LOCUS       NM_173780               7545 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus Kruppel-like transcription factor 8 (Klf8), transcript
            variant 1, mRNA.
ACCESSION   NM_173780
VERSION     NM_173780.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7545)
  AUTHORS   Dobrivojevic M, Habek N, Kapuralin K, Curlin M and Gajovic S.
  TITLE     Kruppel-like transcription factor 8 (Klf8) is expressed and active
            in the neurons of the mouse brain
  JOURNAL   Gene 570 (1), 132-140 (2015)
   PUBMED   26071188
  REMARK    GeneRIF: Klf8 is highly expressed in various regions of the mouse
            brain and in particular in the neurons, where it was localized in
            the cell nuclei.
REFERENCE   2  (bases 1 to 7545)
  AUTHORS   Funnell AP, Mak KS, Twine NA, Pelka GJ, Norton LJ, Radziewic T,
            Power M, Wilkins MR, Bell-Anderson KS, Fraser ST, Perkins AC, Tam
            PP, Pearson RC and Crossley M.
  TITLE     Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a
            genetic interaction and a role for these factors in embryonic
            globin gene silencing
  JOURNAL   Mol Cell Biol 33 (15), 2976-2987 (2013)
   PUBMED   23716600
  REMARK    GeneRIF: KLF3 and KLF8 have overlapping roles in vivo and
            participate in the silencing of embryonic globin expression during
            development.
REFERENCE   3  (bases 1 to 7545)
  AUTHORS   Lee H, Kim HJ, Lee YJ, Lee MY, Choi H, Lee H and Kim JW.
  TITLE     Kruppel-like factor KLF8 plays a critical role in adipocyte
            differentiation
  JOURNAL   PLoS One 7 (12), e52474 (2012)
   PUBMED   23285057
  REMARK    GeneRIF: KLF8 is a key component of the transcription factor
            network that controls terminal differentiation during adipogenesis.
REFERENCE   4  (bases 1 to 7545)
  AUTHORS   Lu H, Wang X, Li T, Urvalek AM, Yu L, Li J, Zhu J, Lin Q, Peng X
            and Zhao J.
  TITLE     Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a
            novel Kruppel-like factor 8-interacting and -regulating protein
  JOURNAL   J Biol Chem 286 (23), 20335-20344 (2011)
   PUBMED   21518760
  REMARK    GeneRIF: PARP-1 as a novel KLF8-binding and -regulating protein and
            provided new insights into the mechanisms underlying the regulation
            of KLF8 nuclear localization, stability, and functions.
REFERENCE   5  (bases 1 to 7545)
  AUTHORS   Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van
            Campenhout C, Floss T, Kuhn R, Wurst W, Lickert H and Rossant J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
REFERENCE   6  (bases 1 to 7545)
  AUTHORS   Suda S, Rai T, Sohara E, Sasaki S and Uchida S.
  TITLE     Postnatal expression of KLF12 in the inner medullary collecting
            ducts of kidney and its trans-activation of UT-A1 urea transporter
            promoter
  JOURNAL   Biochem Biophys Res Commun 344 (1), 246-252 (2006)
   PUBMED   16615998
REFERENCE   7  (bases 1 to 7545)
  AUTHORS   Suske G, Bruford E and Philipsen S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
REFERENCE   8  (bases 1 to 7545)
  AUTHORS   Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T,
            Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K
            and Araki K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 7545)
  AUTHORS   Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M,
            Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A and
            Cortese R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 7545)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ113466.1, AK044185.1, AL671912.8 and AK087851.1.
            
            [WARNING] On Jan 12, 2024 this sequence was replaced by
            NM_173780.6.
            
            On Oct 21, 2017 this sequence version replaced NM_173780.4.
