgg ggctagagag atgactcagt ggtgaagagc
     3061 accgactgct cttgcagagg tcctgagttc aagtcccagc agccacatgg tggctcacaa
     3121 ccatctgtaa tgggatccga tgccctcttc tggtgtgtct gaagacatct gcagtgtacc
     3181 cgtgtacatt aaataaatga atgaataaat acatctttaa aaaaagcaag gaagaatgag
     3241 agcaagcaaa gacagacaga cagaagacac caaagcaaca tggattcagc atctacccac
     3301 agcggcctca gagtgggacc ctgctttcga ttgttctcag ggcacctact taatttatca
     3361 tagcgtatta tgcaggccta cttatccacg gtgtcagagg ataagtgaaa ggtcaccctg
     3421 ccactcgacc cagagatagg tttgcccata ggtcaggagt ggccatatat aactcagaag
     3481 gacatgattg gcttctaaga aacacactgg ctgttctggc cgttggcact ttgtgaggac
     3541 ggtcagggat gcttgtatcc atgtcttccc tctgtcctgc ttccctccta gtccagggtc
     3601 tgtatcttct ccccagcctc cgaaacaccc ccttttaact ttccctttgg gaaagaaaat
     3661 ggtagtggac cctggactgg agagcttctt cgaagacgct tgtatttcta aaaatgaaag
     3721 cacctcagga aagctctgct cagccacaga tcaagactat taaaaaacgt aacttcaagc
     3781 atgcggggtg gtggttggaa gtgtttagaa gcaagcacat ttagggctgg ggggtggggt
     3841 ggggtgtgct tactttaggc gcatgagttt gatctctagc actgacatta aaaaaaaatt
     3901 ctgggtacag cctcatacgc ccatcttaaa gctgggaagg cagacactgg gagatacctg
     3961 aggctttgtg gggacagcca tcctaggcta accagaaagt ctcagtctcc agcctcaggg
     4021 agagacttgc aaaacaaact gtgtggatcc tgcagaccaa cattaaaggt tgacctttgg
     4081 cctctacaca tacttatccc cccccccccc cgcgaccccc aacccacaaa cctcagcact
     4141 aaactcttct taagctaaca aattgtttgt attggaatct ctgccctggg aggggagaac
     4201 agcctcatag gcaggagtcg gagtttcagc ttcccctgac gtcagagggg ggcgccccct
     4261 gtccgacatc tctgcctttg gaagcgtctc cccagctagg cagccactga gtatttactg
     4321 agcacccctc catgagggtg aacctctcta atgttacgca ggagttagga accaccacat
     4381 ctagatggct cacagcctta ggaaggagct agcatagcca gctttggggg acccagaaga
     4441 aaggtctccc aagggaggga tgcaaacatt ttcttggctg ctgctctggt tcccagctgt
     4501 gagcaggggc gggggggggg ggggggggga gccacttgtg aagcccagcc ttcactagaa
     4561 agctctacca ctgagtgcgt tccccacgcc ctccctccct ttccaggcaa gtctggggac
     4621 ttgtttgagg tgtgagctgt gaaggtaagg ctggggatca gagcctagtg agctatttgc
     4681 ataagcaccc tatttcaggt gaaaggtaaa cccaccctct cccactccca ccaagaaccc
     4741 agacttttat acttaggggt catgataaac cttcctgaag agaacccctc cttccgagga
     4801 agctggccag ccccggtttc tgctggagtt tttgctgtgg gttccacttt gtgcctccct
     4861 ccctgtgaag cgctggctct gcaggcagag ctgctgaggg cttcactcat ttcacactcg
     4921 tgtgtccttt ttgtgtgggg actagaacac tggtacgtcg tcaccaaaag agccagcctg
     4981 ccctagctgc ccacagatgc caccctcccc caagacctgt gttgctgcat catcaggtag
     5041 aagtctcgcc atcacggata cctcagaccc actttcaagt ctctgctagt ctagcgcgcg
