LOCUS       NM_001081403            4718 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus kelch-like 14 (Klhl14), mRNA.
ACCESSION   NM_001081403 XM_006525822 XM_979146
VERSION     NM_001081403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4718)
  AUTHORS   Qiu,T., Huteckova,B., Seppala,M., Cobourne,M.T., Chen,Z.,
            Hovorakova,M., Buchtova,M. and Tucker,A.S.
  TITLE     Molecular profiling of the vestibular lamina highlights a key role
            for Hedgehog signalling
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36971701
REFERENCE   2  (bases 1 to 4718)
  AUTHORS   Sahni,V., Itoh,Y., Shnider,S.J. and Macklis,J.D.
  TITLE     Crim1 and Kelch-like 14 exert complementary dual-directional
            developmental control over segmentally specific corticospinal axon
            projection targeting
  JOURNAL   Cell Rep 37 (3), 109842 (2021)
   PUBMED   34686337
  REMARK    GeneRIF: Crim1 and Kelch-like 14 exert complementary
            dual-directional developmental control over segmentally specific
            corticospinal axon projection targeting.
REFERENCE   3  (bases 1 to 4718)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   4  (bases 1 to 4718)
  AUTHORS   Li,S., Liu,J., Min,Q., Ikawa,T., Yasuda,S., Yang,Y., Wang,Y.Q.,
            Tsubata,T., Zhao,Y. and Wang,J.Y.
  TITLE     Kelch-like protein 14 promotes B-1a but suppresses B-1b cell
            development
  JOURNAL   Int Immunol 30 (7), 311-318 (2018)
   PUBMED   29939266
  REMARK    GeneRIF: KLHL14 promotes B-1a development in mice
REFERENCE   5  (bases 1 to 4718)
  AUTHORS   Zhang,J., Weinrich,J.A.P., Russ,J.B., Comer,J.D., Bommareddy,P.K.,
            DiCasoli,R.J., Wright,C.V.E., Li,Y., van Roessel,P.J. and
            Kaltschmidt,J.A.
  TITLE     A Role for Dystonia-Associated Genes in Spinal GABAergic
            Interneuron Circuitry
  JOURNAL   Cell Rep 21 (3), 666-678 (2017)
   PUBMED   29045835
REFERENCE   6  (bases 1 to 4718)
  AUTHORS   Wildner,H., Das Gupta,R., Brohl,D., Heppenstall,P.A.,
            Zeilhofer,H.U. and Birchmeier,C.
  TITLE     Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice
            reveals new markers for distinct dorsal horn interneuron
            populations contributing to nociceptive reflex plasticity
  JOURNAL   J Neurosci 33 (17), 7299-7307 (2013)
   PUBMED   23616538
REFERENCE   7  (bases 1 to 4718)
  AUTHORS   Giles,L.M., Li,L. and Chin,L.S.
  TITLE     Printor, a novel torsinA-interacting protein implicated in dystonia
            pathogenesis
  JOURNAL   J Biol Chem 284 (32), 21765-21775 (2009)
   PUBMED   19535332
REFERENCE   8  (bases 1 to 4718)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140283.3 and AC158903.4.
            
            On or before Jun 24, 2019 this sequence version replaced
            XM_006525822.2, NM_001081403.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK173163.1, AK018108.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-659               AC140283.3         109231-109889       c
            660-1655            AC140283.3         106292-107287       c
            1656-1777           AC140283.3         79453-79574         c
            1778-1867           AC158903.4         27173-27262
            1868-1946           AC158903.4         34371-34449
            1947-2137           AC158903.4         41733-41923
            2138-2296           AC158903.4         42004-42162
            2297-2454           AC158903.4         45191-45348
            2455-4718           AC158903.4         47318-49581
FEATURES             Location/Qualifiers
     source          1..4718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.96 cM"
     gene            1..4718
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /note="kelch-like 14"
                     /db_xref="GeneID:225266"
                     /db_xref="MGI:MGI:1921249"
     exon            1..659
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /inference="alignment:Splign:2.1.0"
     exon            660..1655
