LOCUS       NM_011803               4217 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 6 (Klf6), mRNA.
ACCESSION   NM_011803
VERSION     NM_011803.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4217)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4217)
  AUTHORS   Li,N., Xue,Y., Zhu,C., Chen,N., Qi,M., Fang,M. and Huang,S.
  TITLE     The zinc-finger transcription factor KLF6 regulates cardiac
            fibrosis
  JOURNAL   Life Sci 351, 122805 (2024)
   PUBMED   38851422
  REMARK    GeneRIF: The zinc-finger transcription factor KLF6 regulates
            cardiac fibrosis.
REFERENCE   3  (bases 1 to 4217)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   4  (bases 1 to 4217)
  AUTHORS   Bao,S., Zheng,W., Yan,R. and Xu,J.
  TITLE     miRNA-21 promotes the progression of acute liver failure via the
            KLF6/autophagy/IL-23 signaling pathway
  JOURNAL   Mol Med Rep 29 (5) (2024)
   PUBMED   38516774
  REMARK    GeneRIF: miRNA-21 promotes the progression of acute liver failure
            via the KLF6/autophagy/IL-23 signaling pathway.
REFERENCE   5  (bases 1 to 4217)
  AUTHORS   Malin,J., Martinez-Ruiz,G.U., Zhao,Y., Shissler,S.C., Cowan,J.E.,
            Ding,Y., Morales-Sanchez,A., Ishikawa,M., Lavaert,M., Das,A.,
            Butcher,D., Warner,A.C., Kallarakal,M., Chen,J., Kedei,N.,
            Kelly,M., Brinster,L.R., Allman,D. and Bhandoola,A.
  TITLE     Expression of the transcription factor Klf6 by thymic epithelial
            cells is required for thymus development
  JOURNAL   Sci Adv 9 (46), eadg8126 (2023)
   PUBMED   37967174
  REMARK    GeneRIF: Expression of the transcription factor Klf6 by thymic
            epithelial cells is required for thymus development.
REFERENCE   6  (bases 1 to 4217)
  AUTHORS   Fischer,E.A., Verpont,M.C., Garrett-Sinha,L.A., Ronco,P.M. and
            Rossert,J.A.
  TITLE     Klf6 is a zinc finger protein expressed in a cell-specific manner
            during kidney development
  JOURNAL   J Am Soc Nephrol 12 (4), 726-735 (2001)
   PUBMED   11274234
REFERENCE   7  (bases 1 to 4217)
  AUTHORS   Gregory,R.C., Lord,K.A., Panek,L.B., Gaines,P., Dillon,S.B. and
            Wojchowski,D.M.
  TITLE     Subtraction cloning and initial characterization of novel
            epo-immediate response genes
  JOURNAL   Cytokine 12 (7), 845-857 (2000)
   PUBMED   10880228
REFERENCE   8  (bases 1 to 4217)
  AUTHORS   Slavin,D., Sapin,V., Lopez-Diaz,F., Jacquemin,P., Koritschoner,N.,
            Dastugue,B., Davidson,I., Chatton,B. and Bocco,J.L.
  TITLE     The Kruppel-like core promoter binding protein gene is primarily
            expressed in placenta during mouse development
  JOURNAL   Biol Reprod 61 (6), 1586-1591 (1999)
   PUBMED   10570007
REFERENCE   9  (bases 1 to 4217)
  AUTHORS   Inuzuka,H., Wakao,H., Masuho,Y., Muramatsu,M.A., Tojo,H. and
            Nanbu-Wakao,R.
  TITLE     cDNA cloning and expression analysis of mouse zf9, a Kruppel-like
            transcription factor gene that is induced by adipogenic hormonal
            stimulation in 3T3-L1 cells
  JOURNAL   Biochim Biophys Acta 1447 (2-3), 199-207 (1999)
   PUBMED   10542316
REFERENCE   10 (bases 1 to 4217)
  AUTHORS   Philipsen,S. and Suske,G.
  TITLE     A tale of three fingers: the family of mammalian Sp/XKLF
            transcription factors
  JOURNAL   Nucleic Acids Res 27 (15), 2991-3000 (1999)
   PUBMED   10454592
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY128594.1 and AK146615.1.
