LOCUS       NM_001135093            2970 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 14 (Klf14), mRNA.
ACCESSION   NM_001135093 XM_001476241 XM_884028
VERSION     NM_001135093.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Mao,X., Li,Y., Zhong,Y., Chen,R., Wang,K., Huang,D. and Luo,X.
  TITLE     Kruppel-like factor 14 ameliorated obesity and related metabolic
            disorders by promoting adipose tissue browning
  JOURNAL   Am J Physiol Endocrinol Metab 325 (6), E744-E754 (2023)
   PUBMED   37938176
  REMARK    GeneRIF: Kruppel-like factor 14 ameliorated obesity and related
            metabolic disorders by promoting adipose tissue browning.
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Hou,Y., Song,Q., Wang,Y., Liu,J., Cui,Y., Zhang,X., Zhang,J.,
            Fu,J., Cao,M., Zhang,C., Liu,C., Wang,X., Duan,H. and Wang,P.
  TITLE     Downregulation of Kruppel-like factor 14 accelerated cellular
            senescence and aging
  JOURNAL   Aging Cell 22 (10), e13950 (2023)
   PUBMED   37551728
  REMARK    GeneRIF: Downregulation of Kruppel-like factor 14 accelerated
            cellular senescence and aging.
REFERENCE   4  (bases 1 to 2970)
  AUTHORS   Chen,X., Shi,W., Xie,Y., Wang,Y., Yao,Q., Ke,H., Xu,X., Liu,H.,
            Liu,P. and Zhou,X.
  TITLE     Hepatic Kruppel-like factor 14 regulates lipid metabolism in
            nonalcoholic steatohepatitis mice
  JOURNAL   FASEB J 37 (8), e23070 (2023)
   PUBMED   37389939
  REMARK    GeneRIF: Hepatic Kruppel-like factor 14 regulates lipid metabolism
            in nonalcoholic steatohepatitis mice.
REFERENCE   5  (bases 1 to 2970)
  AUTHORS   Chen,L., Sha,M.L., Chen,F.T., Jiang,C.Y., Li,D., Xu,C.L., Pan,D.S.,
            Xu,Z.J., Tang,Q.L., Xia,S.J., Sun,L.H., Fan,G.J. and Shao,Y.
  TITLE     Upregulation of KLF14 expression attenuates kidney fibrosis by
            inducing PPARalpha-mediated fatty acid oxidation
  JOURNAL   Free Radic Biol Med 195, 132-144 (2023)
   PUBMED   36584797
  REMARK    GeneRIF: Upregulation of KLF14 expression attenuates kidney
            fibrosis by inducing PPARalpha-mediated fatty acid oxidation.
REFERENCE   6  (bases 1 to 2970)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2970)
  AUTHORS   Gonzalez,C.R., Vallcaneras,S.S., Calandra,R.S. and Gonzalez
            Calvar,S.I.
  TITLE     Involvement of KLF14 and egr-1 in the TGF-beta1 action on Leydig
            cell proliferation
  JOURNAL   Cytokine 61 (2), 670-675 (2013)
   PUBMED   23317878
  REMARK    GeneRIF: The presence of progesterone induced the gene expression
            of egr-1 and also KLF14, indicating that this steroid channels the
            signaling pathway into a non-canonical mechanism.
REFERENCE   8  (bases 1 to 2970)
  AUTHORS   Himes,K.P., Koppes,E. and Chaillet,J.R.
  TITLE     Generalized disruption of inherited genomic imprints leads to
            wide-ranging placental defects and dysregulated fetal growth
  JOURNAL   Dev Biol 373 (1), 72-82 (2013)
   PUBMED   23085235
REFERENCE   9  (bases 1 to 2970)
  AUTHORS   Parker-Katiraee,L., Carson,A.R., Yamada,T., Arnaud,P., Feil,R.,
            Abu-Amero,S.N., Moore,G.E., Kaneda,M., Perry,G.H., Stone,A.C.,
            Lee,C., Meguro-Horike,M., Sasaki,H., Kobayashi,K., Nakabayashi,K.
            and Scherer,S.W.
  TITLE     Identification of the imprinted KLF14 transcription factor
            undergoing human-specific accelerated evolution
  JOURNAL   PLoS Genet 3 (5), e65 (2007)
   PUBMED   17480121
  REMARK    GeneRIF: KLF14 gene is intronless, and is monoallelically expressed
            from the maternal allele in both human and mouse.
REFERENCE   10 (bases 1 to 2970)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121800.2.
