LOCUS       NM_008453               5088 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 3 (basic) (Klf3),
            transcript variant 1, mRNA.
ACCESSION   NM_008453 XM_914517
VERSION     NM_008453.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5088)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5088)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   3  (bases 1 to 5088)
  AUTHORS   Li,Y., Wang,Y., Zou,Q., Li,S. and Zhang,F.
  TITLE     KLF3 Transcription Activates WNT1 and Promotes the Growth and
            Metastasis of Gastric Cancer via Activation of the WNT/beta-Catenin
            Signaling Pathway
  JOURNAL   Lab Invest 103 (6), 100078 (2023)
   PUBMED   36827869
  REMARK    GeneRIF: KLF3 Transcription Activates WNT1 and Promotes the Growth
            and Metastasis of Gastric Cancer via Activation of the
            WNT/beta-Catenin Signaling Pathway.
REFERENCE   4  (bases 1 to 5088)
  AUTHORS   Hao,J., Yang,X., Zhang,C., Zhang,X.T., Shi,M., Wang,S.H., Mi,L.,
            Zhao,Y.T., Cao,H. and Wang,Y.
  TITLE     KLF3 promotes the 8-cell-like transcriptional state in pluripotent
            stem cells
  JOURNAL   Cell Prolif 53 (11), e12914 (2020)
   PUBMED   32990380
  REMARK    GeneRIF: KLF3 promotes the 8-cell-like transcriptional state in
            pluripotent stem cells.
REFERENCE   5  (bases 1 to 5088)
  AUTHORS   Knights,A.J., Vohralik,E.J., Houweling,P.J., Stout,E.S.,
            Norton,L.J., Alexopoulos,S.J., Yik,J.J., Mat Jusoh,H.,
            Olzomer,E.M., Bell-Anderson,K.S., North,K.N., Hoehn,K.L.,
            Crossley,M. and Quinlan,K.G.R.
  TITLE     Eosinophil function in adipose tissue is regulated by Kruppel-like
            factor 3 (KLF3)
  JOURNAL   Nat Commun 11 (1), 2922 (2020)
   PUBMED   32523103
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5088)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
REFERENCE   7  (bases 1 to 5088)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   8  (bases 1 to 5088)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Basic Kruppel-like factor functions within a network of interacting
            haematopoietic transcription factors
  JOURNAL   Int J Biochem Cell Biol 31 (10), 1169-1174 (1999)
   PUBMED   10582345
  REMARK    Review article
REFERENCE   9  (bases 1 to 5088)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Mammalian Kruppel-like transcription factors: more than just a
            pretty finger
  JOURNAL   Trends Biochem Sci 24 (6), 236-240 (1999)
   PUBMED   10366853
  REMARK    Review article
REFERENCE   10 (bases 1 to 5088)
  AUTHORS   Crossley,M., Whitelaw,E., Perkins,A., Williams,G., Fujiwara,Y. and
            Orkin,S.H.
  TITLE     Isolation and characterization of the cDNA encoding BKLF/TEF-2, a
            major CACCC-box-binding protein in erythroid cells and selected
            other cells
  JOURNAL   Mol Cell Biol 16 (4), 1695-1705 (1996)
   PUBMED   8657145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130535.4.
            
            On Dec 5, 2019 this sequence version replaced NM_008453.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143838.1, SRR11927938.4039983.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC130535.4         91668-91938         c
            272-367             AC130535.4         78629-78724         c
            368-851             AC130535.4         73102-73585         c
            852-1002            AC130535.4         72430-72580         c
            1003-1163           AC130535.4         68189-68349         c
            1164-5088           AC130535.4         62558-66482         c
FEATURES             Location/Qualifiers
     source          1..5088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 33.49 cM"
     gene            1..5088
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /note="Kruppel-like transcription factor 3 (basic)"
                     /db_xref="GeneID:16599"
                     /db_xref="MGI:MGI:1342773"
     exon            1..271
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..367
