LOCUS       NM_001033352            3895 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kelch-like 21 (Klhl21), mRNA.
ACCESSION   NM_001033352 XM_144142 XM_907018
VERSION     NM_001033352.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3895)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3895)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3895)
  AUTHORS   Huang,G., Kaufman,A.J., Xu,K., Manova,K. and Singh,B.
  TITLE     Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3
            protein to selectively promote midbody localization and activity of
            Cul3KLHL21 protein complex during abscission
  JOURNAL   J Biol Chem 292 (37), 15254-15265 (2017)
   PUBMED   28620047
  REMARK    GeneRIF: Data (including data from studies using cells cultured
            from knockout mice) suggest that Sccro neddylates Cul3 with Nedd8,
            promoting Cul3/Klhl21 complex formation and localization of Cul3
            during telophase. (Sccro = squamous cell carcinoma-related
            oncogene; Cul3 = cullin 3; Nedd8 = neural precursor cell expressed,
            developmentally down-regulated protein 8; Klhl21 = kelch-like
            protein 21)
REFERENCE   4  (bases 1 to 3895)
  AUTHORS   Mei,Z.Z., Chen,X.Y., Hu,S.W., Wang,N., Ou,X.L., Wang,J., Luo,H.H.,
            Liu,J. and Jiang,Y.
  TITLE     Kelch-like Protein 21 (KLHL21) Targets IkappaB Kinase-beta to
            Regulate Nuclear Factor kappa-Light Chain Enhancer of Activated B
            Cells (NF-kappaB) Signaling Negatively
  JOURNAL   J Biol Chem 291 (35), 18176-18189 (2016)
   PUBMED   27387502
  REMARK    GeneRIF: data clearly demonstrate that KLHL21 negatively regulates
            TNFalpha-activated NF-kappaB signaling via targeting IKKbeta,
            providing new insight into the mechanisms underlying NF-kappaB
            regulation in cells.
REFERENCE   5  (bases 1 to 3895)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL611927.21.
            
            On May 2, 2007 this sequence version replaced NM_001033352.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154493.1, BC060201.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1073              AL611927.21        10342-11414
            1074-1479           AL611927.21        13751-14156
            1480-1552           AL611927.21        15758-15830
            1553-3895           AL611927.21        16786-19128
FEATURES             Location/Qualifiers
     source          1..3895
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 82.82 cM"
     gene            1..3895
                     /gene="Klhl21"
                     /gene_synonym="1810045K06Rik; D330008A20; mKIAA0469"
                     /note="kelch-like 21"
                     /db_xref="GeneID:242785"
                     /db_xref="MGI:MGI:1919288"
     exon            1..1073
                     /gene="Klhl21"
                     /gene_synonym="1810045K06Rik; D330008A20; mKIAA0469"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1479
                     /gene="Klhl21"
                     /gene_synonym="1810045K06Rik; D330008A20; mKIAA0469"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1552
                     /gene="Klhl21"
                     /gene_synonym="1810045K06Rik; D330008A20; mKIAA0469"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..3895
                     /gene="Klhl21"
                     /gene_synonym="1810045K06Rik; D330008A20; mKIAA0469"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcggtg ccggacgcgc tggggcgtcc ctgtgacccg cagctccgcg tcatggagcg
       61 gccggcgcct ttggctgtgc tgcccttctc cgatcccgcg cacgccctaa gcctgttgcg
      121 cggcctcagt caactgcgcg ccgagcgcaa gttcctggat gtgaccctgg aggcggcggg
      181 cggccgcgac ttccccgcgc accgcgccgt gctggcggcc gctagtccct acttccgcgc
      241 catgttcgcg ggccagctgc gcgagagccg cgccgagcgc gtgcgcctgc acggggtgcc
      301 gcccgacatg ctgcagctgc tcctggactt cagctacacc ggcagagtgg cggtgagcgg
      361 cgacaacgcc gagccgctgc tgcgcgccgc cgacctgctg cagttccccg ccgtgaagga
      421 ggcgtgcggc gccttcctgc agcagcagct cgacctggcc aactgcctgg acatgcagga
      481 cttcgccgag gccttcagct gctcggggct ggcgagcgct gcgcaacgct tcatcctgcg
      541 ccacgtgggc gaactgggcg ccgagcaact ggagaggctg ccgctggcgc gcctgctgcg
