LOCUS       NM_078477               2652 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Kruppel-like transcription factor 16 (Klf16), mRNA.
ACCESSION   NM_078477
VERSION     NM_078477.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2652)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2652)
  AUTHORS   Xin,Y., Su,P., Liu,Y., Gu,S., An,X., Zhang,X., Yan,J., Guo,Y.,
            Zhou,J. and Yang,G.
  TITLE     Knock out hepatic Kruppel-like factor 16 (KLF16) improve myocardial
            damage and promoted myocardial protection of myocardial
            ischemia-reperfusion via anti-oxidative and anti-inflammation
            effects by TFAM/PPARbeta signal passage
  JOURNAL   Bioengineered 12 (2), 10219-10231 (2021)
   PUBMED   34823421
  REMARK    GeneRIF: Knock out hepatic Kruppel-like factor 16 (KLF16) improve
            myocardial damage and promoted myocardial protection of myocardial
            ischemia-reperfusion via anti-oxidative and anti-inflammation
            effects by TFAM/PPARbeta signal passage.
REFERENCE   3  (bases 1 to 2652)
  AUTHORS   Hayashi,S., Manabe,I., Suzuki,Y., Relaix,F. and Oishi,Y.
  TITLE     Klf5 regulates muscle differentiation by directly targeting
            muscle-specific genes in cooperation with MyoD in mice
  JOURNAL   Elife 5, e17462 (2016)
   PUBMED   27743478
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2652)
  AUTHORS   Jang,M.K., Lee,S. and Jung,M.H.
  TITLE     RNA-Seq Analysis Reveals a Negative Role of KLF16 in Adipogenesis
  JOURNAL   PLoS One 11 (9), e0162238 (2016)
   PUBMED   27611969
  REMARK    GeneRIF: results indicate that KLF16 inhibits adipogenesis through
            downregulation of PPARgamma expression
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2652)
  AUTHORS   Wang,J., Galvao,J., Beach,K.M., Luo,W., Urrutia,R.A., Goldberg,J.L.
            and Otteson,D.C.
  TITLE     Novel Roles and Mechanism for Kruppel-like Factor 16 (KLF16)
            Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5)
            Expression in Retinal Ganglion Cells
  JOURNAL   J Biol Chem 291 (35), 18084-18095 (2016)
   PUBMED   27402841
  REMARK    GeneRIF: methylation of only six of 98 CpG dinucleotides within the
            EphA5 promoter blocks its transactivation by KLF16 but enables
            transactivation by KLF2 and KLF15.
            Erratum:[J Biol Chem. 2016 Oct 7;291(41):21422. doi:
            10.1074/jbc.A116.732339.. PMID: 27825077]
REFERENCE   6  (bases 1 to 2652)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
REFERENCE   7  (bases 1 to 2652)
  AUTHORS   Lee,S.H., Kim,Y.M., Yajima,S., Ha,J.M., Ha,B.J., Kim,O.S.,
            Ohsawa,K. and Mouradian,M.M.
  TITLE     Genomic organization and promoter characterization of the murine
            dopamine receptor regulating factor (DRRF) gene
  JOURNAL   Gene 304, 193-199 (2003)
   PUBMED   12568728
REFERENCE   8  (bases 1 to 2652)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2652)
  AUTHORS   D'Souza,U.M., Lammers,C.H., Hwang,C.K., Yajima,S. and
            Mouradian,M.M.
  TITLE     Developmental expression of the zinc finger transcription factor
            DRRF (dopamine receptor regulating factor)
  JOURNAL   Mech Dev 110 (1-2), 197-201 (2002)
   PUBMED   11744383
  REMARK    GeneRIF: DRRF mRNA is expressed uniquely during development at all
            time points tested with high levels observed at E12, E14 and E16 in
            various tissues
REFERENCE   10 (bases 1 to 2652)
  AUTHORS   Hwang,C.K., D'Souza,U.M., Eisch,A.J., Yajima,S., Lammers,C.H.,
            Yang,Y., Lee,S.H., Kim,Y.M., Nestler,E.J. and Mouradian,M.M.
  TITLE     Dopamine receptor regulating factor, DRRF: a zinc finger
            transcription factor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7558-7563 (2001)
   PUBMED   11390978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044577.1 and AC152058.8.
