LOCUS       NM_029436               6683 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kelch-like 24 (Klhl24), mRNA.
ACCESSION   NM_029436 XM_358791
VERSION     NM_029436.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6683)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6683)
  AUTHORS   Liu,Y., Cui,J., Zhang,J., Chen,Z., Song,Z., Bao,D., Xiang,R., Li,D.
            and Yang,Y.
  TITLE     Excess KLHL24 Impairs Skin Wound Healing through the Degradation of
            Vimentin
  JOURNAL   J Invest Dermatol 143 (7), 1289-1298 (2023)
   PUBMED   36716923
  REMARK    GeneRIF: Excess KLHL24 Impairs Skin Wound Healing through the
            Degradation of Vimentin.
REFERENCE   3  (bases 1 to 6683)
  AUTHORS   Cui,J., Zhao,Q., Song,Z., Chen,Z., Zeng,X., Wang,C., Lin,Z.,
            Wang,F. and Yang,Y.
  TITLE     KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption
            Causes Alopecia
  JOURNAL   J Invest Dermatol 142 (8), 2079-2087 (2022)
   PUBMED   35066002
  REMARK    GeneRIF: KLHL24-Mediated Hair Follicle Stem Cells Structural
            Disruption Causes Alopecia.
REFERENCE   4  (bases 1 to 6683)
  AUTHORS   Lin,Z., Li,S., Feng,C., Yang,S., Wang,H., Ma,D., Zhang,J., Gou,M.,
            Bu,D., Zhang,T., Kong,X., Wang,X., Sarig,O., Ren,Y., Dai,L.,
            Liu,H., Zhang,J., Li,F., Hu,Y., Padalon-Brauch,G., Vodo,D.,
            Zhou,F., Chen,T., Deng,H., Sprecher,E., Yang,Y. and Tan,X.
  TITLE     Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of
            keratin 14 and human skin fragility
  JOURNAL   Nat Genet 48 (12), 1508-1516 (2016)
   PUBMED   27798626
REFERENCE   5  (bases 1 to 6683)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165282.2.
            
            On Apr 21, 2004 this sequence version replaced NM_029436.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044892.1, SRR10223969.16583.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC165282.2         30806-30923         c
            119-181             AC165282.2         26423-26485         c
            182-1162            AC165282.2         20834-21814         c
            1163-1347           AC165282.2         13732-13916         c
            1348-1466           AC165282.2         12475-12593         c
            1467-1655           AC165282.2         10421-10609         c
            1656-1844           AC165282.2         8179-8367           c
            1845-6683           AC165282.2         733-5571            c
FEATURES             Location/Qualifiers
     source          1..6683
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.36 cM"
     gene            1..6683
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /note="kelch-like 24"
                     /db_xref="GeneID:75785"
                     /db_xref="MGI:MGI:1923035"
     exon            1..118
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            119..181
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            182..1162
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2045
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /note="KRIP6; kainate receptor-interacting protein for
                     GluR6"
                     /codon_start=1
                     /product="kelch-like protein 24"
                     /protein_id="NP_083712.4"
                     /db_xref="CCDS:CCDS28042.1"
                     /db_xref="GeneID:75785"
                     /db_xref="MGI:MGI:1923035"
