LOCUS       NM_027910               2139 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus kelch domain containing 3 (Klhdc3), transcript variant
            1, mRNA.
ACCESSION   NM_027910
VERSION     NM_027910.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2139)
  AUTHORS   Zhang,P., Gao,K., Zhang,L., Sun,H., Zhao,X., Liu,Y., Lv,Z., Shi,Q.,
            Chen,Y., Jiao,D., Li,Y., Gu,W. and Wang,C.
  TITLE     CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis
            through promoting p14ARF degradation
  JOURNAL   Cell Death Differ 29 (4), 758-771 (2022)
   PUBMED   34743205
  REMARK    GeneRIF: CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses
            ferroptosis through promoting p14(ARF) degradation.
REFERENCE   2  (bases 1 to 2139)
  AUTHORS   Ohinata,Y., Sutou,S. and Mitsui,Y.
  TITLE     Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon
            mediated-gene formation in mammals
  JOURNAL   DNA Res 10 (2), 79-84 (2003)
   PUBMED   12755172
REFERENCE   3  (bases 1 to 2139)
  AUTHORS   Ohinata,Y., Sutou,S. and Mitsui,Y.
  TITLE     A novel testis-specific RAG2-like protein, Peas: its expression in
            pachytene spermatocyte cytoplasm and meiotic chromatin
  JOURNAL   FEBS Lett 537 (1-3), 1-5 (2003)
   PUBMED   12606021
  REMARK    GeneRIF: cloned human and mouse Peas cDNAs (hPEAS/mPeas) and
            analyzed their tissue and stage-specific expressions; may be
            involved in meiotic recombination process
REFERENCE   4  (bases 1 to 2139)
  AUTHORS   Ohinata,Y., Sutou,S., Kondo,M., Takahashi,T. and Mitsui,Y.
  TITLE     Male-enhanced antigen-1 gene flanked by two overlapping genes is
            expressed in late spermatogenesis
  JOURNAL   Biol Reprod 67 (6), 1824-1831 (2002)
   PUBMED   12444059
REFERENCE   5  (bases 1 to 2139)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF169399.1, AK004964.1, AK141673.1 and BE945284.1.
            
            On Jul 30, 2009 this sequence version replaced NM_027910.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018154.1, AK004964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CF169399.1         1-26
            27-942              AK004964.1         4-919
            943-1042            AK141673.1         775-874
            1043-2122           AK004964.1         1020-2099
            2123-2139           BE945284.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..2139
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /note="kelch domain containing 3"
                     /db_xref="GeneID:71765"
                     /db_xref="MGI:MGI:2651568"
     exon            1..229
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            230..382
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            383..595
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..1590
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /note="testis intracellular mediator protein; protein
                     Peas"
                     /codon_start=1
                     /product="kelch domain-containing protein 3"
                     /protein_id="NP_082186.2"
                     /db_xref="CCDS:CCDS28834.1"
                     /db_xref="GeneID:71765"
                     /db_xref="MGI:MGI:2651568"
                     /translation="MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQI
                     DVHIFNAVSLRWTKLPPVRPAVRGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGAC
                     NVLYAFDVNTHKWSTPRVSGAVPGARDGHSACVLGKIMYIFGGYEQLADCFSNDIHKL
                     DTSTMTWTLVCTKGNPARWRDFHSATMLGNHMYVFGGRADRFGPFHSNNEIYCNRIRV
                     FDTRTEAWLDCPHTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPGSF
                     TWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDF
                     SPSLKTLCKLAVIQYSLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG"
     exon            596..772
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            773..888
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            889..960
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1174
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1261
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1370
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1444
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1523
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..2126
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2105..2110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /note="hexamer: TATAAA"
     polyA_site      2126
                     /gene="Klhdc3"
                     /gene_synonym="1300011D16Rik; Peas"
                     /note="major polyA site"
ORIGIN      
        1 cgcccacccg ctccccatct ttcggccctg gggtaattcg tggactacaa gtccctgaag
       61 ctgtcgggcc ggcaattctc actgcacgtg cgcgtcccgc tgcccgccgg aaggacgaag
      121 tctggcagtg tttatctcgt tggggaccga ggaatcggtt ggcgggcaac gggttctagg
      181 ctgctggcag cgcgaggacc cgcggcccca ccccggcccg gcctggcagt ttctagtcct
      241 ggcagcatac gagccacagc tgtcaaagga actcctcgtg cctgtagaca ccctgggtga
      301 ccccagggac aacggatcag cttgacaaga acgctctgtg aggggctaat caaccatggt
      361 tacatggagt tccctgtcct aggtagcaga ggcagcaggc cgtgccgggg gggcatgttc
      421 ctgtaacctg tggcccaggg gatgttacgg tggacagtgc atctggaggg cgggccacgc
      481 agggtgaacc atgctgcagt ggctgtcggg caccgagtat attccttcgg gggttactgc
      541 tctggggaag actacgaaac actacggcag atagatgtgc acattttcaa tgctgtgtcc
      601 ttgcgttgga caaagctgcc cccagtgagg cctgccgtcc gagggcaggc tcctgtcgtt
      661 ccctacatgc gctatgggca ctcaaccgtc ctcattgatg acaccgtctt cctttggggt
      721 gggcgcaatg acactgaagg ggcctgcaac gtactctacg cctttgatgt caatactcac
      781 aagtggtcta caccccgagt gtcaggggca gttcctgggg cacgggacgg acattcagct
      841 tgtgtcctgg gcaagatcat gtacattttt gggggatatg aacagctggc cgactgcttt
      901 tccaacgaca tccacaagct ggataccagc accatgacat ggactcttgt ttgtacaaag
      961 ggcaatcctg cacgttggag ggacttccac tcagccacaa tgctgggcaa tcacatgtat
     1021 gtctttgggg gccgtgcaga ccgctttggg ccatttcatt ccaacaatga gatctactgt
     1081 aatcgaattc gagtctttga taccagaacg gaggcctggc tcgactgtcc tcacacgccg
     1141 gtgctgcctg aggggcgcag gagccattca gcctttggct acaatggaga gctgtacatc
     1201 tttggtggct acaatgcaag gctgaatcgg catttccatg acctctggaa gtttaatcct
     1261 gggtccttta cctggaagaa gattgaacca aaggggaaag gaccgtgtcc ccgccgccgc
     1321 cagtgttgct gtattgttgg tgataaaatt gtcctctttg gcggtaccag cccctctccc
     1381 gaggaaggcc tgggggatga atttgacctc atagatcatt ctgacttaca catcttggac
     1441 ttcagcccta gtctgaagac tctgtgcaag ctggcggtga ttcagtatag cctggaccag
     1501 tcctgtctgc cccatgacat caggtgggag ctcaacgcca tgaccaccaa cagcaatatc
     1561 agccgcccca ttgtctcctc ccatggctag gaagtttatg ctgcctcccc tactgagccc
     1621 tctcttgtct tcattgcccc tgcccttctc acccgcctgc ccctttggac cctggactcg
     1681 gtatacctcc acgtggagtt gatggactag aggtgttttc tgtgctgtga attcagtggg
     1741 gagttttttg ggggagggca tttccctccc tccttgggcc gagggcccct tcccttggtg
     1801 ctctgtcccc atccacctcc ctccaccgct cctgggcctt tgctctgccc cagtctggct
     1861 gggtagccag gctgtgtgtg ctggaaaggg acaggagtgg gagaagccag cagtgttgga
     1921 gcctcaggag cctccctctc cccatgacca ccctctccct gcttgagcat cgcccgggag
     1981 ctgagaggag cctcggctgt tggcatgaaa ccccctcccc aacccgcggt ggtggggacc
     2041 aacagacagc ttcacccttc cttgagctgt tgctgtaccc ctgaagctca ggcagctctg
     2101 actttataaa acctaaaacc tccaaaaaaa aaaaaaaaa
//
