LOCUS       NM_153128               3200 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus kelch-like 12 (Klhl12), transcript variant 2, mRNA.
ACCESSION   NM_153128 XM_982196 XM_982238 XM_982269 XM_982302
VERSION     NM_153128.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T,
            Englmaier L, Akkuratova N, Yang Y, Haring M, Dyachuk V, Bock C,
            Farlik M, Piacentino ML, Boismoreau F, Hilscher MM, Yokota C, Qian
            X, Nilsson M, Bronner ME, Croci L, Hsiao WY, Guertin DA, Brunet JF,
            Consalez GG, Ernfors P, Fried K, Kharchenko PV and Adameyko I.
  TITLE     Spatiotemporal structure of cell fate decisions in murine neural
            crest
  JOURNAL   Science 364 (6444) (2019)
   PUBMED   31171666
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H,
            Yoshida N and Miki H.
  TITLE     Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a
            pool of inactive dishevelled protein
  JOURNAL   Curr Biol 20 (21), 1945-1952 (2010)
   PUBMED   20970343
REFERENCE   4  (bases 1 to 3200)
  AUTHORS   Rondou P, Haegeman G, Vanhoenacker P and Van Craenenbroeck K.
  TITLE     BTB Protein KLHL12 targets the dopamine D4 receptor for
            ubiquitination by a Cul3-based E3 ligase
  JOURNAL   J Biol Chem 283 (17), 11083-11096 (2008)
   PUBMED   18303015
  REMARK    GeneRIF: KLHL12 specifically interacts with the D4 polymorphism,
            thereby building up a Cul3-E3 ligase complex with substrate
            specificity toward the D4 receptor
REFERENCE   5  (bases 1 to 3200)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034170.1 and CD364043.1.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_153128.4.
            
            On Jul 24, 2015 this sequence version replaced NM_153128.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction in the 3' coding sequence compared to variant 1.
            The resulting isoform (2) has the same N- and C-termini but is
            shorter compared to isoform 1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC034514.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1534              AK034170.1         3-1536
            1535-2740           AK034170.1         1618-2823
            2741-3200           CD364043.1         1-460
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..3200
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /note="kelch-like 12"
                     /db_xref="GeneID:240756"
                     /db_xref="MGI:MGI:2385619"
     exon            1..135
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            136..336
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1767
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kelch-like protein C3IP1; kelch-like protein 12;
                     CUL3-interacting protein 1"
                     /codon_start=1
                     /product="kelch-like protein 12 isoform 2"
                     /protein_id="NP_694768.1"
                     /db_xref="CCDS:CCDS35715.1"
                     /db_xref="GeneID:240756"
                     /db_xref="MGI:MGI:2385619"
                     /translation="MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDF
                     PAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTAATMEILLDFVYTETVHVTVEN
                     VQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQK
                     HFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPDL
                     LQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRAR
                     LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVI
                     GGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRR
                     HTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGIIYCLGGYDGLNILNSVEKYDPHT
                     GHWTNVTPMATKRSAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLS
                     SIECYDPIIDSWEVVASMGTQRCDAGVCVLREK"
     exon            337..490
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..708
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..858
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..973
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1080
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1276
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1435