            
            Transcript Variant: This variant (1) encodes the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044185.1, SRR10662772.3045327.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               CJ113466.1         2-298
            298-764             AK044185.1         2-468
            765-765             AL671912.8         73454-73454
            766-1946            AK044185.1         470-1650
            1947-2737           AK044185.1         1653-2443
            2738-3143           AL671912.8         84791-85196
            3144-4752           AK044185.1         2850-4458
            4753-4970           AK087851.1         300-517
            4971-5848           AL671912.8         87024-87901
            5849-6858           AK087851.1         1398-2407
            6859-7173           AK087851.1         2409-2723
            7174-7412           AK087851.1         2725-2963
            7413-7413           AL671912.8         89466-89466
            7414-7540           AK087851.1         2965-3091
            7541-7545           AL671912.8         89594-89598
FEATURES             Location/Qualifiers
     source          1..7545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..7545
                     /gene="Klf8"
                     /gene_synonym="BKLF3; ZNF74"
                     /note="Kruppel-like transcription factor 8"
                     /db_xref="GeneID:245671"
                     /db_xref="MGI:MGI:2442430"
     exon            1..345
                     /gene="Klf8"
                     /gene_synonym="BKLF3; ZNF74"
                     /inference="alignment:Splign:2.1.0"
     exon            346..418
                     /gene="Klf8"
                     /gene_synonym="BKLF3; ZNF74"
                     /inference="alignment:Splign:2.1.0"
     exon            419..492
                     /gene="Klf8"
                     /gene_synonym="BKLF3; ZNF74"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..1488
                     /gene="Klf8"
                     /gene_synonym="BKLF3; ZNF74"
                     /note="Kruppel-like factor 8"
                     /codon_start=1
                     /product="Krueppel-like factor 8"
                     /protein_id="NP_776141.1"
                     /db_xref="CCDS:CCDS30481.1"
                     /db_xref="GeneID:245671"
                     /db_xref="MGI:MGI:2442430"
                     /translation="MDKFIDNMDVRIKSESGSMQVFKQVTGPVPTRDPSARADRRNMT
                     SPSFLAASPMENPALFNDIKIEPPEELLESDFNMPQVEPVDLSFHKPKAPLQPASMLQ
                     APIRPPKPPTAPQAIMVPTSADTVTSAAIPTVLTPGSILASSQGTGGQPILHVIHTIP
                     SVSLPNKMSGLKTIPLVVQSLPMVYTSLPTDGSPAAITVPLIGGDGKSAGSVKVDPAS
                     MCPLEFPSDSDESAIESGSSALQSLQGFHHEPATMVHMQGEESLDLKRRRIHQCDFAG
                     CSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTD
                     CNRSFSRSDHLSLHRRRHDTM"
     exon            493..1054
                     /gene="Klf8"
                     /gene_synonym="BKLF3; ZNF74"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1166
                     /gene="Klf8"
                     /gene_synonym="BKLF3; ZNF74"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1306
                     /gene="Klf8"
