LOCUS       NM_173427               5871 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kelch domain containing 7A (Klhdc7a), mRNA.
ACCESSION   NM_173427
VERSION     NM_173427.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5871)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844480.29 and AW124675.1.
            
            On Oct 12, 2006 this sequence version replaced NM_173427.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5462              AL844480.29        141781-147242       c
            5463-5871           AW124675.1         1-409               c
FEATURES             Location/Qualifiers
     source          1..5871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 71.03 cM"
     gene            1..5871
                     /gene="Klhdc7a"
                     /gene_synonym="B230308G19Rik"
                     /note="kelch domain containing 7A"
                     /db_xref="GeneID:242721"
                     /db_xref="MGI:MGI:2444612"
     exon            1..5854
                     /gene="Klhdc7a"
                     /gene_synonym="B230308G19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..2714
                     /gene="Klhdc7a"
                     /gene_synonym="B230308G19Rik"
                     /note="novel kelch domain containing protein"
                     /codon_start=1
                     /product="kelch domain-containing protein 7A"
                     /protein_id="NP_775603.2"
                     /db_xref="CCDS:CCDS38935.1"
                     /db_xref="GeneID:242721"
                     /db_xref="MGI:MGI:2444612"
                     /translation="MLPTGEGAEGQDWHLDMQLPSKVVLSAAALLLVTAAYKLYKSRP
                     APVGQAGRNNKDHKAENETEALGQLAFQEAPPGTLPRGRRRRKASKGAGTSLDYSLVD
                     PEDPCILDISRSEEATRKGSDESQGRQCPDSQQVPPPCGGQEAGTDVRGKPNPPHLPH
                     SGCEPTSSSGRLIPGVGGSCVGDKLSPWPDSRPPEETGSGDLEAPNGWTDLTLVNGDM
                     NQSWIFTHMTGVSRGEAGVLQAAADMGLATQQQEGATNASHTFSSVARIRMEENIIQK
                     AEGPGLKGRVYDYFVESTSKADSRPVPCPAALADAPSPGPGPEPLVTGAASRDEAANT
                     AGGGASEAASPQPVASPSAPGFSRKVSLLQIAENPELQLQPEGFRMPLPAHLDQRAQL
                     SSACSHGEPHVQLVAGTNFFHIPLTPASALDVRLDLGNCYEMLTLAKRQGLETLKEAA
                     YKVLSDNYLQVLRSPDIYGGLSGAERELILQRRFRGHKRLVVADMCPQDDSGRLCCYD
                     NVQDAWHPLAQLPPEAMSRGCALCTLFNYLFVVSGCQEPGGQPSNRVFCYNPLTAIWS
                     EVCPLNQARPHCRLVALEGHLYAIGGECLNTVERYDPRLDRWTFAPPLPNDTFALAHT
                     ATVCANEIFVTGGSLRYLLLRFSTQEQRWWAGPTGGSKDRTAEMVAVNGFLYRFDLNR
                     SLGISVYRCSASTRLWYECATYRLPYPDAFQCAVVDDHIYCVGRRRMLCFLADHISPR
                     FVSKELKGFPSARGTLLPAVLTLPVPDVPQTPV"
     regulatory      5459..5464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhdc7a"
                     /gene_synonym="B230308G19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5481
                     /gene="Klhdc7a"
                     /gene_synonym="B230308G19Rik"
     regulatory      5825..5830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhdc7a"
                     /gene_synonym="B230308G19Rik"
                     /note="hexamer: CATAAA"
     regulatory      5834..5839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhdc7a"
                     /gene_synonym="B230308G19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5844
                     /gene="Klhdc7a"
                     /gene_synonym="B230308G19Rik"
     polyA_site      5854
                     /gene="Klhdc7a"
                     /gene_synonym="B230308G19Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggatttgcaa aagagaaaat aaacaccctc acacacagac caacagtgtg gcttctaggc
