LOCUS       NM_008452               1816 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Kruppel-like transcription factor 2 (lung) (Klf2),
            mRNA.
ACCESSION   NM_008452 XM_982078
VERSION     NM_008452.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1816)
  AUTHORS   Chen,Q., Rong,H., Zhang,L., Wang,Y., Bian,Q. and Zheng,J.
  TITLE     KLF2 Orchestrates Pathological Progression of Infantile Hemangioma
            through Hemangioma Stem Cell Fate Decisions
  JOURNAL   J Invest Dermatol 144 (8), 1850-1864 (2024)
   PUBMED   38382868
  REMARK    GeneRIF: KLF2 Orchestrates Pathological Progression of Infantile
            Hemangioma through Hemangioma Stem Cell Fate Decisions.
REFERENCE   2  (bases 1 to 1816)
  AUTHORS   Gao,L., Lee,H., Goodman,J.H. and Ding,L.
  TITLE     Hematopoietic stem cell niche generation and maintenance are
            distinguishable by an epitranscriptomic program
  JOURNAL   Cell 187 (11), 2801-2816 (2024)
   PUBMED   38657601
REFERENCE   3  (bases 1 to 1816)
  AUTHORS   Kang,K., Xiang,J., Zhang,X., Xie,Y., Zhou,M., Zeng,L., Zhuang,J.,
            Kuang,J., Lin,Y., Hu,B., Xiong,Q., Yin,Q., Su,Q., Liao,X., Wang,J.,
            Niu,Y., Liu,C., Tian,J. and Gou,D.
  TITLE     N6-methyladenosine modification of KLF2 may contribute to
            endothelial-to-mesenchymal transition in pulmonary hypertension
  JOURNAL   Cell Mol Biol Lett 29 (1), 69 (2024)
   PUBMED   38741032
  REMARK    GeneRIF: N6-methyladenosine modification of KLF2 may contribute to
            endothelial-to-mesenchymal transition in pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1816)
  AUTHORS   Tamargo,I.A., Baek,K.I., Xu,C., Kang,D.W., Kim,Y., Andueza,A.,
            Williams,D., Demos,C., Villa-Roel,N., Kumar,S., Park,C., Choi,R.,
            Johnson,J., Chang,S., Kim,P., Tan,S., Jeong,K., Tsuji,S. and Jo,H.
  TITLE     HEG1 Protects Against Atherosclerosis by Regulating Stable
            Flow-Induced KLF2/4 Expression in Endothelial Cells
  JOURNAL   Circulation 149 (15), 1183-1201 (2024)
   PUBMED   38099436
  REMARK    GeneRIF: HEG1 Protects Against Atherosclerosis by Regulating Stable
            Flow-Induced KLF2/4 Expression in Endothelial Cells.
REFERENCE   5  (bases 1 to 1816)
  AUTHORS   Santamaria,R., Cruz-Caballero,J., Gkontra,P., Jimenez-Montiel,A.,
            Clemente,C., Lopez,J.A., Villalba-Orero,M., Vazquez,J., Hutloff,A.,
            Lara-Pezzi,E. and Arroyo,A.G.
  TITLE     Capillary pruning couples tissue perfusion and oxygenation with
            cardiomyocyte maturation in the postnatal mouse heart
  JOURNAL   Front Cell Dev Biol 11, 1256127 (2023)
   PUBMED   38020883
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1816)
  AUTHORS   Wani,M.A., Means,R.T. Jr. and Lingrel,J.B.
  TITLE     Loss of LKLF function results in embryonic lethality in mice
  JOURNAL   Transgenic Res 7 (4), 229-238 (1998)
   PUBMED   9859212
REFERENCE   7  (bases 1 to 1816)
  AUTHORS   Kuo,C.T., Veselits,M.L., Barton,K.P., Lu,M.M., Clendenin,C. and
            Leiden,J.M.
  TITLE     The LKLF transcription factor is required for normal tunica media
            formation and blood vessel stabilization during murine
            embryogenesis
  JOURNAL   Genes Dev 11 (22), 2996-3006 (1997)
   PUBMED   9367982
REFERENCE   8  (bases 1 to 1816)
  AUTHORS   Kuo,C.T., Veselits,M.L. and Leiden,J.M.
  TITLE     LKLF: A transcriptional regulator of single-positive T cell
            quiescence and survival
  JOURNAL   Science 277 (5334), 1986-1990 (1997)
   PUBMED   9302292
  REMARK    Erratum:[Science. 1997 Oct 31;278(5339):788-9. doi:
            10.1126/science.278.5339.785e.. PMID: 9381186]
REFERENCE   9  (bases 1 to 1816)
  AUTHORS   Lim,S.K., Bieker,J.J., Lin,C.S. and Costantini,F.
  TITLE     A shortened life span of EKLF-/- adult erythrocytes, due to a
            deficiency of beta-globin chains, is ameliorated by human
            gamma-globin chains
  JOURNAL   Blood 90 (3), 1291-1299 (1997)
   PUBMED   9242564
REFERENCE   10 (bases 1 to 1816)
  AUTHORS   Anderson,K.P., Kern,C.B., Crable,S.C. and Lingrel,J.B.
  TITLE     Isolation of a gene encoding a functional zinc finger protein
            homologous to erythroid Kruppel-like factor: identification of a
            new multigene family
  JOURNAL   Mol Cell Biol 15 (11), 5957-5965 (1995)
   PUBMED   7565748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131962.1 and BF023555.1.
