LOCUS       NM_001357677            3248 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 10 (Klf10),
            transcript variant 3, mRNA.
ACCESSION   NM_001357677 XM_006520046 XM_036159317
VERSION     NM_001357677.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3248)
  AUTHORS   Luo,H.Y., Mu,W.J., Chen,M., Zhu,J.Y., Li,Y., Li,S., Yan,L.J.,
            Li,R.Y., Yin,M.T., Li,X., Chen,H.M. and Guo,L.
  TITLE     Hepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of
            NASH in mice
  JOURNAL   Metabolism 155, 155916 (2024)
   PUBMED   38615945
  REMARK    GeneRIF: Hepatic Klf10-Fh1 axis promotes exercise-mediated
            amelioration of NASH in mice.
REFERENCE   2  (bases 1 to 3248)
  AUTHORS   Pan,X., Hu,S., Xu,Y., Gopoju,R., Zhu,Y., Cassim Bawa,F.N., Wang,H.,
            Wang,J., Batayneh,Z., Clark,A., Zeng,Y., Lin,L., Wang,X., Yin,L.
            and Zhang,Y.
  TITLE     Kruppel-like factor 10 protects against metabolic
            dysfunction-associated steatohepatitis by regulating
            HNF4alpha-mediated metabolic pathways
  JOURNAL   Metabolism 155, 155909 (2024)
   PUBMED   38582490
  REMARK    GeneRIF: Kruppel-like factor 10 protects against metabolic
            dysfunction-associated steatohepatitis by regulating
            HNF4alpha-mediated metabolic pathways.
REFERENCE   3  (bases 1 to 3248)
  AUTHORS   Xin,L., Liu,Z.Y., Liu,C.X., Sheng,J., Zhou,Q., Yuan,Y.W., Yue,Z.Q.,
            Lu,H. and Gan,J.H.
  TITLE     KLF10/CBS increases the sensitivity of gastric carcinoma cells to
            methionine restriction by promoting sulfur transfer pathway
  JOURNAL   Exp Cell Res 437 (1), 114007 (2024)
   PUBMED   38499142
  REMARK    GeneRIF: KLF10/CBS increases the sensitivity of gastric carcinoma
            cells to methionine restriction by promoting sulfur transfer
            pathway.
REFERENCE   4  (bases 1 to 3248)
  AUTHORS   Tatarenko,Y., Li,M., Pouletaut,P., Kammoun,M., Hawse,J.R.,
            Joumaa,V., Herzog,W., Chatelin,S. and Bensamoun,S.F.
  TITLE     Multiscale analysis of Klf10's impact on the passive mechanical
            properties of murine skeletal muscle
  JOURNAL   J Mech Behav Biomed Mater 150, 106298 (2024)
   PUBMED   38096609
  REMARK    GeneRIF: Multiscale analysis of Klf10's impact on the passive
            mechanical properties of murine skeletal muscle.
REFERENCE   5  (bases 1 to 3248)
  AUTHORS   Peng,R., Shang,J., Jiang,N., Chi-Jen,H., Gu,Y., Xing,B., Hu,R.,
            Wu,B., Wang,D., Xu,X. and Lu,H.
  TITLE     Klf10 is involved in extracellular matrix calcification of
            chondrocytes alleviating chondrocyte senescence
  JOURNAL   J Transl Med 22 (1), 52 (2024)
   PUBMED   38217021
  REMARK    GeneRIF: Klf10 is involved in extracellular matrix calcification of
            chondrocytes alleviating chondrocyte senescence.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3248)
  AUTHORS   Hollnagel,A., Oehlmann,V., Heymer,J., Ruther,U. and Nordheim,A.
  TITLE     Id genes are direct targets of bone morphogenetic protein induction
            in embryonic stem cells
  JOURNAL   J Biol Chem 274 (28), 19838-19845 (1999)
   PUBMED   10391928
REFERENCE   7  (bases 1 to 3248)
  AUTHORS   Fautsch,M.P., Vrabel,A., Rickard,D., Subramaniam,M., Spelsberg,T.C.
            and Wieben,E.D.
  TITLE     Characterization of the mouse TGFbeta-inducible early gene (TIEG):
            conservation of exon and transcriptional regulatory sequences with
            evidence of additional transcripts
  JOURNAL   Mamm Genome 9 (10), 838-842 (1998)
   PUBMED   9745041
REFERENCE   8  (bases 1 to 3248)
  AUTHORS   Yajima,S., Lammers,C.H., Lee,S.H., Hara,Y., Mizuno,K. and
            Mouradian,M.M.
  TITLE     Cloning and characterization of murine glial cell-derived
            neurotrophic factor inducible transcription factor (MGIF)
  JOURNAL   J Neurosci 17 (22), 8657-8666 (1997)
   PUBMED   9348334
REFERENCE   9  (bases 1 to 3248)
  AUTHORS   Blok,L.J., Grossmann,M.E., Perry,J.E. and Tindall,D.J.