                     /gene_synonym="BKLF3; ZNF74"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..7545
                     /gene="Klf8"
                     /gene_synonym="BKLF3; ZNF74"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggatggg gtggagccgc tgggtggggt ctgggacagg cagctgggag aaaccaaaag
       61 ggaaaaaaag aaaaccattg cccctgaaat ccttaacgct gggcgaggga cgctcgtgcg
      121 aatgagggga gaggagggtt ttagatctta ccaccactcc cgccaccggc taactccctt
      181 atacccttct gtctcgcctt aagatcagta atatctagtg taccggcatc tccctaagtc
      241 ttcctgggct cggttcgtgg cgcgaggcag cgaagacccc gtgcgtgcgc tgcccctggc
      301 aggggctgca aggaaaggat gccttcggag gcgcagaacc ccaaagaagc cagctcctga
      361 attctgttac tccatcagtg gcttggaaag tcagatacat cttgagaact ctgaaataat
      421 atggataaat tcatagacaa catggatgtc cgaattaaat cagaaagtgg ttcgatgcag
      481 gtattcaaac aggtcactgg ccctgttccg accagagatc cttctgcgag agcagacaga
      541 aggaatatga cttctccatc attcctggct gccagcccaa tggagaaccc agctctgttt
      601 aatgatatca agatcgagcc cccagaagag ctcctggaga gtgatttcaa catgccccag
      661 gtggaacctg ttgatctctc ctttcacaaa ccgaaggctc cgctccagcc tgctagcatg
      721 ctgcaagctc caatccgtcc tcccaagcca ccgactgcac ctcaagccat tatggtgcct
      781 acttcagctg acacagtcac ttcggcagcc attcctactg ttctcactcc gggctctatc
      841 ctggcctcgt ctcaggggac cggtggccag ccgattttac atgtgatcca caccatcccc
      901 tcagtcagtt tgccaaataa gatgagtgga ctaaagacaa tcccactggt ggtccagtct
      961 ttgcctatgg tctataccag tctgcctaca gatgggagcc ctgcagccat tactgtccca
     1021 ctcattggag gagacggcaa aagtgctgga tcggtcaaag ttgaccccgc ctccatgtgc
     1081 ccactggagt ttccaagtga tagtgatgag agtgcaattg aaagtggctc ttcagcctta
     1141 cagagtctcc agggatttca tcatgagcca gcgacaatgg tccacatgca gggagaagag
     1201 tctcttgact taaagagaag acggattcat cagtgtgact ttgcaggatg cagcaaagtg
     1261 tacaccaaaa gctctcacct gaaagctcac cgcagaatcc atacaggaga gaagccttac
     1321 aagtgcacct gggatggctg ttcctggaaa tttgctcgct cggatgagct tactcgccat
     1381 ttccgtaagc acacgggcat caagccattc cggtgcacag actgcaaccg cagtttttct
     1441 cgatctgacc acttgtccct ccaccgccgg cgtcatgaca ccatgtgaat atcacaggcc
     1501 acagcaggca cgctgcaatg gcctcctgag tgtgtgctga agttgtaact acgtttgcct
     1561 ctttgactac aacttgcccc catgattggg gtccgaacag cctactgagc caggttaatg
     1621 agactggaaa acaagttagc tggtctccca tgcggctctt catattccac tttcacctct
     1681 tcactgtcca gacttcagtt tttgcaacct cttcctgggt tgaattcagt gcggcgccca
     1741 tggctgccct ccctgatccc tcatgctaca ttatagacat ttttcctaca ataacaaaca
     1801 aaacaggaat caaactcaag gctgtgaaca aacatccgct gctctcccct cccccctggt
     1861 ttctcttgtt ttctaaagat tttattcaca tgtgtgtata tatatataca catatatgtg
     1921 tatgtatata tatatatata tatatactgt aaccagtact taatatcact tagcaatgtc
     1981 ctaaaatgag ggtttttttt caaagttgta gctacaaggg gcataacagt agagttggtt
     2041 gatcaaattt acatagaatt gagtctgaaa tacagagtct catgctaacc gtgaaggttt
     2101 tgtagatcca gttttacttg ttcttaacag tttggtttac aggcagtgcc agccctcctt
     2161 ttgaagttca tcaagagcaa tgaagggatt ccttgacctc cttttcctcc tcatgctcct
     2221 ttagaataaa aggttttatg gcacaattcc attcttttta ggttaagttt ggacaaatat
     2281 tcaaagcaca gaaagataga tcagtaggga gaagtattct aggaaaatac gtgggcagtg
     2341 acaggcaaga gcagacctgg gagcaccctg tgaacaatta cttggataag gtgttagaac
