LOCUS       NM_198305               3014 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus kelch-like 17 (Klhl17), mRNA.
ACCESSION   NM_198305 XM_149560
VERSION     NM_198305.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3014)
  AUTHORS   Hu,H.T. and Hsueh,Y.P.
  TITLE     KLHL17 differentially controls the expression of AMPA- and KA-type
            glutamate receptors to regulate dendritic spine enlargement
  JOURNAL   J Neurochem 168 (9), 2155-2169 (2024)
   PUBMED   38898681
  REMARK    GeneRIF: KLHL17 differentially controls the expression of AMPA- and
            KA-type glutamate receptors to regulate dendritic spine
            enlargement.
REFERENCE   2  (bases 1 to 3014)
  AUTHORS   Hu,H.T., Lin,Y.J., Wang,U.T., Lee,S.P., Liou,Y.H., Chen,B.C. and
            Hsueh,Y.P.
  TITLE     Autism-related KLHL17 and SYNPO act in concert to control
            activity-dependent dendritic spine enlargement and the spine
            apparatus
  JOURNAL   PLoS Biol 21 (8), e3002274 (2023)
   PUBMED   37651441
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3014)
  AUTHORS   Hu,H.T., Huang,T.N. and Hsueh,Y.P.
  TITLE     KLHL17/Actinfilin, a brain-specific gene associated with infantile
            spasms and autism, regulates dendritic spine enlargement
  JOURNAL   J Biomed Sci 27 (1), 103 (2020)
   PUBMED   33256713
  REMARK    GeneRIF: KLHL17/Actinfilin, a brain-specific gene associated with
            infantile spasms and autism, regulates dendritic spine enlargement.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3014)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CAAA01066806.1, AY423764.1 and CN666867.1.
            
            On Jul 31, 2009 this sequence version replaced NM_198305.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170825.1, AK154523.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               CAAA01066806.1     40-233              c
            195-2701            AY423764.1         173-2679
            2702-3014           CN666867.1         17-329
FEATURES             Location/Qualifiers
     source          1..3014
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 88.63 cM"
     gene            1..3014
                     /gene="Klhl17"
                     /note="kelch-like 17"
                     /db_xref="GeneID:231003"
                     /db_xref="MGI:MGI:2678948"
     exon            1..202
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2024
                     /gene="Klhl17"
                     /note="actinfilin"
                     /codon_start=1
                     /product="kelch-like protein 17"
                     /protein_id="NP_938047.1"
                     /db_xref="CCDS:CCDS38999.1"
                     /db_xref="GeneID:231003"
                     /db_xref="MGI:MGI:2678948"
                     /translation="MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPAPEAERARPRQ
                     ARPAAPMEGAMQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIR
                     AHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNV
                     QTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQH
                     FVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLM
                     KCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRR
                     CEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAV
                     GGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNS
                     AERYDPLTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNSW
                     TPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWESVAPMNIRRS
                     THDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLN
                     FPPPSSPTLSVSSTSL"
     exon            203..462
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            463..584
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            585..806
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            807..923
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1137
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1282
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1450
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1539