  TITLE     Characterization of an early growth response gene, which encodes a
            zinc finger transcription factor, potentially involved in cell
            cycle regulation
  JOURNAL   Mol Endocrinol 9 (11), 1610-1620 (1995)
   PUBMED   8584037
REFERENCE   10 (bases 1 to 3248)
  AUTHORS   Stone,B. and Wharton,W.
  TITLE     Targeted RNA fingerprinting: the cloning of
            differentially-expressed cDNA fragments enriched for members of the
            zinc finger gene family
  JOURNAL   Nucleic Acids Res 22 (13), 2612-2618 (1994)
   PUBMED   7518916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122459.2.
            
            On or before Sep 2, 2022 this sequence version replaced
            XM_036159317.1, NM_001357677.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.10832997.1,
                                           SRR13861859.815641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC122459.2         152644-152791       c
            149-352             AC122459.2         151782-151985       c
            353-583             AC122459.2         149707-149937       c
            584-1496            AC122459.2         148700-149612       c
            1497-3248           AC122459.2         146498-148249       c
FEATURES             Location/Qualifiers
     source          1..3248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.15 cM"
     gene            1..3248
                     /gene="Klf10"
                     /gene_synonym="Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1;
                     Tieg1"
                     /note="Kruppel-like transcription factor 10"
                     /db_xref="GeneID:21847"
                     /db_xref="MGI:MGI:1101353"
     exon            1..148
                     /gene="Klf10"
                     /gene_synonym="Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1;
                     Tieg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1756
                     /gene="Klf10"
                     /gene_synonym="Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1;
                     Tieg1"
                     /note="isoform 3 is encoded by transcript variant 3; TGFB
                     inducible early growth response 1; krueppel-like factor
                     10; GDNF-inducible factor; transcription factor GIF;
                     TGFB-inducible early growth response protein 1;
                     Kruppel-like factor 10; transforming growth
                     factor-beta-inducible early growth response protein 1"
                     /codon_start=1
                     /product="Krueppel-like factor 10 isoform 3"
                     /protein_id="NP_001344606.2"
                     /db_xref="GeneID:21847"
                     /db_xref="MGI:MGI:1101353"
                     /translation="MLNFGASLQQASGAGSCLGARQLGGGVGTARRGGRVSRREPWGR
                     APGARAVGAARLGACRDCLRGLRLPETAVGRMLQMREGKMELISEKPREGMHPWDKAE
                     QSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEDDSLLPGTPDLQTVPAFCLT
                     PPYSPSDFEPSQGSNLTASAPSTGHFKSFSDAAKPPGATPFKEEEKNPLAAPPLPKAQ
                     ATSVIRHTADAQLCNHQSCPVKAASILNYQDNSFRRRTHGNVEATRKNIPCAAVSPNR
                     SKPEPSTVSDGDEKAGAALYDFAVPSSETVICRSQPAPSSPVQKSVLVSSPTVSTGGV
                     PPLPVICQMVPLPANNSLVSTVVPSTPPSQPPAVCSPVLFMGTQVPEGTVVFVVPQPV
                     VQSPRPPVVSPSGTRLSPIAPAPGFSPSAARVTPQIDSSRVRSHICSHPGCGKTYFKS
                     SHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRS
                     DHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPTPASAQ"
     exon            149..352
                     /gene="Klf10"
                     /gene_synonym="Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1;
                     Tieg1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..583
                     /gene="Klf10"
                     /gene_synonym="Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1;
                     Tieg1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..1496
                     /gene="Klf10"
                     /gene_synonym="Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1;
                     Tieg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..3248
                     /gene="Klf10"
                     /gene_synonym="Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1;
                     Tieg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3226..3231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf10"