     2401 tgctgttaat cccaagcctc gttcagaggg cagcctgttg aaacatcact ttcgatgggc
     2461 tccactgtac tgttgattct tttgtttaca taaggcaacc attcagcgta ttacctgatg
     2521 agaaattgca cactgagcac gttatagaga ggtgaggggt tgcactaaag gaattttgtt
     2581 tacttcatgc cattttgggc atttgttctt ctctttctaa tgggatggaa gaggttttct
     2641 ttctgacact gacatataga aagcattttt ttggatgttt tacaacttct attaataccc
     2701 aagccattta ttttatttag atataacaac aagatgctta atatacattt ggttgcccaa
     2761 tcagactgtt cataatattc tctggggcat aaaaccttct gttcctggcc ctggacctca
     2821 tatctacctc ttcgtggcat atttcctctc ctggggaaaa aggagagggg ctttgtatta
     2881 gtaggattgg acacagcctc tcgcctaaag gttttcttca tatgaaacct ttatttcttg
     2941 gcagatattc aaaatgttct ggcttgaaca atttaggtta ctacctcctg tggctgtact
     3001 ttctaactaa agcctagaat tctaccatcc agaaggggtc ctgtctactt ctacccatcc
     3061 ctcacgtttt acagatgagg caaatacggg tcagattctt tctccagata attccttgag
     3121 gccttacaga cctgtataca ccgtctccca gggatcacac tagtaaacca aattaaagaa
     3181 aaagaagtta tgtgattggt tgcaatattt gtccaatttt atgttacact tcagaaaact
     3241 ttaaattcat gtatatttgg tgacaaagta agtagggtgt gcttatggtc atgaccactt
     3301 aacaccaggc acacagtgtt tcaagtcaca ttttttgata attctagatt tgttttaatt
     3361 taccttgttt caagtttcaa tgtctttgca gagcataaat tctccataag ttaaggccta
     3421 cttgtacttt tcaacgtggc atgtaggttt tactgttact gctttggtaa gggatctgtc
     3481 ctgactctgg gtgtacaagt tccaggctgt atactaatta ctaagcacta atcaatatct
     3541 agggctagtc tactaatggg gaccacaatg taaaacagat tgaaaaatgt atattcctac
     3601 catatatggg cttaagctta taattgagta gttggtacaa tactatagaa cagagtccaa
     3661 agggttatgt acttctgttc cactttggat cctaaatttg ttttccagag attggaattg
     3721 gcatgtgccc cttagacttc aggatattga gacatatgtt tattaatgag cactatgaaa
     3781 ttatagtact cataagggtg atcagctgag gatcccagat actgatgttc ctagcatctc
     3841 tgagccttta ttcaagtatg tttctgcaga gtcttaatag actttgcaaa tgctttgtcc
     3901 attgtcttta gccaagaacc aattctaacc atattctctt tgctcttttt gttcccaaat
     3961 ggcaaaaatc tttccagtta caagcatagt ctttacaaat gtgtcatgat taagagaact
     4021 tcgcagagta aatgaactca aacagtacag tgcagaatta ctgcaccaaa agcacatacg
     4081 tttgctacat agtgggatat aaaggaaacc attccacttc tcttggttaa catctgaggt
     4141 ttaactaagt gtaatgggct tacaacagcc aaagactgtt aggatgacat ttgcctagga
     4201 tatggaaatt gtgtctggat ggataatatt caggagttta ttgtagtgaa gtttctccct
     4261 ctgtagacat ctggcagctg aacataattg ttggtaattg ccattgtaaa gtgtaagaaa
     4321 tgtaaactgg tttgatggat tagtggagtt cattatgtac aaacccacga atgtttgtaa
     4381 agagaatttc tttttaaata aactttacat gttggaactc tttttttgag attttcagga
     4441 aaatgtgaag gtagaacaga gttcctgctg actctacatt atatatttgt ttggtatact
     4501 tgttacaatt agtgaaatta taccgataca ttaatattaa ctacaatcaa tgctttcgtc
     4561 agactacctt ggcttttatc tgctgttctt tttttctgtt ttaataccgc cttcaaaata
     4621 caacattgta ttaataataa cagctcctta ttctcctcgt tgtgatagct tcttggagtt
     4681 ctttgttctc aaggaccttg gagtatgttt ttcagttggg gtgtatttta tattcttctc
     4741 atgaaaattt tctcattaaa aaaaaaaaaa acgaggtcaa tgaaagctag gcatggtggc
     4801 aaacactttc cttttaatcc cagcacttgg gaggcaaagg caagtggatc tctggtctac
     4861 agagtgagtt ccaggacagc cagggctaca cagaggaaaa ccctgtctca gaaaactaaa
     4921 ctaaactaaa ctaaactaaa ctaaactaaa ccctacctta atgaacccaa tggatttggg
