LOCUS       NM_178357               3982 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Kruppel-like transcription factor 11 (Klf11), mRNA.
ACCESSION   NM_178357 NM_153401
VERSION     NM_178357.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3982)
  AUTHORS   Grande,J., Jones,T.L., Sun,Z., Chanana,P., Jaiswal,I.,
            Leontovich,A., Carapanceanu,N., Carapanceanu,V., Saadalla,A.,
            Osman,A., Famuyide,A.O., Daftary,G.S., Khan,Z. and Khazaie,K.
  TITLE     Host immunity and KLF 11 deficiency together promote fibrosis in a
            mouse model of endometriosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166784 (2023)
   PUBMED   37321514
  REMARK    GeneRIF: Host immunity and KLF 11 deficiency together promote
            fibrosis in a mouse model of endometriosis.
            Erratum:[Biochim Biophys Acta Mol Basis Dis. 2024
            Mar;1870(3):166923. doi: 10.1016/j.bbadis.2023.166923.. PMID:
            37949756]
REFERENCE   2  (bases 1 to 3982)
  AUTHORS   Gu,Y., Zhou,Y., Ju,S., Liu,X., Zhang,Z., Guo,J., Gao,J., Zang,J.,
            Sun,H., Chen,Q., Wang,J., Xu,J., Xu,Y., Chen,Y., Guo,Y., Dai,J.,
            Ma,H., Wang,C., Jin,G., Li,C., Xia,Y., Shen,H., Yang,Y., Guo,X. and
            Hu,Z.
  TITLE     Multi-omics profiling visualizes dynamics of cardiac development
            and functions
  JOURNAL   Cell Rep 41 (13), 111891 (2022)
   PUBMED   36577384
REFERENCE   3  (bases 1 to 3982)
  AUTHORS   Zhou,C., Sun,P., Hamblin,M.H. and Yin,K.J.
  TITLE     Genetic deletion of Kruppel-like factor 11 aggravates traumatic
            brain injury
  JOURNAL   J Neuroinflammation 19 (1), 281 (2022)
   PUBMED   36403074
  REMARK    GeneRIF: Genetic deletion of Kruppel-like factor 11 aggravates
            traumatic brain injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3982)
  AUTHORS   De Lorenzo,S.B., Vrieze,A.M., Johnson,R.A., Lien,K.R., Nath,K.A.,
            Garovic,V.D., Khazaie,K. and Grande,J.P.
  TITLE     KLF11 deficiency enhances chemokine generation and fibrosis in
            murine unilateral ureteral obstruction
  JOURNAL   PLoS One 17 (4), e0266454 (2022)
   PUBMED   35413089
  REMARK    GeneRIF: KLF11 deficiency enhances chemokine generation and
            fibrosis in murine unilateral ureteral obstruction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3982)
  AUTHORS   Zhao,G., Chang,Z., Zhao,Y., Guo,Y., Lu,H., Liang,W., Rom,O.,
            Wang,H., Sun,J., Zhu,T., Fan,Y., Chang,L., Yang,B.,
            Garcia-Barrio,M.T., Chen,Y.E. and Zhang,J.
  TITLE     KLF11 protects against abdominal aortic aneurysm through inhibition
            of endothelial cell dysfunction
  JOURNAL   JCI Insight 6 (5), 141673 (2021)
   PUBMED   33507881
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3982)
  AUTHORS   Song,C.Z., Gavriilidis,G., Asano,H. and Stamatoyannopoulos,G.
  TITLE     Functional study of transcription factor KLF11 by targeted gene
            inactivation
  JOURNAL   Blood Cells Mol Dis 34 (1), 53-59 (2005)
   PUBMED   15607700
  REMARK    GeneRIF: results from genetic knockout suggest that KLF11 is not
            absolutely required for hematopoiesis, growth, and development
REFERENCE   7  (bases 1 to 3982)
  AUTHORS   Wang,Z., Peters,B., Klussmann,S., Bender,H., Herb,A. and
            Krieglstein,K.