                     /translation="MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEYFDFSS
                     GSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRES
                     REMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLE
                     EQLDPCNCLGIQRFADTHSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICS
                     DELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQ
                     NSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTEC
                     YDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVAS
                     LNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT
                     SCIGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAG
                     GLTKAVYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYD
                     PATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL"
     exon            1163..1347
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1466
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1655
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1844
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..6683
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4383..4388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /note="hexamer: TATAAA"
     polyA_site      4406
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /note="major polyA site"
     regulatory      4564..4569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4584
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
     regulatory      4852..4857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4873
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
     regulatory      5056..5061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5077
                     /gene="Klhl24"
                     /gene_synonym="1110046J11Rik; 4930429H24Rik;
                     6530402O20Rik"
ORIGIN      
        1 gacggtcaca tgtttccttt gttgtgagca gtggcagaga ctggcggtgg ctcgaggaga
       61 cgccggcgca gcagggacgg gggtcgccgc tcgtgccgct tccagcctgc gccgagaggt
      121 gtgaaaattt aaataacaca agtattttgc ctggggcttt ggtcaaacaa atgctgagaa
      181 gttacataaa gaagatccct aggagccatt tctcagcaat tatatagtca actgatgtaa
      241 caatggtact aatattggga cgcagattaa acagagagga tcttggggtg cgtgattccc
      301 cagcaactaa gcgtaaagtt tttgaaatgg accccaaatc tctgacaggt catgagtatt
      361 ttgacttctc ttcaggatca tcccatgctg aaaacatcct ccagatattt aatgagttcc
      421 gagacagccg cttattcaca gatgtcatta tctgtgtgga aggaaaagaa ttcccatgcc
      481 atcgagctgt cctctcagcc tgcagcagct acttcagagc catgttctgt aacgaccaca
      541 gggagagccg agaaatgctg gttgagatca atggcatttt agctgaagct atggaatgct
      601 ttctgcagta tgtgtatact gggaaggtga agatcacaac agagaatgtc cagtacctct
      661 tcgaaacctc cagcctcttt cagattagtg ttctccgtga tgcttgtgcc aagttcttag
      721 aggaacagct tgatccttgc aattgcctag gaatccagcg ctttgccgac acccactcgc
      781 tcaaaacact cttcacaaaa tgcaagacct ttgcattaca gacttttgag gatgtgtccc
      841 agcatgaaga atttctcgag cttgacaaag atgaacttat tgattatatc tgcagtgatg
      901 aacttgttat tggtaaagag gagatggttt ttgaggccgt catgcgctgg gtctaccggg
      961 cggttgatct gcgaagacca ctgttacatg agctcctgac gcacgtcagg cttcctctct
     1021 tgcatcccaa ctactttgtt cagacagttg aagtggacca gttgatccag aattcccccg
     1081 agtgttatca gttgctgcac gaagcaaggc ggtaccacat acttggcaat gaaatgatgt
     1141 ccccaaggac taggccacgc aggtctactg gctattcaga ggtgatagtt gtggttggag
