LOCUS       NM_029416               3595 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 17 (Klf17), mRNA.
ACCESSION   NM_029416 XM_003689358 XM_003689359 XM_003946144 XR_887799
VERSION     NM_029416.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3595)
  AUTHORS   Yang,Q., Cao,Q., Yu,Y., Lai,X., Feng,J., Li,X., Jiang,Y., Sun,Y.,
            Zhou,Z.W. and Li,X.
  TITLE     Epigenetic and transcriptional landscapes during cerebral cortex
            development in a microcephaly mouse model
  JOURNAL   J Genet Genomics 51 (4), 419-432 (2024)
   PUBMED   37923173
REFERENCE   2  (bases 1 to 3595)
  AUTHORS   Hu,Y., Wang,Y., He,Y., Ye,M., Yuan,J., Ren,C., Wang,X., Wang,S.,
            Guo,Y., Cao,Q., Zhou,S., Wang,B., He,A., Hu,J., Guo,X., Shu,W. and
            Huo,R.
  TITLE     Maternal KLF17 controls zygotic genome activation by acting as a
            messenger for RNA Pol II recruitment in mouse embryos
  JOURNAL   Dev Cell 59 (5), 613-626 (2024)
   PUBMED   38325372
  REMARK    GeneRIF: Maternal KLF17 controls zygotic genome activation by
            acting as a messenger for RNA Pol II recruitment in mouse embryos.
REFERENCE   3  (bases 1 to 3595)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3595)
  AUTHORS   Wang,S.H., Hao,J., Zhang,C., Duan,F.F., Chiu,Y.T., Shi,M.,
            Huang,X., Yang,J., Cao,H. and Wang,Y.
  TITLE     KLF17 promotes human naive pluripotency through repressing MAPK3
            and ZIC2
  JOURNAL   Sci China Life Sci 65 (10), 1985-1997 (2022)
   PUBMED   35391627
  REMARK    GeneRIF: KLF17 promotes human naive pluripotency through repressing
            MAPK3 and ZIC2.
REFERENCE   5  (bases 1 to 3595)
  AUTHORS   Wang,C., Wang,Z., He,M., Zhou,T., Niu,Y., Sun,S., Li,H., Zhang,C.,
            Zhang,S., Liu,M., Xu,Y., Dong,N. and Wu,Q.
  TITLE     Kruppel-like factor 17 upregulates uterine corin expression and
            promotes spiral artery remodeling in pregnancy
  JOURNAL   Proc Natl Acad Sci U S A 117 (32), 19425-19434 (2020)
   PUBMED   32719113
  REMARK    GeneRIF: Kruppel-like factor 17 upregulates uterine corin
            expression and promotes spiral artery remodeling in pregnancy.
REFERENCE   6  (bases 1 to 3595)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   7  (bases 1 to 3595)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 3595)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 3595)
  AUTHORS   Gumireddy,K., Li,A., Gimotty,P.A., Klein-Szanto,A.J., Showe,L.C.,
            Katsaros,D., Coukos,G., Zhang,L. and Huang,Q.
  TITLE     KLF17 is a negative regulator of epithelial-mesenchymal transition
            and metastasis in breast cancer
  JOURNAL   Nat Cell Biol 11 (11), 1297-1304 (2009)
   PUBMED   19801974
  REMARK    GeneRIF: demonstrate that KLF17 expression is significantly
            downregulated in primary human breast cancer samples and that the
            combined expression pattern of KLF17 and Id1 can serve as a
            potential biomarker for lymph node metastasis in breast cancer
REFERENCE   10 (bases 1 to 3595)
  AUTHORS   Yan,W., Burns,K.H., Ma,L. and Matzuk,M.M.
  TITLE     Identification of Zfp393, a germ cell-specific gene encoding a
            novel zinc finger protein
  JOURNAL   Mech Dev 118 (1-2), 233-239 (2002)
   PUBMED   12351194
  REMARK    GeneRIF: ZFP393 functions as a germ cell-specific transcription
            factor that plays important roles in spermatid differentiation and
            oocyte development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ074269.1, AK139827.1 and CJ205589.1.
