LOCUS       NM_009769               1728 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 5 (Klf5), mRNA.
ACCESSION   NM_009769
VERSION     NM_009769.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Deng,M., Tan,X., Peng,X., Zheng,W., Fu,R. and Tao,S.
  TITLE     HDAC6 promotes inflammation in lupus nephritis mice by regulating
            transcription factors MAFF and KLF5 in renal fibrosis
  JOURNAL   Ren Fail 46 (2), 2415517 (2024)
   PUBMED   39412062
  REMARK    GeneRIF: HDAC6 promotes inflammation in lupus nephritis mice by
            regulating transcription factors MAFF and KLF5 in renal fibrosis.
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Lin,Z., Bao,R., Niu,Y. and Kong,X.
  TITLE     KLF5-mediated pyroptosis of airway epithelial cells leads to airway
            inflammation in asthmatic mice through the miR-182-5p/TLR4 axis
  JOURNAL   Mol Immunol 170, 9-18 (2024)
   PUBMED   38593669
  REMARK    GeneRIF: KLF5-mediated pyroptosis of airway epithelial cells leads
            to airway inflammation in asthmatic mice through the
            miR-182-5p/TLR4 axis.
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Zhang,B., Liu,M., Mai,F., Li,X., Wang,W., Huang,Q., Du,X., Ding,W.,
            Li,Y., Barwick,B.G., Ni,J.J., Osunkoya,A.O., Chen,Y., Zhou,W.,
            Xia,S. and Dong,J.T.
  TITLE     Interruption of KLF5 acetylation promotes PTEN-deficient prostate
            cancer progression by reprogramming cancer-associated fibroblasts
  JOURNAL   J Clin Invest 134 (14), e175949 (2024)
   PUBMED   38781024
  REMARK    GeneRIF: Interruption of KLF5 acetylation promotes PTEN-deficient
            prostate cancer progression by reprogramming cancer-associated
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Tao,S., Tan,X., Chai,W., Peng,X., Zheng,W., Fu,R. and Deng,M.
  TITLE     Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr mice via
            inhibition of MX1 transcription
  JOURNAL   Immun Inflamm Dis 11 (7), e937 (2023)
   PUBMED   37506140
  REMARK    GeneRIF: Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr
            mice via inhibition of MX1 transcription.
REFERENCE   6  (bases 1 to 1728)
  AUTHORS   Sun,R., Chen,X. and Yang,V.W.
  TITLE     Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is
            a positive regulator of cellular proliferation
  JOURNAL   J Biol Chem 276 (10), 6897-6900 (2001)
   PUBMED   11152667
  REMARK    GeneRIF: Study shows that KLF5 is a positive regulator of cellular
            proliferation as demonstrated by the appearance of a transformed
            phenotype in cells overexpressing KLF5
REFERENCE   7  (bases 1 to 1728)
  AUTHORS   Ziemer,L.T., Pennica,D. and Levine,A.J.
  TITLE     Identification of a mouse homolog of the human BTEB2 transcription
            factor as a beta-catenin-independent Wnt-1-responsive gene
  JOURNAL   Mol Cell Biol 21 (2), 562-574 (2001)
   PUBMED   11134343
REFERENCE   8  (bases 1 to 1728)
  AUTHORS   Ohnishi,S., Laub,F., Matsumoto,N., Asaka,M., Ramirez,F., Yoshida,T.
            and Terada,M.
  TITLE     Developmental expression of the mouse gene coding for the
            Kruppel-like transcription factor KLF5
  JOURNAL   Dev Dyn 217 (4), 421-429 (2000)
   PUBMED   10767086
REFERENCE   9  (bases 1 to 1728)
  AUTHORS   Conkright,M.D., Wani,M.A., Anderson,K.P. and Lingrel,J.B.
  TITLE     A gene encoding an intestinal-enriched member of the Kruppel-like
            factor family expressed in intestinal epithelial cells
  JOURNAL   Nucleic Acids Res 27 (5), 1263-1270 (1999)
   PUBMED   9973612
REFERENCE   10 (bases 1 to 1728)
  AUTHORS   Imhof,A., Schuierer,M., Werner,O., Moser,M., Roth,C., Bauer,R. and
            Buettner,R.
  TITLE     Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and
            AP-2rep, a novel wt-1/egr-related zinc finger repressor
  JOURNAL   Mol Cell Biol 19 (1), 194-204 (1999)
   PUBMED   9858544
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC165154.2.