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1613
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1795
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..3014
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl17"
                     /note="hexamer: AATAAA"
     polyA_site      2718
                     /gene="Klhl17"
                     /note="major polyA site"
ORIGIN      
        1 gggtctgcgg cgacgggcga gcgcccgagt ggagcgagcg gccgggcggg cacccgcgtc
       61 ccaatccgtc catcagggtc gcggctttgg cggctggagt tatgcagccc cgtggcgagc
      121 ggccggcggg caggacgcaa agtcccgagc acagcagccc ggggcccggg cctgaggcgc
      181 caccgccgcc ccaaccgccg gcccccgagg cagagcgagc tcggccccgg caggcccggc
      241 ctgcagcccc gatggaaggt gcgatgcagc tgttgagcag agagggtcac agtgtggcac
      301 acaactcaaa gcggcactac catgatgctt ttgtggctat gagccgcatg cggcagcgtg
      361 gcctcctgtg cgacatcgtc ctgcatgtgg ctgccaagga gatccgggct cataaggtgg
      421 tgttggcctc ctgtagcccc tacttccacg ccatgttcac aaatgagatg agtgagagcc
      481 gccagacaca tgtgacactg catgacattg acccgcaagc cttagaccag ctggtgcagt
      541 ttgcatacac agctgagatc gtggtgggcg agggcaacgt tcagactctg ctcccagctg
      601 ccagccttct acagttgaat ggtgttcgag atgcctgctg caagttcctc ctgagccagc
      661 tggacccttc caactgcctg ggcattcgag gatttgcaga cacacactca tgcagtgacc
      721 tgctcaaggc agcacacagg tacgtgctgc agcacttcgt ggatgtggcc aagactgagg
      781 agttcatgct gttgccactg aagcaggtgc tggaattggt ctctagtgat agcctgaacg
      841 tgccctcaga ggaagatgtg taccgtgcag tcctgagctg ggtcaaacat gacgtagaca
      901 ctcggaggca gcatgtacca aggttgatga agtgtgtacg gctgcctctg ctgagccgag
      961 acttcctcct gggccacgtg gatgccgaaa gccttgtgag gcatcaccct gactgcaagg
     1021 atctgctcat cgaggccctt aagttccacc tgctgcctga gcagagaggt gttctgggaa
     1081 ccagccgcac gagaccccgt cgatgtgagg gcgctggccc tgtgctcttt gctgtcggtg
     1141 gtgggagcct gttcgcgatc cacggagact gtgaagcgta tgacacgcgg actgaccgtt
     1201 ggcatgtggt ggcctccatg tctacacgtc gggctcgtgt aggagttgct gccgtcggga
     1261 accgactgta tgctgtgggc ggctacgatg gaacctcaga cctggctacg gtggagtcct
     1321 atgaccctgt gacaaacaca tggcagcccg aggtctccat gggcacaagg cggagctgcc
     1381 taggtgtagc tgctctgcat gggctcctgt atgcagctgg tggctacgat ggggcttcct
     1441 gcctcaacag tgctgaacga tatgacccac tgacgggaac atggacatcc attgctgcca
     1501 tgagcacccg gaggcgatat gtgcgtgtgg ccacacttga tgggaacctg tacgccgtgg
     1561 gtggttatga cagctcgtca cacctggcca ccgtggagaa gtatgagccc caggtgaatt
     1621 catggacacc tgtagcttcc atgctgagcc ggcgcagctc agcaggagta gcagtgctgg
     1681 agggtgccct gtatgtcgca gggggcaatg atggcacaag ctgcctcaac tcagtggaga
     1741 gatatagcac caaggctggt gcctgggaga gtgtggcacc catgaatatc cgcaggagca
     1801 cacatgacct ggtggccatg gacggctggc tctacgccgt ggggggcaat gacggcagct
     1861 ccagcctcaa ctccatagag aagtacaacc cgaggaccaa caagtgggtg gcggcatcct
     1921 gcatgttcac aagacgcagc agtgtgggcg tggcggtgct ggagctgctc aacttcccac
     1981 caccttcctc acccacgctg tctgtgtcct ctaccagcct ctgacacgcg ccagactgca
     2041 cagaggccct gcagcccccc acatgcctta aaccctacgg ggtggcccta ccgactctgt
     2101 cttctctacc aagtgttagg gcagatcacg tagcccacca gagatttcct gtccttcggt
     2161 cttggtctcg gtgttcattt gtcctcgttc atttatgtgt gcgctgtttg tctactcacg
     2221 tatttattga ctcactattt actgatggat gagaagtgct gcagctacag gttcacacat
     2281 ttactctcga ttgtcagctc tcctgcattg aggggaccaa ggaccccttc ggagtgttct
     2341 cttgcctgtc tccctctgtg ggacaataga gaatgctggg tagacactca ctgaaggagg
     2401 atgagcaaca cagctgggcc ttgcaagcag gaaggggcag agcaactgtg gcaacaggag
     2461 cagcggcaag ggctttctaa gaagatgatg cagaccccta gccagcgctt tgcacacagc
     2521 acttatctgt ctctgccagg cactatccct gaaggacaca aagcagcctt atttcctatg
     2581 tcccgtgtac acagtgtgat gtcttttctg ggtcttctat ggagctgggc acacaacatg
     2641 cacttagatc ctacacagca atatgagcca acttgaacaa taaacatgtt tcttgggctc
     2701 catgggcctg aggctgaatg tccatctttg gccccctttg taccttctgc tgtggctcta
     2761 cagcacatct ttggctcctc tctggacaac agagtgaagg tctacaggca agtgtgcagc
     2821 cagactcaaa cgctacctta acgtctgggg ctgcaaaatg gcacttctgc attcaagtgg
     2881 aacagagact ggctgtcatc ctagtcttga ggctcctggg atctgggagt gtggggccaa
     2941 tgaggaagat agccttagga acccgagagg cacgtggcct ctttcttgca tttgattaaa
     3001 ctttggggac cctg
//