            
            On or before Feb 15, 2015 this sequence version replaced
            XR_887799.1, XM_003946144.1, XM_003689358.1, XM_003689359.1,
            NM_029416.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139827.1, BC064748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CJ074269.1         6-39
            35-2427             AK139827.1         2-2394
            2428-2589           AK139827.1         2396-2557
            2590-3588           AK139827.1         2559-3557
            3589-3595           CJ205589.1         370-376
FEATURES             Location/Qualifiers
     source          1..3595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.46 cM"
     gene            1..3595
                     /gene="Klf17"
                     /gene_synonym="7420700M05Rik; D4Ertd561e; Gzf; Zfp393"
                     /note="Kruppel-like transcription factor 17"
                     /db_xref="GeneID:75753"
                     /db_xref="MGI:MGI:2181068"
     exon            1..166
                     /gene="Klf17"
                     /gene_synonym="7420700M05Rik; D4Ertd561e; Gzf; Zfp393"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1147
                     /gene="Klf17"
                     /gene_synonym="7420700M05Rik; D4Ertd561e; Gzf; Zfp393"
                     /note="zinc finger protein 393; germ cell specific zinc
                     finger protein; Kruppel-like factor 17"
                     /codon_start=1
                     /product="Krueppel-like factor 17"
                     /protein_id="NP_083692.2"
                     /db_xref="CCDS:CCDS18537.1"
                     /db_xref="GeneID:75753"
                     /db_xref="MGI:MGI:2181068"
                     /translation="MEQDNKEQAMHQPPMDNKMLVPVSNVPVSSGNSGFHQPPATQYL
                     PEMMRSYMASAEELRCNEREWESQLIRSLPEHGVRCPSQLAPIPFQNYCQRSIGRGSH
                     VMPVGSSGTLGVTISFSENLMPQGGLPSSRGVSVMAHSSAPAMPYPMPPTVPATTGSL
                     KHGILLVPGMASAGTHAVAPFMDQMLHSINPCNPEMLPARFQQLLPLDSQDSLVTESN
                     TQEEPFVREPPTPAPEGAESPSTSRGATRRQSPVSRPYVCTYNSCGKSYTKRSHLVSH
                     QRKHTGVKPFACDWNGCTWKFFRSDELGRHKRIHTRYRPHKCDECDREFMRSDHLRQH
                     KRTHLPK"
     exon            167..965
                     /gene="Klf17"
                     /gene_synonym="7420700M05Rik; D4Ertd561e; Gzf; Zfp393"
                     /inference="alignment:Splign:2.1.0"
     exon            966..3595
                     /gene="Klf17"
                     /gene_synonym="7420700M05Rik; D4Ertd561e; Gzf; Zfp393"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2052
                     /gene="Klf17"
                     /gene_synonym="7420700M05Rik; D4Ertd561e; Gzf; Zfp393"
                     /note="major polyA site"
ORIGIN      
        1 gcaaataaaa actccacgca gccattgtgg gattatggcg tagtagtgtt gggacccacg
       61 cctgtgacgg tgtaagggcc gggcagcctc ccgtttgttc tcaacttggg tctcagccgg
      121 catggagcag gacaataagg aacaggctat gcaccagcct cccatggata ataagatgtt
      181 ggtgccagtg tcgaatgtgc ccgtgtcttc tggaaacagc ggatttcatc agccaccagc
      241 cactcaatac ttaccagaga tgatgaggtc ctatatggca tcagctgagg agctcagatg
      301 caatgagaga gaatgggaat cacagctcat taggtcgctg cctgagcatg gtgtgaggtg
      361 cccctcccag ctggctccta tacctttcca gaattattgt cagagatcga ttgggagggg
      421 atcccacgtg atgccagttg gaagttcagg tactctggga gtgaccattt ccttcagtga
      481 gaatctaatg cctcagggtg gcctgccaag ttcccgtgga gtctcagtga tggcccatag
      541 cagtgcccca gcaatgcctt atcctatgcc tccaacagta cctgccacca cgggctcttt
      601 aaaacatgga atattgttgg tcccaggcat ggcttccgct gggacccatg ctgtggctcc
      661 gtttatggat cagatgttgc actccataaa tccctgcaat cctgagatgc tcccagctag
