LOCUS       NM_177784               4621 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus kelch-like 23 (Klhl23), transcript variant 1, mRNA.
ACCESSION   NM_177784 XM_992834
VERSION     NM_177784.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4621)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072626.1, AK048518.1 and AI425639.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_177784.5.
            
            On Oct 31, 2009 this sequence version replaced NM_177784.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072626.1, AK048518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4047              BC072626.1         1-4047
            4048-4614           AK048518.1         3947-4513
            4615-4621           AI425639.1         557-563
FEATURES             Location/Qualifiers
     source          1..4621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.95 cM"
     gene            1..4621
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /note="kelch-like 23"
                     /db_xref="GeneID:277396"
                     /db_xref="MGI:MGI:2683536"
     exon            1..273
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            274..1487
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1951
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /codon_start=1
                     /product="kelch-like protein 23"
                     /protein_id="NP_808452.2"
                     /db_xref="CCDS:CCDS16100.1"
                     /db_xref="GeneID:277396"
                     /db_xref="MGI:MGI:2683536"
                     /translation="MALKGQEDYIFHFKDSSHPVDFLDAFRTFYMDGLFTDITLQCPS
                     GIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEI
                     TKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGMHSFAEFHVCSELEKESRR
                     ILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRIEC
                     IYNLLSYINIDIDPVYLKTALGLQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMY
                     IIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNID
                     ALDTVWIYNSEGDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPL
                     KEKWLPIANMIKGVGNATACVLHEVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLIT
                     ASPHPEYGLCSVPFENKLYLVGGQTTITECYDPEQNEWRETAPMMERRMECGAVIMNG
                     CIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCVYNV"
     exon            1488..1640
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..4617
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4024..4029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /note="hexamer: ATTATA"
     regulatory      4034..4039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      4040
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /note="major polyA site"
     polyA_site      4053
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
     regulatory      4572..4577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
                     /note="hexamer: TATAAA"
     polyA_site      4617
                     /gene="Klhl23"
                     /gene_synonym="C130068N17Rik"
ORIGIN      
        1 agtaactcga gaatcttagg tgcctggatt cagccttgac ctaggctacc cccactttcc
       61 ctggaagctt ccaggttaac tcctagtgtg cttaagcagc cccaaagctc cttcctgcgc
      121 gctctgctgg aggcagcatg gagtttatgg gaaagcagct acttgtggca tttgaaggca
      181 gccctaatag aagaccgtag tttcgccttc ttctctcggc actttctctc tccccgcacg
      241 ccaagggcca gggccggcaa gaggacagag aagcatggct ctaaaaggac aagaagatta
      301 catttttcat ttcaaggatt cgtcgcatcc agtggatttt ctggatgcat tcagaacgtt
      361 ttacatggat ggactattta ctgatattac ccttcagtgt ccttcaggca taatcttcca
      421 ttgtcaccga gctgttttag ctgcctgcag caattatttt aaggcaatgt tcacagctga
      481 catgaaagaa aaatttaaaa gtaaaataaa actgtcgggc atccaccatg atattttgga
      541 aggccttgta aattatgcat atacttctca aattgaaatt actaagagaa atgtacagag
      601 ccttcttgaa gcagcggatc tgctgcagtt tctttctgta aagaaggcgt gtgagcagtt
      661 tctggtcagg cacctggaca ttgataactg tatcgggatg cactcttttg cagaattcca
      721 tgtgtgctca gaactagaga aggaatcccg caggatcctc tgctccaggt ttaaggaagt
      781 ttggcagcaa gaagaatttc tggaaatcag ccttgaaaag tttctcttta tcttgtccag
      841 aaagaatctg agtgtctgga aggaagaggc tatcttagag ccggtcatta agtggactgc
      901 tcacgatgta gagaatcgaa tcgaatgcat ctacaacctg ctaagctata tcaacataga
      961 catagaccca gtgtacttaa agacggctct aggccttcaa agaagctgcc tgctaactga
     1021 aaataagata cgttccctaa tatacaatgc cttgaatccc atgcataaag agatttccca