            
            On Apr 27, 2007 this sequence version replaced NM_009769.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012958.1, AB025099.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               AC165154.2         95845-96376         c
            533-1406            AC165154.2         92813-93686         c
            1407-1466           AC165154.2         91590-91649         c
            1467-1728           AC165154.2         81655-81916         c
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 49.43 cM"
     gene            1..1728
                     /gene="Klf5"
                     /gene_synonym="4930520J07Rik; Bteb2; CKLF; IKLF"
                     /note="Kruppel-like transcription factor 5"
                     /db_xref="GeneID:12224"
                     /db_xref="MGI:MGI:1338056"
     exon            1..532
                     /gene="Klf5"
                     /gene_synonym="4930520J07Rik; Bteb2; CKLF; IKLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1645
                     /gene="Klf5"
                     /gene_synonym="4930520J07Rik; Bteb2; CKLF; IKLF"
                     /note="BTE-binding protein 2; transcription factor BTEB2;
                     intestinal-enriched krueppel-like factor; basic
                     transcription element-binding protein 2; Kruppel-like
                     factor 5"
                     /codon_start=1
                     /product="Krueppel-like factor 5"
                     /protein_id="NP_033899.2"
                     /db_xref="CCDS:CCDS27311.1"
                     /db_xref="GeneID:12224"
                     /db_xref="MGI:MGI:1338056"
                     /translation="MPTRVLTMSARLGPLPQPPAAQDEPVFAQLKPVLGAANPARDAA
                     LFSGDDLKHAHHHPPAPPPAAGPRLPSEELVQTRCEMEKYLTPQLPPVPIISEHKKYR
                     RDSASVVDQFFTDTEGIPYSINMNVFLPDITHLRTGLYKSQRPCVTQIKTEPVTIFSH
                     QSESTAPPPPPAPTQALPEFTSIFSSHQTTAPPQEVNNIFIKQELPIPDLHLSVPSQQ
                     GHLYQLLNTPDLDMPSSTNQTAVMDTLNVSMAGLNPHPSAVPQTSMKQFQGMPPCTYT
                     MPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPA
                     TLPVNSPTLPPVRYNRRSNPDLEKRRIHFCDYNGCTKVYTKSSHLKAHLRTHTGEKPY
                     KCTWEGCDWRFARSDELTRHYRKHTGAKPFQCMVCQRSFSRSDHLALHMKRHQN"
     exon            533..1406
                     /gene="Klf5"
                     /gene_synonym="4930520J07Rik; Bteb2; CKLF; IKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1466
                     /gene="Klf5"
                     /gene_synonym="4930520J07Rik; Bteb2; CKLF; IKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1728
                     /gene="Klf5"
                     /gene_synonym="4930520J07Rik; Bteb2; CKLF; IKLF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggggcag gtacgcgctc tcttaggttg ctggtggagc ttgggggtgg cgggagcggg
       61 ttccggcgag agggtgagcg agcgctgggg cggggcggga gaaagtggct gcccgaggac
      121 ctcggcggtg acgcgtggcc gagcccagga gccccgatct ccgtgcccgc cttcgtgagc
      181 gtctggctgc cggcccaggg gtcccccgcc gcggcccccc gccgagtccg ccgtcccgtg
      241 ccagcccgag cgaggtggga tcgcgatcgc tccgtgtccc gctcccgtaa tccccagacc
      301 gtccatgccc acgcgggtgc tgaccatgag cgcccgcctg ggaccactgc cccagccgcc
      361 ggccgcgcag gacgagcccg tgttcgcgca gctcaagccg gtgctgggcg ctgcgaaccc
      421 ggcccgcgac gcggcgctct tctccggaga cgatctgaaa cacgcgcacc accacccgcc
      481 tgcgccgccg ccagccgctg gcccgcgact gccctcggag gagctggtcc agacaagatg
      541 tgaaatggag aagtatctga cccctcagct ccctccagtt ccgataattt cagagcataa
      601 aaagtataga cgagacagtg cctcagtggt agaccagttc ttcactgaca ctgaaggcat
      661 accttacagc atcaacatga acgtcttcct ccctgacatc actcacctga gaactggcct
      721 ctacaaatcc cagagaccat gcgtaacaca gatcaagaca gaacctgtta ccattttcag
      781 ccaccagagc gagtcgacgg cccctcctcc tcctccggcc cccacccagg ctctccccga
      841 gttcactagt atcttcagct cccaccagac cacagcgcca ccacaggagg tgaacaatat
      901 cttcatcaaa caagaacttc ctataccaga tcttcatctc tctgtccctt cccagcaggg
      961 ccacctgtac cagctgttga atacaccgga tctagacatg cccagttcga caaaccagac
     1021 ggcagtaatg gacaccctta atgtttctat ggcaggcctt aacccacacc cctctgctgt
     1081 tccacagacg tcaatgaaac agttccaggg catgccccct tgcacgtaca ccatgccaag
     1141 tcagtttctt ccacagcagg ccacctactt tcccccgtca ccaccaagct cagagcctgg
     1201 aagtcccgat agacaagctg agatgctgca gaatctcacc ccacctccgt cctatgccgc
     1261 tacaattgct tccaaactgg cgattcacaa cccaaattta cctgccactc tgccagttaa
     1321 ttcgccaact ctcccacctg tcagatacaa cagaaggagt aacccggatc tggagaagcg
     1381 acgtatccac ttctgcgatt ataatggttg cacaaaagtt tatacaaagt cgtctcactt
     1441 aaaagctcac ctgaggactc atacgggcga gaagccctac aagtgcacct gggagggctg
     1501 cgactggagg tttgcccggt cggatgagct gacccgccac tacaggaagc acacgggcgc
     1561 caagccgttc cagtgcatgg tgtgccaacg cagcttctcc cgctccgacc acctcgcgct
     1621 gcacatgaag cgccaccaga actgagcgag cgagcgctgc gcccacccgc ctgacgcctt
     1681 gcagtccgct ctgccatcct ttaaaccgca gacctaactt cataaaaa
//
