LOCUS       NM_178771               3069 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kelch-like 26 (Klhl26), transcript variant 2, mRNA.
ACCESSION   NM_178771
VERSION     NM_178771.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3069)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3069)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   3  (bases 1 to 3069)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049946.1.
            
            On Apr 6, 2007 this sequence version replaced NM_178771.2.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049946.1, BC098185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3069              AK049946.1         1-3069
FEATURES             Location/Qualifiers
     source          1..3069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..3069
                     /gene="Klhl26"
                     /gene_synonym="C630013N10Rik; Klkl26"
                     /note="kelch-like 26"
                     /db_xref="GeneID:234378"
                     /db_xref="MGI:MGI:2443079"
     exon            1..94
                     /gene="Klhl26"
                     /gene_synonym="C630013N10Rik; Klkl26"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1859
                     /gene="Klhl26"
                     /gene_synonym="C630013N10Rik; Klkl26"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kelch-like protein 26"
                     /codon_start=1
                     /product="kelch-like protein 26 isoform 2"
                     /protein_id="NP_848886.1"
                     /db_xref="CCDS:CCDS40373.1"
                     /db_xref="GeneID:234378"
                     /db_xref="MGI:MGI:2443079"
                     /translation="MAESGGSSGSSQSPERPSSLADRNGALKCTFSAAGHSTGLLQGL
                     AALRAQGQLLDVVLTVNSEAFHAHKVVLAACSDYFRAMFTGGMREANQAVIQLQGVSA
                     RGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEDFLKAAMSVETCLHIG
                     QMATTFSLTSLRESVDAFTFRHFLQIAAEEDFLRLPLERLVFFLQSNRLQSCAEIDLF
                     RAAVRWLQHDPARRARASLVLRHVRFPLMQPAELVDSVQTLDVMLDDALCRQYLLEAF
                     SYHVLPCRQHDMQSPRTAVRSDVASLVAFGGTPYTDSDRAVSSKVFQLPEPGARHFRE
                     LTEMELGCSHAGVAVLDNFVYVAGGQHLQHRSGEGAVDACYRYDPQRNRWLRLRALRE
                     SRVQFQLTALGGLLYATGGRNRAGSLASVERYCPRRDSWDFACPLKRRTWGHAGAAAA
                     GRLYISGGYGVSAEDKKALQCYDPAADRWEPRAPMREPRVLHAMLGAAGRIYALGGRM
                     DHVDRCFDVLAVEYYVPDADQWTSVTPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVT
                     GIVQVYNTETDEWERDLHFPESFAGIACAAVLLPRSGHGR"
     exon            95..277
                     /gene="Klhl26"
                     /gene_synonym="C630013N10Rik; Klkl26"
                     /inference="alignment:Splign:2.1.0"
     exon            278..3069
                     /gene="Klhl26"
                     /gene_synonym="C630013N10Rik; Klkl26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl26"
                     /gene_synonym="C630013N10Rik; Klkl26"
                     /note="hexamer: AATAAA"
     polyA_site      3029
                     /gene="Klhl26"
                     /gene_synonym="C630013N10Rik; Klkl26"
                     /note="major polyA site"
ORIGIN      
        1 tcagcgcgcc gccccatcgc tcgggcgcgc ggcggaagat ggcggagtcc ggtggcagca
       61 gcggctctag tcagagcccc gagcgcccga gcagcttggc cgacaggaat ggggcactta
      121 agtgcacctt ctctgcagct ggccacagca ctggcctcct gcagggcctg gctgccctcc
      181 gtgcacaggg ccagctgctc gatgtggtcc tcactgtcaa cagtgaagcc tttcatgcgc
