LOCUS       NM_023184               2373 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 15 (Klf15),
            transcript variant 1, mRNA.
ACCESSION   NM_023184
VERSION     NM_023184.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2373)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2373)
  AUTHORS   Hu,Y., Cao,H., Sheng,J., Sun,Y., Zhu,Y., Lin,Q., Yi,N., He,S.,
            Peng,L. and Li,L.
  TITLE     Functional role of circRNA CHRC through miR-431-5p/KLF15 signaling
            axis in the progression of heart failure
  JOURNAL   J Genet Genomics 51 (8), 844-854 (2024)
   PUBMED   38575112
  REMARK    GeneRIF: Functional role of circRNA CHRC through miR-431-5p/KLF15
            signaling axis in the progression of heart failure.
REFERENCE   3  (bases 1 to 2373)
  AUTHORS   Li,L. and Feldman,B.J.
  TITLE     White adipocytes in subcutaneous fat depots require KLF15 for
            maintenance in preclinical models
  JOURNAL   J Clin Invest 134 (13), e172360 (2024)
   PUBMED   38949025
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2373)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   5  (bases 1 to 2373)
  AUTHORS   Fang,G., Tian,Y., Huang,S., Zhang,X., Liu,Y., Li,Y., Du,J. and
            Gao,S.
  TITLE     KLF15 maintains contractile phenotype of vascular smooth muscle
            cells and prevents thoracic aortic dissection by interacting with
            MRTFB
  JOURNAL   J Biol Chem 300 (5), 107260 (2024)
   PUBMED   38582447
  REMARK    GeneRIF: KLF15 maintains contractile phenotype of vascular smooth
            muscle cells and prevents thoracic aortic dissection by interacting
            with MRTFB.
REFERENCE   6  (bases 1 to 2373)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
REFERENCE   7  (bases 1 to 2373)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
REFERENCE   8  (bases 1 to 2373)
  AUTHORS   Mori,T., Sakaue,H., Iguchi,H., Gomi,H., Okada,Y., Takashima,Y.,
            Nakamura,K., Nakamura,T., Yamauchi,T., Kubota,N., Kadowaki,T.,
            Matsuki,Y., Ogawa,W., Hiramatsu,R. and Kasuga,M.
  TITLE     Role of Kruppel-like factor 15 (KLF15) in transcriptional
            regulation of adipogenesis
  JOURNAL   J Biol Chem 280 (13), 12867-12875 (2005)
   PUBMED   15664998
  REMARK    GeneRIF: KLF15 plays an essential role in adipogenesis in 3T3-L1
            cells through its regulation of PPAR gamma expression
REFERENCE   9  (bases 1 to 2373)
  AUTHORS   Otteson,D.C., Liu,Y., Lai,H., Wang,C., Gray,S., Jain,M.K. and
            Zack,D.J.
  TITLE     Kruppel-like factor 15, a zinc-finger transcriptional regulator,
            represses the rhodopsin and interphotoreceptor retinoid-binding
            protein promoters
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2522-2530 (2004)
   PUBMED   15277472
REFERENCE   10 (bases 1 to 2373)
  AUTHORS   Gray,S., Feinberg,M.W., Hull,S., Kuo,C.T., Watanabe,M.,
            Sen-Banerjee,S., DePina,A., Haspel,R. and Jain,M.K.
  TITLE     The Kruppel-like factor KLF15 regulates the insulin-sensitive
            glucose transporter GLUT4
  JOURNAL   J Biol Chem 277 (37), 34322-34328 (2002)
   PUBMED   12097321
  REMARK    GeneRIF: KLF15 is an important regulator of GLUT4 in both adipose
            and muscle tissues.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163346.3.
            
            On Sep 23, 2017 this sequence version replaced NM_023184.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138824.1, AK009739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC163346.3         38720-38869         c
            151-1254            AC163346.3         33922-35025         c
            1255-2373           AC163346.3         26207-27325         c
FEATURES             Location/Qualifiers
     source          1..2373
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6"
     gene            1..2373
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /note="Kruppel-like transcription factor 15"
                     /db_xref="GeneID:66277"
                     /db_xref="MGI:MGI:1929988"
     exon            1..150
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            151..1254
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1423
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     krueppel-like factor 15; cardiovascular Krueppel-like
                     factor; Kruppel-like factor 15"
                     /codon_start=1
                     /product="Krueppel-like factor 15 isoform 1"
