LOCUS       NM_001311136            3281 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus kelch-like 12 (Klhl12), transcript variant 1, mRNA.
ACCESSION   NM_001311136 XM_006529560
VERSION     NM_001311136.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3281)
  AUTHORS   Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T,
            Englmaier L, Akkuratova N, Yang Y, Haring M, Dyachuk V, Bock C,
            Farlik M, Piacentino ML, Boismoreau F, Hilscher MM, Yokota C, Qian
            X, Nilsson M, Bronner ME, Croci L, Hsiao WY, Guertin DA, Brunet JF,
            Consalez GG, Ernfors P, Fried K, Kharchenko PV and Adameyko I.
  TITLE     Spatiotemporal structure of cell fate decisions in murine neural
            crest
  JOURNAL   Science 364 (6444) (2019)
   PUBMED   31171666
REFERENCE   2  (bases 1 to 3281)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3281)
  AUTHORS   Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H,
            Yoshida N and Miki H.
  TITLE     Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a
            pool of inactive dishevelled protein
  JOURNAL   Curr Biol 20 (21), 1945-1952 (2010)
   PUBMED   20970343
REFERENCE   4  (bases 1 to 3281)
  AUTHORS   Rondou P, Haegeman G, Vanhoenacker P and Van Craenenbroeck K.
  TITLE     BTB Protein KLHL12 targets the dopamine D4 receptor for
            ubiquitination by a Cul3-based E3 ligase
  JOURNAL   J Biol Chem 283 (17), 11083-11096 (2008)
   PUBMED   18303015
  REMARK    GeneRIF: KLHL12 specifically interacts with the D4 polymorphism,
            thereby building up a Cul3-E3 ligase complex with substrate
            specificity toward the D4 receptor
REFERENCE   5  (bases 1 to 3281)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034170.1 and CD364043.1.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_001311136.2.
            
            On Jul 24, 2015 this sequence version replaced XM_006529560.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034170.1, SRR1660821.100632.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2821              AK034170.1         3-2823
            2822-3281           CD364043.1         1-460
FEATURES             Location/Qualifiers
     source          1..3281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..3281
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /note="kelch-like 12"
                     /db_xref="GeneID:240756"
                     /db_xref="MGI:MGI:2385619"
     exon            1..135
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            136..336
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1848
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kelch-like protein C3IP1; kelch-like protein 12;
                     CUL3-interacting protein 1"
                     /codon_start=1
                     /product="kelch-like protein 12 isoform 1"
                     /protein_id="NP_001298065.1"
                     /db_xref="CCDS:CCDS78687.1"
                     /db_xref="GeneID:240756"
                     /db_xref="MGI:MGI:2385619"
                     /translation="MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDF
                     PAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTAATMEILLDFVYTETVHVTVEN
                     VQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQK
                     HFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPDL
                     LQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRAR
                     LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVI
                     GGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRR
                     HTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGIIYCLGGYDGLNILNSVEKYDPHT
                     GHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTT
                     PRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVASMGTQRCDAGVCVLR
                     EK"
     exon            337..490
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..708
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..858
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..973
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1080
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1276
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1435
