LOCUS       NP_808439                574 aa            linear   ROD 30-APR-2024
DEFINITION  kelch-like protein 18 isoform 1 [Mus musculus].
ACCESSION   NP_808439
VERSION     NP_808439.2
DBSOURCE    REFSEQ: accession NM_177771.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 574)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 574)
  AUTHORS   Lewis,M.A., Ingham,N.J., Chen,J., Pearson,S., Di Domenico,F.,
            Rekhi,S., Allen,R., Drake,M., Willaert,A., Rook,V., Pass,J.,
            Keane,T., Adams,D.J., Tucker,A.S., White,J.K. and Steel,K.P.
  TITLE     Identification and characterisation of spontaneous mutations
            causing deafness from a targeted knockout programme
  JOURNAL   BMC Biol 20 (1), 67 (2022)
   PUBMED   35296311
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 574)
  AUTHORS   Ingham,N.J., Banafshe,N., Panganiban,C., Crunden,J.L., Chen,J.,
            Lewis,M.A. and Steel,K.P.
  TITLE     Inner hair cell dysfunction in Klhl18 mutant mice leads to low
            frequency progressive hearing loss
  JOURNAL   PLoS One 16 (10), e0258158 (2021)
   PUBMED   34597341
  REMARK    GeneRIF: Inner hair cell dysfunction in Klhl18 mutant mice leads to
            low frequency progressive hearing loss.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 574)
  AUTHORS   Chaya,T., Tsutsumi,R., Varner,L.R., Maeda,Y., Yoshida,S. and
            Furukawa,T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
  REMARK    GeneRIF: suggest that Cul3-Klhl18 modulates rod Talpha
            translocation during light/dark adaptation through Unc119
            ubiquitination
REFERENCE   5  (residues 1 to 574)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 574)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (residues 1 to 574)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (residues 1 to 574)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132103.3, BY195998.1, BY248410.1, CK619719.1, CB247282.1,
            CF739377.1 and BC065167.1.
            
            On Nov 22, 2004 this sequence version replaced NP_808439.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173029.1, SRR1660819.97496.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.92 cM"
     Protein         1..574
                     /product="kelch-like protein 18 isoform 1"
                     /note="kelch-like protein 18"
                     /calculated_mol_wt=63556
     Region          19..134
                     /region_name="BTB_POZ_KLHL18"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 18 (KLHL18); cd18247"
                     /db_xref="CDD:349556"
     Region          34..552
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          135..241
                     /region_name="BACK_KLHL18"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 18 (KLHL18); cd18457"
                     /db_xref="CDD:350532"
     Region          282..322
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          289..336
                     /region_name="Kelch 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4F2.1)"
     Region          326..369
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          337..383
                     /region_name="Kelch 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4F2.1)"
     Region          373..417
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          384..430
                     /region_name="Kelch 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4F2.1)"
     Region          420..464
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          432..477
                     /region_name="Kelch 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4F2.1)"
     Region          467..511
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          479..524
                     /region_name="Kelch 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4F2.1)"
     Region          514..557
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          525..571
                     /region_name="Kelch 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4F2.1)"
     CDS             1..574
                     /gene="Klhl18"
                     /gene_synonym="A930041K15"
                     /coded_by="NM_177771.5:101..1825"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23567.1"
                     /db_xref="GeneID:270201"
                     /db_xref="MGI:MGI:2143315"
ORIGIN      
        1 mvedgaeele dlvhfsvsel psrgygvmee irrqgklcdv tlkigdhkfs ahrivlaasi
       61 pyfhamftnd mmeckqdeiv mqgmdpsale alinfayngn laidqqnvqs llmgasflql
      121 qsikdacctf lrerlhpknc lgvrqfaetm mcavlydaan sfihqhfvev slseeflalp
      181 ledvlelvsr delnvkseeq vfeaalawvr ydreqrgpcl pellsnirlp lcrpqflsdr
      241 vqqddlvrcc hkcrdlvdea kdyhlmperr phlpafrtrp rcctsiagli yavgglnsag
      301 dslnvvevfd pianrwekch pmttarsrvg vavvngllya iggydgqlrl stveaynpet
      361 dtwtrvgsmn skrsamgtvv ldgqiyvcgg ydgnsslnsv etyspetdkw tvvtpmssnr
      421 saagvtvfeg riyvsgghdg lqifssvehy nhhtatwhpa asmlnkrcrh gaaslgskmf
      481 vcggydgsgf lsiaemyssv adqwclivpm htrrsrvslv ascgrlyavg gydgqsnlss
      541 vemydpetdr wtfmapmach eggvgvgcip llti
//