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1534
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1640
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..3182
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtactccgag actggagttt accacggaga ctgctccgca gcggctggtc cgggcggcag
       61 cggcggcgct ccggctgctc agccgcctgg gagcccggcg cctagcacct cggctcggac
      121 ggcccaggag ccctgtgctt gatgggcggc attatggccc ctaaagacat aatgacaaac
      181 actcacgcta agtccatcct caactccatg aactccctca ggaagagcaa caccctctgt
      241 gatgtgacct tgagagtgga gcagaaagac ttccctgcgc atcggattgt gctggccgcc
      301 tgcagtgatt atttctgtgc catgttcact agtgagcttt cagagaaggg gaagccgtat
      361 gttgacattc aaggtttaac tgctgctacc atggagatcc tgctggactt cgtgtacaca
      421 gaaacagtac atgtgacagt ggagaatgtt caagaactgc tccctgcagc ctgtcttctt
      481 cagctgaaag gtgtgaaaca agcctgctgt gagttcttag aaagtcagct ggatccatct
      541 aattgcctgg gtatcaggga ttttgctgaa actcacaatt gcgttgacct gatgcaagca
      601 gctgaggtgt ttagccagaa gcattttcct gaagtggtgc agcacgagga gttcattctt
      661 ctgagtcaag gggaggtgga gaagctaatc aagtgcgacg agattcaggt ggattctgaa
      721 gagccagtct ttgaggctgt tatcaactgg gtgaagcatg ccaagaagga gcgagaagag
      781 tctttacctg acctcttaca gtatgttcgg atgcccctgc tgacccccag gtacattaca
      841 gatgtaattg atgctgagcc tttcatccgc tgtagtttac aatgcagaga tctagttgat
      901 gaagcaaaga agtttcacct gaggcctgaa cttcggagtc agatgcaagg acccagaaca
      961 agggcccggc taggagccaa tgaagtgctt ctggtggttg ggggcttcgg aagccagcag
     1021 tctcctattg atgtggtaga gaagtatgac cccaagacac aggagtggag ctttttacca
     1081 agtatcactc gcaagagacg gtatgtggcc tcagtttcct tacatgatcg gatctatgta
     1141 attggtggct acgatggccg ttcccgcctc agttcggtgg aatgtctaga ctatacagca
     1201 gacgaagatg gagtgtggta ctctgtggcc cctatgaatg tgcggcgagg ccttgctgga
     1261 gccaccactc tgggagatat gatttacgtc tctggaggct ttgatggaag taggcgtcat
     1321 acaagtatgg agcggtatga cccaaacatc gatcagtgga gtatgctggg agatatgcag
     1381 acagctcgag agggcgcagg actagtagtg gccagcggaa taatctattg tctaggagga
     1441 tatgatggct tgaacatatt aaattcagtt gagaaatatg atccccatac aggacactgg
     1501 actaacgtta cgcctatggc caccaagcgt tctgcttata acattcgcac tgattcctgg
     1561 acaactgtca caagtatgac cacgcctcga tgctatgtag gggccacagt gcttcgaggg
     1621 agactctatg caattgcagg atacgatggg aattctctgc tgagcagcat tgagtgttat
     1681 gaccctatca tcgacagctg ggaagtagta gcctccatgg gaacccagcg ttgtgatgct
     1741 ggtgtgtgtg ttctccgaga aaagtaactg ttattttaac accagctgga gccagtgact
     1801 actccaagga acagtttgtg ggagaatcaa ggatcctttc cagaatgttt attcctcact
     1861 gtgtgcacag ggggattcca ggcaccagtg ctgagatgat gattgtactt gtttgatgca
     1921 cactctcctt cgcactggtc atcttgctca gaagcatggg ggggggcagg tactccaggg
     1981 aagagaatgc acgtttggat gtgggaaacc agatcatggc tctctgtggt ctgaggagca
     2041 ctttcttact gtttctaact taccatgtgc ttgggaggat gtatgtatgt atgtttgtat
     2101 ggatgtatgt tgtgcctcat atattgcaga gaataaggtg agtatggcct gctagatgtg
     2161 ggcagtgtcc atcctaggtg attggaagga tatcagttta tacaagcttg gtaaaatgaa
     2221 agtctttttc cctctcagaa gcaaaaatac cttttctaaa tacagaggta gctcaagcca
     2281 ccacagttcc ttgctgtagg aaaacactat cactgttaaa atttgagagg ccaagaagga
     2341 agattcatgc tgtcctcact taggaagaca ttgttggtgc agagatttga ataagtggct
     2401 ggagctgaat ggaatgtagg tgaacccaga agatcactga agtgtaaatt ggaaggctgg
     2461 aaaggacatg ttatttgatt tcacagtctt tctaatgtaa aatgttgtac catcttggca
     2521 ctggagactt gagagattaa cagtggaaaa ggttagaata agagatgctg taaatgtgca
     2581 gagttcaata tacctgtggt aaactagaaa tatctgtgat tttacaattg tcttagtccc
     2641 tgccagggct cctatagcag tggcagtttg gtcttcaaat gggtgaaaag accatcttcc
     2701 tggcgaatca agtgctacca cgttactacg cctccacact atttatttgg ggatgggtgg
     2761 ggtggctgca gcctagtagt tcaggtacgt gattactgcc ctgttgttta gggcacactt
     2821 ccactaagga gtgcttaaga ctgctgtgtg tggtatgttc agttttcttc ctgctatatc
     2881 ttctgtacct gtctttacag tgtattttac tcatcctgaa acaaaataat caaggacaat
     2941 tgaaaatctt ttgttagttt ctataccttc gtatagaatg gcagttctag gcacctctgt
     3001 gtcgtggtga aactcttgag ttactggtat agcaaatagg agaatgtggc agcctaaact
     3061 gggctacact ttccttttgc tctggaatcc cacttttcct ctttccttga attgtgtttg
     3121 ctgacagagt taatttcctt tgtatttttt taagaaaaca ttaaaatgga ctgtctcaaa
     3181 tgaaaaaaaa aaaaaaaaaa
//
