LOCUS       NM_145605               2083 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus kelch domain containing 4 (Klhdc4), mRNA.
ACCESSION   NM_145605
VERSION     NM_145605.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2083)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2083)
  AUTHORS   Poncet,N., Halley,P.A., Lipina,C., Gierlinski,M., Dady,A.,
            Singer,G.A., Febrer,M., Shi,Y.B., Yamaguchi,T.P., Taylor,P.M. and
            Storey,K.G.
  TITLE     Wnt regulates amino acid transporter Slc7a5 and so constrains the
            integrated stress response in mouse embryos
  JOURNAL   EMBO Rep 21 (1), e48469 (2020)
   PUBMED   31789450
REFERENCE   3  (bases 1 to 2083)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121975.3, BY086869.1, AK161674.1 and AV374981.1.
            
            On Aug 8, 2009 this sequence version replaced NM_145605.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012312.1, AK161674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC121975.3         118135-118149       c
            16-123              BY086869.1         2-109
            124-2078            AK161674.1         100-2054
            2079-2083           AV374981.1         250-254
FEATURES             Location/Qualifiers
     source          1..2083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.76 cM"
     gene            1..2083
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /note="kelch domain containing 4"
                     /db_xref="GeneID:234825"
                     /db_xref="MGI:MGI:2384569"
     exon            1..188
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1844
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /codon_start=1
                     /product="kelch domain-containing protein 4"
                     /protein_id="NP_663580.2"
                     /db_xref="CCDS:CCDS22729.1"
                     /db_xref="GeneID:234825"
                     /db_xref="MGI:MGI:2384569"
                     /translation="MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQ
                     TLDAKKTQVTETPCPPPSPRLNASLSAHPEKDELILFGGEYFNGQKTFMYNELYIYSI
                     RKDTWTKVDIPGPPPRRCAHQAVVVPQGGGQLWVFGGEFASPDGEQFYHYKDLWVLHL
                     ATKTWEQIRSTGGPSGRSGHRMVAWKRQLILFGGFHESARDYIYYSDVYTFSLDTFQW
                     SKLSPSGPGPTPRSGCLMAVTPQGSIAIYGGYSKQRVKKDVDKGTQHSDMFLLKPAEG
                     GEGKWAWTRINPSGVKPTARSGFSVAVAPNHQILVFGGVCDEEEEESLEGSFFSDLYI
                     YDSAKSRWFAAQLKGPKSEKKKRRRGKAEDPEGTTEQETGGSSAPEPLEVIKEVVSED
                     GTVVTIKQVLTPSGLGVQPSPKADDSASEASSTGQEPCPRSNAMLAVKHGLLYVYGGM
                     FEAGDRQVTLSDLYCLDLHKMEEWKTLVEMDPKSQEWLEESDSEEDSSSDEESADGED
                     EDQEDSAEEGADPQHPEVARGEQFEEYLSRTEQHWLKLARSHVGPEAKEKKVLKVAQA
                     MAKSCFDDAVQDIAQARH"
     exon            189..280
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            281..359
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            360..458
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            459..595
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            596..688
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..848
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            849..924
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1133
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1536
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1647
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..2083
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2061
                     /gene="Klhdc4"
                     /gene_synonym="G430025P05Rik"
                     /note="major polyA site"
ORIGIN      
        1 tatagcgcgc cgctcgtttc cggcccggca gaacatcatc attcatttgc ctccggttgt
       61 ctcccgggcg ccgcttccga atcggcgcga tgggcaagaa gggaaagaag gagaagaagg
      121 gccgcggcgc ggagaagacg gccgccaaga tggagaagaa ggtgtccaag cgctcgcgga
      181 aggaggagga agacctggag gccctcatag cccatttcca gaccttggat gccaaaaaga
      241 cccaggtcac agaaacacca tgtcctccac cctccccacg gttaaacgcc tccctgtctg
      301 ctcatcctga gaaagatgag ctgatccttt tcggaggtga atatttcaat ggccaaaaaa
      361 ccttcatgta taatgaactc tacatctaca gtatcagaaa ggacacctgg acaaaagttg
      421 acatccctgg cccacctccc aggcgctgtg ctcatcaggc tgtggtggta ccccagggtg
      481 gtgggcagct gtgggtcttc ggtggggagt ttgcatctcc cgatggcgag cagttctacc
      541 attacaagga cctctgggtc ctgcacttgg ccaccaagac ctgggaacag attcgatcaa
      601 cagggggtcc ttcaggtcga agcgggcatc ggatggtggc ctggaagcga cagctaattc
      661 tttttggtgg cttccatgaa agtgcaaggg actacatcta ctacagtgat gtgtacacct
      721 tcagcctgga caccttccag tggagcaagc tgtccccatc aggccccggg cccacgccca
      781 ggtcaggctg cctgatggct gtcactcccc agggcagcat agccatctat ggaggttact
      841 caaagcagag agtcaagaaa gatgtggaca aaggcaccca gcactcagac atgttcctgc
      901 tgaagcctgc ggaaggggga gaaggcaaat gggcttggac caggattaac ccttcggggg
      961 tcaagcctac tgcaaggtct ggcttttctg tggctgtggc tccaaatcat cagatactgg
     1021 tcttcggggg cgtgtgtgat gaggaagagg aggagagcct ggagggctcc ttcttcagtg
     1081 acctgtatat ctatgattcg gccaagagtc gctggtttgc agcacagctg aagggcccca
     1141 agtctgagaa gaagaaacgg aggcggggca aggcagagga tcctgaaggc accactgaac
     1201 aggagactgg ggggagcagt gccccagagc cactggaggt gataaaagag gtggtgtctg
     1261 aagacgggac agtggtcacc attaagcaag tactcactcc ctcagggttg ggggtgcagc
     1321 cctcacctaa ggctgatgac agtgcctcag aggccagcag cactggacag gagccatgcc
     1381 ctcgttccaa cgccatgctg gctgtcaagc atggactgct gtacgtctat ggcggcatgt
     1441 ttgaagctgg tgaccgccag gtgaccctta gtgacctcta ctgccttgac cttcacaaga
     1501 tggaagagtg gaaaaccttg gtggagatgg atccgaaatc ccaggagtgg ctggaggagt
     1561 cggactcaga agaggacagc agctcagatg aagagagtgc agatggagag gatgaagacc
     1621 aggaggacag tgctgaggag ggagcagatc cgcagcaccc agaggtggcc cgtggggagc
     1681 aattcgaaga gtacctgtcc cggactgagc agcactggct gaagctggcc cggagccatg
     1741 tggggcctga agcaaaggag aagaaagtgt tgaaagtagc ccaggccatg gcaaaatcat
     1801 gctttgatga tgcagttcaa gacattgcac aggccagaca ctagactgcg caatggtttc
     1861 accatcactg gtgtcgagcc aggagtgagg aggccctgca gagtggtctt ctgtgagcct
     1921 tgggtgccca cagtctgacg ggggctagcc tgacttcaca gtggcttctg tccacgtgga
     1981 acgagggtta gagtgggatg tgaatttgag gcccacaggc tgtgtgcttc tgtcataata
     2041 aaactgggct gtgtgctcta aggttttctt tcttctacag agc
//