  TITLE     Gene structure and evolution of Tieg3, a new member of the Tieg
            family of proteins
  JOURNAL   Gene 325, 25-34 (2004)
   PUBMED   14697507
REFERENCE   8  (bases 1 to 3982)
  AUTHORS   Fernandez-Zapico,M.E., Mladek,A., Ellenrieder,V., Folch-Puy,E.,
            Miller,L. and Urrutia,R.
  TITLE     An mSin3A interaction domain links the transcriptional activity of
            KLF11 with its role in growth regulation
  JOURNAL   EMBO J 22 (18), 4748-4758 (2003)
   PUBMED   12970187
  REMARK    GeneRIF: KLF11 is downregulated in human cancers, inhibits cell
            growth in vitro and in vivo, and suppresses neoplastic
            transformation
REFERENCE   9  (bases 1 to 3982)
  AUTHORS   Hsieh,C.M., Fukumoto,S., Layne,M.D., Maemura,K., Charles,H.,
            Patel,A., Perrella,M.A. and Lee,M.E.
  TITLE     Striated muscle preferentially expressed genes alpha and beta are
            two serine/threonine protein kinases derived from the same gene as
            the aortic preferentially expressed gene-1
  JOURNAL   J Biol Chem 275 (47), 36966-36973 (2000)
   PUBMED   10973969
REFERENCE   10 (bases 1 to 3982)
  AUTHORS   Scohy,S., Gabant,P., Van Reeth,T., Hertveldt,V., Dreze,P.L., Van
            Vooren,P., Riviere,M., Szpirer,J. and Szpirer,C.
  TITLE     Identification of KLF13 and KLF14 (SP6), novel members of the
            SP/XKLF transcription factor family
  JOURNAL   Genomics 70 (1), 93-101 (2000)
   PUBMED   11087666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038397.1 and DV654709.1.
            
            On Jul 18, 2009 this sequence version replaced NM_178357.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060642.1, AK050156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3825              AK038397.1         99-3923
            3826-3982           DV654709.1         466-622
FEATURES             Location/Qualifiers
     source          1..3982
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.49 cM"
     gene            1..3982
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /note="Kruppel-like transcription factor 11"
                     /db_xref="GeneID:194655"
                     /db_xref="MGI:MGI:2653368"
     exon            1..196
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1663
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /note="TIEG-3; TGFB-inducible early growth response
                     protein 3; transforming growth factor-beta-inducible early
                     growth response protein 3; TGFB inducible early growth
                     response 2; TGFB inducible early growth response 3;
                     TGFB-inducible early growth response protein 2b;
                     Kruppel-like factor 11"
                     /codon_start=1
                     /product="Krueppel-like factor 11"
                     /protein_id="NP_848134.1"
                     /db_xref="CCDS:CCDS25842.1"
                     /db_xref="GeneID:194655"
                     /db_xref="MGI:MGI:2653368"
                     /translation="MHSPGSTGPGDGRAADIMDICESILERKRHDSERSTCSVLEQTD
                     IEAVEALVCMSSWGQRSQMRPLTPVSDSGDVTTAVLMDTAAPDLPKDFHSFSTLCITP
