LOCUS       NM_053105               4109 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kelch-like 1 (Klhl1), mRNA.
ACCESSION   NM_053105
VERSION     NM_053105.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4109)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4109)
  AUTHORS   Perissinotti,P.P., Martinez-Hernandez,E., He,Y., Koob,M.D. and
            Piedras-Renteria,E.S.
  TITLE     Genetic Deletion of KLHL1 Leads to Hyperexcitability in
            Hypothalamic POMC Neurons and Lack of Electrical Responses to
            Leptin
  JOURNAL   Front Neurosci 15, 718464 (2021)
   PUBMED   34566565
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4109)
  AUTHORS   Bruining,H., Matsui,A., Oguro-Ando,A., Kahn,R.S., Van't
            Spijker,H.M., Akkermans,G., Stiedl,O., van Engeland,H.,
            Koopmans,B., van Lith,H.A., Oppelaar,H., Tieland,L., Nonkes,L.J.,
            Yagi,T., Kaneko,R., Burbach,J.P., Yamamoto,N. and Kas,M.J.
  TITLE     Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in
            Long-Term Social and Object Recognition and Sensorimotor
            Development
  JOURNAL   Biol Psychiatry 78 (7), 485-495 (2015)
   PUBMED   25802080
REFERENCE   4  (bases 1 to 4109)
  AUTHORS   Perissinotti,P.P., Ethington,E.A., Almazan,E.,
            Martinez-Hernandez,E., Kalil,J., Koob,M.D. and
            Piedras-Renteria,E.S.
  TITLE     Calcium current homeostasis and synaptic deficits in hippocampal
            neurons from Kelch-like 1 knockout mice
  JOURNAL   Front Cell Neurosci 8, 444 (2015)
   PUBMED   25610372
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4109)
  AUTHORS   Aromolaran,K.A., Benzow,K.A., Cribbs,L.L., Koob,M.D. and
            Piedras-Renteria,E.S.
  TITLE     T-type current modulation by the actin-binding protein Kelch-like 1
  JOURNAL   Am J Physiol Cell Physiol 298 (6), C1353-C1362 (2010)
   PUBMED   20147652
  REMARK    GeneRIF: KLHL1 interacts with Cav3.2 and modulates T-type calcium
            currents by increasing current deactivation kinetics and current
            density and calcium influx.
REFERENCE   6  (bases 1 to 4109)
  AUTHORS   Aromolaran,K.A., Benzow,K.A., Koob,M.D. and Piedras-Renteria,E.S.
  TITLE     The Kelch-like protein 1 modulates P/Q-type calcium current density
  JOURNAL   Neuroscience 145 (3), 841-850 (2007)
   PUBMED   17289272
REFERENCE   7  (bases 1 to 4109)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 4109)
  AUTHORS   He,Y., Zu,T., Benzow,K.A., Orr,H.T., Clark,H.B. and Koob,M.D.
  TITLE     Targeted deletion of a single Sca8 ataxia locus allele in mice
            causes abnormal gait, progressive loss of motor coordination, and
            Purkinje cell dendritic deficits
  JOURNAL   J Neurosci 26 (39), 9975-9982 (2006)
   PUBMED   17005861
REFERENCE   9  (bases 1 to 4109)
  AUTHORS   Benzow,K.A. and Koob,M.D.
  TITLE     The KLHL1-antisense transcript (KLHL1AS) is evolutionarily
            conserved
  JOURNAL   Mamm Genome 13 (3), 134-141 (2002)
   PUBMED   11919683
REFERENCE   10 (bases 1 to 4109)
  AUTHORS   Nemes,J.P., Benzow,K.A., Moseley,M.L., Ranum,L.P. and Koob,M.D.
  TITLE     The SCA8 transcript is an antisense RNA to a brain-specific
            transcript encoding a novel actin-binding protein (KLHL1)
  JOURNAL   Hum Mol Genet 9 (10), 1543-1551 (2000)
   PUBMED   10888605
  REMARK    Erratum:[Hum Mol Genet 2000 Nov 1;9(18):2777]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154580.2, CT025590.5, AC131920.7 and AC131989.8.
