LOCUS       NM_178253               2594 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kelch domain containing 1 (Klhdc1), transcript variant
            1, mRNA.
ACCESSION   NM_178253 XM_987617
VERSION     NM_178253.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099934.14.
            
            On Oct 29, 2022 this sequence version replaced NM_178253.5.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144621.1, BC119568.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC099934.14        150117-150265
            150-220             AC099934.14        159005-159075
            221-338             AC099934.14        159623-159740
            339-457             AC099934.14        160180-160298
            458-536             AC099934.14        161944-162022
            537-620             AC099934.14        164427-164510
            621-704             AC099934.14        166275-166358
            705-763             AC099934.14        166821-166879
            764-876             AC099934.14        167753-167865
            877-949             AC099934.14        171401-171473
            950-1034            AC099934.14        176494-176578
            1035-1087           AC099934.14        178078-178130
            1088-2594           AC099934.14        191385-192891
FEATURES             Location/Qualifiers
     source          1..2594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 28.74 cM"
     gene            1..2594
                     /gene="Klhdc1"
                     /note="kelch domain containing 1"
                     /db_xref="GeneID:271005"
                     /db_xref="MGI:MGI:2672853"
     exon            1..149
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1274
                     /gene="Klhdc1"
                     /note="isoform 1 is encoded by transcript variant 1; kelch
                     domain-containing protein 1"
                     /codon_start=1
                     /product="kelch domain-containing protein 1 isoform 1"
                     /protein_id="NP_839984.1"
                     /db_xref="CCDS:CCDS25949.1"
                     /db_xref="GeneID:271005"
                     /db_xref="MGI:MGI:2672853"
                     /translation="MADPQAFCVAEERSGHCAVVDGHFLYVWGGYVSIEDNEVYLPND
                     EMWTYDIDSGLWKMHLMEGELPPSMSGSCGACIHGRLYVFGGYDDKGYSNRLYFVNLR
                     TRDGTYTWEKITKFDGQPPTPRDKLSCWVYKDRLIYFGGYGYRRHSELQECFDVHDAS
                     WEEQIFWGWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRVLQ
                     TRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAITDDKLFLFGGLNADNIPLSD
                     GWIHNITTNCWKQLRHLPYTRPRLWHTACLGKENEIMVFGGSKDNLLFLDTGHCNDLL
                     IFQTQPYSLLRSCLDCIGKNAIILKSQISLLPPKLLQQVLKKITFWTAANYRKEQRIR
                     KEETENNQPRVSSC"
     exon            150..220
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..338
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..457
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..536
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..620
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..704
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..763
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..876
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..949
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1034
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1087
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..2594
                     /gene="Klhdc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1412..1417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhdc1"
                     /note="hexamer: AATAAG"
     polyA_site      1432
                     /gene="Klhdc1"
