LOCUS       NM_177771               4573 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kelch-like 18 (Klhl18), transcript variant 1, mRNA.
ACCESSION   NM_177771
VERSION     NM_177771.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4573)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4573)
  AUTHORS   Lewis,M.A., Ingham,N.J., Chen,J., Pearson,S., Di Domenico,F.,
            Rekhi,S., Allen,R., Drake,M., Willaert,A., Rook,V., Pass,J.,
            Keane,T., Adams,D.J., Tucker,A.S., White,J.K. and Steel,K.P.
  TITLE     Identification and characterisation of spontaneous mutations
            causing deafness from a targeted knockout programme
  JOURNAL   BMC Biol 20 (1), 67 (2022)
   PUBMED   35296311
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4573)
  AUTHORS   Ingham,N.J., Banafshe,N., Panganiban,C., Crunden,J.L., Chen,J.,
            Lewis,M.A. and Steel,K.P.
  TITLE     Inner hair cell dysfunction in Klhl18 mutant mice leads to low
            frequency progressive hearing loss
  JOURNAL   PLoS One 16 (10), e0258158 (2021)
   PUBMED   34597341
  REMARK    GeneRIF: Inner hair cell dysfunction in Klhl18 mutant mice leads to
            low frequency progressive hearing loss.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4573)
  AUTHORS   Chaya,T., Tsutsumi,R., Varner,L.R., Maeda,Y., Yoshida,S. and
            Furukawa,T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
  REMARK    GeneRIF: suggest that Cul3-Klhl18 modulates rod Talpha
            translocation during light/dark adaptation through Unc119
            ubiquitination
REFERENCE   5  (bases 1 to 4573)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4573)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 4573)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 4573)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132103.3, BY195998.1, BY248410.1, CK619719.1, CB247282.1,
            CF739377.1 and BC065167.1.
            
            On Feb 7, 2007 this sequence version replaced NM_177771.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173029.1, SRR1660819.97496.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC132103.3         169756-169835
            81-418              BY195998.1         2-339
            419-580             BY248410.1         339-500
            581-1043            CK619719.1         187-649
            1044-1304           CB247282.1         392-652
            1305-1777           CF739377.1         173-645
            1778-4573           BC065167.1         1474-4269
FEATURES             Location/Qualifiers
     source          1..4573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.92 cM"
     gene            1..4573
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /note="kelch-like 18"
                     /db_xref="GeneID:270201"
                     /db_xref="MGI:MGI:2143315"
     exon            1..229
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1825
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kelch-like protein 18"
                     /codon_start=1
                     /product="kelch-like protein 18 isoform 1"
                     /protein_id="NP_808439.2"
                     /db_xref="CCDS:CCDS23567.1"
                     /db_xref="GeneID:270201"
                     /db_xref="MGI:MGI:2143315"
                     /translation="MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKI
                     GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLA
                     IDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAAN
                     SFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGP
