LOCUS       NM_001122780            3374 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus kelch-like 25 (Klhl25), transcript variant 2, mRNA.
ACCESSION   NM_001122780
VERSION     NM_001122780.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3374)
  AUTHORS   Tian,M., Hao,F., Jin,X., Sun,X., Jiang,Y., Wang,Y., Li,D.,
            Chang,T., Zou,Y., Peng,P., Xia,C., Liu,J., Li,Y., Wang,P., Feng,Y.
            and Wei,M.
  TITLE     ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of
            fatty acid metabolism to facilitate iTreg differentiation
  JOURNAL   Elife 10, e62394 (2021)
   PUBMED   34491895
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3374)
  AUTHORS   Najas,S., Pijuan,I., Esteve-Codina,A., Usieto,S., Martinez,J.D.,
            Zwijsen,A., Arbones,M.L., Marti,E. and Le Dreau,G.
  TITLE     A SMAD1/5-YAP signalling module drives radial glia
            self-amplification and growth of the developing cerebral cortex
  JOURNAL   Development 147 (13) (2020)
   PUBMED   32541003
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3374)
  AUTHORS   Ikegami,K., Saigoh,K., Fujioka,A., Nagano,M., Kitajima,K., Sato,C.,
            Masubuchi,S., Kusunoki,S. and Shigeyoshi,Y.
  TITLE     Effect of expression alteration in flanking genes on phenotypes of
            St8sia2-deficient mice
  JOURNAL   Sci Rep 9 (1), 13634 (2019)
   PUBMED   31541165
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3374)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 3374)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 3374)
  AUTHORS   Hrabe de Angelis,M.H., Flaswinkel,H., Fuchs,H., Rathkolb,B.,
            Soewarto,D., Marschall,S., Heffner,S., Pargent,W., Wuensch,K.,
            Jung,M., Reis,A., Richter,T., Alessandrini,F., Jakob,T., Fuchs,E.,
            Kolb,H., Kremmer,E., Schaeble,K., Rollinski,B., Roscher,A.,
            Peters,C., Meitinger,T., Strom,T., Steckler,T., Holsboer,F.,
            Klopstock,T., Gekeler,F., Schindewolf,C., Jung,T., Avraham,K.,
            Behrendt,H., Ring,J., Zimmer,A., Schughart,K., Pfeffer,K., Wolf,E.
            and Balling,R.
  TITLE     Genome-wide, large-scale production of mutant mice by ENU
            mutagenesis
  JOURNAL   Nat Genet 25 (4), 444-447 (2000)
   PUBMED   10932192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY241272.1 and AK143086.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143086.1, BC011221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY241272.1         2-45
            45-3374             AK143086.1         2-3331
FEATURES             Location/Qualifiers
     source          1..3374
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 43.81 cM"
     gene            1..3374
                     /gene="Klhl25"
                     /gene_synonym="2810402K13Rik; Enc-1"
                     /note="kelch-like 25"
                     /db_xref="GeneID:207952"
                     /db_xref="MGI:MGI:2668031"
     exon            1..136
                     /gene="Klhl25"
                     /gene_synonym="2810402K13Rik; Enc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..1941
                     /gene="Klhl25"
                     /gene_synonym="2810402K13Rik; Enc-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1917
                     /gene="Klhl25"
                     /gene_synonym="2810402K13Rik; Enc-1"
                     /note="ectoderm-neural cortex protein 2; ectoderm-neural
                     cortex-1; ENC-2"
                     /codon_start=1
                     /product="kelch-like protein 25"
                     /protein_id="NP_001116252.1"
                     /db_xref="CCDS:CCDS21369.1"
                     /db_xref="GeneID:207952"
                     /db_xref="MGI:MGI:2668031"
                     /translation="MSVSVHETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCM
                     FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLL
                     DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQ
                     CRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWV
                     KHDLEQRKAHLPLLLRNVRLALLPSDCLKNAVSGEALLMADECTKLILDEAFRCKTKI
                     LLNDGVVTSPFARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFS
                     ASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYV
                     VGGHTSLAGIFPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFG
                     GTSIHRDMVSKVQCFDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEYTAASA
                     YRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN
                     CITTVPYSLIPTAFVSTWKHLPA"
