LOCUS       NM_010638               4481 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 9 (Klf9), mRNA.
ACCESSION   NM_010638 XM_912207
VERSION     NM_010638.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4481)
  AUTHORS   Zhang,L., Zhang,M., Huang,J., Huang,J., Zhang,Y., Zhang,Y.,
            Chen,H., Wang,C., Xi,X., Fan,H., Wang,J., Jiang,D., Tian,J.,
            Zhang,J. and Chang,Y.
  TITLE     Klf9 is essential for cardiac mitochondrial homeostasis
  JOURNAL   Nat Cardiovasc Res 3 (11), 1318-1336 (2024)
   PUBMED   39528719
REFERENCE   2  (bases 1 to 4481)
  AUTHORS   da Cunha Menezes,E., de Abreu,F.F., Davis,J.B., Maurer,S.V.,
            Roshko,V.C., Richardson,A., Dowell,J., Cassella,S.N. and
            Stevens,H.E.
  TITLE     Effects of gestational hypothyroidism on mouse brain development:
            Gabaergic systems and oxidative stress
  JOURNAL   Dev Biol 515, 112-120 (2024)
   PUBMED   39048051
REFERENCE   3  (bases 1 to 4481)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4481)
  AUTHORS   Zhang,Y., Du,C., Wang,W., Qiao,W., Li,Y., Zhang,Y., Sheng,S.,
            Zhou,X., Zhang,L., Fan,H., Yu,Y., Chen,Y., Liao,Y., Chen,S. and
            Chang,Y.
  TITLE     Glucocorticoids increase adiposity by stimulating Kruppel-like
            factor 9 expression in macrophages
  JOURNAL   Nat Commun 15 (1), 1190 (2024)
   PUBMED   38331933
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4481)
  AUTHORS   Shen,C. and Wang,H.
  TITLE     Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar
            Macrophages Via Regulating TLR2 Expression
  JOURNAL   Rejuvenation Res 27 (1), 17-23 (2024)
   PUBMED   38062733
  REMARK    GeneRIF: Age-Associated KLF9 Enhances the Inflammatory Response of
            Alveolar Macrophages Via Regulating TLR2 Expression.
REFERENCE   6  (bases 1 to 4481)
  AUTHORS   Morita,M., Kobayashi,A., Yamashita,T., Shimanuki,T., Nakajima,O.,
            Takahashi,S., Ikegami,S., Inokuchi,K., Yamashita,K., Yamamoto,M.
            and Fujii-Kuriyama,Y.
  TITLE     Functional analysis of basic transcription element binding protein
            by gene targeting technology
  JOURNAL   Mol Cell Biol 23 (7), 2489-2500 (2003)
   PUBMED   12640131
REFERENCE   7  (bases 1 to 4481)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4481)
  AUTHORS   Martin,K.M., Metcalfe,J.C. and Kemp,P.R.
  TITLE     Expression of Klf9 and Klf13 in mouse development
  JOURNAL   Mech Dev 103 (1-2), 149-151 (2001)
   PUBMED   11335124
REFERENCE   9  (bases 1 to 4481)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Mammalian Kruppel-like transcription factors: more than just a
            pretty finger
  JOURNAL   Trends Biochem Sci 24 (6), 236-240 (1999)
   PUBMED   10366853
  REMARK    Review article
REFERENCE   10 (bases 1 to 4481)
  AUTHORS   Imhof,A., Schuierer,M., Werner,O., Moser,M., Roth,C., Bauer,R. and
            Buettner,R.
  TITLE     Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and
            AP-2rep, a novel wt-1/egr-related zinc finger repressor
  JOURNAL   Mol Cell Biol 19 (1), 194-204 (1999)
   PUBMED   9858544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121973.2.