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1345
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /note="basic krueppel-like factor; CACCC-box-binding
                     protein BKLF; Kruppel-like factor 3 (basic)"
                     /codon_start=1
                     /product="Krueppel-like factor 3"
                     /protein_id="NP_032479.1"
                     /db_xref="CCDS:CCDS19301.1"
                     /db_xref="GeneID:16599"
                     /db_xref="MGI:MGI:1342773"
                     /translation="MLMFDPVPVKQEAMDPVSVSFPSNYIESMKPNKYGVIYSTPLPD
                     KFFQTPEGLTHGIQVEPVDLTVNKRGSPPAAGGSPSSLKFPSHRRASPGLSMPSSSPP
                     IKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHL
                     QQPLMVSLSEEMDNSNSGMPVPVIESYEKPLLQKKIKIEPGIEPQRTDYYPEEMSPPL
                     MNPVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHL
                     KAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHL
                     ALHRKRHMLV"
     exon            368..851
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1002
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1163
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..5088
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1719..1724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /note="hexamer: AGTAAA"
     polyA_site      1739
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
     regulatory      5068..5073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /note="hexamer: AATAAA"
     polyA_site      5088
                     /gene="Klf3"
                     /gene_synonym="9930027G08Rik; Bklf; Tef-2"
                     /note="major polyA site"
ORIGIN      
        1 gcagagcgag cggcgccggc gtcatgtgac tgcccagagt tggtgccaag gagccagagg
       61 ggagcgggga gccgagccgc gcggagccgc ggccggagcg cagtgcgagc gccacccgag
      121 ccaaccccac ccgcgcgtcc gtgcggtcgc ggtccctatc ccggacgccg tccggcccga
      181 agcgcttgac ctgccggccc gcggggttcc gggcgccggg gagccgggcc tgggtttctt
      241 ggccgctgcg ctcggcaccg cgcttggcag agccagacat cagaacaccc tagaaggcgt
      301 ggctgaaagg atgctcatgt ttgatccagt ccctgtcaag caggaggcca tggaccctgt
      361 ctcggtgtcc ttcccgtcga attacataga atcgatgaag cccaacaaat atggggtcat
      421 ttactccaca ccgttgcctg ataagttctt ccagacccca gaaggcctca ctcacgggat
      481 acaggtggag ccggtggacc tcacggtgaa caagcggggc tccccgcctg ctgcgggcgg
      541 ttctccttcc tctctgaagt tcccgtccca ccggagagcg tcacctggcc tcagcatgcc
      601 ctcctccagt ccgcccatta agaagtactc gcccccttct cctggcgtgc agccctttgg
      661 agtacccctg tctatgccgc ctgtgatggc agccgcgctg tccagacacg gaatccggag
      721 cccaggcatc ctccccgtca ttcagcccgt cgtggtccag cccgttcctt ttatgtatac
      781 cagccacctg cagcagcctc tcatggtttc cttgtcggaa gagatggaca attcaaacag
      841 cggcatgcca gtacctgtaa ttgaatcata tgagaagccc ttattacaga aaaaaattaa
      901 aatagagcct ggaattgaac cacagaggac tgactattac cctgaagaaa tgtcaccccc
      961 tttaatgaac ccagtgtccc ccccgcaagc cttgttgcaa gagaaccatc cttccgtcat
     1021 cgtgcagcct gggaagagac ctctacctgt ggaatccccg gatacccaaa ggaagcgcag
     1081 gatacacaga tgcgactatg atgggtgcaa taaggtctac actaagagct cgcacttgaa
     1141 agcacacaga agaactcata caggagaaaa gccgtacaaa tgcacctggg aaggctgcac
     1201 gtggaagttc gctcggtctg atgaactgac gagacatttc cgaaaacaca ctgggatcaa
     1261 acctttccag tgtccagact gtgaccgaag cttctctcgc tctgaccacc ttgccctaca
     1321 caggaaacgc cacatgctag tctgaaaacc tgtctccagc tcagtgtgat tccccgctct
     1381 tcctggcctc tctctctttc tctctctctc tctcctatct ctttctcttc tccttctgcc
     1441 cgttatctaa ctcattttta tatgtacatt ttaatttcga ttcagctggt ctggatctct
     1501 gaatttatat cattcaagac ttccatatgg tcagtagttg atactctaac cctcccctcc
     1561 ttaccacggg tcagacctaa agaatgtgaa cattattttt tccggggatg ctaagcaaac
     1621 cctccttaca gatacattta atgtaacgag aacaagggaa catgtaaact aacgaccaat
     1681 ttgtcggttt ctccatgtat tcctcaaaag aatgtcaaag taaatgtatt agaaatgcag
     1741 tatccagcct attagtcctt gccagagacc ttcgactttc tgccacattt tgtgtttgac
     1801 gacagaaaga attctgtccc tgttaccagc tagcgagacc tacaagatgt caagctggac