                     CLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAF
                     RTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANRWEKCHPMTTARSRVGVAVV
                     NGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYD
                     GNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHY
                     NHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIV
                     PMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDRWTFMAPMACHEGGVGV
                     GCIPLLTI"
     exon            230..360
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     exon            361..501
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     exon            502..700
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     exon            701..861
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     exon            862..998
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1221
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1326
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1438
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..4530
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4509..4514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /note="hexamer: AATAAA"
     polyA_site      4528
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /note="major polyA site"
ORIGIN      
        1 ggcttcgcgt tctgggcagc cttcagcgtg agcccttgcc ccgccctggt tagtgtgaag
       61 cctgctggcc aggcctgcgc agttgcggcg gccggggaag atggtggagg acggcgcgga
      121 ggagctggag gacttggtgc atttctccgt gtcggagttg cctagtcgcg gctacggcgt
      181 catggaggag atccggcggc agggcaagct atgcgacgtg acgctaaaga ttggggacca
      241 caagttcagt gctcaccgga tcgtcttagc ggcctccatc ccgtacttcc atgctatgtt
      301 tacgaacgac atgatggagt gcaagcagga tgagattgta atgcagggaa tggacccaag
      361 tgccctggag gctctcatca actttgctta taatggcaac cttgctatcg accagcagaa
      421 tgtgcagtcc ctgctgatgg gggcaagctt cctgcagctg cagagcatca aagatgcttg
      481 ctgcacgttc ctccgagaaa ggcttcaccc caaaaattgc ctgggtgtgc gccagtttgc
      541 cgagacgatg atgtgtgctg tgttgtacga tgcagccaac agcttcatcc accagcactt
      601 tgtagaggtg tctctgtccg aagagttcct ggccctgccc ttggaagacg tgcttgagct
      661 ggtgtcccgg gatgagctga atgtgaagtc agaggagcag gtttttgaag ctgcattggc
      721 ctgggtcagg tatgaccggg agcagagggg accatgcctg cccgagctgc tgtccaatat
      781 ccgcctgcct ctttgccggc cccagttctt atcagatcga gtgcagcaag atgacctggt
      841 acggtgctgt cacaaatgca gggacctggt cgatgaagca aaggactatc atctgatgcc
      901 agagcgccgg ccccacctgc cagctttcag gactcggccc cgatgctgca cgtccatcgc
      961 tgggctcatc tacgctgtgg ggggcctcaa ctcagcaggt gattccctga atgtggtgga
     1021 agtgttcgac cctatcgcca atcgctggga aaagtgccat cccatgacaa cagcccgaag
     1081 ccgtgtgggt gtggctgtgg tgaacgggct cctctatgct atcgggggat atgatggtca
     1141 gttgcggctg agcaccgtgg aggcctacaa tcctgagacg gacacatgga cccgagtggg
     1201 gagcatgaat agcaagcgaa gtgccatggg gacagtcgtg ctggatggac agatctacgt
     1261 gtgtggaggc tatgacggca actcctccct caactctgtg gagacctact cacctgagac
     1321 ggacaagtgg acagtggtga ctccgatgag ctcaaaccgg agtgctgctg gggtgacagt
     1381 ctttgagggc aggatatatg tgtcaggagg ccacgatggc ttgcagatct tcagcagtgt
     1441 ggaacactac aaccaccaca cggccacctg gcacccggca gccagcatgc tcaacaagcg
     1501 ctgccgacac ggagccgcct ccctgggaag caagatgttt gtctgtgggg gctatgatgg
     1561 ctctggcttc ctcagtattg ctgagatgta cagctctgtg gcagaccagt ggtgtctcat
     1621 agtacccatg cacacacgcc ggagccgggt ctccctcgtg gccagctgtg ggcgcctcta
     1681 tgcagtggga ggttacgatg gacagtcaaa cctaagctca gtggagatgt acgacccaga