       61 atctggtgac agttctgctc agagattcct tcctctttga atccctgttg gacactccct
      121 cccaccaggg gctgcaggtg actgatctga agctcgggcc cctccagtcg ggaccctccc
      181 tcctttcagg caaggatcca aagaggccag ctgcaacctt agccatcccc tgccccattg
      241 ccgactcagt ggactcaaag tcacctctgc tccagcaacc gctggccaga tccggctagg
      301 gactccctcc cactccacag caggatccag gaactggtcc ctattgggca atcattaatc
      361 ggattcttgg cattcctctg tccctggcca gcatgctccc cactggagaa ggagcagagg
      421 gccaggactg gcatttggac atgcagctgc ccagcaaggt ggtgctgtcc gcagctgcgc
      481 tgctcctggt aactgcggct tacaaactct acaagtccag acctgcccca gtcgggcagg
      541 cagggagaaa caacaaggac cacaaagcag aaaatgaaac agaggccttg ggacaacttg
      601 ccttccagga ggctccaccg gggaccctgc caaggggtcg aagacgcagg aaggccagca
      661 agggggctgg gacctcactg gactacagct tggtggatcc agaagacccc tgcatcctgg
      721 acatttccag gtctgaagag gccacaagaa aaggctctga tgaaagtcag ggcaggcagt
      781 gtccagactc tcagcaggtg cctcctccct gtggtggcca ggaagccgga acagatgtta
      841 gaggtaagcc caaccctccc cacctccctc attcaggctg tgaacctacg agctcctcag
      901 gcagacttat cccaggagtg ggtggcagct gtgtgggtga caagctctct ccatggccag
      961 acagcagacc cccagaggaa acaggatctg gggacctgga agcccccaac ggttggactg
     1021 atcttacact ggtcaatggt gacatgaacc agagttggat cttcacccac atgacagggg
     1081 tcagcagggg agaggccggg gtcctccagg ctgctgcaga catgggcttg gccacgcagc
     1141 agcaggaagg agccaccaac gcctcccata ctttctcatc tgtggcccgg atccggatgg
     1201 aggagaatat tatacaaaag gcagagggac cagggctgaa gggcagagta tatgactatt
     1261 tcgtggagtc cacgtcgaag gctgactcca ggccagtccc ctgcccagca gctctggctg
     1321 atgctccatc ccctgggcct ggaccagagc cccttgtcac tggagcagcc tccagagacg
     1381 aagccgctaa cacagccggt ggtggtgcat ctgaagcagc atccccacag cctgtggcat
     1441 ccccatctgc accgggcttc agcagaaagg tgagcctcct gcagatcgct gagaacccag
     1501 agctccaact gcagcctgaa ggcttcagga tgccccttcc tgcccacctg gaccagagag
     1561 cccaactcag ctcagcctgc agccacgggg agccccacgt gcagcttgta gctgggacca
     1621 atttcttcca catcccgctc accccggctt cagctctgga tgtccgcctg gacctgggca
     1681 actgctatga gatgctgacc ttggccaaga ggcagggcct agagaccctg aaggaggcag
     1741 cctacaaggt attgagtgat aactaccttc aggtcctccg cagcccagac atctatgggg
     1801 gcctgagcgg agcagagcgg gagctgattc tccagcgcag gttccgtggc cacaagcgcc
     1861 tggtggtggc agacatgtgt ccccaggatg atagtggccg cctctgttgc tatgacaatg
     1921 tgcaggatgc ttggcaccct ctggcccagc tgcccccgga agccatgtcc cggggttgtg
     1981 cactctgtac cctattcaat tatctgtttg tggtgtctgg ctgccaggaa cctgggggcc
     2041 aaccctccaa ccgcgtcttc tgctacaacc ccctgacggc aatctggagt gaggtgtgcc
     2101 cactgaacca ggctcggcct cactgccggc tggtggccct ggaggggcac ctctatgcca
     2161 ttggaggtga gtgtttgaat acagtggagc gttatgaccc tcgcctggac cgctggacct
     2221 ttgccccgcc tctcccaaac gatacatttg ccctggcaca cacagccacg gtgtgcgcca
     2281 atgagatctt tgtcaccggg ggcagcctgc gctacttgct gctccgattc tcgacccagg
     2341 aacagcgttg gtgggccggc cccaccgggg gcagcaagga ccgcacggcc gagatggtgg
     2401 ctgtgaatgg ctttctctac cgttttgacc tcaaccgcag cctgggcatc agcgtgtacc
     2461 gctgcagtgc cagcacccgg ctctggtatg agtgtgccac ataccgctta ccttaccctg
     2521 atgccttcca gtgcgccgtt gtggatgatc atatctattg tgtgggacgc aggcgcatgc
     2581 tctgcttcct ggcggaccac atctcaccca ggtttgtgtc taaggaatta aagggtttcc
     2641 cttctgcacg gggcaccctt ctgcctgccg tcttgacctt gcctgtcccg gatgtgcctc
     2701 agacccctgt ctagcagtcc ctcagctggg ctccatcagg attcagaaaa acccctttgc
     2761 ctatcactct gggtaagaag caggcaggaa catgacaggc cgtggagtgg aaagttctct
     2821 ctcctgtacc acaggctatg gggccttgga ggattcttga aaagccacat tacaggtctg
     2881 ccacaacatt gaagccagag cctagcattc cacgacagct ggaatctcac aacttcgtga