            
            On Mar 26, 2008 this sequence version replaced NM_008452.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131962.1, U25096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AK131962.1         2-87
            87-510              BF023555.1         69-492
            511-1816            AK131962.1         512-1817
FEATURES             Location/Qualifiers
     source          1..1816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.99 cM"
     gene            1..1816
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /note="Kruppel-like transcription factor 2 (lung)"
                     /db_xref="GeneID:16598"
                     /db_xref="MGI:MGI:1342772"
     exon            1..88
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1081
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /note="Kruppel-like factor 2 (lung); lung krueppel-like
                     factor"
                     /codon_start=1
                     /product="Krueppel-like factor 2"
                     /protein_id="NP_032478.2"
                     /db_xref="CCDS:CCDS22412.1"
                     /db_xref="GeneID:16598"
                     /db_xref="MGI:MGI:1342772"
                     /translation="MALSEPILPSFATFASPCERGLQERWPRNEPEAGGTDEDLNNVL
                     DFILSMGLDGLGAENPPEPPPQPPPPAFYYPEPGAPPPYSIPAASLGTELLRPDLDPP
                     QGPALHGRFLLAPPGRLVKAEPPEVDGGGYGCAPGLAHGPRGLKLEGAPGATGACMRG
                     PAGRPPPPPDTPPLSPDGPLRIPASGPRNPFPPPFGPGPSFGGPGPALHYGPPAPGAF
                     GLFEDAAAAAAALGLAPPATRGLLTPPSSPLELLEAKPKRGRRSWPRKRAATHTCSYT
                     NCGKTYTKSSHLKAHLRTHTGEKPYHCNWEGCGWKFARSDELTRHYRKHTGHRPFQCH
                     LCDRAFSRSDHLALHMKRHM"
     exon            89..905
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1816
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /note="hexamer: ATTAAA"
     polyA_site      1513
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /note="major polyA site"
ORIGIN      
        1 acacacagtc cctgccatgg cgctcagcga gcctatcttg ccgtcctttg ccactttcgc
       61 cagcccgtgc gagcgcggcc tccaggagcg ctggccgcga aatgaacccg aggcgggcgg
      121 cacggatgag gacctaaaca acgtgttgga cttcatcctc tccatgggat tggacggtct
      181 gggcgccgaa aatcctcccg agcccccgcc gcagcccccg ccgcctgcct tctactaccc
      241 ggagccgggt gctccgccgc cctacagcat ccccgcggcc agcctgggaa cagagctgct
      301 gcgccccgac ctggacccgc ctcaggggcc ggctctgcac ggccgcttcc tcctcgcgcc
      361 tcccgggcgg ctagtgaagg ccgagccccc cgaggtggac ggcggcggct acggctgcgc
      421 tccgggcctg gcccacggac cgcgcgggct gaagctcgag ggcgccccag gagcgacagg
      481 tgcatgcatg cggggtcccg ccggccgccc cccgccgccc ccggacacgc cgccgctcag
      541 ccccgacggc cccctgcgca tcccggcgtc cggtccccgc aacccgttcc cgccgccctt
      601 cggtcccggc cccagcttcg gcggtcccgg ccccgcgttg cactacgggc ctcccgcgcc
      661 tggcgccttc ggtcttttcg aggacgcggc ggcagcggcg gcggcgctgg gcttggctcc
      721 acctgccacg cgcggtctcc tcacgccgcc ctcgtccccg ctggagctgc tggaggccaa
      781 gcccaaacgc ggccgccgct cctggccccg caagcgcgcc gccacacata cttgcagcta
      841 caccaactgc ggcaagacct acaccaagag ctcgcaccta aaggcgcatc tgcgtacaca
      901 cacaggtgag aagccttatc attgcaactg ggaaggatgc ggctggaagt tcgcgcgctc
      961 tgacgagctt acccgccact accgaaagca cacaggtcac agaccctttc agtgccactt
     1021 gtgcgaccgg gccttctcca ggtccgacca cctggccttg cacatgaagc gacacatgta
     1081 gcctgggtcg actcggctag cccatgcgcg actgtggcag gttccacgcg cggggcacgg
     1141 tccccttgca aacagactgc tatttattgg accttaggac agagccggac aagtgtggcc
     1201 acaggaaaat gactctgcca ccagttctgg cccccacagt gactgaaggc cccaggaaag
     1261 aagacaggag tctgtgaaga atgttttcaa aatggtgcaa taattgactt atttccctcg
     1321 ggtccccact agaggatcga ggctagatgc cttgtgagaa atgcctttga gtttactgtc
     1381 cccaacgttt ttataatatt gtatataaga ctatgaccga ttgtatttct ataagggaga
     1441 cgatggcatc tctgccgcct gcttcgtttt tatacgactt ttttttaatt aaagttttgg
     1501 atctttggag gaatcacggt agtggtgtgg ctggggatag ggtaggtcct gaggggacag
     1561 ggagcagtca gtgcctgtgg ccaaggtcac cagctgcagc ccccagctgc caaggcctgt
     1621 gggttcgcta taaatgtaaa catggtgttt taggattgag cacaggttat ttttaagtct
     1681 gctactttga gccataattt gccccacccc caccccctgt atcccaagtg ggaaaagcct
     1741 tggctccact gatgtggctg accattcctt tttttagaaa gaaaaataga aaagaaaatt
     1801 aaaaaccttt tcctgg
//