                     /gene_synonym="Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1;
                     Tieg1"
                     /note="hexamer: AATAAA"
     polyA_site      3248
                     /gene="Klf10"
                     /gene_synonym="Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1;
                     Tieg1"
                     /note="major polyA site"
ORIGIN      
        1 agacagcgcg gagcgcggtg gcgtcgacgt ctagtgtctc agtgctcccg tctgtggcta
       61 actaagcagc cagcagccag gcagctcgcg acctgcggcc aggcagccaa ccatgctcaa
      121 cttcggcgct tctctccagc aagcttcggg ggcagggtcc tgccttggag cccgacagct
      181 tggcggggga gtcgggaccg cgagacgcgg gggccgcgtg tcgaggcggg aaccgtgggg
      241 ccgcgcgcct ggagcccgtg ctgtgggcgc cgcacgtctg ggagcctgca gagactgctt
      301 gcgggggctc aggctgccgg aaacagcagt cggacgaatg ctgcagatgc gggaggggaa
      361 aatggaacta atttctgaaa agcccagaga ggggatgcat ccctgggaca aagctgagca
      421 gagtgacttt gaagcggtgg aagcgctcat gtccatgagc tgcgactgga agtctcattt
      481 caagaaatac cttgaaaaca ggcctgtcac accagtgtct gatacctccg aggatgacag
      541 cttgcttcca gggacgcctg accttcagac agtcccagca ttttgtttaa cgccacctta
      601 cagcccctct gacttcgaac cctcccaagg gtcaaatctg actgcatcag cgccatctac
      661 tggccacttc aaatctttct ccgatgctgc caagcctcca ggcgccactc ctttcaaaga
      721 ggaggaaaag aatcctttag ctgcccctcc tcttcctaag gctcaagcca ccagtgtcat
      781 ccgtcacaca gctgatgccc aactgtgcaa ccaccagtcc tgccccgtga aagcagctag
      841 catcctcaac tatcaggaca attctttccg gagaagaacc cacggaaatg ttgaggctac
      901 tcgaaagaac ataccctgtg ctgcagtgtc accaaacaga tccaagcctg agcccagcac
      961 agtgtccgat ggtgatgaga aggcgggcgc tgcactatat gactttgctg tgccttcctc
     1021 agagacagta atttgtaggt ctcagccagc tccttcgtcc ccagtgcaga agtcagtact
     1081 ggtgtcttca cctacagtat ccactggggg agtgccaccc ctgcctgtca tctgccagat
     1141 ggttcccctt cctgccaaca actctcttgt tagcacagtt gtccccagca ctcctcctag
     1201 ccagccacca gctgtctgct cacctgtgtt gttcatgggc actcaggtgc ctgagggcac
     1261 cgtcgtgttt gtggtacccc agcccgttgt gcagagccca aggcctccag tggtgagccc
     1321 cagtggcacc agactgtctc ccattgcccc tgctcctgga ttctctcctt cagcagcaag
     1381 ggtcactcct cagattgact cgtccagagt aagaagtcac atctgtagcc acccagggtg
     1441 tggcaagact tactttaaaa gttcccatct gaaggcccac gtgaggacac acacagggga
     1501 aaaacctttc agctgcagct ggaaaggctg tgaaaggagg tttgctcgct ccgatgaact
     1561 gtccagacac cggcggacac acacaggtga gaagaagttt gcctgtccca tgtgtgaccg
     1621 tcggtttatg aggagcgacc atttaaccaa gcatgcccga cgccacctat cagccaagaa
     1681 gctgccaaac tggcaaatgg aagttagcaa gttaaatgac attgctctgc ctccgacccc
     1741 tgcttccgca cagtgacggc cagaagatgg agacgcagaa taaactttgg tcagagtcag
     1801 gagccagtga tggtgtcaag tgcttctgca aggctgtggc cctccaaaag ggcctaaagt
     1861 agaagccctg gcctggggga ggccccgcct gggtgaaatg acaagaagtg cttcagccac
     1921 aggcaggtca cagaggacag ggctcagttc ttaccacaga gagagaggag aaccctttta
     1981 ttcctccctt attttagtct ggaaagtttc ggctgaggtg agcgcagcac aggttttgaa
     2041 tcacatacac attggggact ttgtttttgc catttatact tgagaccagc tttgcagtgt
     2101 gattctttca aaggattggt ttcaagaata tagaggctgg aaattacggt acagaaatgg
     2161 agctagaaaa tgagtttgtg ttacacagag atgtcatctt ctcctagagt tatcttgttt
     2221 cttattccta gtctttccag tcaaatccgt ggatgtagct aagtatatct aaaactcatt
     2281 tttccactat tgttggtatt tgaagttgaa cagctgtaca ttgctgtggg ggagccaaag
     2341 gattggaacc ctcattaatt taattgcttg gaaatgcagc taaaattctt ctttggcatt
     2401 ttgttttgaa agtttaggca ttttactcta ctttagattt tagtttgctt gcagtttttt
     2461 gtgtagattt gaaaattgta taccaatgtg ttttctgtag gcttaaaata cactgcactt
     2521 tgtttagaaa aaaatctgga gatgaaaata tgtattataa agaagagatg tcaagaattt
     2581 gagataactc cttgagaaag ttggctttat gtcatcagca aaggacactt aacgtcaagc
     2641 atacactgtg gtttttttgt ttttttgttt ttttttttca aattagaaag tttaatgacc
     2701 gttacagatg gacagtgtct ttttatttat aggagttttt caggatgtca gagtagatag
     2761 gtaggaaaat tgttattaga acattcgctt ctaccttgaa aaggatgtta atgtggtcat
     2821 gttcttagca ccacagtgtc tgggcatctg ggaaactccg agactttttt aaagtgtcat
     2881 gatgtgatca cacctgcagt ttggggcatc gaatccaggg ccttgcatgt cttctgtaag
     2941 agctctcatc gctgacctgt atcccccgca agagcaatga cttttgctaa cagtatttct
     3001 tttctgttgt aaagtggaca gatgatacac ttggtcgcaa aggtaaatta ttcaaaatcc
     3061 acagtgaaaa cctcaccaca ctttcccatt taaactattt ccatatctca gaggtttctg
     3121 acatgcaaac ttgaaccctt gaaagaagag ttttcttaaa aattataaaa aatcacgagt
     3181 tacaatttgc acaatatttt ttgttgaact ttataccttg tttacaataa agacttttct
     3241 ttggtata
//