     2941 gtgactgacc cagcactgtg attcaagtca gaattcctgg taggggcggt ttcaggatcc
     3001 cacagaaatg aagggacaca gtcttctccc aatcacagtt ccaggggcca gggtacctcc
     3061 agaggacttc tcaagctggt tgggtttctg tgtgctacca tagaccaccc tcttaagcaa
     3121 tggtctcacc aattcctaag cattgaggcc cactttagaa gcttctagaa gcacctggag
     3181 cacaggtgga aagaactgaa ggagggtttg ggcaggagca ggaagcagct caggatagcc
     3241 ctgaggtttg gccagcagga caggcacagc tgaagctgaa ggcatccaca gtaacactgt
     3301 ttgagagcat attgaccaag gcccactttt gttgttgttg ttacctcagg ttctgtgtgc
     3361 tggaaggaga aaggcatcca tcttgacagg agttctattt gcatattaat cattgcacaa
     3421 ttgaggtctt aggaggcaga tgtggttcca ggctcccttt tccgggcccc tgccacgccc
     3481 acaaccacct gacctcaata gaccgccccc ccccccccca gagttcagaa tcctctctgc
     3541 ctgggcaggg cagccaccat tcttcagctc atccatgtga ccagctctgt gtctggtggc
     3601 cgtctggtgg ccagtggccg tctcatctgc ctcgttggat gagaaggaac aaggaaaggc
     3661 aggcctggga tggagccatg gagttggaag attctagtgg agcatccagg cccccaatct
     3721 tttatattga aggggatcca acttccagga tgaaaggcag agagcctggt ccacctgcct
     3781 actaagccct tgctccattc tcagggagac aaagatgttg agagaaaagt gatgatgctc
     3841 tagagatgag tcaggagcca gggggtgcga gtcacagacg gggcggggcc tgacaagagg
     3901 acggatgaca aaaacctgga cactgtcact ataaaaacct tcccagatcc caggggtggc
     3961 catgcagctg cgggaactga ggctggggca ctctggggaa gatttggggt taggatgtag
     4021 aacaaggaag agctgtgcca tggagatgag aagagggcat ttggtgtact gtgcaaggtg
     4081 actattcctg gccagagacc tagaggagga accagctgga cacacttgaa ttgaaagctg
     4141 agcaagaaag gctgtctgag ccatggtgga tccccaggga gggaatgtcc cctcccccct
     4201 gccccttgcc tcccctacca aagtcacgtc acattactca catcaacctc tgagaaacat
     4261 tggggtgggg gaaatggatg gcttcagtaa aaggactcaa aggggacatt gccaggctga
     4321 ggtggggcaa ggtgcttttg ggagatacac ccagcttcca ggcacaggct agcccgaaga
     4381 tgaaacatgt taaggaaact tccagaagcc tgtggcacac caaaagtaag aaccaggcaa
     4441 gtgattccag ggaagctgca aaaaagaaaa accaaaaccc ccccaaaacc ccaaaaaccc
     4501 tgtgttctag atcccagtga attgtgagtg tgatctttat tgaaagaagg ggcgctgaga
     4561 ctaagctgtt gtatatccct taggctcacg tggcagacat caccaatcaa ttcctgatga
     4621 gcccttataa tgacctcaga actgttcaaa acagaagccc cacagtcatg gcccgtaggt
     4681 cagagctggc atgtcgttac tggcttgacg aggagctggt ttggggagtg aagtggttat
     4741 agcagagcca agtaacccag ggaacccagc agaggcacgg tggacagagt tcactggtga
     4801 gatgaacacg tgcagtctgt ttgggccagg ctgggcactg ctcttcgggt gggggagcag
     4861 cagtgtccca gtggaggaga acaagctgat tcagagacca agcacaggca cagaaagagc
     4921 ctgaactcag cgtgcttaac tgctaaggca agggcaaagc aggccctgca agacaatcgg
     4981 gcctccgaga ggaaatgtat cgaaatgtat caaaatgtat gggaggaggg atcaggttgg
     5041 agattcaccc agagggaagg ggaagggttt tgccacaaag gcaaggggac agggctgctt
     5101 ctgaggagga cagtctcagg gtggtagagg gatagaccac tgatctggct ttgttccctg
     5161 ggagagaagc cgatttggta tacttgggga cagttacaag ggagtcacag gtaccctgtc
     5221 catgtctgcg gctgtgggca gcctgctggc tcagagtcta attcccactt gactttagga
     5281 aacagcctag ggtctgggga catcctggcc tcagcctccg agtagcctaa gcatcagggg
     5341 gctctgagga ctatctgtct tgcttctttt ctaataagag ttcttactgc tttaggggag
     5401 gaaagatgat gtgagggtta ttttccactt taagcctgtc catgtccctt tatagaaaaa
     5461 taaatagaca attggaagat agagaaatgt atttttaaaa aactctcaat tctgccaccc
     5521 aaagatgtct cctgaggggt gtgtgtccct ggggtctctt tcttctgttt gtaggttttg
     5581 tttggcttgg tttttgcccg ggtgtgtttg tgctgaacat acaattctgt tgcttccttc
     5641 tgcacacagc gtttttcaga ataagcatct tcccgtgtta ttacaaaccc tcggtaaaca
     5701 tcattttcaa aaggcactga atattcctcc cactgaatgg atcgcacttt atttaaacac
     5761 gttcccctcc tgttgggccc gtggattccc ccccaccccc acccctgttg gtttcttttt
     5821 ctctcataaa taaaataaat ggtctttgtt tctcaaaaaa aaaaaaaaaa a
//