     regulatory      2240..2245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhdc1"
                     /note="hexamer: ATTAAA"
     polyA_site      2272
                     /gene="Klhdc1"
     regulatory      2575..2580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klhdc1"
                     /note="hexamer: AATAAA"
     polyA_site      2594
                     /gene="Klhdc1"
                     /note="major polyA site"
ORIGIN      
        1 gttccgttcg cgcgtgcgag cgggcgccga gctggctggg ccccggaggg cggatggcgg
       61 acccgcaggc gttctgcgtg gccgaggagc gcagcggcca ctgcgcagtg gtggacggac
      121 acttcctcta cgtgtggggg ggctacgtgt ctattgaaga caatgaggta tatttgccaa
      181 atgatgaaat gtggacctac gatattgata gtgggctgtg gaaaatgcac ctaatggaag
      241 gggagctccc cccctccatg tcgggaagct gcggggcttg catccacgga aggctctatg
      301 tctttggagg ctatgacgac aaaggataca gcaaccggct ttactttgtc aatttacgaa
      361 caagagatgg aacttacacc tgggaaaaaa tcaccaagtt tgatggacaa ccacccacac
      421 cacgtgataa actttcctgc tgggtatata aagacagatt aatatatttc ggtggttatg
      481 ggtacaggag gcacagtgag cttcaagaat gttttgatgt tcatgatgca tcatgggaag
      541 aacagatatt ctgggggtgg cacaatgacg tccatgtgtt tgacacaaag acgaggacgt
      601 ggtctcaacc agaaattaaa ggtggagttc caccacagcc acgagccgcg cactcatgtg
      661 cagttctggg aaataagggt tacgtctttg gcggacgtgt tttgcaaacc aggatgaatg
      721 acctacacta tctaaaccta gacacctggg tctggtctgg aaggatttct gttaatggag
      781 aaagccccaa acaccggtca tggcacactt taacagcaat aactgatgat aagcttttcc
      841 tatttggtgg actaaatgca gataatattc cactaagtga tggctggatt cataatataa
      901 caacaaactg ttggaaacaa cttagacatt taccgtacac caggcccagg ttatggcaca
      961 cagcctgtct gggaaaagaa aatgaaataa tggtatttgg tgggagcaaa gacaacttac
     1021 ttttcttgga tacaggtcac tgtaatgatt tattgatctt tcaaacacag ccctattcac
     1081 tgctcaggtc atgtcttgac tgcattggga aaaatgctat cattttaaaa agtcaaatat
     1141 ctttattacc tcctaaactt ctgcagcaag tcctcaaaaa aataacattt tggactgcag
     1201 ctaattaccg aaaggagcaa agaatccgaa aggaagagac agaaaataat cagccgagag
     1261 tcagtagctg ctgagccctc caggtccagt gtggctgcgt gcttgcatca gaccacacgt
     1321 cccaccctcc actgcagtga aggctggatt taaggacaca gtgggaaaca catgtttggc
     1381 taatgtgatt acatggtaca ggagatatgg aaataagatg tagttaacga tgtatctgtg
     1441 tgtttgttta ctgatttact tgtaatagaa tgtgttcgtc ctggaaataa gtacagtagc
     1501 aacagatctt aacttggtgt gcacactttt cttgaaagat tatataaatt tgaaagacag
     1561 aaatagctct aatatcttca taaatcctgt aatacaactg tggacataga tataaaacta
     1621 ttcctaatta acttccacat taagatcacc taagtgtctc cttaaatagc accatcagga
     1681 cttttcgtcc ccattgttga gcagggaagc gtgtttagtg gttctggctc cgtcccgcta
     1741 tgactgggtg gaggttggtt tttctaccag ctttgaaatg ttggggtgtg ggttattagt
     1801 agcttttaag acatgataag atatactttg ctttgggaaa agtgtttcta aaatattatt
     1861 tgtaagtaat gtggggtggt aatccagtat ttttgactct ctaaccttcc ccaccccacc
     1921 tgagctgtgc tgctctacag atgtgatgtc cacacggtga caacctcctg ctgctcttgg
     1981 ggccagccat ccagaaacag gaggttatac tgttacatta gtcaaaacgg tcttaggcca
     2041 ttttgagaca cctttcttca tattatatgc cttccttcca ttacagctaa ttaccttctt
     2101 tccattacaa tgaattacta aagggttcag tctatgacat taccccctca ctgttaccat
     2161 ggaagttatt tctgaccttt acaattctgg gagagtatat ttctataatg tatataattt
     2221 atagtgaaaa ctgtacttga ttaaactgta gatatgtttt atacatgctg tattttggat
     2281 gtgtaaagct tctatttatg tgttggacta gtttgtgttt acaatctatt tattgaacac
     2341 agtatagatt tattgcctca cagctttgtc agtgtgcatc agtcagagtt catttcagtg
     2401 tggcgctggc aacgtggctc agtgtgcaaa gtgctgagcg agcccagtgg acctggctcc
     2461 atcctggcac cagcataggc cagggggaga gagctaacgc cataaagatc actctctgac
     2521 cttcacatgt gcccaaacat aagatgcaca caatacaata atatcaaata aataaataaa
     2581 acttaaactt ttca
//