     1861 ccaccgtctc gccttcgccc tccccacgat tcgcctgttg acctggctca cctgctcagc
     1921 taaatcagct cctttgtcct ctgtggcacc tgaagctcat gtggagggct ttgacatccc
     1981 tgggagctga gcaggagctg ttgccttagg tgggccatgt gctcccatag tgtgaggaag
     2041 aaggagaaga tattggaaat ggaggaggga gtcagcgatt cctggctagg accggctgga
     2101 ccatcaacat ctgggaaatt cacattagct gtgcagtgca tttgttaaat gtccatcccc
     2161 aggcacaact tggccgagca cacctttgct gcaaagctgg ataccgagag ggttatccat
     2221 ctgtgccacc accacctccg ttcctgcagg atccttcatt gtcgatcatg aagccttgag
     2281 agtaaggaat ccacagaaat atttgttcag tcatgtaaaa aaaaaacaaa aaacaaaaac
     2341 ttttgaggca gtataaaatg gtctcttctc cccccacccc ccaacctact aagagtgttt
     2401 ttgcaaacag gaaaacattg agtggtacta atactcccat atccaatgag ccacatagct
     2461 ttcatatgga gcttttctgt gtgagctgta tggtgccaaa ccagcaatca tttgtgtcta
     2521 tgacacatag tataaaagag catccactaa gcttgagcag agtcactcaa ttaagacctg
     2581 agtgacacta tttgtaaata tacctagtgt gaagcacata gatctttatt ttggtgactt
     2641 tttttttttt ttgaaaaata gagaaaacca caattcaggg atttatatat gtagcttgaa
     2701 gattcccaca agtttctgcc agagctagca atttcctgtc aggtaccctg ttaggacaaa
     2761 ccagaagcaa tgactcgtgt tgatgttgca gataaatagc accattattt ggggggaagg
     2821 ttttttttgt ttcgttttgt ttttcaaaag caggcttttg aacaccacag tctaaatgcc
     2881 aatgaaaaca gttcatagat tgcagaaatg tcactggttc caaatctgag aaataaaatg
     2941 ggcacaatgg tcagatatgg ctgcctctga ccagtagtcc cttcatcccc tcacaaagga
     3001 tggaggagaa gggggggagg ggaatcctga agagttatcc cagccacaac tcaggatcca
     3061 acactacctg aactgggagg aacaccctac cggattgttc ttggatgtcg gggagtgaga
     3121 ggtcttggag ccctgcactt gcagggaact tgatttgatg gcactatgtt catagttgtg
     3181 ggggctgcac tcgggaggcc ctgctcagcc ctgtgaacca actgaggggg gaatgtgggt
     3241 aaaaactgca aagaaatgtt atcttagctc ttgggttcct tttctttccc tttttagcac
     3301 tgaaaaaaaa agtctgtttg ggctattaaa gcatgctaat taggctcttg cctttctttt
     3361 tgtttgcaac gatgacatga attgaggagt gagtgtctct tgggaaagca gggtctccct
     3421 tgtcagtgtt ccttagcgtt catgccacca ccatcgtgtc ttgaagtggt tcttctgcag
     3481 ggcactgaag agtcccgttt gtttagtgtt tgttccaatt tgtatgctcc gacccagtga
     3541 gcagcggggt agggtgcaag gaaggaccct tagctttgct tcaaaccaag aatagttaat
     3601 agcaccatgg cgtatttaaa ttttgttcaa aagtctttat tatattactc tttagcttgc
     3661 ttagatcatg ttaacagaaa gatccatttt aactctgaaa gaaaagtaac ccagagaagc
     3721 cattctctag tcccatgcta gtctgatata attttagtta attggccctt accaaatttc
     3781 ctatatatat atatatatat atatatgtat gtatgtatgt atgtatgtat gtatttgtat
     3841 tttactatga tagttgagaa atttagtctc ttagtattct tttgtttggt tgtttggttg
     3901 ggttttttgt cttttgtttg tttgggtttt tgtttttgtt tttattttag ctgtttttgt
     3961 gcatgataca agttaagatg ccctggatgt ttgattttgg atgacatgct atgttcttgt
     4021 cagtggtggt tcatttgcag taaattgatg aggacaggct gtaaacatga agccagcact
     4081 gtgtaaatca ttacagagtt cattcagtta ctgctcaagt ctcatctggg ggaagttcca
     4141 aaaataacca acatcttgtg tttttgagtt tcacagtggg aagggtacat cattaaatgg
     4201 gcattttgca ctcgaaagtc acttggtttg gagactgtgt gtagcatagc tttgttcaac
     4261 taagaagata ctaaatatgc agatgttgca agagccttgg aacagaatta caggggagtg
     4321 atatatgtat atgtatgttt tattaaacac ccacctgcac tatcagtatt gcactaatgt
     4381 ggaatttgag agactattgc tgatattgta atctgcgcac cattccttag attgttaaaa
     4441 aagacaatct cagagatcaa aggttttata atttggtttg aaattagaat tgtcttgaag
     4501 gagttgctaa cgtacatgaa gtcacttgag ttctctttat tctcttcttg gtcaaggtta
     4561 acagtttcta aacgattgca aattcactta agtaatacat ttacaaagcc attttacatg
     4621 cattaaaaga gggctacaat gtgttttaca aatactagca cttttttttc ctgttatgta
     4681 cctagtgtta gagggtcaga ataatctttc tgcttggcat ctcttaaaac ctacctgcaa
     4741 gcatagcagg cttattgcat ttacagttct ttaatacttg tataaactat gcagaaattt
     4801 ttaataaagt gtaatatatt ttataagcta ataagactga atgggtaaag gtttttagca
     4861 tgcattagta tacttgcaaa tactgaaaca ttttggtaat ctttcttact aaagatgtga
     4921 atgtttaatg taccttctgt ttctaccctg tagtccaatg ggaattcagt aatgacattt
     4981 tgtcatgtca aactgtgaac ataaatttgt actgtacagt cctcatatac tatatacagt
     5041 atgcaatata tgtattatat acttgttaat aaaaccatct gaatatta
//