     4981 tccaaacaac cacacaagtg agttactatt ttcataacat catctttcta tgacttatca
     5041 ttcttcatat tatccttagt cacatgacta agatagtgtc tgagatttct cccctatacc
     5101 ctttttccta tcatcatact gcagtctttg gagggaactt actgtgctca gcccacatat
     5161 acagaaatgg tgagttaggt actatgtcct tgagagcaag tgttcaaata ttttggaatt
     5221 tttctgcatt gggagctttg cctcctctct tatttattta cttatatgtt tatttttgtc
     5281 aacatggact cattgatatt tattttatag attatcttat aattcaatgc aacttttatt
     5341 ttgttgctca aattgtaact ttaactgtta ggagcttttt tttgaattga tcatgaagtc
     5401 ttgtttgcat acccccatta ttgttttttg ttttcagtaa gtgagtaatt tttggtgttg
     5461 caagatgttc cagacacatc ttgcttttgt tttatggagg acaattctat aatcaggcat
     5521 tttgtcaata agttgtaatc ccttttactg aagaattata accaaggtgt aggtactata
     5581 tatgtttgct actttgcaga tatttcttca agttctcagt cactagaaca aagaaataca
     5641 tgcatatatt aagttttata tatacaaatg cttgtaaaca cttccatata taatcatctt
     5701 tatgatgatt tatataagtt tatatcattg tcttcagtcc ttagttatct gcatatcttt
     5761 ccattctatc tggaagaaca atagctcatc ttctgccatt tattattttt taaaatccat
     5821 attaatacta atgaaataca tattaacagt gtcttatgtg ttatcctgta gtatacccat
     5881 gagaaaagtc aactagaacc tggtgcttat gtacacgata gtaacatttt tagaacttca
     5941 actctttgaa acaaaatgat ctacaagatt cttgaattag agataatctg tattctcaat
     6001 tctatcctag tccccaaatg ctttctcata catgaaacaa accatcagtg attgacctag
     6061 ccttgaataa gccaagggag catgttgatc ctctgtagta tgttaattcc tatagaaggg
     6121 atcaaagaga aagcagctgc atgggtctaa tttgaagaaa cacttagcac tgtccttttc
     6181 tctactgaaa atggatctct gacaactggg cagtaccctg atttgcctct cttctgtatt
     6241 ttccccagtt tttaggcaag tcacatcacc tctctgtgcc tctattaacc catctcgaaa
     6301 tggggatcca catatctacc tcacaggagt gttgtgaggc ttcttattgt tttaaaaaaa
     6361 gtgtaatctc taaacgagta agaaagtatt ataatcatta ctatgatgat aattagagta
     6421 ccctatatgt atcctatgga aaaggagatt agcctcattg ttagtaaaca gctaaaatta
     6481 agtcaataaa agatcaatga agcgtggcca ctggaagcaa gattatttat tctgttaccc
     6541 tcactttccc tatatcctct aagtatagga ctatcaagtg tttccagact cgaaacatac
     6601 gaggacccaa aacagtagga ggcaaagtag attgtcattt tcaaattgtg tttcttctcc
     6661 ctttcttact ctggttggac tgcattacat agaactttgt cagaagcaca aagacaattt
     6721 ctcaaagggt ttcagtcttt gatcagttct gttccatcaa ttaagatttc tctttctgcg
     6781 tgtactgtac attgaacagt caaggtagga ggggagtggg tgggttggtt gggttgggca
     6841 tggactggga gagaagggaa attacagatg tgttttccaa acacctgtta tcactttcca
     6901 tttctttttt ttctggtggt gggtgtgggg caagggaaga gatactattt tgttaacaaa
     6961 ttctccttcc cttccagtag atgtttccta gggtcagtac aaatagctgt gttggacctt
     7021 acttttataa ctatgttgta tacagtgttg ttttcattgt attttcgaat aaagggggaa
     7081 gaaagtccct agtgctggcc atccctgttt ttgacaggag gtcacaacag gagagcagca
     7141 gcagaagctg actctgtggt ggggaaagga gcctgcaatg aagggattta ttggattttt
     7201 gtcattcttt aaagaaatta taaagcagta tattacacat tagtctctat gactcttctg
     7261 tttgagcctc ctcattttag tgctttagag cagcacctat tttcactcca ttttatactt
     7321 gttcctgttg aagtatggtg ttgagcaatc tctcatagac aagtctgtgg tgtacctata
     7381 gagaattgcc tcagtaagcg tggctaccca gaggttactc tgacgtagct cagtggggcg
     7441 ctcccattgt agcttccagg ccaggctgtg tgcttgagta ctaagcagtc atgttctgtc
     7501 tgattactgt acttttttaa taataaaaat attttaaacc agaaa
//
