LOCUS       NM_010637               3057 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus Kruppel-like transcription factor 4 (gut) (Klf4),
            mRNA.
ACCESSION   NM_010637
VERSION     NM_010637.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3057)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3057)
  AUTHORS   Tan,Y., Wang,J., Liu,C., Wu,S., Zhou,M., Zhang,Y., Yin,T. and
            Yang,J.
  TITLE     KLF4 regulates trophoblast function and associates with unexplained
            recurrent spontaneous abortion
  JOURNAL   J Transl Med 22 (1), 922 (2024)
   PUBMED   39390495
  REMARK    GeneRIF: KLF4 regulates trophoblast function and associates with
            unexplained recurrent spontaneous abortion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3057)
  AUTHORS   Gao,Y., Lin,Y., Li,Y., Zeng,W. and Chen,Z.
  TITLE     Interplay of RUNX2 and KLF4 in initial commitment of odontoblast
            differentiation
  JOURNAL   J Cell Biochem 125 (7), e30577 (2024)
   PUBMED   38720665
  REMARK    GeneRIF: Interplay of RUNX2 and KLF4 in initial commitment of
            odontoblast differentiation.
REFERENCE   4  (bases 1 to 3057)
  AUTHORS   Kang,K., Sun,C., Li,H., Liu,X., Deng,J., Chen,S., Zeng,L., Chen,J.,
            Liu,X., Kuang,J., Xiang,J., Cheng,J., Liao,X., Lin,M., Zhang,X.,
            Zhan,C., Liu,S., Wang,J., Niu,Y., Liu,C., Liang,C., Zhu,J.,
            Liang,S., Tang,H. and Gou,D.
  TITLE     N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the
            phenotypic switch of pulmonary artery smooth muscle cells
  JOURNAL   Cell Mol Life Sci 81 (1), 256 (2024)
   PUBMED   38866991
  REMARK    GeneRIF: N6-methyladenosine-driven miR-143/145-KLF4 circuit
            orchestrates the phenotypic switch of pulmonary artery smooth
            muscle cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3057)
  AUTHORS   Ding,H., Tong,J., Lin,H., Ping,F., Yao,T., Ye,Z., Chu,J., Yuan,D.,
            Wang,K., Liu,X. and Chen,F.
  TITLE     KLF4 inhibited the senescence-associated secretory phenotype in
            ox-LDL-treated endothelial cells via PDGFRA/NAMPT/mitochondrial ROS
  JOURNAL   Aging (Albany NY) 16 (9), 8070-8085 (2024)
   PUBMED   38728249
  REMARK    GeneRIF: KLF4 inhibited the senescence-associated secretory
            phenotype in ox-LDL-treated endothelial cells via
            PDGFRA/NAMPT/mitochondrial ROS.
REFERENCE   6  (bases 1 to 3057)
  AUTHORS   Yet,S.F., McA'Nulty,M.M., Folta,S.C., Yen,H.W., Yoshizumi,M.,
            Hsieh,C.M., Layne,M.D., Chin,M.T., Wang,H., Perrella,M.A.,
            Jain,M.K. and Lee,M.E.
  TITLE     Human EZF, a Kruppel-like zinc finger protein, is expressed in
            vascular endothelial cells and contains transcriptional activation
            and repression domains
  JOURNAL   J Biol Chem 273 (2), 1026-1031 (1998)
   PUBMED   9422764
REFERENCE   7  (bases 1 to 3057)
  AUTHORS   Ton-That,H., Kaestner,K.H., Shields,J.M., Mahatanankoon,C.S. and
            Yang,V.W.
  TITLE     Expression of the gut-enriched Kruppel-like factor gene during
            development and intestinal tumorigenesis
  JOURNAL   FEBS Lett 419 (2-3), 239-243 (1997)
   PUBMED   9428642
  REMARK    GeneRIF: Paper describes that expression of Klf4 is developmentally
            regulated and is decreased in a mouse model of intestinal
            tumorigenesis.
REFERENCE   8  (bases 1 to 3057)
  AUTHORS   Shields,J.M. and Yang,V.W.
  TITLE     Two potent nuclear localization signals in the gut-enriched
            Kruppel-like factor define a subfamily of closely related Kruppel
            proteins
  JOURNAL   J Biol Chem 272 (29), 18504-18507 (1997)
   PUBMED   9218496
  REMARK    GeneRIF: Paper identifies two potent nuclear localization signals
            (NLSs) in Klf4 that are similar to those of two other KLFs: Klf1
            and Klf2.
REFERENCE   9  (bases 1 to 3057)
  AUTHORS   Garrett-Sinha,L.A., Eberspaecher,H., Seldin,M.F. and de
            Crombrugghe,B.