            
            On Feb 8, 2019 this sequence version replaced NM_010638.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028544.1, BC138725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1034              AC121973.2         49707-50740         c
            1035-4481           AC121973.2         23837-27283         c
FEATURES             Location/Qualifiers
     source          1..4481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 17.9 cM"
     gene            1..4481
                     /gene="Klf9"
                     /gene_synonym="2310051E17Rik; BTEB-1; Bteb1; Gm9971"
                     /note="Kruppel-like transcription factor 9"
                     /db_xref="GeneID:16601"
                     /db_xref="MGI:MGI:1333856"
     exon            1..1034
                     /gene="Klf9"
                     /gene_synonym="2310051E17Rik; BTEB-1; Bteb1; Gm9971"
                     /inference="alignment:Splign:2.1.0"
     CDS             530..1264
                     /gene="Klf9"
                     /gene_synonym="2310051E17Rik; BTEB-1; Bteb1; Gm9971"
                     /note="basic transcription element binding protein 1;
                     BTE-binding protein 1; GC-box-binding protein 1;
                     Kruppel-like factor 9; transcription factor BTEB1"
                     /codon_start=1
                     /product="Krueppel-like factor 9"
                     /protein_id="NP_034768.2"
                     /db_xref="CCDS:CCDS29706.1"
                     /db_xref="GeneID:16601"
                     /db_xref="MGI:MGI:1333856"
                     /translation="MSAAAYMDFVAAQCLVSISNRAAVPEHGGAPEAERLRLPEREVT
                     KEHGDPGDTWKDYCTLVTIAKSLLDLNKYRPIQTPSVCSDSLESPDEDIGSDSDVTTE
                     SGSSPSHSPEERQDSGSAPSPLSLLHSGVASKGKHASEKRHKCPYSGCGKVYGKSSHL
                     KAHYRVHTGERPFPCTWPDCLKKFSRSDELTRHYRTHTGEKQFRCPLCEKRFMRSDHL
                     TKHARRHTEFHPSMIKRSKKALASPL"
     exon            1035..4481
                     /gene="Klf9"
                     /gene_synonym="2310051E17Rik; BTEB-1; Bteb1; Gm9971"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4453..4458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf9"
                     /gene_synonym="2310051E17Rik; BTEB-1; Bteb1; Gm9971"
                     /note="hexamer: AATAAA"
     regulatory      4462..4467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf9"
                     /gene_synonym="2310051E17Rik; BTEB-1; Bteb1; Gm9971"
                     /note="hexamer: AATAAA"
     polyA_site      4474
                     /gene="Klf9"
                     /gene_synonym="2310051E17Rik; BTEB-1; Bteb1; Gm9971"
                     /note="major polyA site"
     polyA_site      4481
                     /gene="Klf9"
                     /gene_synonym="2310051E17Rik; BTEB-1; Bteb1; Gm9971"
                     /note="major polyA site"
ORIGIN      
        1 ggagaggcgc ggcgcggcag gaccaggggc tcagcggccg tcggcggacg cgggaagaag
       61 tgtctcgtag gcgcggagcc ccactcagcc ccggcccccc tcgtccgcgt actcggctga
      121 tgccccgggg cgtcagctcg gcggagaggc ggtcgaggac gtgcgcctgg ctcgcagttg
      181 gctttctctg ggactccgac acgtttgcag tcgaataaac ttgcgaccgc cacgtgtggc
      241 atctctccga ggagggcgcg cccatcgtgg gatcgcgcgg ggcgccgggc agggcggcgg
      301 cgacagcggc ggagccggcc gcggctgctg cgtgcggagg cgctgccggt tacgtaaaga
      361 tgaggggctg aggtcgcctc ggcgctcccg cgagtcgcaa gctcccgcgc ccccgccccc
      421 tcggccgcgc cgcaccgcgc tcgtcgtccg aggccagggc agggctagcc gaagctccgc
      481 agccaccttc aagtttggcc gcaccgcccg ggctgccgtc gcccgcacca tgtccgcggc
      541 cgcctacatg gacttcgtgg ctgcccagtg tctggtttcc atctccaacc gcgccgccgt
      601 gccggagcac gggggcgctc cggaagccga gcggctgcga ctacctgagc gcgaggtgac
      661 caaggaacac ggtgacccgg gggacacctg gaaggattat tgcacgctgg tcactatcgc
      721 caagagcttg ttggacctca acaaataccg acccatccag accccctcgg tgtgcagcga
      781 cagtctggag agtcccgatg aggatatagg atccgacagc gacgtgacca ccgaatctgg
      841 gtcgagtcct tcccacagcc cggaggagag acaggattct ggcagcgcgc ccagcccact
      901 ctccctcctc cactctggag tggcttcgaa ggggaaacac gcctccgaaa agaggcacaa
      961 gtgcccctac agtggctgtg ggaaagtcta tggaaaatcc tcccatctta aagcccatta
     1021 cagagtgcat acaggtgaac ggccctttcc ctgcacgtgg ccagactgcc ttaaaaagtt