      601 ctacctgcgc gacgacgggc tgtgcgtgcc caaggaggag gcggcctacc agctggcgct
      661 gcgctgggtg cgcgcggacc cgccgcgccg cgcgccgcac tggccgcagt tgctggaggc
      721 tgtgcgcctg cccttcgtgc gccgcttcta cctgctggca cacgtggagg ccgagccact
      781 ggtggcgcgc tgcccacctt gcctgcgcct gctgcgcgag gcccgcgact tccaggcggc
      841 tcgctacgac cggcacgacc gcgggccctg cccccgcatg cgtccgcgcc cgtccaccgg
      901 cctggccgag atcctggtgc tggtgggagg ttgtgaccag gactgcgacg agctggttac
      961 ggtcgactgc tacaatccgc agaccggcca gtggcgttac ctggccgagt tccccgatca
     1021 cttaggtggg ggctatagta tcgtggctct gggcaacgac atctacgtga cgggcgggtc
     1081 tgatggctcc cggctctatg actgcgtgtg gagatacaat tcgagtgtga acgagtggac
     1141 ggaggtggca cccatgctca aggcccgaga gtaccacagc tcctcagtgc tagacggcct
     1201 tctgtatgtg gtggcagccg acagcacgga gcgctatgac catgccaccg actcctggga
     1261 ggcactgcag cccatgacct accccatgga caactgctct accactgcct gccgaggccg
     1321 actctatgcc attggctccc tggcaggcaa ggagaccatg gtgatacagt gctatgaccc
     1381 agacactgat ctgtggtcgc tggtgaactg tggccagctc ccaccgtggt cctttgcgcc
     1441 caagactgtg actttgaatg gactcatgta cttcgtcagg gatgactctg ccgaggtgga
     1501 cgtctacaac cccactaaag acgaatggga caagatccca tccatgaatc aggtacacgt
     1561 tgggggcagc ctggccgtcc tgggaggcaa actctatgtc tctggggggt acgacaacac
     1621 ctttgaactc tcggacgtgg tggaggcata tgacccagag acccgggcct ggagtgtggt
     1681 ggggcggctt ccagagccca ccttctggca cggcagcgtg agcatcttcc gccagttcat
     1741 gccacagaca ccggcagggg ggcgtggctt cgagctgaac agtggtagca atgacgtgga
     1801 tgcaggctac cacaggctgc cacagaaccc cgaggagctg cattagccca ggcctggccc
     1861 aggggaggac cttggtgtaa ggggcctggc acctgcaggg aagtggctcc agggtgctta
     1921 gtgagcgcct cagtgtactg tgtaaaggtt ctgtgtattc agggcctatg tcacagcttc
     1981 tggggactaa ataaggtggt ggtgaccacc atcatgaatc agccttcaga agttaccccc
     2041 agctcgtagc atccagctca ctgtgcaggg agcctctcct tgccctctcc tgggcctgtg
     2101 tgctcccagg gcagaaggtc ctgtaatggt aagaaagtgg cctggcttgg agcactggga
     2161 atcagggaaa acaaaggcta gagtgaagtg ctaaactccc catccagtcc caaggctcct
     2221 ccaatgctgc aggtagagag gtgttcacac cactgtcggg gtctcaccgt ataggaatta
     2281 agtactaaga ctgagctggt ggactgtcac agtgtgagtc caagctctgt ccctatagca
     2341 cgtgttcttg cctggcaagg aggccctccc tgggactctc ctggaggaca gggagcaaag
     2401 ctcacagagc tggcttgctg tggtggctcc tcgggggcct cactgacact tagctaaggg
     2461 cctgggagca gagacccctg cttctaaaga gagccgagtg gggcggcccc agcacttggc
     2521 cgtaggtttg aaaagctagc tgacctagga tttctagggt catagggcca gggacacaag
     2581 tactagggca cctggaccac agcttagggg atccctgggt ttctttgtga ctttgagtgg
     2641 tttcatgagt ttgggagctg agaccccctt gtaaccggtg ggtttgcctg gggtttgtta
     2701 tcttttgggg ggaagaggcc attaggactt tttgttatag acaaagccaa agttcagagt
     2761 tgcctttttc tagtgaactc aagggcagat gaggctctag gaacagaagt ttctatccca
     2821 tcacatgcct actgctgcct tcttgtccag ctggcagagg gggctgcctt aatttcctcc
     2881 tgttttgaaa gccatgttct agaatgctct gctgggcacc tgactctggg aaagatggta
     2941 ggtagagggc agtgctctcc caaccgatgc ccgctggtga cctagggttc ccttggggat
     3001 gtgtgggtta gggttaggct tgtttcattt tctggtgcca ccaacccatc cttccagcga
     3061 gtgctttctt ttctctgaac cttaaaaaga gctgcctccc agggccacca gagttgtcgc
     3121 tctgctatgg agtgccttgc cacagcaggg tggggtcctg tgtgtgtgtg tgtgtgtgtg
     3181 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttgtgtat ggagtgcctt gccacagcag
     3241 ggtggggtcc tgtgtatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttcagtac
     3301 cgaggacagt gttgttcagt cctcttgggg acaggctagg aggctttcca gaggaaggac
     3361 acgacctgca gcaattaact gcaggatagt gcacacttgc acagggcccc tctgccctgc
     3421 tccagagcta ctcaggtttc cacatcaggg cccctccaaa actaaggata gtaagaattg
     3481 taagcacttt gtgtgcccac cgggagtcca ggactgtccc tccctgggcg tcacctctgc
     3541 cactggctct gggctgtaac ccactgctta tcacatgtct ctacactaac agggattgaa
     3601 gctgggccac ctgggtatgg gattgtccct gtcacatgta caaagctttt atatgttagg
     3661 acaaaactta agttatgaga gaagttctgt gcctagtatt gatctataag ggatttttct
     3721 tatatttatg acttgagaga cttaggaaga ctgcctgcct gccttaggaa ggcggcactc
     3781 agtcaccagt ggctgggcag atttgtatat ttatttttgt ctgttctgta gcttctgtgt
     3841 ccagcatcct gaggtcttag ggtgcttccc taatttttga aataaaatgt ttcct
//