  TITLE     A gene for a novel zinc-finger protein expressed in differentiated
            epithelial cells and transiently in certain mesenchymal cells
  JOURNAL   J Biol Chem 271 (49), 31384-31390 (1996)
   PUBMED   8940147
REFERENCE   10 (bases 1 to 3057)
  AUTHORS   Shields,J.M., Christy,R.J. and Yang,V.W.
  TITLE     Identification and characterization of a gene encoding a
            gut-enriched Kruppel-like factor expressed during growth arrest
  JOURNAL   J Biol Chem 271 (33), 20009-20017 (1996)
   PUBMED   8702718
  REMARK    GeneRIF: Paper describes the first identification of the mouse
            Kruppel-like factor 4 or KLF4 (gut) that appears to be an inhibitor
            of cell growth.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732494.16, AA389216.1, CF163360.1, AK141244.1 and BQ034021.1.
            
            On Apr 1, 2008 this sequence version replaced NM_010637.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155343.1, U70662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               AL732494.16        26602-27091         c
            491-656             AA389216.1         22-187
            657-1089            CF163360.1         1-433
            1090-2253           AK141244.1         2-1165
            2254-2958           AL732494.16        21839-22543         c
            2959-3057           BQ034021.1         1-99                c
FEATURES             Location/Qualifiers
     source          1..3057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 29.76 cM"
     gene            1..3057
                     /gene="Klf4"
                     /gene_synonym="EZF; Gklf; Zie"
                     /note="Kruppel-like transcription factor 4 (gut)"
                     /db_xref="GeneID:16600"
                     /db_xref="MGI:MGI:1342287"
     exon            1..609
                     /gene="Klf4"
                     /gene_synonym="EZF; Gklf; Zie"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..2056
                     /gene="Klf4"
                     /gene_synonym="EZF; Gklf; Zie"
                     /note="gut-enriched krueppel-like factor; epithelial zinc
                     finger protein EZF; Kruppel-like factor 4 (Gut enriched
                     kruppel-like factor) (Epithelial zinc-finger protein EZF);
                     Kruppel-like factor 4 (gut)"
                     /codon_start=1
                     /product="Krueppel-like factor 4"
                     /protein_id="NP_034767.2"
                     /db_xref="CCDS:CCDS18195.2"
                     /db_xref="GeneID:16600"
                     /db_xref="MGI:MGI:1342287"
                     /translation="MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRPAGAPTNRW
                     REELSHMKRLPPLPGRPYDLAATVATDLESGGAGAACSSNNPALLARRETEEFNDLLD
                     LDFILSNSLTHQESVAATVTTSASASSSSSPASSGPASAPSTCSFSYPIRAGGDPGVA
                     ASNTGGGLLYSRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPP
                     GGGLMGKFVLKASLTTPGSEYSSPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQ
                     EAVPSCTVSRSLEAHLSAGPQLSNGHRPNTHDFPLGRQLPTRTTPTLSPEELLNSRDC
                     HPGLPLPPGFHPHPGPNYPPFLPDQMQSQVPSLHYQELMPPGSCLPEEPKPKRGRRSW
                     PRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRH
                     YRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF"
     exon            610..730
                     /gene="Klf4"
                     /gene_synonym="EZF; Gklf; Zie"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1715
                     /gene="Klf4"
                     /gene_synonym="EZF; Gklf; Zie"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1880
                     /gene="Klf4"
                     /gene_synonym="EZF; Gklf; Zie"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..3044
                     /gene="Klf4"
                     /gene_synonym="EZF; Gklf; Zie"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf4"
                     /gene_synonym="EZF; Gklf; Zie"
