LOCUS       NM_021366               6396 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 13 (Klf13), mRNA.
ACCESSION   NM_021366
VERSION     NM_021366.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6396)
  AUTHORS   Yang,S., Xiong,L., Yang,G., Xiang,J., Li,L., Kang,L. and Liang,Z.
  TITLE     KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle
            atrophy
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (5), 1869-1882 (2024)
   PUBMED   38973459
  REMARK    GeneRIF: KLF13 restrains Dll4-muscular Notch2 axis to improve the
            muscle atrophy.
REFERENCE   2  (bases 1 to 6396)
  AUTHORS   Yang,S., Xiang,J., Ma,C., Yang,G., Wang,X., Liu,H., Fan,G., Kang,L.
            and Liang,Z.
  TITLE     Sp1-like protein KLF13 acts as a negative feedback regulator of
            TGF-beta signaling and fibrosis
  JOURNAL   Cell Rep 42 (4), 112367 (2023)
   PUBMED   37029927
REFERENCE   3  (bases 1 to 6396)
  AUTHORS   Zeng,N., Jian,Z., Zhu,W., Xu,J., Fan,Y. and Xiao,F.
  TITLE     KLF13 overexpression protects sepsis-induced myocardial injury and
            LPS-induced inflammation and apoptosis
  JOURNAL   Int J Exp Pathol 104 (1), 23-32 (2023)
   PUBMED   36583453
  REMARK    GeneRIF: KLF13 overexpression protects sepsis-induced myocardial
            injury and LPS-induced inflammation and apoptosis.
REFERENCE   4  (bases 1 to 6396)
  AUTHORS   Bernhardt,C., Sock,E., Frob,F., Hillgartner,S., Nemer,M. and
            Wegner,M.
  TITLE     KLF9 and KLF13 transcription factors boost myelin gene expression
            in oligodendrocytes as partners of SOX10 and MYRF
  JOURNAL   Nucleic Acids Res 50 (20), 11509-11528 (2022)
   PUBMED   36318265
  REMARK    GeneRIF: KLF9 and KLF13 transcription factors boost myelin gene
            expression in oligodendrocytes as partners of SOX10 and MYRF.
REFERENCE   5  (bases 1 to 6396)
  AUTHORS   Malwade,S., Gasthaus,J., Bellardita,C., Andelic,M., Moric,B.,
            Korshunova,I., Kiehn,O., Vasistha,N.A. and Khodosevich,K.
  TITLE     Identification of Vulnerable Interneuron Subtypes in 15q13.3
            Microdeletion Syndrome Using Single-Cell Transcriptomics
  JOURNAL   Biol Psychiatry 91 (8), 727-739 (2022)
   PUBMED   34838304
REFERENCE   6  (bases 1 to 6396)
  AUTHORS   Kaczynski,J., Zhang,J.S., Ellenrieder,V., Conley,A., Duenes,T.,
            Kester,H., van Der Burg,B. and Urrutia,R.
  TITLE     The Sp1-like protein BTEB3 inhibits transcription via the basic
            transcription element box by interacting with mSin3A and HDAC-1
            co-repressors and competing with Sp1
  JOURNAL   J Biol Chem 276 (39), 36749-36756 (2001)
   PUBMED   11477107
REFERENCE   7  (bases 1 to 6396)
  AUTHORS   Martin,K.M., Metcalfe,J.C. and Kemp,P.R.
  TITLE     Expression of Klf9 and Klf13 in mouse development
  JOURNAL   Mech Dev 103 (1-2), 149-151 (2001)
   PUBMED   11335124
REFERENCE   8  (bases 1 to 6396)
  AUTHORS   Scohy,S., Gabant,P., Van Reeth,T., Hertveldt,V., Dreze,P.L., Van
            Vooren,P., Riviere,M., Szpirer,J. and Szpirer,C.
  TITLE     Identification of KLF13 and KLF14 (SP6), novel members of the
            SP/XKLF transcription factor family
  JOURNAL   Genomics 70 (1), 93-101 (2000)
   PUBMED   11087666
REFERENCE   9  (bases 1 to 6396)
  AUTHORS   Asano,H., Li,X.S. and Stamatoyannopoulos,G.