            
            On Apr 11, 2007 this sequence version replaced NM_078477.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB619371.1, AK154524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1537              AK044577.1         2-1538
            1538-2652           AC152058.8         145463-146577       c
FEATURES             Location/Qualifiers
     source          1..2652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2652
                     /gene="Klf16"
                     /gene_synonym="BTEB4; DRRF"
                     /note="Kruppel-like transcription factor 16"
                     /db_xref="GeneID:118445"
                     /db_xref="MGI:MGI:2153049"
     exon            1..550
                     /gene="Klf16"
                     /gene_synonym="BTEB4; DRRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..852
                     /gene="Klf16"
                     /gene_synonym="BTEB4; DRRF"
                     /note="dopamine receptor regulating factor; BTE-binding
                     protein 4; transcription factor BTEB4; basic transcription
                     element-binding protein 4; Kruppel-like factor 16"
                     /codon_start=1
                     /product="Krueppel-like factor 16"
                     /protein_id="NP_510962.2"
                     /db_xref="CCDS:CCDS24026.1"
                     /db_xref="GeneID:118445"
                     /db_xref="MGI:MGI:2153049"
                     /translation="MSAAVACVDYFAADVLMAISSGAVVHRGRPGPEGAGPAAGLDVR
                     ATRREATPPGTPGAPPPPATAPGPGGATAAPHLLAASILADLRGGPVVATAASTAGGT
                     SPVSSSSAASSPSSGRAPGAAKSHRCPFHGCAKAYYKSSHLKSHLRTHTGERPFACDW
                     PGCDKKFARSDELARHHRTHTGEKRFPCPLCTKRFTRSDHLTKHARRHPGFRPELLRR
                     PGARSVSPSDSLPCSLAGSPTPSPVPSPAPAGL"
     exon            551..2652
                     /gene="Klf16"
                     /gene_synonym="BTEB4; DRRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2627..2632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf16"
                     /gene_synonym="BTEB4; DRRF"
                     /note="hexamer: ATTAAA"
     polyA_site      2649
                     /gene="Klf16"
                     /gene_synonym="BTEB4; DRRF"
                     /note="major polyA site"
ORIGIN      
        1 gcactctagc agccgctgcc ggccggacgg gcgtaggtcc caccgcctcc gcttctctcc
       61 cgccgccgat tccgtgtctc cgcgtccttg cccggcatgt cggcggccgt ggcgtgtgtg
      121 gattactttg ccgccgacgt gctcatggcc atctcctcgg gagccgtggt gcatcgcgga
      181 cgacccggcc ccgagggcgc gggccccgct gccggtctgg atgtgcgcgc cacgcgccgc
      241 gaggccacgc cgccggggac ccctggggca ccgccaccgc cagctacggc tccggggccg
      301 ggaggcgcca ccgctgcgcc ccacctgctg gccgccagca tcctggccga tctgagaggc
      361 gggccggtag tcgccaccgc agccagcacc gcggggggca cctctccggt ctcctcctcc
      421 tcagccgctt cgtctccctc ttcgggccgc gcccccggcg ccgccaaaag ccaccgctgt
      481 cccttccatg gctgcgccaa agcctattac aagtcttcgc acctcaagtc acacctgcgg
      541 actcacacag gtgagcggcc ctttgcctgc gactggcctg gctgtgacaa gaagttcgcc
      601 cgttctgatg agctggcccg ccaccaccgg acgcacaccg gggagaagcg cttcccctgc
      661 cccctgtgta ccaagcggtt cacccgaagc gaccacctga ccaagcacgc ccggcgacat
      721 cccggcttcc gcccggaact cctgcgacga cctggtgccc gcagcgtctc gcccagcgac
      781 tcgctgccct gcagcttggc tggaagcccc acacctagcc ctgtccccag cccagctcct
      841 gctggcttgt agagccctga cgtgtccacc ctgagtggcc tccttactgg gcctcagcag
      901 ggatttctat caagggacac atctgtcctc tggagagcct gtgtcctgga gttccagccc
      961 acctcaagaa agcagcaagg ggactgagaa tggacttggg tcacctgggg ggcctgggag
     1021 gtggcctcag gttctgtctg taaatagcca tggttaactg tcctgtcccc tctgcaggga
     1081 ccccaaatgg gcagttggca ggccccccca tcccttcctg ccaccctctg ctttccctcc
     1141 tgggtggcgt tgggcatgaa gcctacccca ctccttgtct tcagccccct agtcacccct
     1201 ccaggttggg acacaggtac acagagccat aggtgactgg ggcttcccat gggcccctac
     1261 ctgtccccac tccactgaaa gccattggcg gaagttcagg gaaatggggg gggtgcagcc
     1321 tggctgaccc ccttccatgg gtactcaaat ctcaggtgtc cataggttct gccctcaata
     1381 agggcccccc actcccagcc ccaggggtac aggagaccca cagttttcag agaacttagg
     1441 gctgtggggt acaggtgggg cacgtggagg tgcatccccc acatccccgc tcaccttggg
     1501 tgtggtgctg ggcagatggg aaagaaatta tttattgtcc tctctgactg ctggtgtggg
     1561 ggggcctggc tccccctatc tgggtgtgca tatgtgtgag agagacagtg ggtgtctggt
     1621 gcctggggct tagcctcctt actcccactg ggttagggtc cctgagtttg gcctttgtgg
     1681 cattgcgtct cagacaatct ataggacccc tgcggccatc gggctatgga tacagggctc
     1741 tggtctgccg tcatgtgctc cacactctcg ggtgtctgca gagggtggcc ttggactcca
     1801 ggattgggaa cagggcgttc agctcctgga ccttctgggg tagctcgggt tttttttttt
     1861 tttgcacagg atagatttat ttttttcagg ctctgagttc catgttccag tgggggtccc
     1921 cttgtgtggc cgtcatcctc aggggtgagt ggggaaggtc tcaggagagt ctacagtagg
     1981 atcctctact actgcagact ggatttcttt tctagaaagg caattaggga ttgccacaca
     2041 cacaccaaga aattggggac acagagaaag ttgagctgcc ctgtgttggc tgtggggggt
     2101 ttactggcat tcccatttgt tccagaatct tccatcatga aatgagggag gctttgggta
     2161 atgctacctt tacctgagcc tacatgaggg aggtcaccct tctggagctg ggctgagggc
     2221 cctgggccag ctcctctcct gggtacttcc atttgcccct tctctttggc cacagaaatg
     2281 agatgcctta gtttgcaggg tgggtggggg gctggggcca attctttttg tcttttggat
     2341 gtatcttgct tcatcccagc tcctgctggt ctcctgtcct tcctgtaaac agggggaaag
     2401 gactgaggtt cttaggagtt aactccataa gcaatcagag cttttccgtg atgtcctccc
     2461 ccagcccccc aacttcaggt tctgattgat aactgggact tgggtctaac cattgaaggg
     2521 tgatgaacgc agggcaggca ggacaagggt cctaagggat ttatttgttc tttctgtagg
     2581 gggcacctct cctccattcc gcctggcctc tcacccatat atttaaatta aagaagccct
     2641 ttttaaaaac ct
//