                     /note="hexamer: AATAAA"
     polyA_site      3044
                     /gene="Klf4"
                     /gene_synonym="EZF; Gklf; Zie"
                     /note="major polyA site"
ORIGIN      
        1 agttccccgg ccaagagagc gagcgcggct ccgggcgcgc ggggagcaga ggcggtggcg
       61 ggcggcggcg gcacccggag ccgccgagtg cccctccccg cccctccagc cccccaccca
      121 gcaacccgcc cgtgacccgc gcccatggcc gcgcgcaccc ggcacagtcc ccaggactcc
      181 gcaccccgcg ccaccgccca gctcgcagtt ccgcgccacc gcggccattc tcacctggcg
      241 gcgccgcccg cccaccgccc ggaccacagc ccccgcgccg ccgacagcca cagtggccgc
      301 gacaacggtg ggggacactg ctgagtccaa gagcgtgcag cctggccatc ggacctactt
      361 atctgccttg ctgattgtct atttttataa gagtttacaa cttttctaag aatttttgta
      421 tacaaaggaa cttttttaaa gacatcgccg gtttatattg aatccaaaga agaaggatct
      481 cgggcaatct gggggttttg gtttgaggtt ttgtttctaa agtttttaat cttcgttgac
      541 tttggggctc aggtacccct ctctcttctt cggactccgg aggaccttct gggcccccac
      601 attaatgagg cagccacctg gcgagtctga catggctgtc agcgacgctc tgctcccgtc
      661 cttctccacg ttcgcgtccg gcccggcggg aagggagaag acactgcgtc cagcaggtgc
      721 cccgactaac cgttggcgtg aggaactctc tcacatgaag cgacttcccc cacttcccgg
      781 ccgcccctac gacctggcgg cgacggtggc cacagacctg gagagtggcg gagctggtgc
      841 agcttgcagc agtaacaacc cggccctcct agcccggagg gagaccgagg agttcaacga
      901 cctcctggac ctagacttta tcctttccaa ctcgctaacc caccaggaat cggtggccgc
      961 caccgtgacc acctcggcgt cagcttcatc ctcgtcttcc ccggcgagca gcggccctgc
     1021 cagcgcgccc tccacctgca gcttcagcta tccgatccgg gccgggggtg acccgggcgt
     1081 ggctgccagc aacacaggtg gagggctcct ctacagccga gaatctgcgc cacctcccac
     1141 ggcccccttc aacctggcgg acatcaatga cgtgagcccc tcgggcggct tcgtggctga
     1201 gctcctgcgg ccggagttgg acccagtata cattccgcca cagcagcctc agccgccagg
     1261 tggcgggctg atgggcaagt ttgtgctgaa ggcgtctctg accacccctg gcagcgagta
     1321 cagcagccct tcggtcatca gtgttagcaa aggaagccca gacggcagcc accccgtggt
     1381 agtggcgccc tacagcggtg gcccgccgcg catgtgcccc aagattaagc aagaggcggt
     1441 cccgtcctgc acggtcagcc ggtccctaga ggcccatttg agcgctggac cccagctcag
     1501 caacggccac cggcccaaca cacacgactt ccccctgggg cggcagctcc ccaccaggac
     1561 tacccctaca ctgagtcccg aggaactgct gaacagcagg gactgtcacc ctggcctgcc
     1621 tcttccccca ggattccatc cccatccggg gcccaactac cctcctttcc tgccagacca
     1681 gatgcagtca caagtcccct ctctccatta tcaagagctc atgccaccgg gttcctgcct
     1741 gccagaggag cccaagccaa agaggggaag aaggtcgtgg ccccggaaaa gaacagccac
     1801 ccacacttgt gactatgcag gctgtggcaa aacctatacc aagagttctc atctcaaggc
     1861 acacctgcga actcacacag gcgagaaacc ttaccactgt gactgggacg gctgtgggtg
     1921 gaaattcgcc cgctccgatg aactgaccag gcactaccgc aaacacacag ggcaccggcc
     1981 ctttcagtgc cagaagtgtg acagggcctt ttccaggtcg gaccaccttg ccttacacat
     2041 gaagaggcac ttttaaatcc cacgtagtgg atgtgaccca cactgccagg agagagagtt
     2101 cagtattttt ttttctaacc tttcacactg tcttcccacg aggggaggag cccagctggc
     2161 aagcgctaca atcatggtca agttcccagc aagtcagctt gtgaatggat aatcaggaga
     2221 aaggaagagt tcaagagaca aaacagaaat actaaaaaca aacaaacaaa aaaacaaaca
     2281 aaaaaaacaa gaaaaaaaaa tcacagaaca gatggggtct gatactggat ggatcttcta
     2341 tcattccaat accaaatcca acttgaacat gcccggactt acaaaatgcc aaggggtgac
     2401 tggaagtttg tggatatcag ggtatacact aaatcagtga gcttgggggg agggaagacc
     2461 aggattccct tgaattgtgt ttcgatgatg caatacacac gtaaagatca ccttgtatgc
     2521 tctttgcctt cttaaaaaaa aaaaaagcca ttattgtgtc ggaggaagag gaagcgattc
     2581 aggtacagaa catgttctaa cagcctaaat gatggtgctt ggtgagtcgt ggttctaaag
     2641 gtaccaaacg ggggagccaa agttctccaa ctgctgcata cttttgacaa ggaaaatcta
     2701 gttttgtctt ccgatctaca ttgatgacct aagccaggta aataagcctg gtttatttct
     2761 gtaacatttt tatgcagaca gtctgttatg cactgtggtt tcagatgtgc aataatttgt
     2821 acaatggttt attcccaagt atgcctttaa gcagaacaaa tgtgtttttc tatatagttc
     2881 cttgccttaa taaatatgta atataaattt aagcaaactt ctattttgta tatttgtaaa
     2941 ctacaaagta aaaaaaaatg aacattttgt ggagtttgta ttttgcatac tcaaggtgag
     3001 aaataagttt taaataaacc tataatattt tatctgaacg acaaaaaaaa aaaaaaa
//