     1201 gctgtgaacg agttggagga tttaatcttc catacactga gtgctatgat ccagtaacag
     1261 gagaatggaa gtccttggcc aagcttccag aatttaccaa atccgagtat gcagtctgtg
     1321 cactgaggaa tgatattctt gtttcaggtg gaagaatcaa cagccgtgat gtctggattt
     1381 ataattcaca gttaaatatc tggatcagag ttgcttctct aaataaaggc agatggcgtc
     1441 acaaaatggc tgtccttctt ggtaaagtgt atgttgttgg cggctatgat gggcaaaaca
     1501 ggcttagcag tgtggagtgt tacgattcct tttcaaatcg ttggacggaa gttgctccac
     1561 ttaaggaagc agtgagctct cctgcagtga caagctgtat aggaaaattg tttgtgattg
     1621 gtggaggacc tgatgataat acttgttctg ataaggtcca atcttatgac ccagaaacca
     1681 attcttggct acttcgtgca gctatcccta tcgccaagag gtgcatcaca gctgtctctt
     1741 taaacaacct gatctacgta gctggtgggc tgaccaaggc agtgtattgt tacgatcccg
     1801 ttgaagacta ctggatgcat gtacaaaaca cattcagccg gcaggaaaac tgtggtatgt
     1861 ctgtttgtaa tggtaaaatc tatatcctgg gtggaagacg ggaaaatgga gaagccacag
     1921 atactattct ctgttacgat cctgcgacaa gtatcatcac aggagtggct gcaatgccca
     1981 ggccagtgtc ctaccacggc tgtgtaacta ttcatagata caatgagaag tgctttaagc
     2041 tctaactaaa cccaggatac ctcacacaag aagccaacgt caatccaaga ggaaagtttt
     2101 taaaacgacc acgtgagaac tcaactcctt tgcataaaga aataaataat cctgatgcct
     2161 ttctgaccca aaattccaat atttcaagca gtcataaatc ctttcctgta ctgggggtgg
     2221 gaggttggtt gagtgagacc agtgctcacc tttaccccag cactcagaag gcagacttct
     2281 atacgtttga acccagcctg gtctacataa caagttctag gccagcaaag gttacacaat
     2341 aaggccttgt cttttgaaaa aaaaaagtca taatttggcc tatgaatata ctttggcatt
     2401 tttgaaatac tatgtggggt aggcagtact gcccagtgta aacttcatag ggatttgtga
     2461 accatttttc aggagtgtgt cctgtttttg tcaattatgt agagagtatt gcatgaatga
     2521 agcttttttt tttttttttt ttggttgaat tgcctgatgt taagaatgtt tagaattcat
     2581 tgtgagagga agaaatgagt ttgttttgtt cattcgttca ctttaacaat ttatttaact
     2641 ttgtgtacat tggtagaagg ggatcagatc ccttggaact ggagttacag acagttgtga
     2701 actgccatgt gggtgctgag aactgaaccc cggtcctttg gaagaacaga cagtgctctt
     2761 aaccactgag ccatctctca agccccaaga aatgacttta tccatactgg ttaattctat
     2821 tgaaggcttt ttggggtttt gtttggtgtt ttttctaatt gtaaaagtgt agtgacaatt
     2881 cagctaccat aaaataccaa attttatgac tttatagact attctctgat attaaatact
     2941 ttttgtgagt tgatgtagga gatgtaaaag taaggagatt taaattatac attagtccct
     3001 aaggaaaaat taaaattact attgaagaaa aaaaaaatgt gatccacttt ggttctcagg
     3061 gtatttaatg actcatctgt gcgtccacta aagaatttct ttcctttaaa ctaacatagg
     3121 agttgaaatc ccttttacag agcaaggcag gtgtctgtgt tcaggatctg tttcccaggc
     3181 atggtagtgc agacctgtat ccaggatctg ggaagtgcat caaaagaaac cagatgggct
     3241 gaagagatgg ctcagtgttt acgaacactt cctgcacttg cagagaacct aggtttggtt
     3301 cccaccctta tcaggtagct cacaatttct gcaattctag ttccagggaa tcgaacacct
     3361 tctgtcctcc ctgggcatct acaaatatat ggtgcacata aattcataca ggaacacgtg
     3421 tataaaagaa atatatctta agacaaaatt gcatttgcaa tactgctgta agaaaaacaa
     3481 gaacaggttt gctcctaccc agcctgacag agttggacct aacttgtgtg atgccttgtg
     3541 agtgcctctc cgctgccttg tgagcagtta ttagcctagg agagttgtct aattccttaa
     3601 tatcctacag cagtggggcc tctcacttgt aactctgacc agcagcagtt ccggtctcca
     3661 gagagaaatc tcttatttgg gagagctctt ttatttgtat aaaatactga tcatcatttt
     3721 cagatttcta ttaaattttt ccctctaggt tttttacctc cattttgtaa agcttagcag
     3781 tttgcaaagg gaaatgtgaa atttttctta gacacataag tgaatacagc aggaattagc
     3841 acaactaatt attgtaactt ccagtgccct gggctgcagc aggtgacttg ctgtgtaact
     3901 tcccagtctc tcactataat atactccttg tcaatgacaa tggtgtcaat cgatttctgt