            
            On Jan 12, 2006 this sequence version replaced NM_011803.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146615.1, SRR1660811.111821.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY128594.1         1-50
            51-4217             AK146615.1         2-4168
FEATURES             Location/Qualifiers
     source          1..4217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.94 cM"
     gene            1..4217
                     /gene="Klf6"
                     /gene_synonym="BCD1; Copeb; CPBP; FM2; FM6; Ierepo1;
                     Ierepo3; Zf9"
                     /note="Kruppel-like transcription factor 6"
                     /db_xref="GeneID:23849"
                     /db_xref="MGI:MGI:1346318"
     exon            1..354
                     /gene="Klf6"
                     /gene_synonym="BCD1; Copeb; CPBP; FM2; FM6; Ierepo1;
                     Ierepo3; Zf9"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1107
                     /gene="Klf6"
                     /gene_synonym="BCD1; Copeb; CPBP; FM2; FM6; Ierepo1;
                     Ierepo3; Zf9"
                     /note="core promoter element binding protein; immediate
                     early response, erythropoietin 1; Kruppel-like factor 6"
                     /codon_start=1
                     /product="Krueppel-like factor 6"
                     /protein_id="NP_035933.2"
                     /db_xref="CCDS:CCDS26229.1"
                     /db_xref="GeneID:23849"
                     /db_xref="MGI:MGI:1346318"
                     /translation="MKLSPALPGTVSARTPDRSPPCFPDSEDCLFQPDMDVLPMCSIF
                     QELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKFI
                     LARGEKKEESELKISSSPPEDSLISSSFNYNLETNSLNSDVSSESSDSSEELSPTTKF
                     TSDPIGEVLVNSGNLSSSVISTPPSSPEVNRESSQLWGCGPGDLPSPGKVRSGTSGKS
                     GDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRF
                     ARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALHMKRHL"
     exon            355..931
                     /gene="Klf6"
                     /gene_synonym="BCD1; Copeb; CPBP; FM2; FM6; Ierepo1;
                     Ierepo3; Zf9"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1055
                     /gene="Klf6"
                     /gene_synonym="BCD1; Copeb; CPBP; FM2; FM6; Ierepo1;
                     Ierepo3; Zf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..4217
                     /gene="Klf6"
                     /gene_synonym="BCD1; Copeb; CPBP; FM2; FM6; Ierepo1;
                     Ierepo3; Zf9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1598..1603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf6"
                     /gene_synonym="BCD1; Copeb; CPBP; FM2; FM6; Ierepo1;
                     Ierepo3; Zf9"
                     /note="hexamer: AACAAA"
     polyA_site      1619
                     /gene="Klf6"
                     /gene_synonym="BCD1; Copeb; CPBP; FM2; FM6; Ierepo1;
                     Ierepo3; Zf9"
ORIGIN      
        1 gaggctggca gcggagcttt gaatagggaa gttttgcagg ggttacgctt gcagtcagtc
       61 cgctgtttgc aaatattgcg tgggctcggc gcgctgcggg ctgcgggagg gtccggaccc
      121 ggcgtccgat tgcagcgcca tccagtttgc atgaaacttt cacctgcgct cccgggaaca
      181 gtttctgctc ggactcctga tcgttcacct ccctgttttc ccgacagcga ggactgtctt
      241 ttccaacccg acatggatgt gctcccaatg tgtagcatct tccaggaact acagattgtg
      301 cacgaaacgg gctacttctc ggctctgccg tccctggagg aatattggca acagacctgc
      361 ctggagttgg aacgctatct tcagagtgag ccctgctacg tgtcagcctc tgagataaaa
      421 tttgacagcc aggaagacct gtggaccaaa ttcattctag ctcgggggga gaagaaggag
      481 gaatcagaac tgaagatttc ttctagtccc ccagaggact ctctgatcag ctccagcttt
      541 aattataact tagagaccaa tagcctgaac tctgatgtca gcagtgagtc ttcggacagt
      601 tcagaggaac tttcacccac gaccaaattt acctctgatc ccattggtga agtcttagtc
      661 aattcaggaa atctgagttc ctccgtcatt tccacacctc catcttctcc agaagtgaac
      721 agggaatctt ctcaactatg gggctgtggg ccaggagacc tgccctcacc tgggaaggtt
      781 cgaagtggga cctctgggaa gtctggtgac aagggtaatg gcgacgcctc cccagatggc
      841 agaagacggg tacatcggtg ccactttaat ggctgcagga aagtttacac gaaaagctcc