  TITLE     FKLF-2: a novel Kruppel-like transcriptional factor that activates
            globin and other erythroid lineage genes
  JOURNAL   Blood 95 (11), 3578-3584 (2000)
   PUBMED   10828046
REFERENCE   10 (bases 1 to 6396)
  AUTHORS   Martin,K.M., Cooper,W.N., Metcalfe,J.C. and Kemp,P.R.
  TITLE     Mouse BTEB3, a new member of the basic transcription element
            binding protein (BTEB) family, activates expression from GC-rich
            minimal promoter regions
  JOURNAL   Biochem J 345 Pt 3 (Pt 3), 529-533 (2000)
   PUBMED   10642511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148977.3 and AC127344.3.
            
            On Jul 28, 2009 this sequence version replaced NM_021366.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF251796.1, AK155298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-949               AC148977.3         44701-45649
            950-6396            AC127344.3         527-5973
FEATURES             Location/Qualifiers
     source          1..6396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 34.58 cM"
     gene            1..6396
                     /gene="Klf13"
                     /gene_synonym="0610043C13Rik; 9430029L20Rik; Bteb3;
                     FKLF-2; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /note="Kruppel-like transcription factor 13"
                     /db_xref="GeneID:50794"
                     /db_xref="MGI:MGI:1354948"
     exon            1..949
                     /gene="Klf13"
                     /gene_synonym="0610043C13Rik; 9430029L20Rik; Bteb3;
                     FKLF-2; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..1239
                     /gene="Klf13"
                     /gene_synonym="0610043C13Rik; 9430029L20Rik; Bteb3;
                     FKLF-2; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /note="C2-H2 zinc finger protein; BTE-binding protein 3;
                     transcription factor BTEB3; erythroid transcription factor
                     FKLF-2; basic transcription element-binding protein 3;
                     RANTES factor of late activated T-lymphocytes 1;
                     Kruppel-like factor 13"
                     /codon_start=1
                     /product="Krueppel-like factor 13"
                     /protein_id="NP_067341.2"
                     /db_xref="CCDS:CCDS21331.1"
                     /db_xref="GeneID:50794"
                     /db_xref="MGI:MGI:1354948"
                     /translation="MAAAAYVDHFAAECLVSMSSRAVVHEPREGPEPRPEGAAAAAPT
                     LPRVDERRDGKDSASLFVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPAPP
                     APPPGPEPASPGQAGAPAAPPSPAWSEPEAALEQEPGPAGSGEPGLRQRGRRGRSRAD
                     LESPQRKHKCHYAGCEKVYGKSSHLKAHLRTHTGERPFACSWQECNKKFARSDELARH
                     YRTHTGEKKFSCPICEKRFMRSDHLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRS
                     DASSPTISPASSP"
     exon            950..6396
                     /gene="Klf13"
                     /gene_synonym="0610043C13Rik; 9430029L20Rik; Bteb3;