            
            On or before Sep 21, 2008 this sequence version replaced
            XM_001476241.1, XM_884028.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DQ534758.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 17480121
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2970              AC121800.2         74924-77893
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.54 cM"
     gene            1..2970
                     /gene="Klf14"
                     /gene_synonym="5330411L03Rik; BTEB5"
                     /note="Kruppel-like transcription factor 14"
                     /db_xref="GeneID:619665"
                     /db_xref="MGI:MGI:3577024"
     exon            1..2970
                     /gene="Klf14"
                     /gene_synonym="5330411L03Rik; BTEB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2840..2845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf14"
                     /gene_synonym="5330411L03Rik; BTEB5"
                     /note="hexamer: AGTAAA"
     polyA_site      2862
                     /gene="Klf14"
                     /gene_synonym="5330411L03Rik; BTEB5"
ORIGIN      
        1 gcagacaaga taatttccca ggctgctggg aatgccatag cccgcgcggc agcgcgatcc
       61 aggggtgtcc tcgggccggg gcgggtcccc gccacccccg caggcttcag tgcgtcaggg
      121 cgcgtcaggc ggggcgggct cggctccggc agcagcggct gcgggcggcg agcggcgcgc
      181 accggcttcc agctcgtctg gctccaagcg gcgggacgga cgctcccggg gactctccgg
      241 cccgcggctg gccgcgctcg gacggcgctc gcccgcaacc gggcgccgcc agcatgtcgg
      301 ccgccgtggc ttgcctggac tacttcgctg ccgagtgcct ggtgtctatg tccacccgcg
      361 ccgtgctgca ccggcgcgca acggaccccg aaggcgcgag cgcagcggct gtctccgagg
      421 tgggtgcagt gtctcgggag tcggcgggga agggtaccgg gtcacggggg gtgctgtgga
      481 tacccccagt cctccaggtc cccaccccga gccccggaga aggcgatggc gcgccccacc
      541 tgctggctgc gagcgctttg gctgatttaa gctgtggtgc ccgggaagac ttcagggaag
      601 actccgaaga agctccgtgt gcctcaacta gctgcttcga gccgacctgg tgctccagcc
      661 ctactggggg ctctgagcct acccaggcct tcttcgagga tgagctctct gacgccgaga
      721 gctcctgcag tgattctgct atcctggatg cgcctgaggc ctcagaggag ccggatgaca
      781 gcggagaagt gcccgagggg cccccagggg cccgccctgc gccatcaacg ggcccgacgt
      841 accgaaggag gcagattacg cccgcatcca agcgacatca gtgctccttc catggctgca
      901 acaaggccta ctacaagtcg tcgcacctca agtcacacca gcgtacccac acgggggaac
      961 gccccttctc ctgtgattgg ctcgactgcg acaagaagtt tacgcgttct gatgagctag
     1021 cccgccacta caggacgcac accggtgaaa agcgcttctc ctgcccgctg tgtcccaagc
     1081 agttctctcg gagcgaccac ctgaccaagc atgctcgtcg ccatccaact taccatcccg
     1141 acatgatcga gtaccgaggt cgtcgtcgca ctccccgccc tgagccacca cccccagcca
     1201 tggtggaaag ctctggttcc gactccagct cctcttctgg ccaggagacc agcttcactg
     1261 cttgcctgta ggactgtctt gctgtctatc tttccctcaa gcacaacccc cacccccgct
     1321 gccccccagg ccgttgtcca tgccttctct ctgtccattc ctattttcca gggtcattag
     1381 accgaggtac agactggttg ctccgcactg gggatgggtt cagacaaact tgtcggactc
     1441 tggagaggga ctgggagcca gaagatagca ggaagtcctg caacacaaac atcttctgaa
     1501 atgaacggtt tcttccaaac agcctgcagg aacctttgag aagggatgaa ctctccagcg
     1561 tactgaagtt tcttccctcc atggcaccag agatgtaaaa ctgaattctg agatgctgga
     1621 ggatctccca gttccaaatg actctggtgt ctcacccatt ggccagggcg gactttggag
     1681 agggtgtcca gggtggcagc cttggaaatg tccagatttg gatgaagaga ggcctttgga
     1741 aacagaaaat atttctattt ctgtaaacag caatgtttac taatttattt tcggtatctt
     1801 gtaaacaaaa attcaggttg atgggaagct aatgtctttg actctcccga ttgccccagc
     1861 tacctctgct ttgtggatgt atggctggga gatgcttttt ggtgcctggg gagtggtatg
     1921 agtctgcttg cagttcctat agcgtaattt tgaaccccgc actcgcattg taaccttttt
     1981 tttttttttt tttttcaatt ccttctcagg ggtggtaact ttctggctca cgattatgga
     2041 gagattggtt aagtattttg gaaacaatca taacagcaca agagagaaaa ggctggtctg
     2101 aaatagcttc tccttcacct agaatgcaag cccaagtaac ttttgagtgg gacaggtaca
     2161 aaacagcact tttcacaacc tttgttagct gttccattgg agcggagaga tgaagttcct
     2221 gatgccccac cctaagtaat cttaggggta gtagagtcta ttcacctctt agtggcttag
     2281 tagggcttaa tttcagtgaa ggtctgtaca ttgttgtttc tgttacaggt gaattggtgg
     2341 gtgaggggga aaagtgagag attggttaat tttagagagc tgctgtcttg gatttggggt
     2401 gagagcagct agacaatagc tgttatcaaa taggagcacc tttctctagc atcagaatct
     2461 taggttaaaa cctcagggcc cttctgcccc cttgaaggaa taagatatca gaagtattct
     2521 tctgttgtgt gtcccagcta ctgtggattg aaatcactga tgtttgtgtg tacgtgtgtg
     2581 tgtgcgtata cgtgtgtgtt tctttcatta aatatgaggc tgaaaggcct ttcctaaccc
     2641 gatgaggtcc cctatgatcc cctcctgcat atcttaaacc acccatcaat cacacttgta
     2701 aagggtgttg tgatctcatg gagttgtaag agtcacttga gtaagcaaat tgctttcccc
     2761 tgttttatag attaaaacgc tgatgcttaa attatcttaa aagttatatg ctaagtttct
     2821 gccaagagct aagagtaaaa gtaaaatgta ttgactttta aatggtgttc ctttgtgatt
     2881 gtgttcccat gttctcaccc tacctcccta tcaccatgat ccccctgcca tcctgttttc
     2941 tgctgctgct ataaatcttt aaatgctgag
//
