LOCUS       NM_029742               5962 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kelch domain containing 10 (Klhdc10), transcript
            variant 1, mRNA.
ACCESSION   NM_029742 XM_133019
VERSION     NM_029742.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5962)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5962)
  AUTHORS   Yamaguchi,N., Sekine,S., Naguro,I., Sekine,Y. and Ichijo,H.
  TITLE     KLHDC10 Deficiency Protects Mice against TNFalpha-Induced Systemic
            Inflammation
  JOURNAL   PLoS One 11 (9), e0163118 (2016)
   PUBMED   27631783
  REMARK    GeneRIF: results suggest that KLHDC10 is a cell-type specific
            regulator of necroptosis that ultimately contributes to the
            development of TNFalpha-induced SIRS
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5962)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   4  (bases 1 to 5962)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   5  (bases 1 to 5962)
  AUTHORS   Lee,Y.J., Park,C.W., Hahn,Y., Park,J., Lee,J., Yun,J.H., Hyun,B.
            and Chung,J.H.
  TITLE     Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely
            linked to Peg1/Mest(1)
  JOURNAL   FEBS Lett 472 (2-3), 230-234 (2000)
   PUBMED   10788617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134796.1, BC060132.1 and BC056496.1.
            
            On Jul 24, 2015 this sequence version replaced NM_029742.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060132.1, AK085130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                CJ134796.1         2-55
            55-4237             BC060132.1         1-4183
            4238-5962           BC056496.1         1197-2921
FEATURES             Location/Qualifiers
     source          1..5962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.52 cM"
     gene            1..5962
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /note="kelch domain containing 10"
                     /db_xref="GeneID:76788"
                     /db_xref="MGI:MGI:1924038"
     exon            1..296
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1459
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /note="isoform 1 is encoded by transcript variant 1; kelch
                     domain-containing protein 10"
                     /codon_start=1
                     /product="kelch domain-containing protein 10 isoform 1"
                     /protein_id="NP_084018.1"
                     /db_xref="CCDS:CCDS19971.1"
                     /db_xref="GeneID:76788"
                     /db_xref="MGI:MGI:1924038"
                     /translation="MSAAQGWDRNRRRGGGAAGGASGVSGAGAAGGGRGTGQLNRFVQ
                     LSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLY
                     VFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHG
                     NNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKRPSRIYGQAMALINGSLYV
                     FGGTTGYIYSTDLHKLDLNTMVWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGT
                     SWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGE
                     VILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSL
                     FKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQELIERLK"
     exon            297..383
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     exon            384..605
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     exon            606..760
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     exon            761..909
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     exon            910..994
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1061
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1109
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1249
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..5937