     exon            1942..3374
                     /gene="Klhl25"
                     /gene_synonym="2810402K13Rik; Enc-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3353..3358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl25"
                     /gene_synonym="2810402K13Rik; Enc-1"
                     /note="putative"
ORIGIN      
        1 ggcggggcgg gaaggccgga gaaactagtt tgttggcagc gcccgtgcgg ttcggctacg
       61 ggatcgcggc cgggactggt gagccggccg ggggcggcgg cagcggcggg gactgcagag
      121 cctgtggggc cgcacggttg gtacacgatg tcagtcagtg ttcacgagac ccgcaagtcg
      181 aggagcagca cgggctccat gaacatctca gtcttccaca aggcttcaca ccctgactgt
      241 gtgctggccc acctcaacac tctgcgcaag cactgcatgt tcacggatgt cacactctgg
      301 gctggtgacc gagcctttcc ttgccatcgt gcggtgctgg ctgcctccag ccgatacttt
      361 gaggccatgt tcagccacgg cctgcgggaa agccgggatg atacggtcaa cttccaggac
      421 aacctgcacc ccgaggtgtt ggagctgctg ttggactttg cctactcttc tcgcatcgtc
      481 atcaatgagg agaacgcgga gtcactacta gaggctggtg acatgctgca gttccatgat
      541 gtccgggatg cagctgctga gttcctggag aagaatcttt ccccctccaa ctgccttggc
      601 atgatggtgc tgtctgatgc ccaccagtgc cgacggctct acgagttctc atgccgaatg
      661 tccctggtgc attttgagac ggtgcggcag agcgaggact tcaacagtct ctctagggac
      721 acgctgttgg acctcatctc cagagatgag ctggagactg aggatgagcg cgtggtcttt
      781 gaggccatcc tgcagtgggt gaagcatgac ttagagcaga ggaaggctca cctgcccctg
      841 ctcctgcgta acgtgcgact ggccctgctg ccctcagact gcctgaagaa tgccgtatct
      901 ggagaggccc tcctcatggc ggacgagtgc accaagctca tcttagacga ggccttccgc
      961 tgcaagacca agatcttgct gaatgatggt gtggtcacca gtccctttgc ccggcctcgc
     1021 aaggcaggtc acacactgct catcttggga ggccagacct tcatgtgtga caagatctac
     1081 caagtggacc acaaagccaa ggagattatc cccaaggcag atctgccaag cccccggaag
     1141 gagttcagtg cttcagcgat tggttgcaag gtctatgtga ctggaggcag gggctctgag
     1201 aatggagtct ctaaggatgt ctgggtgtat gacactgtcc atgaggaatg gtctaaggcc
     1261 gcccctatgc tgattgcccg ctttggccat ggctcagccg agctggagaa ctgtctctat
     1321 gtggtggggg ggcatacatc cctagcaggt attttccctg cctccccttc tgtctccctg
     1381 aagcaagtag agaaatatga ccctggggat aataagtgga ctatggtggc ccccatgaga
     1441 gacggtgtca gcaatgctgc agtggtgagt gccaagctga aactctttgt gtttggaggg
     1501 accagcatcc accgagatat ggtgtccaaa gtccagtgtt ttgacccctc ggagaaccgg
     1561 tggacaatca aagcagagtg tccccagccc tggcgataca cagccgccgc tgtcctgggc
     1621 agccagatct tcatcatggg aggtgataca gagtacacag cagcttcagc ctaccgcttc
     1681 gactgtgaga ccaaccagtg gacgcggatt ggggacatga cagccaaacg catgtcctgt
     1741 catgccgtgg cttcaggcaa caagctgtat gtggtgggag gctactttgg gacccagagg
     1801 tgtaagaccc tggactgcta tgaccctact tcagacacat ggaactgcat caccactgtg
     1861 ccctactctc tcattcccac ggcctttgtt agcacctgga agcatctgcc tgcatgaaag
     1921 gcacctttgg agcccagcca gactgcgtgg ttcctcctgc ctgggccaga agctgacagc
     1981 tccagcccca ggcggcagca gctcaagctg tccttaactc taggcagaga aatgaagttc
     2041 tccagcgtca cctgtgctct ggtgtccaaa gctggcagcg gctcgtgtgg agagaagcgt
     2101 ccagaggcac gggctggcac cagcaaccaa cgacatttgt gcagagcctt gaggctgatt
     2161 gtcacccagg cctggcaatg gctaccaggg aagagcaggg gtcccttggc ccagcagcac
     2221 agcctttgac tgtagggctg cctgtgggag gtgggaatgt ttctccatag tctcctggac
     2281 atcagggagc atagtctaac tgaagacata ttttataagg gacagaaccc ccagggcaac
     2341 ccggcctcag atggtaccca caaggcttca tcaacagatg gtaccagacc cctaaggtca
     2401 aggggagatg gcctgtgtgc cctctgtcaa gcactagctc cccctcctaa gaggcgactt
     2461 ctgggaagct tccatggaca tagggcagat gcctgtgacc agccagacac tgctaagagt
     2521 cccccagcag gactctaggt cccccagcgc tggtaggggt ctgatgcttg ccctccttag
     2581 aggcacagaa gagcagcatg atatacctgc cagtagtact gggcctcttt tctggacacc
     2641 cacctgcctt agtcctgtgt cctgcctgct ccataagagg gcagtcatga gtcgaatggc
     2701 agagggactc ccacggtcac tgcagtttgc acagaggttg tattgctgtc attgtggatc
     2761 taggaccaag gctcccatca tgcctgctat cctccttggc accagctggc agcctgaatc
     2821 ctgtctgatt ttcttccttg agctcagaaa gaaggatccg aagaaacttc ccaaatgtgt
     2881 ttctcaagga ttcctcccca gtgtctcccc ggcattaggt tttcggagac actttcttct
     2941 tatgccagtg tggataccag gctcatccct tgtttgtcta gtgctcttgg tttccggcac
     3001 aggatgggga gtgttccatc gttggtggct tcccattact gcatcaggac ggagcatcca
     3061 gagtgggttc tgatctggac ggaagtggag ttgcagtaca gaccagtttg gtcagccttc
     3121 aaggtcctca cagctcagcc tactactgct ggcgtaggtg acttagtcac acactggccc
     3181 tcatctgagg tccagctggc ttcccattcc acctcaggga cagtcttgct ggagaattac
     3241 tggctcctgg cctgtggact atgccatctg cactaatcgg tctgcacagc acagaggacc
     3301 tagccatggt gcttgcctga gcatgggtgt tgcttttatt agtttctaac ttaataaaag
     3361 tgcggacatt cttg
//