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1534
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1721
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..3263
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtactccgag actggagttt accacggaga ctgctccgca gcggctggtc cgggcggcag
       61 cggcggcgct ccggctgctc agccgcctgg gagcccggcg cctagcacct cggctcggac
      121 ggcccaggag ccctgtgctt gatgggcggc attatggccc ctaaagacat aatgacaaac
      181 actcacgcta agtccatcct caactccatg aactccctca ggaagagcaa caccctctgt
      241 gatgtgacct tgagagtgga gcagaaagac ttccctgcgc atcggattgt gctggccgcc
      301 tgcagtgatt atttctgtgc catgttcact agtgagcttt cagagaaggg gaagccgtat
      361 gttgacattc aaggtttaac tgctgctacc atggagatcc tgctggactt cgtgtacaca
      421 gaaacagtac atgtgacagt ggagaatgtt caagaactgc tccctgcagc ctgtcttctt
      481 cagctgaaag gtgtgaaaca agcctgctgt gagttcttag aaagtcagct ggatccatct
      541 aattgcctgg gtatcaggga ttttgctgaa actcacaatt gcgttgacct gatgcaagca
      601 gctgaggtgt ttagccagaa gcattttcct gaagtggtgc agcacgagga gttcattctt
      661 ctgagtcaag gggaggtgga gaagctaatc aagtgcgacg agattcaggt ggattctgaa
      721 gagccagtct ttgaggctgt tatcaactgg gtgaagcatg ccaagaagga gcgagaagag
      781 tctttacctg acctcttaca gtatgttcgg atgcccctgc tgacccccag gtacattaca
      841 gatgtaattg atgctgagcc tttcatccgc tgtagtttac aatgcagaga tctagttgat
      901 gaagcaaaga agtttcacct gaggcctgaa cttcggagtc agatgcaagg acccagaaca
      961 agggcccggc taggagccaa tgaagtgctt ctggtggttg ggggcttcgg aagccagcag
     1021 tctcctattg atgtggtaga gaagtatgac cccaagacac aggagtggag ctttttacca
     1081 agtatcactc gcaagagacg gtatgtggcc tcagtttcct tacatgatcg gatctatgta
     1141 attggtggct acgatggccg ttcccgcctc agttcggtgg aatgtctaga ctatacagca
     1201 gacgaagatg gagtgtggta ctctgtggcc cctatgaatg tgcggcgagg ccttgctgga
     1261 gccaccactc tgggagatat gatttacgtc tctggaggct ttgatggaag taggcgtcat
     1321 acaagtatgg agcggtatga cccaaacatc gatcagtgga gtatgctggg agatatgcag
     1381 acagctcgag agggcgcagg actagtagtg gccagcggaa taatctattg tctaggagga
     1441 tatgatggct tgaacatatt aaattcagtt gagaaatatg atccccatac aggacactgg
     1501 actaacgtta cgcctatggc caccaagcgt tctggtgctg gagtagccct actgaatgac
     1561 catatttatg tggtgggggg gtttgatggt acagcccacc tttcttctgt tgaagcttat
     1621 aacattcgca ctgattcctg gacaactgtc acaagtatga ccacgcctcg atgctatgta
     1681 ggggccacag tgcttcgagg gagactctat gcaattgcag gatacgatgg gaattctctg
     1741 ctgagcagca ttgagtgtta tgaccctatc atcgacagct gggaagtagt agcctccatg
     1801 ggaacccagc gttgtgatgc tggtgtgtgt gttctccgag aaaagtaact gttattttaa
     1861 caccagctgg agccagtgac tactccaagg aacagtttgt gggagaatca aggatccttt
     1921 ccagaatgtt tattcctcac tgtgtgcaca gggggattcc aggcaccagt gctgagatga
     1981 tgattgtact tgtttgatgc acactctcct tcgcactggt catcttgctc agaagcatgg
     2041 gggggggcag gtactccagg gaagagaatg cacgtttgga tgtgggaaac cagatcatgg
     2101 ctctctgtgg tctgaggagc actttcttac tgtttctaac ttaccatgtg cttgggagga
     2161 tgtatgtatg tatgtttgta tggatgtatg ttgtgcctca tatattgcag agaataaggt
     2221 gagtatggcc tgctagatgt gggcagtgtc catcctaggt gattggaagg atatcagttt
     2281 atacaagctt ggtaaaatga aagtcttttt ccctctcaga agcaaaaata ccttttctaa
     2341 atacagaggt agctcaagcc accacagttc cttgctgtag gaaaacacta tcactgttaa
     2401 aatttgagag gccaagaagg aagattcatg ctgtcctcac ttaggaagac attgttggtg
     2461 cagagatttg aataagtggc tggagctgaa tggaatgtag gtgaacccag aagatcactg
     2521 aagtgtaaat tggaaggctg gaaaggacat gttatttgat ttcacagtct ttctaatgta
     2581 aaatgttgta ccatcttggc actggagact tgagagatta acagtggaaa aggttagaat
     2641 aagagatgct gtaaatgtgc agagttcaat atacctgtgg taaactagaa atatctgtga
     2701 ttttacaatt gtcttagtcc ctgccagggc tcctatagca gtggcagttt ggtcttcaaa
     2761 tgggtgaaaa gaccatcttc ctggcgaatc aagtgctacc acgttactac gcctccacac
     2821 tatttatttg gggatgggtg gggtggctgc agcctagtag ttcaggtacg tgattactgc
     2881 cctgttgttt agggcacact tccactaagg agtgcttaag actgctgtgt gtggtatgtt
     2941 cagttttctt cctgctatat cttctgtacc tgtctttaca gtgtatttta ctcatcctga
     3001 aacaaaataa tcaaggacaa ttgaaaatct tttgttagtt tctatacctt cgtatagaat
     3061 ggcagttcta ggcacctctg tgtcgtggtg aaactcttga gttactggta tagcaaatag
     3121 gagaatgtgg cagcctaaac tgggctacac tttccttttg ctctggaatc ccacttttcc
     3181 tctttccttg aattgtgttt gctgacagag ttaatttcct ttgtattttt ttaagaaaac
     3241 attaaaatgg actgtctcaa atgaaaaaaa aaaaaaaaaa a
//