      241 acaaggtggt cttggcagcc tgcagtgact actttagggc catgttcact ggcggcatgc
      301 gtgaggccaa ccaggctgtc atccagctgc agggtgtgtc tgcacgtggc ctgcgtcaca
      361 tcatcgattt tgcctacagt gctgaggtga cactggacct agactgtgtg caggacgtgc
      421 tgggtgctgc cgtgtttctg cagatgctgc cggtggtgga gctgtgcgag gacttcctga
      481 aagctgccat gagcgtagag acgtgcctgc acattggcca gatggctacc accttcagcc
      541 tgacatcact gcgtgagtca gtagatgcct tcacattccg ccacttcctg cagatagcag
      601 cagaagagga ctttctgcgc ctgccactcg agcgccttgt cttctttctg cagagcaacc
      661 ggctgcagag ctgcgccgag attgacctgt tccgcgctgc tgtgcgctgg ctgcagcatg
      721 atcctgcccg ccgcgcccgt gccagccttg tgctacgcca cgtgcgcttc ccgctcatgc
      781 aacctgctga actggtggac agcgtgcaga cactcgacgt catgctcgac gatgccctgt
      841 gtcgccagta cctgctggag gccttcagct accacgtgct gccctgccgc cagcatgaca
      901 tgcagtcgcc tcgcactgct gtgcgctctg atgtagcgtc cctggtggcc ttcgggggca
      961 caccttatac cgacagcgac cgagctgtca gcagcaaggt gttccagtta cctgagccag
     1021 gagcacgcca cttccgcgag ctcacggaga tggaactggg ctgtagccac gcgggcgtgg
     1081 ctgtgctgga taacttcgtg tacgtggcag gcggccagca tctgcagcac cgcagtggcg
     1141 aaggcgctgt ggacgcctgc taccgctatg atccacagcg caatcgctgg ctgcggctgc
     1201 gagcactgcg tgagagccgc gtgcagttcc agctcactgc actgggaggg ctgttgtatg
     1261 ccaccggtgg ccgaaatcgc gcgggcagcc tggcgtctgt ggagcgctac tgcccacgcc
     1321 gtgacagctg ggattttgcc tgcccactca agcgccgtac ctggggccat gcgggtgccg
     1381 cagctgctgg tcgcctctac atctcaggtg gttatggcgt ctcagcggag gacaagaagg
     1441 cgctgcagtg ctatgatcca gcagccgacc gctgggagcc cagggcgccc atgcgtgagc
     1501 cccgcgtgct gcacgcaatg ttgggcgctg ctggccgcat ctatgcccta ggtggccgca
     1561 tggaccacgt ggaccgctgc ttcgatgtgc tggctgtgga gtactacgtg ccggatgccg
     1621 accagtggac cagtgtgaca cccatgcgag ctggtcagtc ggaagctggc tgctgtctac
     1681 tagagaggaa gatctacatc gtgggtggct acaactggag gctgaacaat gtcacaggca
     1741 tcgttcaggt gtacaacact gagacggatg agtgggagag agacctgcac ttccccgagt
     1801 cctttgcagg cattgcctgt gctgctgtcc tgctgccccg ctcaggccat gggaggtagc
     1861 ttgggatcct ggctgtgttc cccacaagtg tcagaccccc agcccagggg tccctacctc
     1921 ccagccccaa gtcaacagag agagagatct ggtccccaag gtttaggtgc catggcagcc
     1981 attgcccagt gggtgtctct gcactgtcct gtgtggttag gtcttggtat ctctcatccc
     2041 tagccagaca gatgaaagct tgtggacaga aaacaccaag tccagggagg agcaactctc
     2101 cttgtctcct gactaaactc ttctgtttaa aatcctagcc tggatttctg ccgtgggatc
     2161 cacaaggcag agagactctt cagattaccc tctgaactcc acgtgggcat catggaacac
     2221 acatgcacgc acacaatcaa atgagtaaga ttgtaaatca gctctctggt gcctggacag
     2281 cattcaggat gcaggagtca gagtgtgtcc cagaggcccc ctgacaggtg acagatgcag
     2341 ccaagtcttc atcaccaacc tccctggccc gcttgacttg tggattctgg agcatcccaa
     2401 aggcccctgt cccgttaacc cagcattctt tgcctgtgcc accccctttt ataagaagac
     2461 agagctaata agtgaggcat ggtgtggcct tttccaatac cctggaggct aaagagggag
     2521 gagaatcatt gcaagttcta ggccagccag gaccacagcc ctgaaatgag gaaacccaca
     2581 aaaaacaaaa gcagagaaac cacaaaagcc acctcaggtg aggaggcctg tgtcagctgg
     2641 cccgggagga gagccagctg ggggcccatc taacatgttg gctatagaaa gccatgctcc
     2701 caggtctggc ccaccctcgg gtggggtggt gggaggtgct atggccgtga gccccagcag
     2761 cctcattcga tggcagccct gctttgtttt gctgtttaaa tcctgaactc tcatcttcat
     2821 attttgttta atttttttct tgtttaagga agccagcccc actgtcttcc aaatgagtat
     2881 gttctctggt gatctaaggt gtcccttgct gctcagagtc atggatgtca tcgttgtacg
     2941 gccgctcagc acatgagtaa ttaatcccag tcctttgctg cagcctctgc tgatcagtcc
     3001 tttgatttaa taaaggcatt atggaggaag gatggagcag acctgtgctc tacgcctgcc
     3061 acctgtgtg
//