      721 gttccagcaa ttgctacctt tagactccca agattcactt gtgactgagt caaataccca
      781 ggaagaacct ttcgtacgtg agccgcccac acctgctcca gagggggcag agagccccag
      841 tacttcaaga ggggcaacca ggagacagtc cccagtttca aggccttatg tctgcacata
      901 taacagctgt ggaaaatctt ataccaagcg ctctcacctt gtgagtcacc aacgcaaaca
      961 cacaggtgtg aagcccttcg catgtgactg gaacggatgt acgtggaagt tcttccgctc
     1021 tgatgagctt ggacgacaca aacggattca taccagatac cgaccacata aatgcgatga
     1081 gtgtgatcga gagttcatga gatctgacca tctcaggcag cacaaaagaa cgcatctgcc
     1141 caagtaagac ttcctgcagc ctcaagccaa caatggatag acagatgaga cagacagtcc
     1201 tcttgctcct gctcgggagc ttcagctctt tcctgtagtc tctaacccaa gattcagttg
     1261 ctcaagacca gatcatctct gggaaggtga aggttcggat ggagacagga agtggtgggg
     1321 aagcccacac gaagctctgg atgtcaccat gtgtttctca aaatctggta ccctcccctc
     1381 tcagagatta ctgacttctg ccagctgaga aggcagagcc agagatagga ttttactaga
     1441 aagcttttat ctcctgtcaa ccccaagtgt ggctctctca tgactgttcc acaaaatccc
     1501 atgttctctc cctgggcctt ccaggttcca gggccagacc atgggaaagg tctttgaact
     1561 ctgtgctttt ttacatctta gtgctggaac attctggata tacaatgttg tcttacctca
     1621 gattctctct ggccttcact gtccgcatgc ccagagttgg tctcttccct ccactcttgg
     1681 gatagaatgc ccatttcaag acatggcatc tggcatttca tggggccacc caaaccaagc
     1741 cttgtgagga gactaatatg aatgggagat gggagagagg caggcagcaa atctcccccc
     1801 aacctccatg aattgttgca agacatcgta tcgctgacag cacaatctgt ggggagacct
     1861 gctacacagc cagcggacat gcctgcatct tcaaggttgg ccatcttgga actgttgcct
     1921 tgggccactt cccattcttt ccctttcact tgatctcctt cctatacctt ggctttgaat
     1981 atcccaaata aaagtgtata ggccatttaa gatggcctgg ggagtaggag ggttgacaaa
     2041 ccccctcagt aacttcaggt ggcagattgt cattatacac acatgtgcag aggtcagaga
     2101 caacttagag tccatgatct ttagtgtagg tccctgggat tgaactcagg ctgtcagcct
     2161 tggcagcaag tacctttgat acaggttata ttatgtagcc taggctgact agcagctttc
     2221 ctgtatttgc ctggaaagtt ctggagttaa accacccagc tggcttcagg ttgcctctcc
     2281 tgcctggctt tctggttttg aggggcagta gctatcctgg tcatctagaa cttattatat
     2341 aaacttggcc attttactga gcatgaagct aacataaaga accctgtggg ggctcaaaga
     2401 ttaaattgaa aagaagggag aaaaaaagaa aaaaaagaaa aggaagtaaa aaggaacttg
     2461 gtcatgccca agccagtggc agagttagat cccaggtatc gtgtctgccc tacaaagtgg
     2521 gtctcttcct taagacctgg caccttctaa agatagtcta tagacttagg tccagtcccg
     2581 tgccaagtac cgactatagg aaggtgatgc catcttaggc ttaagggacc atgttcgacc
     2641 tagctaggtg cagtggctcc tggcaagttc tccagagtca gctcacaagc ctccacaaca
     2701 caggacctga ggggctgagg gacagctaaa ggatgtacta ggaacaaaag acctcaaatg
     2761 tatgtcatag tcaaacccaa aggactcagc cgtgcctcat tctctggaca tggtccttgt
     2821 gttctggttg agctctgcac tgggcactgg ggggttagag gcaaagtcac catgactgtt
     2881 aaggagcaga aaagaccatg gggaaaactt tgaatatgtt aagtgcagtc aggctccaga
     2941 tgctctgtta taagcccaga cttaccctca ggctctggga aagcccccaa cagccttggc
     3001 tctgccggct ctgttctgca tggccactga ctgggtcact aggcaaagca actgcgggca
     3061 gccattctga cacgttaaag aagggctcct ctgtgttgag ctccaggcaa ctgaggttag
     3121 ggatagcaga agtctcttgt tcccattgac cagtctcttc tttggggcaa gccatctgtg
     3181 gaaacaatgg gccagaactg gtctccatct tccccatgac catgtatgag accaacagac
     3241 ggggttgtta ggatgcaaga tgagagctct cctgatagca acacttgcta agggtgaact
     3301 ggagataaac ggtgaccaga gctgatccct gcctgtagaa gtcagagcta ctgaaagagc
     3361 tgttagaaaa tgctgtgaac tagtttggtg tgaccagtcg tacatatgat acaacatact
     3421 tgccacttta agtcatttga gtctctgagc ctccagagat gaaaccactt ttggattttg
     3481 gtaactgtta ctatcgtcat catatgtgaa cccatcccta aaccatgcag tggttagttt
     3541 tatatgactt tactggtttt actctgtctg agctccaata aattttaata caaag
//