                     FKLF-2; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3981..3986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf13"
                     /gene_synonym="0610043C13Rik; 9430029L20Rik; Bteb3;
                     FKLF-2; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /note="hexamer: AACAAG"
     polyA_site      3999
                     /gene="Klf13"
                     /gene_synonym="0610043C13Rik; 9430029L20Rik; Bteb3;
                     FKLF-2; FKLF2; NSLP1; RFLAT-1; RFLAT1"
     regulatory      6376..6381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf13"
                     /gene_synonym="0610043C13Rik; 9430029L20Rik; Bteb3;
                     FKLF-2; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /note="hexamer: AATAAA"
     polyA_site      6396
                     /gene="Klf13"
                     /gene_synonym="0610043C13Rik; 9430029L20Rik; Bteb3;
                     FKLF-2; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /note="major polyA site"
ORIGIN      
        1 acaccgagcc gcggcgcgca cggaggctgt cccgcctgcc acaatgcacg gtggaactgc
       61 gaccacaact tgcaggggtc gtgcctaacg tcgcctccgc tcgacgtccc taagacaggc
      121 cgactctgac gccgcacgcg gaccctcctt actggagccc cccatgcgct caccctccag
      181 tgcccggcca ggcggacgcg gagccgcgcg ggtgacggca gaagcggcta cgcgcccagc
      241 ctagcccagc ccagcccagc cggagaagag ggcgcgccgc gcccccgccc cccgccgctc
      301 ccggaggccg tgggtgcgga tgcgccgctg acgactcctg cgagagcacc gcgcgcccta
      361 gcccgcagca tggcagccgc cgcctatgtg gaccactttg ccgccgagtg cctcgtgtcc
      421 atgtccagcc gcgcagtcgt gcacgagccg cgggaaggac ctgaaccccg gcccgagggc
      481 gcggccgccg ccgcccccac actgccccgc gttgacgagc gccgcgacgg caaggacagc
      541 gcctcgcttt tcgtggtggc tcggatccta gcggacctca accagcaggc gccggcgccc
      601 gcccccgcgg aacgcagaga aggggccgct gcgcgcaagg cgaggacccc ctgccgcctg
      661 ccgcctgcgc cccctgcgcc gccacccggc ccagagcccg cctccccggg acaagcaggc
      721 gcgccggccg cgccccccag ccccgcgtgg agcgagccgg aggcggcatt ggagcaggag
      781 cccggccccg cggggagcgg cgagcctggc ctcagacaaa ggggtcggcg aggccggagc
      841 cgcgcggacc tcgagtcccc gcagaggaag cacaagtgcc actacgcggg ctgcgagaaa
      901 gtttacggga aatcttcgca cctcaaggcg cacctgagaa ctcacacagg tgagaggcct
      961 ttcgcctgca gctggcagga gtgcaacaag aagttcgcac gctcggacga gctggcacgg
     1021 cactatcgca cgcacacggg cgagaagaag ttcagctgcc ccatctgtga gaagcgcttc
     1081 atgcggagcg accacctgac gaagcacgca cgccgccacg ccaacttcca cccaggcatg
     1141 ctgcagcggc gcggcggggg ctcgaggacc ggctcgctca gcgactacag ccgctccgat
     1201 gccagcagcc ccaccatcag cccggccagc tcaccctgag cacccgcgcc tggaccgcgc
     1261 ctcctcaccc ctttggtaat aggaaagctg agcgaacttg agaagtccac agcaaaacag
     1321 ttttcttcac ctcaggtgtc aatttttaac aaaaagaaaa aaaaaatctc aaaaaaaaaa
     1381 ttaaaacaaa acaaaaacac cacccacaaa ttgcacaaat acagctatcc acgaagatga
     1441 gattcagcgg tgttgaaccc ccctctcccc caccccaccc cccctttctc agggatgaac
     1501 gcggtccacg aggtcagtga gggcatgcct ttctgccgcc ttactttgta catagatttg