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5920..5925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /note="hexamer: AATAAA"
     polyA_site      5937
                     /gene="Klhdc10"
                     /gene_synonym="2410127E18Rik; mKIAA0265"
                     /note="major polyA site"
ORIGIN      
        1 agccattggt tgctggagag cccggcgcta ccccggcccc cgtctcccgg gtctcttgag
       61 gagcccggga aggaggctcg gctcgcgctg ccggggcagg ggcttgccgg gaccgggctg
      121 cggcaatcgt tagcgggcca tgtcggctgc ccagggctgg gaccggaacc gccggcgggg
      181 aggaggcgcg gccggcgggg ccagcggggt tagcggggcc ggcgcggccg gcgggggtcg
      241 gggcaccgga cagctcaacc gattcgtgca gctctcggga cggccgcacc tgccaggtaa
      301 gaagaaaata cggtgggacc cagttaggag gcgcttcatt cagtcctgtc ccatcataag
      361 gatccctaac aggttcttga gaggccacag acctccccca gcccgcagtg gacaccgttg
      421 tgtggcagac aataccaatc tctatgtgtt tggagggtat aacccagact atgatgaatc
      481 gggagggccg gataacgaag actaccctct cttcagggag ctttggcggt atcattttgc
      541 aacaggcgtg tggcaccaga tgggtacaga tggctacatg ccccgggaat tggcatcaat
      601 gtcacttgtg ctgcatggaa acaacctgtt agtgttcgga ggtacaggca tcccgtttgg
      661 tgagagcaac ggcaatgacg tccatgtctg caatgtgaag tacaagagat gggctctact
      721 cagctgtcgg gggaagaggc ccagccgtat atacggacag gccatggccc tcatcaatgg
      781 gtccctttat gtctttgggg gaacaaccgg ctacatctat agcacagacc tgcacaagtt
      841 agatctcaac accatggtgt ggacacaact caaaccaaac aacctgtcct gtgacctgcc
      901 ggaggagagg tacagacatg aaattgctca tgacgggcag aggatttaca tcttgggagg
      961 aggtacttcc tggacagcct attccttaaa caagatccat gcatacaacc ttgaaacaaa
     1021 tgcatgggag gagatcgcaa caaaacctca tgaaaaaata ggttttcctg cagcccgacg
     1081 atgtcacagt tgtgttcaaa ttaaaaatga tgtcttcatt tgtgggggct ataatggaga
     1141 agtgatcctg ggagacatct ggaagctgaa tctgcagacg tttcagtggg tgaagctccc
     1201 tgccaccatg ccagagcccg tttactttca ctgtgcggct gtcactcctg ctggttgcat
     1261 gtacatccac ggaggagtgg tgaacatcca tgaaaacaaa cggactgggt cgctgtttaa
     1321 gatctggctg gtggtaccta gcctgctgga actggcatgg gagaagctgc tcgcggcctt
     1381 ccccaaccta gcaaacctct cccgaacaca gctcctgcac cttggactca cacaggaact
     1441 catcgagcgt ttgaaatgaa gatttctgga ctgttcattg atactggaaa tgttaattta
     1501 aagagactcc tttatttatg ggcagtgtag aatgtgctac aaagaggatt ggctaccctg
     1561 atcaaggcct tattcagaaa atacatcaga tgcctttttg tgaatgggtt tagtttatgg
     1621 acatttcact ttctcatgtg ctttcttctt tgctcccctc cctcctgccc ctcataatgc
     1681 accccacact tatgcactcc ctctttcttg atggagttga gggaatgtct gaaagtccct
     1741 taataatgtt aagaatcaag agagagaaat tgttgccttt tttttttaat tctgagcata
     1801 ttgaccatgt caactaacac tacagattaa aatatcatca acaaacacaa agcttaaaaa
     1861 gccagcaaca acaactcttg gtctgggaga tagagcgaga acactagtct tggtagccta
     1921 gcaggttgtt cttaagtctg gatgttgagt tagtgtttct gagatgtgcg gagtggctgg
     1981 actcaacggt gcttcatgac ttgctgtaaa aatgcctgac cttgacacta gcaggcagct
     2041 cagtgacgtc tgattagcga tcccttcaat cctgtaacgc tccggtggtt agcgttggcc
     2101 tgccaatgtt tagtgtgtct gtcatcatca ccctctgttg ttgtctctca aattaaatgt
     2161 atatggcatc aagttctttc caggcagttc tgaacttccc ttgtgcttat taatggcttt
     2221 aaatatgtct ttgacttctt ggtgggggat tgtagactct taagtgtgtg atgtaaatgt
     2281 ctacggacag tagatagagc acagcacccg cacccttcag gcttaactgt cttaccttct
     2341 gcttggggtg ctggctttga ctagcatagc agctgctgct tttttagaac ttgtttctct
     2401 ttaagtctct ggaccatgtc cctgcgtttt cttaaactgt tggttcttga ttgcctcctg
     2461 agcttgttgc ctcctttgct gtccgcttct gtgttcacga tgctgtggtt gcctagtgac
     2521 tggaggaagg tcttaaggga aaaggtacag ggtctccttc tcaagaagca ggggtcattg
     2581 gagagccagc aggaggaagg ggtgagacag ggtgattcgc ttctgttggt gagagatttt
     2641 gtttcctcct ttctggagag aaaagtaacg tacgttttta ctccttttgt cctcaggcag
     2701 ctagaagagc tgaggagtga cttgtgtaag cctatgggtg tccataggtg cagtcaggat
     2761 gctagaggcc tgcaggaggg tgcagccagt cccccctgca ggctccttgc agaggagaca
     2821 tgtaggagat ttcaaacaca tttttccttt aagtgcctct tttccaccta gctttaatat