     1081 gaggtccaca gccaccatgt atatcattgg aggctactac tggcatcctt tatcagaggt
     1141 ccacatatgg gaccctttga caaatgtttg gattcaggga gcagaaatac cagattatac
     1201 cagggagagt tacggtgtta cctgcttagg acctaacatt tatgtgactg gcgggtacag
     1261 gacagataat atagatgctc ttgacacagt gtggatctat aacagtgagg gagatgagtg
     1321 gacagaaggc ctgcccatgc tcaatgccag gtattaccac tgtgcagtca ccttgggggg
     1381 ctgtgtctac gcactaggtg gttacaggaa aggggctcct gccgaagagg ccgagttcta
     1441 tgatcctctg aaagagaagt ggcttcctat cgcaaacatg attaaaggtg tgggaaatgc
     1501 tactgcctgt gtcctacatg aagtcatcta tgtcattggt ggccactgtg gctacagagg
     1561 aagctgcacc tatgacaagg tgcagagcta caattcagac atcaacgaat ggagccttat
     1621 tactgcgagc ccacacccag aatatggact gtgctcagtt ccatttgaaa acaagctcta
     1681 cctagtcggc ggacagacca cgatcacaga gtgctatgac ccggaacaga acgagtggag
     1741 agagacggcg cctatgatgg aaaggaggat ggagtgtggg gctgtcatca tgaatggatg
     1801 catctacgta accgggggct actcctactc aaaggggacg tatctgcaga gtatcgagaa
     1861 atacgatcca gatcttaata agtgggaaat agtgggcaat ctcccgagtg ccatgcggtc
     1921 tcatggatgc gtttgtgtgt ataatgtctg agtccacagg actaaccagg tcctcactag
     1981 gaatgtagtc aagagtgcag agtctatggt gccttggtat tgtgttttgg cacatgctag
     2041 ggcactggaa atttttaatt ctaaccctgc accattctca gacccagtaa ttaatgggaa
     2101 taacaaaaga aaaatgtgat gtgtgtttaa cagttcagtt aggagagtta acccctccta
     2161 gaatctctgc tttttaaagg tagaatggtg tatttgacgc ttggtaaagg tgaaaagtct
     2221 ttgtagtgaa tcttttcttc ctggtagcat cagcactggg tataggtcaa aatcattcat
     2281 tctgagttat aaaatgtctg ttaaaagtct gatgggcatg gtacacatgc ctttaatccc
     2341 agaacttggg aggcagaggc aggcagatct ctgaattgaa ggacatcaag accagcctgg
     2401 tctacatagc aacttccagg ccagccaaag ctacattgag aacctgcctt taaaagtcta
     2461 tgatgtgctg tgtatgttac aggtctctag ctggcaggga tctgaaatgt aaagagggaa
     2521 ccttctctac ctctacaaaa cagcacttta aaagtttccc tttagaatta gttagaacgt
     2581 ggatttactc acagtctctt tcctttgtgg tgtatatgat ttattgctaa tattcattat
     2641 ttactatcag agctacacta aacactgtac aagtgattgt aactgttcaa agagtttaca
     2701 actcaattta aaagaatagc aactctaaaa aggactgagt caacagtcaa atatttgctg
     2761 atgctaaggg ctgttttcat ttttagcttg ggtataagtt gctagtttag gttctggctt
     2821 aagcatgttg gcaaatcctc tttctagtta gatgtctgcg tagacaatgg aatgccaggg
     2881 ccagaaagca tgtagaacag ctgctaggca gtggaacaca catcaaagag aaaaatttgc
     2941 ttttatttgc cagctctgcc actaaccaga ttttgtgact tcagtctctg agtacatctg
     3001 cttcttcatc catgtacacc ggagacatgg atttttctgt atccagagcc gctggaccct
     3061 ttaagccaga tgaggtctgg gtggcctatg agccagatat acccttttcc tctgtgtgct
     3121 tgcagggtca gtccccaaat gtgccatgac ctgagaaaag ggggaagcgc tgctcaagtc
     3181 actcatctaa acgtgagact gtctgctcca cgccaggttg gttttattgt tttgttttta
     3241 aagagagaat acttaatttt tactttaaat aaaaactact tctgacggaa aaaaactttt
     3301 aagaagacta tttaataatc ccttcgggtg gctttttaaa taaatacaac cctttggagt
     3361 tgctatacgg tactttttta taaagagtca taaaagtgac tgtcctgggc tagtgagatg
     3421 actagcaggt gagattgctt acctcgcagg cccaagagct gcatttaacc ctgagaggag
     3481 aacatggact cctgggggct gtcctctgcc tttcacatgt gtgctgtgct acatgtacac
     3541 acacacacac acacacacac acacacgatg gaaggaaatt cgatttttaa agatgactgt
     3601 gtcctttgcc ctgtgagctg tcattatttt taaagaatga tgaaggatgt aaatgcatgg
     3661 gaatgtttat gtctgcattg taaacaatag tcacagtaca gagaagatct tcatgttaaa
     3721 gaaagtgtgc taatggaata gtgaggtgtg ccgccatggc agtaactgtt gggaagactg
     3781 tagacgtacg atgtgtctat gctaagcaag cacggtgcaa gctagtactc acactgtcac
     3841 acctttacgc atgcgaaagg taatgtgcta aataacacaa gctgttagtg taaggggatg
     3901 tggaatggtc ttaatgaatt tttttctttg tattttcaat aaaaataagt aagtcaccgt
     3961 acatgtggtt aagatgtcct acatgtgagc caactgggtt gaagcagtct aacagtgaaa
     4021 taaattatat tgcactaaaa tctgtaactt taattgtagg ctattttact gtcttctcga
     4081 gaacgtttga tagttaatct gggaagataa tgcactgccc agcagtggtt cacagtttgc
     4141 tttgggggtc agctgagaac aactgcagcc gctttcccat cctgcaccag ctcatccgca
     4201 tcctgtggat gcctaactgc accctcacag ggatgtgtcc ctgtgtgttt cggccacaga
     4261 gaaacccgct ctgccagagc tagagaagct ggcatttgtg aattcacact gaggtccagg
     4321 ccctcgtctt gacttcagta ctctcagtat ccggtcactt catatgtgtg tggtgtgtac
     4381 agtagtgtca ttgtttgtac cgaaaaagca tcctggagtt acttggcgaa tcttgaaaac
     4441 tgtgtggtga ggacattaat tacagctttt ttaaaaaaaa tcctgctttt tgctactgat
     4501 ttgcatgcaa aagaaggatt gagaaagtac acaaattcct gtctgttgtc acaactttta
     4561 aattactgca gtataaatca aaatatgtat ctgatattaa gtaatattta ggtccgaaaa
     4621 a
//