      901 cacttgaaag cacatcagcg cactcacaca ggagaaaagc cttacagatg ctcatgggaa
      961 ggttgtgagt ggcgttttgc aagaagtgat gagttgacca gacacttccg aaagcatacc
     1021 ggtgccaagc cttttaaatg ctcccactgt gacaggtgtt tctccaggtc tgaccacctg
     1081 gccctgcaca tgaagaggca cctctgaagg agcagaggga cgaatcctgt aggctaaaag
     1141 aggcttccag gctaagaggc ggccatggaa ggagggatgc ctgtaacagc caaagcatgc
     1201 cattttgctt cctatccagt tacctccagg ggcctctctt tggaaggtct tttgagggct
     1261 acaaaagtca tgtcaggagt ggcatagcac ccatggtgca tggtgtttgg gtgaccccgg
     1321 actcaccact ggttcctaac cttctgagag gctctaagct tttggccgtg agcatgcgca
     1381 ctgagaatgt tagtgggtgg gatggttgtg ttgaggatct attactgact gtatggtgag
     1441 gcagactttt tttttctccc cctatgtggt atcaaataac tgcaagagac agaaaaaaaa
     1501 aaaagcagtt tgaatgtttt gtgtgtgagg agtataccaa gggatgagtt gaccaccaat
     1561 catttcctga agggtgtctg caccttagaa aaaaataaac aaaaacaaca acaaaaaaat
     1621 aaataaaagt taaaataata aaaaaaaaga tggaaaaaca tggagggtgg gagcgggaac
     1681 tcaggaccca ttgtggtgag tgttaagggc agggggagcc cctgtgcccc tttcctgtgt
     1741 gaaaggactt tctggtgtct ggtgcagcta tagaatgtgc agtgtgtcaa gtagcttgtt
     1801 ttactggcta catggagctc atttgtaacc cattgtataa gctgtattta caaatcgcag
     1861 tggtcatttt cccttataat acaaaaaaac aagtcgtgca tggtctgggg gagctataaa
     1921 cgtttaacat ttttaaattg cgtctccaat cttgattcca attaataagc agctataaga
     1981 tctaatttgt gtagaataat gattccttaa gccatttagg cctggcaaga cacgttctcc
     2041 cccctccccc ccccagatcc ttctattttg taacactccc atgcaaaatg atcttgtgca
     2101 atgtagggtt gtattttcga cgactcggaa tttgaattta cttttttttt gagaatctta
     2161 aggtaccctt tggagaaatt ggacacttgt caaatgtcta aatgctaggg gcctggaaat
     2221 tacccgtcta atatcacatt aggctaagaa cacaaacttt ttttctcaga gtggatcaaa
     2281 ccactaagct tagaaaccgt tttttctcac gcagctacgt ctcttattta tgccttgagg
     2341 actatttctg gttttctagc tgttaatgca ctgttgacct tcataatggt gccttatgca
     2401 actggccctt ctgtggggtc aaatacaggg gaatgggtga cgcatgctta attaaggctc
     2461 ttttttcacc tggcattgta ctgtatcaat gtataatatg gacaaaacaa acaaagaaca
     2521 acaacgacaa caaaaagaac acctctttaa gatcctccac agtgatgaac gaacgggtga
     2581 aaagtccttt gacatgtcaa catgtgttca tttccaacaa cttgactgtc agtgttaaaa
     2641 tggggaaaaa aatagacatg gcaattgaaa actaattctg ctaccatgag actcttttaa
     2701 gagaccttgc acaactgtac agatctcaca tacccacaca cacccacaca cacatacaca
     2761 cacacacaca ccggctgtat ttattatgta acattgtcac acatattaaa gatacagaag
     2821 tattaaacaa acaagaaaaa ccaatgtcaa tatcttgctc aaaaggcaca agttttgagt
     2881 acctgtctag ctatctgttg gtaatactga aagtatactg ctttttgttt tgtttttgtt
     2941 ttttttgaaa aagtggatga aattttttgt gtatgtatat ttgtgtgtat agtatgtgta
     3001 tgtatgtgtg tatatatata ttatatatag ataatatata aatatttttt taagaagaaa
     3061 ctagaatgtt tagctagaaa attctacagc ctgtgaagaa gtatttcaaa atggccataa
     3121 aggaggttaa aagaaattga aaactataac ctaactttta tagaggcttt atctttaatt
     3181 taatagtttg ctggagacat tgttggcgtt gagtcttttc caggctgctg attctgctag
     3241 tcacgattgg caagcctgga ataggggacc ttcggccatt tagaaggggc atgaacaaaa
     3301 tactggccaa ccagctggac tcagacacac aaaggtttta attttccttt cagccttact
     3361 agaagatcta acctaagagt aagctgacca cagggattgt tttttagaat actttttatg
     3421 cagatgaaac tattttttcc agcatgtaga ttcttccagc tttttcaagg agtactttcc
     3481 cggaatttgg cataccacag cgtagacagc tgatatttct gatatttcat ccagctgctt
     3541 ggctttttgg gtgtggatct ttacatatat gagaatgagt ctggctgggc tggtatttcg
     3601 tttgatcttc ctggaaacga gcaatgatta aagctccctt aactgctttt tgttttgttt
     3661 tgttttattg tatctggcct gatgaataca tttctctaca gaactgattt cattttgctc
     3721 aaggggaaaa tgcacttttg tttggcaatt caaaatccta gcacttgatt tgctggattt
     3781 tggaaaactc cttttttggc cctgctgtgt gcttatccat agcaattcca ttaagtaaga
     3841 aggtaaacag aagagagagg aaacttgtgc tggcgcgtct cacttatgaa acacagcgac
     3901 gttgctggac tggctggggc tgggtgccgt ccgtgtcgat gctgtaactt taatactaag
     3961 cagtccattc tggtcaggtg acaactgagc ctcaatcaag caggaacttt tgcttgaaat
     4021 taaaaaaaaa aatttctatt agtgaaattt ctttatttct ttttttttga agcaccctgt
     4081 tatctaaaga atctttgtaa gatttttgta aaattttgtt ttacaagatt ttatttgaaa
     4141 ttgttttttg cgagattgtt atatttctgt atgaatgtat tttttattcg aataacataa
     4201 aaagaattct tatcagc
//