                     PQSPELTEPSTGTPVPSQVVNSKGCMVTALPPSPAGGPRTLSKREPLEPASGSSCRAV
                     MTSVIRHTGESPAPTRFPTGPTQEQRASDSGEGQERLLDHLEALQDTRLANGLLVTNL
                     VSCQPCLHKSGGSFPTDKGQQTGWPAAVQTCLPKNPESDLSRKITPLISVPVSSPPVL
                     CQMIPVAGQNGLFSAFLKPPTQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLP
                     QNTFPQPAACPSSVMAIGNTKLLPLAPAPVFLASSQNCAPQVDFSRRRNYVCNFPGCR
                     KTYFKSSHLKAHLRTHTGEKPFTCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCD
                     RRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRITLAESPGSILEPLPASG"
     exon            197..448
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..1382
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..3982
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /note="hexamer: AATAAA"
     polyA_site      2047
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /note="major polyA site"
     regulatory      3956..3961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /note="hexamer: TATAAA"
     polyA_site      3982
                     /gene="Klf11"
                     /gene_synonym="9830142A17; D12Ertd427e; Tieg2; Tieg2b;
                     Tieg3"
                     /note="major polyA site"
ORIGIN      
        1 gggccgcgcg gaggcagagc cgcgcggcaa ggaaggcgga ggtgcgcgcc gggaacagac
       61 gctcgggaca ccgccgcccg ccgcacacgt gcagcctccg ccgcacgcag ggctcctgcc
      121 tcgcagcatt gctgcctgca ggccatacgg caccatgcac tcgccgggct ccaccggccc
      181 cggcgacggg cgcgcggctg acatcatgga catttgtgag tcgatcctgg agaggaagcg
      241 gcatgacagc gaaaggtcca catgcagcgt cctggagcag acggacatcg aagctgtgga
      301 agctcttgtc tgcatgagct cttggggtca gaggtcccag atgagacccc tcacgcctgt
      361 ctctgactct ggtgacgtca ccactgctgt gcttatggac acagctgcac ctgatctacc
      421 aaaggacttc cattcttttt caactctgtg tataactcct cctcagagcc cagagctcac
      481 ggagccgtca acagggaccc ctgttccttc ccaagtagtt aactccaaag gatgcatggt
      541 cactgccctc cccccatccc ctgctggggg ccccagaaca ctgagcaaga gggaaccact
      601 ggagccagcc tcagggtcct cctgcagggc tgtgatgacc agtgtgatcc gtcacaccgg
      661 ggagagtcct gctcctacgc gcttcccaac tggccccact caagagcaac gagcatccga
      721 cagcggagaa ggacaggagc gtttgctgga ccacctcgaa gccttgcagg acacacgctt
      781 ggcaaatggc ttactcgtca ctaacttggt ttcctgtcag ccttgcttgc acaagtccgg
      841 tggttcgttc cccactgaca aaggtcaaca gacaggatgg cccgctgctg ttcagacctg
      901 cttaccaaag aatcctgaaa gtgacttgtc aaggaaaatc acccctctga tttctgtccc
      961 tgtatccagt ccccctgtcc tttgccagat gatccctgtg gctggacaga atggcttgtt
     1021 ctcagccttt ttgaaacctc ctacccagtt gcctgcaggg actatcaagc ccatcctacc
     1081 ccaagctgct tcaatgtctc agcctgtgtt catgggccca cctgtgcctc agggaactgt
     1141 gatgctggtc ttgccacaga acaccttccc ccagcctgct gcctgtccat ccagtgtcat
     1201 ggccattgga aataccaagc tgttgcccct tgcccctgca ccagtgttcc ttgcctccag
     1261 ccagaactgt gcccctcagg tagacttttc ccgaaggagg aactatgttt gcaacttccc
     1321 aggatgccgg aagacctact tcaaaagttc ccaccttaaa gctcatcttc gcactcacac
     1381 aggggagaag ccttttacct gcagctggga cggctgtgac aagaagttcg caaggtcaga
     1441 tgaactgtct cgccaccgca ggactcacac gggagagaag aagtttgtgt gtcctgtgtg