     1081 ctcgcgctcg gatgagctga cccgccacta ccggacccac actggggaaa agcagttccg
     1141 ttgcccactg tgtgagaaga gattcatgag gagtgaccat ctcaccaagc atgcccggcg
     1201 tcacaccgag ttccatccca gcatgatcaa gagatcaaaa aaggctcttg ccagcccctt
     1261 gtgaggtgct ccccatggca gccaggcaga gatgggtccc cggaaggaca gagctcccag
     1321 gaaacagact gacacatgga aatctgccac agcagaggcg cgctggccac aggaggtcac
     1381 tgcttctttg gccaatattc tgatatctcc ctgcactgtt tccaaaaagc acatggtagc
     1441 cctaaggtca aagtcaacat ttggtcccct tgcagaggca actctgaacc gtctctgact
     1501 gttggagggc aggcaaataa atgcttttgg tattttctcc tttgtttttg ggggaggggg
     1561 gagggggcaa ggccaagacg aggggtagga ttctgaagat tcagactggt ggtgtacata
     1621 cgtctgactg ggtgagttga cccctggcct cccacagtga ctctggatcc ttgatgcttg
     1681 ctgactctca gaattgtttt ttcttctcat ttaatgtaac gaccggtgtg cttcagtttg
     1741 tttagcagaa ccactctctt gaatcacatt aacttttgag atttaaaaaa aacaaaacaa
     1801 aaaaaaaaaa aacaacaaaa aaaaaccaac cctccatagc acagctgtct tttatgcaag
     1861 caagagcaca cctactccag catgatttgt catctaaaga cttgaaaaca aaacaacaac
     1921 aacaaaaagt tacttatagt caatggataa gcagagtccg aatttacact aatcaagaca
     1981 gaccttcgag gggtcacgat aagtccggaa ctttcaaacc ttgcttcgta tgaattgtac
     2041 tatctgaaca taaactgcac ttttattttc taataccgag ggtgaatacg gtaaatacat
     2101 gctttgaggg tagaagccga cggtctgttt ggcaccacgt tataatctgc ttattttaac
     2161 agtatacaca tttccctgag aacctatggc aaagatggga gggcagaaca tatgaaacac
     2221 atgctgacga gggggaggag gaggggagtg cttttaaaga taacaaaaaa tgagcaaaca
     2281 attttaactt catgaatttg tttgaattcc cccatgcttt ctgataacgc cgtctcgttc
     2341 cacgctcggg actaggacag agcgagagcg gtcggctggc tctctgtagc gttggttgat
     2401 aaatgggtat atagccatca ccaggcctgg aagtgccccc cctttggtgg gggggtgctt
     2461 cttggtctcc ttatgttcta tgaaattccc actatgaggt gcaagagtta tatcaaagga
     2521 agctgaaata cgaaaaaaaa aaagtttgcc cctgtaagta gtaagtgtct agggaaggaa
     2581 gacgccacaa tgaatgactt cagaggccac tctgcagaac agtcccttct ggtgaacata
     2641 ggtcaaagaa acgcacgtga atggcatcac atcactgtct gcatcagtat ccctaccact
     2701 acttagcttg tatctaggtg tctacacaat ggcctgaacc actatatcca tcctttgcca
     2761 tttactgaaa aacttagttt tggcttttac atggccagaa aaacaaactc agttttcata
     2821 gttaaaaaac aaaaaaagaa aacaacaaaa aaaaagaaaa caaaaacctc atttgagggg
     2881 agtcagcagt gatcatgggg aaatgtttac attttttcct tcagaaatac cactttctga
     2941 tgattttatc tgatatttaa aacagggagc tatggtgcac tctagtttgc acatggtgtg
     3001 taaactcggg gttcccacct gcagtgagct ccacatttca cccagcgcat gctcaccccc
     3061 atctcagcgt ggttgctcct gcagtgggca cagggcacag ctgactccga cttccaatac
     3121 gacagccatc actagcgcag tgttttctgt ttaaccaatg tagttgtatc agtagttctc
     3181 tcagaactgc ttttaacatt agggactggg agcagtccac gagctaaaaa ggaaagtgtt
     3241 ttctcatgag aaaacatgtc aggaaaaata aagaacactt tctacctctg tttcagattt
     3301 tgaaacgctt attttaaacc aaattttaat ttctgtgtcc aaaataagtt ttaaggacat
     3361 ctgttcttcc atatgaaata ggttaggctg cccatttctc ccgagctcat gggaaggctg
     3421 tgcatagggt actctgagcg ctgcctttta gtgagtgagg agtttggggt tgcctagcaa
     3481 cttgctaact tgtataaact cagctttccc tcaacagaaa gaaatgaagg aaaaccaagt
     3541 cagtgaaaga caatctttat tgtttcagga gtaaatctgt atgtggcttt tgtcaaacac
     3601 ttaaatggat ataaacgcag caacttgttt gaaaagatgc acaattaacc tcccggaaga
     3661 gttgctactt gccttttcaa gttgtcaacc gacacacatt tgatattctc ttagatgtta
     3721 tagtaacgta acgtataaac tcaaggcttt ttattctttg tgataagtcc tgttttacga
     3781 cgtcagaaaa caggaaccag cattctaatt agatttacta catggagata tggttcaaat
     3841 aggactatta gagttcattg aacactaaaa ctatgaaaca attacttttt atattaaaaa
     3901 gaccatggat ttaacttaca aaaatccaaa tgcaggatag taatttttgt ttactttttt
     3961 aaccaaactg aattttttga aagactatcg caggtgttca aaaagaaaga agccgtttta
     4021 tctaatagtg taagtagatg tcactcatgg aaaatctact agttttaggg ttaagatatc
     4081 tcctctcctt ggttagggaa gaagaaagcc cttcgccatt gtggaatgac accctggctt
     4141 taagctccac atcacgcttc ttttgagaat tatatttggt agttacaatt acagaaacta
     4201 attagtttgt cagttcgcag atagatttag cacagtactc atcactctgg gtagataaga
     4261 tgttctttca cagcggatga atggtctgga acactgtaag atactgatct ttacaactgt
     4321 ttaatcagtt ttatttttgt acagtattag tgacctaagt tattttgctg tcccgttttt
     4381 tgtaaatcaa atgaaattat aaaagaggat tctgaccgta ggtattttgt acatatgtat
     4441 atatgttgtc caaataaaaa taataaatga taaagattaa a
//