     1561 cactctggag tttctgtgag gtttaggatt acattggggc agaacaggac agctggagac
     1621 agtgatgtgg tgtttttgca gaagaccccc cccccccccc caaaggccta ggaccctctc
     1681 ttgcctacca ctcaattgtg gttctctgcc ctttggcctg gctaagagac cggccacctc
     1741 acagggatgt ggtaagccat gacagaccat gggagcactt gcctatggaa ctgtgaagga
     1801 cctctgcctt ctaaggctgg tcctgtctgc ctgcctgcct gcctgcctac ctacctgctt
     1861 ccagaaatcc ttaggaaaat ggaggccaga tgcaaaccct gcctggattg gcacatcatg
     1921 gctgccaacc acccatggag gcggctgggc cctgcctgtc ctacacgaag gcacctggga
     1981 cccttcacta tcacactatg ttctcagact gggaaatagt accctgggca cattgtactg
     2041 gacctgcttc tccccaaaat tgatgttgtt ttatccggct tcctaagctc tcgtgccctg
     2101 ggccactgga caggaccgcc acgccccctc tctgcctctt cagtctgtga gtgtggcagc
     2161 gctcacacat cccacaggac tgatggtggc aacggcatcg tcagttaccg cctcagagca
     2221 gcacagcagg tattccagga gatgctattg gagagacaag gactgctgct ctgggggaca
     2281 ccggatgaaa attgtgggaa tgactttctc agaaccttgg gtacagactt agcagaccca
     2341 cagttccaca ctgttgcatt acccactctt ctgtcctgct tctgcctgcc ctgcttgaga
     2401 gcacccaaac cgcacccagt ctgcagtgtg ggtcagggca ggggtgggtg gcctgctgct
     2461 ggtcgggaca gcaggaatag aaaccaggcc tgctctattt ctcctggagc ctagacctgg
     2521 gctacattgg cttcaggtgc tgggcctcgt cagcaagacc atgttctggt tgctcctttg
     2581 cagatacttg gagtatcatc tcctcccacc ctgcagaggt tcaggcattc ttccccttct
     2641 cccacgaact ctggggccca ggaacacaaa gccccaggac tggatgtgtg tgtgtgtgtg
     2701 tgtgtgtgtg tgtgtgtgcg cgcgcgcgtg agtgtgtatt gggtggtggg tgggtttggg
     2761 atggacatgg gttatcttac agagacctct cttcattttg atgtggagaa ttggcccttg
     2821 tgactcagag ggtcatagat gggcttcctg ggcccagtgt gccttggttg tggccattct
     2881 gcctccgccc caaccctcac acagtgtggg ggtgcagcac aggggaaacc cagagaccat
     2941 gcccagccaa gtctacagtt tccagctgtt gtcatgtggc tcccacatgg atcttgggca
     3001 cccctttcta actacctgtg tcagttacaa gaggctaaca atggcatatg gtggcttctg
     3061 gtggcaccgt aggtgctgag ttaggctgtg gcattgttgc tgccaaaagc aggcgtggtg
     3121 ggtgggggga ggtccctgcc ctggtccagt gtaaagctgg taacagctct gcttgcattt
     3181 cacctgggga agagagtggg gtacgtggcc aggaccttga ctgaagaagg gagccctggg
     3241 tgcttggggt gtggcgatct tcatgctgag ttccaaagtg tagtccctcc caaagtcatt
     3301 tgtgtgaggc agagaaagcc acactctgaa cacatttcat gtctcaggaa ttcacattcc
     3361 agattcagga attttattcc aaagtccttt ggtgcaccta catccacagt tctgaagcca
     3421 gaggcagcag tgtgccccag agaccagcca cggtctctcc ttgggaggag ccaggtgtct
     3481 ccttgtggcc tacctcccca tagagtcaca gcaggaggcc ttctgactcc gccactgtct
     3541 gcacacggga aggataaaag gactctaagc cccatcatct tggaataaaa gaaagagctg
     3601 gtttgtttta gagcgggttg ggggggaggg ggagggagag tgggcatagg ctgtttccaa
     3661 agagagcact taatttaatt tttcctctga atgacccagg gctgttccat ctgatagatg
     3721 gaagggtaac gttgccttaa aacagaaata tgcaggcgtt ggctattttt ggcaaatgaa
     3781 cgtgtcttca ttcccaaagt ggttctcctt taatggcagg gtgtggtcct ttggcatggg
     3841 gccagggcac ccctcataga ccccctctat atcatctggg gcttcagttc atgtcttcaa
     3901 ggggtgggag gaaggaagga acatgactca ctaacttcag ttccaggggc ttttcattag