     3961 tcaaattcag gcagttatca gaaacctagc attggcaaac aactttttcc tcatcttagg
     4021 ataatacaaa tgtattttaa gagtcatgct tagttggaat ctaaattctg agaaaaatgc
     4081 taaaaaatac acttaggaaa tggttttcaa gtcataaatt ataagtgata tagctataga
     4141 aacaatgcag aaaatcatct gtcaggtgag caacagatgt atgtaaaact gagggtatgt
     4201 gtactgtaat tttatagtaa gtatctgcat tatgcttttg ttagagaatg gaaattgttt
     4261 agttcagaaa ttcttaacag ttaagtgtgt gaacaaaagt gttttataaa tgcttaggat
     4321 tctacaaatg ataattgtta ttctcatgta tatttgtaag atcatgtcca ttcataaata
     4381 tatataaaag acttggtcaa agtaaatttg tattttagta tttttgtctg ttgtaaaagt
     4441 attatctact tgtatcttat aatgtttatc tttcatatat tctcatgttt attgcagtaa
     4501 attggaaaaa atcctgaaaa tcagaatttg ttcaaacaaa ttaattttta tgttacaaat
     4561 tatattaaaa gttaccagaa agtacctgaa tcctagaaaa ttaactttta aaagctaccc
     4621 aattggtatt ttaacttcct ttaattactt acctttgcta atccttgata aataatagtg
     4681 gtaagccctg gtttaaaaaa taataatttt gccgggcagt ggtggcacac gcctttaata
     4741 ccagcacttg aggggcagag gcaggcaaat ttctgagttc caggacagcc agggctacac
     4801 agagaaacta tgtcctgaaa aaaataatta attttagggt ataataaatg tattaaaagg
     4861 gctatatcaa ccatcctaga gtcagactat cttcattctg ttatcccata attggcagac
     4921 tttcttttga taggtgatgt ttatatgagc ctctaagtta ggatgtgtgt gtgtttatat
     4981 gtagatagta tgatgtgtac atatatcaca aacacccaat ggtttttgca gtttaattat
     5041 cagaaatttg tataaattaa aaaattagtt gatcatagac aatttgatta cataagacta
     5101 aatttgaaca tttctagagt actctttatt gttgagacag gatctctgta gcctgtgcta
     5161 gcctcaaact cttagcaatt ctttgccttc tgagagctgc agttagaaga ggaagccagg
     5221 accattttct aaaataagca tttcatctga aagtgcagat ctggtcttaa ggatctgtgc
     5281 acctgtgtaa ctacagcgtt acaaggccag gaagcagacc tggagatctg tgtaacgaca
     5341 gtgttacaag gtcagaaagc agacctggag atctgtgtaa cgacagtgtt acaaggccag
     5401 gaagcagacc tggagatctg tgtaacgaca gtgttacaag gccaggaagc agacctggag
     5461 atctgtgtaa cgacagtgtt acaaggccag gaagcagacc tggagagaag cgtgcaaaca
     5521 ccgcttgtgg ctgttcagtt ggaaaggtca tatgttttgt gaatcaacag gaaattacag
     5581 ttggtttttg tgtacatttt catgaacttg aatcctcctc caagtcttct ccatgtactc
     5641 cacaaggtgg cctgacttcc tccctgtctg ctgtactctc ccacactgac tgactgacag
     5701 gaattgggtt ctccacagcc gtttgtcata gatgggcggt tgggatccag gtgtttactc
     5761 cattggaatc aggttttaaa cgaccaaatg ctcagggagg gcattggctt gtctgagtca
     5821 cccatcgggt gtgcaaagca ctctcaccat ttagttgatg gctctagacg gatatgtttc
     5881 agaaatttca cttctagcag tggttaaaca tccattctgc ttggaaagat gacagtgctt
     5941 ggtgagccgg cacactctcc tggtgaatat gaattgtttc tgcatctgct gtcagacccc
     6001 cattttgaaa ctcaggaaag acaaaggtgg gttttctgct tttgtcattg tccaacccag
     6061 gtgtgtgctg ctttttcctg atctgacagt agatttttaa aaatcactct gagagcccat
     6121 gcacatacac gaagagagaa cgggagttgg attatttgtg tgtgccttta acgtcttgag
     6181 aggatacatc ctacagactt catgtggtac caagataatg tccggaagct tcctgtggac
     6241 tgcctcatag tcaacccaag acattactag ttaaaacgat ttggtcttgc tggagttagt
     6301 ggtacagagc tgagtgtggt ggcaatgtct gattccagtc cttgggagat gtgacaagaa
     6361 gatcaggaaa gttccaggac agccatggca acagagccag tttgaggtca gagttggcca
     6421 catgaattcc catgtgagaa acagtaatgg cattgattgg cattgtgtag aaagctggaa
     6481 tgatatcatt tcatccatta ttatgttcca aaccacataa ccaacatgaa aattcactgt
     6541 atcacgtaac cagaatgaag caggttcgct gacctgtgat gcaatagatt tgactagcta
     6601 attatgcttc ttgccacatc tagtgctagg catcaaacag cacttccagg tgtataaact
     6661 aataccagag atgtttcaaa ata
//