     2881 tattcatttt cttttagccc aaaagagatc tctttagttg atatgaaata aaagtcacct
     2941 ttgagttaca gtaaaaaaac gttcctgccc ggtgtgcagt cttagagagg tctcctccct
     3001 ttggctccca acaggcctta tgctccatcc gtgtgggtta agttagtgga gcctttgctc
     3061 tgtggtcctg agtgaagccc ttatctctga gtgaggggat ggacctgcgt ttctggggtc
     3121 ttaaccccca gctctggcca cttcctgttg gtgtggcttt tacttcctgc caccgatagg
     3181 cgcactcctc ataagacccc tctccagagc aagtcagcct gagccactgt gtgctcaaaa
     3241 ctgtgactct gggccaggtc tcctggacac atggtggaag tgtatcccaa actaaataag
     3301 ccatgttttc tagggtgaca gaaggatatt tgtcattggt ttatataggg accaaaggca
     3361 atgttcagcc tctgtgcttt gactcccatg gtccttggac aactgaggct gactctggtt
     3421 ctgttacact agaaagctgt agaaaggggg ctgattcaag ccaacacttg ttggcatcct
     3481 ttttaagcca gttgaaggca gtctctttga gatggatgtt ggaggcctga catcaacgac
     3541 cttctgtatc ttagaagtgc atgttgggtc taaagtgtct ttgaatagaa cactagcgaa
     3601 agtggtgcag gaagcagctg aatgccgcag ccactcacgc acatgttctg gatgccaaat
     3661 gactgtggag aaggacttaa aggaaggtga ctggatcctc tctaagggtc accagcattt
     3721 tggtttctct ataaccagca ctcgggattc ccagtggcat cacctggtgt gggaaggttg
     3781 tgatgcctgc tgcccccctg cctttttgag gtgcgcccag acatcttcct gcagtcctgg
     3841 aagtagaagt gcaatatgta gaaacatatg gtctgtacag attatgtaga atcgacgagt
     3901 gtaaagcagt gacaccactc tttgtacctg tcttgggcaa gtcaacttat taccttagag
     3961 tagaattatg ccaagaactt ttagtgtgat cataagccaa cttcttggta aagctggatt
     4021 tctttcaggt ccatgttttc ttattctagt tataaaaaaa aaggtctgtt cctcagtttg
     4081 ctaggagctg agggtttccc atccctgttt gtactgcctc ccatttgcat gtcttgccca
     4141 ggaataagga agtccacttg aaagtgttgc ccaggtagag aattgaaacc taatgttaat
     4201 acagcccccc cccccatata cgctaactta tctgggaatg taatacctta ttaaatgatg
     4261 ttttctttac gataaggtat tttccacttt acagaaaact gcaaaccagt atataataga
     4321 ttgaaacttt acctgctttt caggacaaac aaaacccttc cttcccactg gcagaaatca
     4381 tctttcaggg cctaatgatt tgatataaaa gcttgcttta tagcattcat gtccagtaca
     4441 gagctagatt ttaaaattat atatatgatg aaaatattaa catttctaga ttaaaagtat
     4501 gactgatctt tcgttatcca ctgtagcaag gtgaaagcac acacaatcga aatccataga
     4561 taatcagtgt ttagccttct ccttcaaaca gttgatttac atatcttgtc ccttcctgtc
     4621 cttcttccac acacatcccc ttttcaaggg acgagaagtc agagaaggaa aagaagctca
     4681 aagaagggcc agcagctagc caggccaggc tcccagttaa cttagacact ggtaggaaaa
     4741 tgaccaccgg tgggaacctt gagcacagcc tgctgctgag ttctctgctg cttcctgacc
     4801 agagagaact cttagttcct gtgggatgaa caggctgtgt tgaacagaaa cagaaacccc
     4861 actgtctgag cacatttcct ggctcttggc aaagcttgct tttttgtttc ctcctttgga
     4921 gtcaccttct gcagtctgat gtcctggtgt gcagcaaggg tgctctgtcc tctcggactg
     4981 tgttggtttt gtcccctgta aaagcagttt gctgttctgt ggtcttagtg atgcttagag
     5041 agtggccctc ccaccaacac tctgacgtag cacaaaaagc cattttcctt tttgttttct
     5101 gttgtttcct ggtgttgggc ttcagggtga atgcaggagg atttattgtt acagccacgc
     5161 ttttcaagag ctggttacca taggtgtaaa ttccattggt ccccaggtac cttagagctc
     5221 tggtagcttt ggctgggcct gaagcaggct cagtgggggt tctgggacct atgtctatat
     5281 gttgtcaccc gtccataagt ttgtgagatt tggaagaaaa aaaaaatatc ttcccttgtc
     5341 tggtgtcaaa agcagagctg tgcttcgatg gtagcgccat ctccttggtg gtctttccat
     5401 gttgttaatc ttttttaaaa cttttgagaa gtttttttaa aggccccact tagtctgcag
     5461 agggcgagtc agaggcagtt ttcagagaaa aggccaattt cactaagtag ttgtgattgc
     5521 tgttgtgtta gttacacagc aggaatataa aggaggcagg gggaagctac tggctggggt
     5581 agtcttaggg agctcacagg cttctccctg cagaggcagt agggacaggc aggaaaggtc
     5641 agcctccctt tggagctgtt cccaggctgg gccaggctct actcttcctg caggcagtgg
     5701 aggccataca cagtgcttgc cttacttcaa agctctttgc cacagtcctg ttgcacagtg
     5761 tggacgtcct tttgcagtct ggtgtgcatg ccatgtgagc aggacagctt tcccgcctct
     5821 cccggtttcc tatgagcaag tgaacctagc ctgaaacgtt ccacctgtac ttccctacct
     5881 tgtcagtgtt cgctgttggt tttctaaaac aatctgatca ataaatctct aaatctaaaa
     5941 aaaaaaaaaa aaaaaaaaaa aa
//