     1741 gacggaccgc tggacattta tggcccccat ggcatgccac gagggggggg ttggtgtggg
     1801 ctgcatccct cttctcacca tctaaggaga ggatgggacg tggtgggcta gggatctggt
     1861 acaagcatag gcgcttcctt ccaggggaga gtcctctcag aagaggcagt ggtggaccag
     1921 aagacggggt gtaatgtgag cttgccagag ggacagtttt tccaggtgct taagtcctct
     1981 ctcactgtgc tgcccttgtg accttaggtt gtcaagatgc acagcacagg acaggagtcc
     2041 ctctggggtc ccacagccag taacacggaa gtgctttgct ggtccaggca cacaggctcc
     2101 atccaagccc agcgaacacc tgctgcagca ctggcccagc tcccccttgc cacagggagc
     2161 actcatgggc aggaggtctt ccagccgagc cttcccttct cctgcagccc tgctgtggcc
     2221 gcttgggaag tgtgggtaaa gctgggagag aagggacacc ctggtgttgt cactgcctgt
     2281 ggtggtgcag ctacagcagc tagcatgctg cgagtgcacg ggctctccct tcgacagggg
     2341 cacagaggac ttggcccctg tctccagcaa gcagggagaa cagaagtctt ccccatgcct
     2401 gattttttgg gaatccagtg aggtctttct ccacttgtcc ccaagaaaca ggaagggaat
     2461 ggagatgctc gagagaaact ggaggaaatg gaaacaagaa aatgttgaag agaaactgga
     2521 aggaaaaggc ttgaagtgaa cattttccac aggacggaaa cagaaaagac actaaaaaca
     2581 aacacacatt tacatggaga accatcaacc atgacaacag tggtgtccac tcccacattc
     2641 ggatcccagg gtcctacgtc ctcctaaagc agtcggggtt tcctctgaat cccacagtgt
     2701 gtctgaaatc aggacattct tgactgacct gtagcaaggt gctcatgggg tttggtctcc
     2761 tcacccacgt cagaggactt tttaaatcat aggcttaggg agcgggttaa attactgcca
     2821 ctcacctctg cccgagctcc caactgtcac cccatggtta cctccctaca ccacccagcg
     2881 ctcccacaga tccccactcc cacgtacatc ctttcccttt ttggccagca agaaacaaca
     2941 tgtctgccca gattcgcact cacccatcca ccatccttga ataactctcc ctcatcacaa
     3001 cgcttccaga gcacattgac catttgtacc tctaggacct aaccaggggc ttgctcctac
     3061 cagccatgga ccagcttggt caggtgactc gtcttccctg ccattccgct attttccatc
     3121 catttgccaa ccctgggtgt ccgtccacct tctctccagc aagatgggcc tttacattca
     3181 agctacgaac gctggcgtca tggtataaag gcttacaaag aaatgtcttt tgctgctgca
     3241 aggaagagat tttctatttc ttcccctgat cttggcaaat gacctcgtga agagactcaa
     3301 tgctcctcct ccctctggat gggaccttac catagcacag aaggacccag agggagactg
     3361 tctcttacca gtgcactggg cagtggggca gaccttcaac tgccgctgcc aaaatctgct
     3421 ttcctaaaat ccttccagta gcgacgagaa ggatataatt gtttctagcc ccaaactggg
     3481 tcttagggtc cggtctgttc cactgtccac ctgattggtt tcttgccctc tgctgcctgc
     3541 ctggatcggc ctagaagacg gttcaggcgg ctctgggtga agcctgcggg ggcagggggg
     3601 tggtcccttt ccccagacca tcaggtttcc cagtgtgtgc aattgccata gattcagaag
     3661 gaaggactct tgttccctgc aatgtaaaga gccgggcctc tgctctaagc acttgaaaat
     3721 aatgttttta tcttaaaaga ctgaacaatc tggtaactga tacatcttaa ctaggctccc
     3781 agtggagcgc cagcatttct tcctgcccct cagtttgcct gctgaggtag actctagggg
     3841 actatgggtc ttggtttcct cttagtccta ttaggagggg tgtatccacg ctcctcttat
     3901 taagtccttc tgtgaatgta ctgcccagcc tcgactgtga aggtgctgag aaccagtccg
     3961 tgggctccca ggtgggcctc ctgggtcctc acgatgcaag cagactgcat ccctagagat
     4021 gatacgccat ctccccaccc cccccgccac cccaccccgg cctgctgctg ccaggttaac
     4081 cttcctgcct ccactcccac ctcctagtgt agacagtgtt tccaagaacc atcaagtcag
     4141 tgttttgatc taggctctga gcacacaagc gaacagaaac atttttatac tcccctgtct
     4201 gagggcgatg gctgatctgt ctcagtgtca gaactgtagg atcatgtgag aacaggcatc
     4261 acccaaggac actggaaaga atgtagcagg aggtgggtcc gacacgcctg gtgggccatg
     4321 gggtctggcc actgcacttc ctcttctcct ctctctctgg gcttcaccag aggtcacaag
     4381 cagaagagag ctgaagccca gcctctgatg gaactaagta ggaatcctga ccctcttcac
     4441 ccacagctat ttcacgggaa acttttattt ataggacgca tgtcttttgt gttgagaaac
     4501 caaagagaaa taaagagaac acgcctaata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4561 aaaaaaaaaa aaa
//