            
            On Feb 7, 2022 this sequence version replaced NM_053105.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094584.1, AK031932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1278              AC154580.2         160604-161881       c
            1279-1461           CT025590.5         125375-125557
            1462-1598           CT025590.5         138654-138790
            1599-1795           CT025590.5         160362-160558
            1796-2008           AC131920.7         196010-196222       c
            2009-2195           AC131920.7         156215-156401       c
            2196-2420           AC131920.7         117220-117444       c
            2421-2583           AC131920.7         67913-68075         c
            2584-2796           AC131920.7         52592-52804         c
            2797-2968           AC131989.8         2002-2173
            2969-4109           AC131989.8         18991-20131
FEATURES             Location/Qualifiers
     source          1..4109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 46.92 cM"
     gene            1..4109
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /note="kelch-like 1"
                     /db_xref="GeneID:93688"
                     /db_xref="MGI:MGI:2136335"
     exon            1..1278
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     CDS             773..3028
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /note="kelch-l like"
                     /codon_start=1
                     /product="kelch-like protein 1"
                     /protein_id="NP_444335.2"
                     /db_xref="CCDS:CCDS27308.1"
                     /db_xref="GeneID:93688"
                     /db_xref="MGI:MGI:2136335"
                     /translation="MSGSGRKDFDVKHILRLRWKLFSHPSPASSSPAGGSCLQQDSGG
                     GSFEHWGPSQSRLLKNQEKGSVSAFWKKPSSSSSSSSSSSSSASSSPFNPLNGTLLPV
                     ATRLQQGAPGQGTQQPARTLFYVESLEEEVVTGMDFSGPEDKGLALKELQAEPASSIQ
                     ATGEGCGHRLTSTNHSLTPQSDLDSSSSEEFYQAVHHAEQSFRKMENYLKQQQLCDVI
                     LIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTG
                     CLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMK
                     VAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQR
                     RCSDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQ
                     SPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVID
                     DKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDG
                     WSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYD
                     PHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDT
                     WTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGR
                     AGACVVVIKQP"
     exon            1279..1461
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1598
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1795
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2008
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2195
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2420
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2583
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2796
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2968
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..4109
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4084..4089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /note="hexamer: AATAAA"
     polyA_site      4103
                     /gene="Klhl1"
                     /gene_synonym="mKIAA1490"
                     /note="major polyA site"
ORIGIN      
        1 atactgtgag gaccttgaca gctttcctgg gcgggctttt ctttggctgc tctatgtttt
       61 ttcccgggat atttattttt ctcctttaca aactgactat ataaaaccgc cccttttctc
      121 atctcagaaa gcatttgact gtccttcgga cacctggcaa gctatcaggg aattatccca
      181 gaggacaggg acagggagca ggtgcacaga cccgcctaag ggttgggggg tgcactactt
      241 ctcgacttga ggctcttttt ctctgcactc atcaaacacg gaactctgag ctgcgaagac
      301 aggagatctg aatagcttcc aaaccacagc tcggcaccga gtgtgtatca gtgtggcgga
      361 gccagctgct gccacctctg gagctgagga gagctcaaac ctctctccct tcctcttgca
      421 tttccagcct ctctttcctc cgggggggtc accacggggg tccccgcaag ctcctcgtgg
      481 attctaagcc cctggtatcc caagacgtca ttcgatctag accggagctt ccccaaagct
      541 cagatcccag caaaaggacc cagactgagc cgcgaggctc tgcagagcgc tcaaggtgcc