     1501 tgaccggcgc ttcatgcgga gtgaccacct gacaaagcac gctcgtcgcc acatgacaac
     1561 caagaagatc ccaggctggc aggcagaggt gggcaagctg aacagaatca ctttggcaga
     1621 gagccccggg agcatcctcg aacccttgcc ggcctctggc tgaggcatcc ttctgtggca
     1681 tccgtcacct gtgggcttct tcaaaagcct cttcaggaat ggaacctgtg tgttcctctc
     1741 caaaaataaa tgtggtctct gggctgttga agtggggagc tggttctgat ggaagtatat
     1801 taattttact tttctggttg ggaccctgtt tgatatcttt tgtagtttta gaactctgac
     1861 tgtctttgtc tgtgtgtgtg tctctgtgtg tgtgtctctg tgtgtgtgtg tgtctgtgtc
     1921 tgtgtgtgtc tgtgtctctg tcgtgtctct gtctctctct ctcttttgta aggaaatgga
     1981 agaaaatttg ctctaaatca ccagcattca aacaaatatt tctgcaataa agtttacaaa
     2041 gtctggattt ttttttatac ctttctattc atgttttgta gaaatgtgac agggtactaa
     2101 tttttatact ttttataaaa atatttatat tgtgctcaaa tcaccagttt gtggatagaa
     2161 aattttacag ccttcttttc catgttttat aacaaagttt tgtaataacc ctgcttaaga
     2221 gtaagcctgg tagttagtca gaaagaagca aaaataacaa gtttgttacc agccttttat
     2281 agtcaatatt ttagatcaga actggttgaa taaagaactc ttaaagggga aaaataaact
     2341 ttgtagttag cttctttgta tcagtttcag gggaaattct agcaatcgat cctatagccc
     2401 acagaactaa gattgtggtt aggtaaaact aatcatgtga gtctcgtgtc cctgtggaag
     2461 gtgtgcccag tctgcctggg ctgctggcca gctgagcagg ggcaaatatg gaatgtggac
     2521 tcctgggcca tctgtctgct aagagcaaat gaccccatgt cctgtctgtg ttaagcacca
     2581 acactaagaa tgtagacgca gaaactctgt atgttacctg ttggcttctg ttgtggtttt
     2641 gtactgcgtg ctagattgaa tgaccacagg gaaaaggaaa tgtctgtact ggttggttaa
     2701 actctccgcc agagtgcagc ttccacaaag caaggccttt gtgcacattc ggctctgggg
     2761 ttcggatgcc tctctgacta tggacaaaac actgagaaac atatcattaa atggcagtgg
     2821 ctgtcaccca actgcttttt caatcattgt gtgtgaagga aattagtttg ctcaaacaag
     2881 aagacttgga atgggtatat tgtagctttc ctgaaaacag atttcaggca ctgcttttac
     2941 gcctcgtgag cgggtgttct gcatccaggt gatcacaaaa acagaatggt tttagataaa
     3001 ttctgggaag ctcaggcagt acagcaagtg tgataacagg tatattgtgc tgtttgggca
     3061 gcctgagact atttttgtgt ggtatgtatt aggttttgta tttgcctttt aatcattggt
     3121 atttaacttt attaaatgat ggcaaggttg aaataattaa acgtaaaatg aggcttttgt
     3181 gttcaggtct tttgagcctt atataaccgt tatgtggtca taccttgtat gttacttgac
     3241 ccctgttaag ctgctgtggt agccgagttc tgtatgtaca tgtgtttagg aactgcccag
     3301 acagcagtct tgctaatgtc tttcaacata atggagtgca ggaaaactaa ctgtatatag
     3361 ctcacgtgtg tcccagcacc ctggtcctgt ccacctgttt taagtcagca tccacactgg
     3421 cgaccgtgta agtgataaat ggcatccaac ttggatgtct tttttcattg tgacatgcag
     3481 agtgctgttc cttgtcctgg catttctgtg ggtagcggaa ggccttgggg tgtttggttg
     3541 ctcatcacag gactttatct gaccagtgtt gtttctaaat gactggtgtg ttgcaatgcc
     3601 attaggtttc catttcccaa ttagatttag aaaccccttt tctgaaagag cccccaacat
     3661 ttgtctactg aaagactaag ttggaaaaca gttcctatct gaaaaggacc cctgagcccc
     3721 agagccccgg gagtggctgc tcccttgagg gccctcccca aatccccacg gcgtggtggt
     3781 gaccccagtg cactttatcg cttgagaagt tcttgatttt tttttaatta ttttgttgag
     3841 cctttcagta gttttagtaa taaaagttta aatgttaaca acttttgttt tatgtaaaag
     3901 actttgactt atttaaatga acatgtgtaa tgtaactttt tttttctttg aatcgtataa
     3961 aattctcttg gttcgcagac aa
//