                     /protein_id="NP_075673.1"
                     /db_xref="CCDS:CCDS20360.1"
                     /db_xref="GeneID:66277"
                     /db_xref="MGI:MGI:1929988"
                     /translation="MVDHLLPVDETFSSPKCSVGYLGDRLASRQPYHMLPSPISEDDS
                     DVSSPCSCASPDSQAFCSCYSAGPGPEAQGSILDFLLSRATLGSGGGSGGIGDSSGPV
                     TWGSWRRASVPVKEEHFCFPEFLSGDTDDVSRPFQPTLEEIEEFLEENMEAEVKEAPE
                     NGSRDLETCSQLSAGSHRSHLHPESAGRERCTPPPGGTSGGGAQSAGEGPAHDGPVPV
                     LLQIQPVAVKQEAGTGPASPGQAPESVKVAQLLVNIQGQTFALLPQVVPSSNLNLPSK
                     FVRIAPVPIAAKPIGSGSLGPGPAGLLVGQKFPKNPAAELLKMHKCTFPGCSKMYTKS
                     SHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARS
                     DHLSKHIKVHRFPRSSRAVRAIN"
     exon            1255..2373
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /note="hexamer: CATAAA"
     polyA_site      2231
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /note="major polyA site"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /note="hexamer: TATAAA"
     polyA_site      2293
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /note="major polyA site"
     regulatory      2321..2326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /note="hexamer: CATAAA"
     polyA_site      2343
                     /gene="Klf15"
                     /gene_synonym="1810013I09Rik; CKLF; hlb444; KKLF"
                     /note="major polyA site"
ORIGIN      
        1 gtgagcggcc ggagagcggg gagagcggcg agcggcgagc gcccagctcg gccgcaggga
       61 gtgcgggctg cggccaggag cgctggacgc gcggccgcat acggagccgg gccgcacgcg
      121 cgaggccgcg ccaggcgacg cggagtccag tcaccacagg ctcggccagg ccagcatggt
      181 ggaccacctg cttccagtgg acgagacctt ctcgtcaccg aaatgctcag tgggttacct
      241 aggggacagg ctggccagcc ggcagccata ccacatgttg ccctcgccca tctcggagga
      301 tgacagcgat gtctccagcc cctgctcttg tgccagccct gactcgcaag ccttctgttc
      361 ctgctacagt gcgggtccag gccctgaggc ccagggcagc atcttggatt tcctcctgtc
      421 ccgggccaca ctgggcagtg gtggtggcag tggaggtatt ggagatagca gtggccctgt
      481 gacctgggga tcatggagga gagcctctgt gcctgtgaag gaggaacatt tctgcttccc
      541 tgaatttctg tcaggggaca ctgatgacgt ctccaggccc ttccagccta ccctggagga
      601 gattgaagaa ttcctggaag agaacatgga ggctgaggtc aaggaggccc cagagaacgg
      661 tagcagggac ctggagacct gtagccagct ctcagctggg tcacaccgga gccaccttca
      721 tccagagtct gctgggagag agcgctgtac cccaccacca ggtggcacga gtgggggtgg
      781 tgcccaaagt gcaggtgagg ggccagcaca tgatggcccc gtgccggtgc tactgcagat
      841 ccagcctgtt gctgtgaagc aggaggcagg tacagggcca gcctccccag ggcaggcccc
      901 agagagcgtc aaggtcgccc agcttctagt caacatccag gggcagacct ttgcactcct
      961 gcctcaagtg gtaccatcct ccaacttgaa cctgccctca aagtttgtgc gaattgcgcc
     1021 tgtgcccatt gccgccaaac ctattggctc aggatcccta gggcccggcc ctgctggcct
     1081 ccttgtgggc cagaagtttc ccaagaaccc agcagcagaa cttctcaaaa tgcacaaatg
     1141 cactttccca ggctgcagca agatgtacac caagagcagc cacctcaagg cccacctgcg
     1201 tcggcacaca ggcgagaagc cctttgcctg cacctggcca ggctgcggct ggaggttttc
     1261 ccgctcagat gagttgtcaa ggcaccggcg atctcactcg ggtgtgaagc cgtaccagtg
     1321 tcccgtgtgc gagaagaaat tcgcgcggag tgaccacctc tccaaacaca tcaaagtgca
     1381 tcgcttccca cgaagcagcc gcgcagtacg cgccatcaac tgagcgcagt ggccgccctt
     1441 ccctccccca gctccacgtt ttgtttttaa atgcaataac ttattgcctc ttttcagaag
     1501 gatgtgacaa tattaccagc cccctccccc ttctgaatct taggaggtat gacccagagc
     1561 caccatggct gcctttctgg ggaagaccta gagtccctat ggtccctggg ggctggttcc
     1621 ccggtggccc aggtggccca ggcaggcctg tgcccttgtg cctttgtgcc ttcctgccag
     1681 ctggaagcag tgtttggggg gcccttgccc tcttcccact gggctcccta cctgggccaa
     1741 agtcaacatc attgctgggg aagaagtgtt ttggctgtgt caaaatagta gctcccagag
     1801 gaagcaagcc atgctgggaa aaaggaagtg ggtcaaaaaa gcgtagggct gcactgtgat
     1861 gtgaggaccg ccatatgcaa gaggcctttg agggtccagg aggatggcca ccctcgctct
     1921 aggccgtaat gcatgtgctt aaatgcaaga caaatggagc catagccagc cgtacccagc
     1981 ctggctcacc ctcctccaga caccagacac cagcctcctg gttgtggtga gaggagaagg
     2041 gaacaggtct ggtggatgcc aagcaactag ttagtgcctc ccagtctgac ctagatttgc
     2101 attcctcatc aggactagaa attagtacca attgaactag cttgttttga caggtctatt
     2161 tcacatccta tgaatgtatg taaataaact gtacataggt acgcatctac ataaaatatc
     2221 ttttaataac acgttgacat ttgtgtaaat ttgaaattta aaaaaattct ataaagttgg
     2281 tgtacatatg ttacaattat gtatattttc tttggtcctt cataaaaaat atatttactt
     2341 tgccaataaa aagaggaaaa aaaaaaagaa ctc
//