     3961 gttcccatct tgtcataata aacaagggat gccttcgaag atgcagtctt cccagacccg
     4021 ggtctgtagt aggatctttg agtttcttgc ggtttatggc catattttct ggtttcagtt
     4081 tgactgagga acccctaggg tgcccaggaa taatactgaa aagtcaaatc tttattttcg
     4141 ggatgggaat cagagatccc acaatgaaag tgcctgagtg aagggagagt tcctacagca
     4201 gtgtcagaac tctggacttc agccatcaag ggtctggagt ttagctcatg tcccaaatga
     4261 gaaagtcctt ctttgcatca gccatattat ggggccactg tctgttcccc cagatgccta
     4321 ctgaattcta cagccataca gaaaatagcc ctttccaaag agggccttcg gttctctctt
     4381 gatgggtgct acgtaggggt ggacagtgat gccctcgatg ggagtgtggt cctggaggtg
     4441 ccctactgtg tcctgccatg ccccttactc acaggacatg agatgcaaag gctccccacc
     4501 tccagcccac accatggcaa ccttgttctg agtccagcat tggggcaggt ggacaattca
     4561 ccagagtgca gcctctgggt gcaaaattct gcaccctggc aaccccagtg aggggtggtt
     4621 tagatgtcgg gatggatgag gggaggtgac attctctgga cccaagagaa atgtggcaga
     4681 acagagcggt tacctttcaa gacgaatgaa tgcctcggcc ccactccgtc cagaagactg
     4741 gcccttttct tgccagaagc aggtgctacg atggactgca cagggtcaca gcatttccta
     4801 gaggcttcag ctgggatctc caccaagcag gggtgccgtc catgtgagac taacctgagc
     4861 aatagcttgg cctcgtctct cagctctgat tgtggctttg gttacaaggc tacctatttt
     4921 gacctctgac aggtgttacc cactgtccct cccccctccc ctgtcccact tcacaaaagg
     4981 tcatttggtt agagacagtg ctggcaggtc tatgtgtagc tatgttgtga tcgggaagag
     5041 atactttgta ggtcacccac ttttgtcttt tttttttttt tttttttttt tttttttctg
     5101 tccaaagttt ccatctgtcc gttctggaag ctgtatcttt caaagctaaa atccagatgt
     5161 ttgactcact gttttgaaat taggatggca tgaggaagag ccaggtcctg tgactaattt
     5221 tcctgattct gagtcttcga aggtttgtcc tggacacatt ccagagaatt tcgtacccaa
     5281 acatggatgc acagtccagc ttactactga tacaggcctg agcactgctg agggagaggc
     5341 ccttcctctt ggtggccagc ggtcccagtc caccagggaa gggaggtttg attggtttct
     5401 ttgacccata cagagttagt ggacttgctc tggaactcta gcctagccca gcccagtcgt
     5461 agtgtcccct cccccccctc ccccatctca cacagcttta aaaccgtact acttttattt
     5521 agaaacaaac aggatggcag agaggacacc tcccccgcat tcctgggggt gggcaggaaa
     5581 cttaggtcag gcctgagagc gggtccggct gtttccctag agtacttact gtgggtaggc
     5641 tgcctgtgct catttgccca atgcctgtgg gccaggttgc ctgtctcagt actgagactc
     5701 tagacttagg agaatcctct cccaggagta gctagttcta cgtcccttgt gactcaagac
     5761 actgcctggt catctgctcc agtggcagac ctgacttaca atgtctaccc tagtatgtgg
     5821 gtagaaggat ctttctgttc ccccattgca cactggagaa gccctgggta ccgagtgtgg
     5881 ggaccccatg gacagtacca taaggctccc tgctgagcca ctatgcattg tggggtcaga
     5941 gctcctgtcc ctccttggtg actgggaatc cctgctgtgg ttttgttgga caggcccagg
     6001 tgactgcttc ccatccaaag ccatcggtgg aacttctggg ggatcctttg ccaaaacccc
     6061 aaggcaaaat ccaaggtcca aggccatttc cagcagcttc ccagttccct ttcccatagg
     6121 aacttttttg ttgaaaccta gctcccaaca tgcttccaaa ggccatgttc cgtctttcct
     6181 ggatcactac agtgaagtat tacagttgta cagtttccca atctggcctt ggcttgctcg
     6241 gataaaactt tgttatgtat tttgtaaggc atagattcta tattgtaatg tcctatgcaa
     6301 aagaaaaaaa attaatgaaa ttgtaaattt tattgtttta acatgtatgc atgtttagtg
     6361 acgtttacat tttgaaataa aatttatgat tcatta
//