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /inference="alignment:Splign:2.1.0"
     CDS             703..2595
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /note="protein interactor of torsinA; protein interactor
                     of Torsin-1A"
                     /codon_start=1
                     /product="kelch-like protein 14"
                     /protein_id="NP_001074872.1"
                     /db_xref="CCDS:CCDS37748.1"
                     /db_xref="GeneID:225266"
                     /db_xref="MGI:MGI:1921249"
                     /translation="MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQF
                     HCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQQQQPQQQPPQQQQPPP
                     QEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVL
                     SVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLL
                     NFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPEL
                     VERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPP
                     GPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHS
                     TNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDT
                     NEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNT
                     KRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPG
                     CAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACATVILPA
                     CVPYNK"
     exon            1656..1777
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1867
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1946
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2137
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2296
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2454
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..4718
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4694..4699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /note="hexamer: AATAAA"
     polyA_site      4718
                     /gene="Klhl14"
                     /gene_synonym="6330403N15Rik; printor"
                     /note="major polyA site"
ORIGIN      
        1 gcagagagaa attgactaat tagcaatgcg cactaaaact tgacggttct ttatagagag
       61 aagagaagag agagggagag agagggagag ggagggaggg gggctcgctt tttccccttc
      121 tttcttccaa agatgtttga aatcgcagtc atttacgctc gacaattttt acaatagcct
      181 tgagccataa ttttgcgagt ctctccagca tccatccccc tgtatggtct ctctctactg
      241 gccaagcacg accatttctc tccccaaccg tggatttcct attactctcg ttacgactca
      301 ctgagcccca ggcccaagga taatgatgtg ttgtttcttg gtagcataat ttgtcacacg
      361 tacatttttt cttcttcttc tcttgcagaa agctctgctc cctctctctc tctccctctc
      421 tctccctctc tctcctctct ctttctctct tttctccctc tcctatattt tcttgctgtt
      481 gctaattcat ggtgatcaaa tgatgtacga caaaataaat tgtacagagt gactgcctgg
      541 agttgggagc cagaaggtgt gttcccctcc caaggagaga gcaaaccttt aaaaaggaag
      601 gacaattgat tttgggggga gcttaagtga gccctgactt tgcagctggc tgacagcagg
      661 ttggaggagg gtttaaagcc aggtgcgcag agtcagctcg ccatgtccag atccggggac
      721 aggacctcca ccttcgaccc cagccacagt gacaacctgc tgcacggtct caacctgctg
      781 tggaggaagc agctattttg cgacgtaacc ctgacagccc aaggccaaca gttccactgc
      841 cacaaggccg tgctggcctc ctgctcgcag tacttccgat cactcttctc cagccacccc
      901 cctctcgggg gaggggtcgg cggccaggac ggcctggggg cccccaagga ccagcagcag
      961 cagcagcagc ctcagcagca gcctccacag cagcagcagc cgccgccaca ggaggagccc
     1021 gggactcctt cctcctcccc cgacgacaag ctgctgacca gccccagagc catcaacaac
     1081 ctagtgctgc agggctgctc gtccatcggg ctgcgcctag tgcttgaata cctctacaca
     1141 gccaacgtga ccctctccct ggacaccgtg gaggaagtgc tgtcggtcag caaaatcctg
     1201 cacattcctc aggtcaccaa gctctgcgtt cagttcctca acgaccagat ctcggtgcag
     1261 aactacaagc aggtgtgcaa gatcgccgca ctgcacggcc tggaggagac caagaagctg
     1321 gccaacaagt acctggtgga agatgtgctg ttgcttaact tcgaggagat gcgtgccctg
     1381 ctggactcgc tgccgccccc cgtggagtcg gagctggcac ttttccagat gtccgtgctg
     1441 tggctggagc acgaccgtga gacccgcatg cagtacgcgc ccgacctcat gaagcgcctc