      601 ggtgtggtct cctggtgaga cgcacagccc cttttaagcc acctttggca ctccgtgtac
      661 accgggtgaa tcctgcctcc tcctctctct ccagaagcca ctggccaccc cagtacgctc
      721 gccaggctac tggtgtgtga gctgcagttc cttggtccac ggttcattaa gcatgtccgg
      781 ctccgggaga aaagacttcg atgtgaagca catcctgcga ctccgctgga aactcttcag
      841 ccatccctcg ccggcctcca gtagcccagc ggggggcagc tgcctgcaac aggacagcgg
      901 aggaggcagc tttgagcact ggggtcctag ccagagtcgg ctgctcaaaa accaggaaaa
      961 gggcagtgtg agcgctttct ggaaaaagcc ttcttcctcc tcttcctcct cctcttcctc
     1021 ctcgtcttct gcttcatctt ctcctttcaa tccgctgaat ggcaccttac taccagttgc
     1081 cacgaggctg cagcaagggg ctcccgggca gggcacccag cagcccgcca ggactctttt
     1141 ctacgtggag tccctagagg aggaggtagt gacaggcatg gacttttctg gaccagagga
     1201 caaaggattg gccctgaaag agctccaagc ggagcctgcc agctctatcc aggcaacagg
     1261 tgaaggatgt ggacacaggt tgacatcgac caatcattca ctgacacctc aaagtgattt
     1321 ggattccagc agctccgaag aattctatca agctgttcac catgctgagc aatcatttag
     1381 aaagatggag aattatttaa agcaacagca gctctgtgat gtcatcctga tagttggaaa
     1441 tcgaaagata cctgctcata ggcttgttct gagttctgtc tctgactatt ttgctgccat
     1501 gtttacaagt gatgtctgtg aagccaagca agaggagatc aagatggaag gcatagaccc
     1561 aaatgcactc tgggatcttg ttcaatttgc atatacaggt tgcttggaat taaaagaaga
     1621 cactattgaa aaccttcttg cagctgcttg ccttctccag ctccctcaag tggtcgaagt
     1681 gtgttgtcac ttcctcatga aacttctgca tccatccaac tgtttaggaa taagggcatt
     1741 tgctgatgct caaggatgca ttgaattaat gaaggtggca cacagctaca ccatggaaaa
     1801 cataatggaa gtaatcagaa atcaagagtt tttactcctt ccagctgaag agctccataa
     1861 actactggcc agtgatgatg taaatgttcc tgatgaagag accattttcc atgcactgat
     1921 gatgtgggtc aagtatgaca tgcagcggag atgtagtgac ctgagtatgc tccttgcctt
     1981 cataagatta ccactgcttc caccacagat actggctgac cttgaaaacc atgcactatt
     2041 caagaatgat ttggaatgtc aaaaactgat tctggaagca atgaaatatc atctattgcc
     2101 cgaaagaaga actttaatgc aaagtccaag aactaagccc agaaaatcta cagttggaac
     2161 tctttatgca gtggggggaa tggataataa caaaggggct acaaccatag agaagtatga
     2221 cctccgaaca aatctgtgga ttcaggctgg aatgatgaat ggcagaaggc ttcagttcgg
     2281 tgtggctgtc attgatgaca agctctttgt aattggaggt cgagatggct taaagacttt
     2341 gaacactgtt gaatgttaca atcccaaaac caagacatgg actgttttgc caccaatgtc
     2401 aacacatagg catggtctag gagtaactgt actggaaggg cctatctatg cagtgggagg
     2461 ccatgacggc tggagctatc tgaacacagt ggaaaggtgg gatccccaga gccagcagtg
     2521 gacatatgta gccagtatgt ccattgctcg gagcacggtt ggagtagcag cactgaatgg
     2581 aaagttgtac tccgttgggg gtcgagatgg aagttcctgt ctgagttcaa tggaatacta
     2641 tgatcctcat acaaataagt ggagcatgtg cgcaccgatg tgtaagagga gagggggtgt
     2701 tggagtggcc acctgtgatg gtttcctgta tgcagtgggt ggccatgatg ctcctgcttc
     2761 aaaccactgt tccaggctcc tggactacgt ggaaaggtat gatccaaaaa cagatacatg
     2821 gaccatggtg gctcctttga gtatgcctag agatgctgtt ggtgtctgtc tccttggtga
     2881 caggctatat gctgttgggg gctatgatgg gcagacttac ctcaacacca tggagtccta
     2941 tgatccacaa actaatgagt ggacacagat ggcttcattg aatattggga gagcaggtgc
     3001 ctgtgtggtt gtcatcaagc aaccttgact gatttatata atgtttgaag ggattttctt
     3061 tgctactgtg gttattttat atcgtgtggt aagagtgaga aagaaattct gagacaagaa
     3121 tttctcaaga acaggatttt tatagattta cctgcttgta acaaaagcag taaaagatca
     3181 aacagaattt tagaaagaaa aaaaaaaggg aacatcagac acaacatctg gccaatagtt
     3241 aattagttca ggaatggtta ttgataatgt ttttcattgt agcatacaat aactagaatt
     3301 accaaaggcg ggtttatcaa aactgacaca tatttgtgat atagatagtt acttaatgac
     3361 tgaccgcttg gttgttctca taatctgtga ggattcccaa gaggtggcca agagtagaag
     3421 ttatactatt ttatctcaca aattctgaac gattttatgt ttttctaatt gaatgtgatg
     3481 atagcaagag gcagaatgtt ttgttgaaac aaatatgctt ctttctcatt ttcctcagct
     3541 atgaaaacaa ttagagagac agatgattgt ctctgcattc agaaaacaaa ctgccctgct
     3601 aatcaaggct gcatattgta tccaaaatga tgattggatt ttattacaac tgtgtcatca
     3661 gtctcgaact ggcaaacaaa aagtactttc cataaagctt gccacatcgc tttgcattgt
     3721 caacccactg agccaaagag tcactgcagc tatgggcatt tgcctcatgc agagttcagt
     3781 ataagcatgg atgttagtta ttctgaatgt taatataccc actgcatgct gaagtccctt
     3841 agaattttgt tctttaaaac aaaacttaga attttgagac aaaatttcca actcattaaa
     3901 ttgggatgat tatgacaaca catagaaggg tgactgacta catattcaca ttccccattt
     3961 tcaaaaatct tacattgata tgcacattgt tttaaaccaa atgtttgtaa ttgttccaaa
     4021 gcgaaatgtg gaacttttat gtaacatcat taatgtatgt ccatgtaaat tatgaagata
     4081 gttaataaat gataaaacgt tcactttta
//