     5101 ccctaggcgg agccttccca cccctcacct ggcagagcag acactagcca ccactagtga
     5161 acactagcga atacagccct gccaaggggc acatctgaaa cctaacgaaa gtgacaaaat
     5221 ggaattgaga cccaaggtta aaccaaggtt agaagcagat tagacaccac tcggatgctg
     5281 attcggacag cggaagtcag cttctgaact ccaaagtcat ttcttctaag tacccaacag
     5341 catcaccatc ccaaaagaga aaaaaaaaag gcagtattat gcaaatgaag tgacctcatt
     5401 tttctgctat gcaataagaa ttcttaattg tatctcatga caagccagtt gtaatatccc
     5461 ctcagcagaa tttttttttg agctgttaca ctttgatatc tgttgtgtaa tgtttgtata
     5521 tctctgagcc agatcctttc aaagattgcc tttttttttt tttttttttt tttttttttg
     5581 taaaattgaa gctatagctt tcaggctaca gttttaatgt agatattctt ataggtagtt
     5641 ttccaggaca ttcgaatcgc tttctatcgt ccatgacaat gaaatgctgt tctgtgtgtc
     5701 gctcacccct agcagtgtgc gcctggagct gtcctgcctt tgtctttctc cctgtctctc
     5761 tctgtctctc tgtctgtctg tctctctgtc tgtctctgtc tctctctgtc tctctgtctc
     5821 tgtctctgtc tctctctctg tctctctctc tctgtctctc tctctctctc tcttctgtct
     5881 gtcgcagaac ccttctgagc tccgggccct cagtggtcta ggaaggtgac tgacttccaa
     5941 gacgcccgtc gcggggcttc ctttcttagt tcccagggac ttacgttaag tgtgactcag
     6001 tgcgtactat gtctctcatc tctgtgtgct catggatctg ttttctgcag ggctgggttg
     6061 gcccacgcgg caatggttct tactgcccgg ccctcaggcc cacactccct aggtggcctg
     6121 gatcctgcag accttgccca ttctccagtg tctccttgct tttggaggtt tttagtattc
     6181 agggcctcct tgactgggtc ctgtttcttt gggaagcttg cgttcccatc acttcggatg
     6241 agccgttctt tgggagggtg gttggtcctg actcgtggga agaatgcgct aagcagattt
     6301 ttcattcgat tttttttctt tctttcttga gctgtcttca ttccaggttc tgttttgtgt
     6361 atttatcatc tgccgcaggc ctcttgtttc tctttttaaa tcttaactta ttattttggg
     6421 gacaggtgcc atttaaaccg cctccatgcc tcttcctgct tgacctgggc tggatcaagt
     6481 tgggaggctg agtaaaccca ttaagttgga ccagagcatc caaggctctg atgaatggaa
     6541 gcaaggagat cagagtgctt tttgtaggct gtgtgtgtgt gtgctactta agccccttgt
     6601 gttcagctgc actgttatct acggagcaag cagaaaatcc agcagcactt ccgacatatg
     6661 gggacaggag aggctactcg gtgtgggtaa tccagccctc gaggccctgt gcagccttta
     6721 ctgtgggact cagagactcc gggctgtagc agcagccgaa gcaggaacgc acggggctgc
     6781 ggcatctgca ggaataaatt gttcttgtgc tgtttttgcc ttcagttata agattgtaaa
     6841 ttatttgccc cccactttgg tggtaataaa ggacccttgt tggacttctt gtttaatttg
     6901 tatatgatgt gtaaaatatc ttctttgaaa gaaaacccaa ggcatggaac gagaatctct
     6961 ctgtgaatat tctggctctc tgctggatat gggccgtcag actggacaca ggcacgggta
     7021 aagtccttga tctggtattt tctgcgtgga tgttagggac catacaccat ggaaaagaac
     7081 acttgccaca tgaacaatac aataaaagcc gagaaacatt cccccaaatg tattattttt
     7141 atagcagtcc attccagctc tccacactgt acatggcgtt ttaataaaag ccgaactgtg
     7201 caaac
//