     1501 cgctttgcgc tcatccccgc cccggagctg gtagagcggg tccagtcggt ggatttcatg
     1561 cgcaccgacc cggtctgcca gaagctgctg ctggacgcca tgaactacca cctgatgccc
     1621 ttcaggcagc actgcaggca gagcctggcc agcagaattc gctctaacaa gaaaatgctg
     1681 ctgttggttg gaggattgcc tcccggacca gaccggctcc ccagcaatct ggttcagtat
     1741 tatgatgacg aaaagaagac atggaaaatc ctcacaatta tgccttacaa cagtgcccac
     1801 cactgcgttg tagaggtaga aaatttcctg ttcgtgttgg gtggagagga ccagtggaac
     1861 ccaaatggaa aacatagtac aaattttgtc agccggtatg atccccgatt taatagttgg
     1921 atccaacttc cacccatgca agaaagaaga gccagtttct atgcatgccg cttggacaag
     1981 catttatatg tgatcggcgg gaggaacgaa accggttacc tgtccagtgt ggagtgctac
     2041 aacctagaca caaacgagtg gcgctatgtg tcatctctgc ctcagccgct ggcagcccat
     2101 gcaggagcag tgcacaatgg gaaaatatat atttcagggg gtgtgcacaa cggagagtac
     2161 gtcccatggt tgtattgcta tgacccagtc atggatgtct gggcccgaaa acaggacatg
     2221 aacacaaaac gtgctattca caccctggct gtgatgaatg atcgcttgta cgcaatcgga
     2281 gggaatcatt tgaaaggttt ctcccacctg gacgtcatgc ttgtggagtg ttatgaccca
     2341 aaaggcgacc agtggaatat tctccaaact cccatcctgg agggtcgaag tggccctggc
     2401 tgtgcggtgc ttgacgacag catttatcta gttggaggat acagctggag tatgggtgcc
     2461 tacaagtcat ctacaatctg ctattgtcca gaaaaaggaa cctggacaga actcgaaggt
     2521 gatgtggctg aacccctggc aggcccagcc tgtgcaacag tcattctacc agcctgtgta
     2581 ccctacaaca aatgacagca ggaaaccacg gcatagtgcc accatccagg gtgcagggac
     2641 agatgatgtg ctgtcctgta tgaaccatgc attccaatgg tacaactgcc caaatccacc
     2701 tttggtttct gatgacttac aagtgactat agaagaaaga ggcctggtct tgagcagaga
     2761 ctcttgttcg caactcagat cacactccaa ttgtggtgac agactcttcc atatcaggct
     2821 ggttttgctt tgttccgcct ttacacaaac tcaagtggag ctgaactttc acaaagggaa
     2881 agataaacca cagaagcctg gccccagaga cctaagacct gtattgtgca ttgtttccta
     2941 actgcatgtg atagacttgg acatttggag aatattttgt acatgaatga ttcaaaatcc
     3001 aacccaccaa atggttaccc tgtattccag aaactcactt gattctgtat tggtaaatgc
     3061 ctggcttctt caccaactcc ataggtaaca cagcaaagga aaaccacaga agacagaaga
     3121 caggcatctt tgtttccaca caatcatatt ttctattcct aacagcttcc cgtgggaaaa
     3181 gtaagctgtt gatctctttg gcaattgttc tctgccagag tcttaagtat gtgtctttga
     3241 tactccttga aaattaaaac taagtacacc ctattgctct tcagctccca gaaacttacg
     3301 cttcctcatt tctcatagca ttttaactag tgaacataag gacaatttgc ctcaatagaa
     3361 gaccaacaac cccatcatgg aatatcacag aaattctttt ggataacaat ttgttccaac
     3421 tttaatccat aatttaaaaa ctgacaaatc actttcagaa attcaggtgc acaagggaaa
     3481 ctttcaagta cgatccaatt atctttctga tccttaaaac acatgacttc cagctgaaga
     3541 gatggctcag tggttcagag cacttactcc tcaggtgtaa gacctgggtt tggttctcag
     3601 cacccatgtg gcaacttaca accatccata gctccagatc cagggcatcc attgcaccag
     3661 gtacacatgc agtgcactta caaacttgtc aacaaaacac ctgtacatgt aaaataaaaa
     3721 taaataactc ttttaaaata atcatttttt taaaaatgga cttgcaaact catagtacct
     3781 ggctgcacac gtcctcgcct ctgtttgtct ggctctagat acctaattct caatcttcct
     3841 ccgctcaccc cattgcttgt tatcactggg gatgcctgga cttggtcaag tgagcaactg
     3901 attcttgttt ttagcaactc aaaacataaa aagatcagga gagcatgaca cggtctcttt
     3961 gtggccagtc agaaaagcaa actaacagaa acatgaatta gaatttcaag ctcatctgag
     4021 tttgaccaac atgttaggca cttacaagag ctgaaatttt ttttttaatc acagaaagtt
     4081 gaacccttca acaaatgtaa tattaaaatt ccaagtaggg gtagccacag gtgagaacaa
     4141 aggccttcat gggaagcttg cacgagcatc tcaaggtggc tgggcatagc agagttcaac
     4201 gaggtttcta cagaaaagtg caatctttgt tgtttttgta tttatttgta tgttcagatc
     4261 caaaggatcc gttgtaaaaa tatatatgtg aatatatata cataaccagt gcaatcagct
     4321 ttcatttcct ttttcttgaa aacatacgac tatatagaaa gaaagacaat aagaacacga
     4381 gaaacgcccc cccccacccc ccggcatcct ggagagcatg agctgtttcc aaaatcggat
     4441 tctcagctgt cactgtttct tccaaaagtt gctatttata caagggtatc agcttttcct
     4501 tagatttgtt ccttgcttta ttttttaatc actagccaaa ttaaataaaa gcatttatga
     4561 gaactctaaa cctttctgta tttgagagag atgcaaactt ctagagtaaa agttgaataa
     4621 aaagtcacag aggatgtaaa ttttgtacag gactagaatg taaatgaagc ttgcttggaa
     4681 ggggaaaact ttaaataaaa ctttatgtat aaattcaa
//
